SG10201405598QA - Pi3 kinase inhibitors and uses thereof - Google Patents
Pi3 kinase inhibitors and uses thereofInfo
- Publication number
- SG10201405598QA SG10201405598QA SG10201405598QA SG10201405598QA SG10201405598QA SG 10201405598Q A SG10201405598Q A SG 10201405598QA SG 10201405598Q A SG10201405598Q A SG 10201405598QA SG 10201405598Q A SG10201405598Q A SG 10201405598QA SG 10201405598Q A SG10201405598Q A SG 10201405598QA
- Authority
- SG
- Singapore
- Prior art keywords
- kinase inhibitors
- kinase
- inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24094709P | 2009-09-09 | 2009-09-09 | |
US37139610P | 2010-08-06 | 2010-08-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201405598QA true SG10201405598QA (en) | 2014-11-27 |
Family
ID=43733099
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201405598QA SG10201405598QA (en) | 2009-09-09 | 2010-09-09 | Pi3 kinase inhibitors and uses thereof |
SG2012016960A SG179085A1 (en) | 2009-09-09 | 2010-09-09 | Pi3 kinase inhibitors and uses thereof |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2012016960A SG179085A1 (en) | 2009-09-09 | 2010-09-09 | Pi3 kinase inhibitors and uses thereof |
Country Status (15)
Country | Link |
---|---|
US (1) | US20110230476A1 (fr) |
EP (1) | EP2475375A4 (fr) |
JP (1) | JP2013504325A (fr) |
KR (1) | KR20120063515A (fr) |
CN (1) | CN102625708A (fr) |
AU (1) | AU2010292198A1 (fr) |
BR (1) | BR112012008385A2 (fr) |
CA (1) | CA2773848A1 (fr) |
IL (1) | IL218555A0 (fr) |
MX (1) | MX339584B (fr) |
NZ (2) | NZ626650A (fr) |
RU (1) | RU2595718C2 (fr) |
SG (2) | SG10201405598QA (fr) |
TW (2) | TWI499592B (fr) |
WO (1) | WO2011031896A2 (fr) |
Families Citing this family (121)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200801012A (en) * | 2006-04-26 | 2008-01-01 | Piramed Ltd | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
LT2300013T (lt) | 2008-05-21 | 2017-12-27 | Ariad Pharmaceuticals, Inc. | Fosforo dariniai kaip kinazių inhibitoriai |
US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
KR20120093220A (ko) | 2009-09-16 | 2012-08-22 | 아빌라 테라퓨틱스, 인크. | 단백질 키나아제 컨쥬게이트 및 인히비터 |
US8946197B2 (en) | 2009-11-16 | 2015-02-03 | Chdi Foundation, Inc. | Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof |
CN102812167A (zh) | 2009-12-30 | 2012-12-05 | 阿维拉制药公司 | 蛋白的配体-介导的共价修饰 |
AR085397A1 (es) | 2011-02-23 | 2013-09-25 | Intellikine Inc | Combinacion de inhibidores de quinasa y sus usos |
AU2012225382B2 (en) * | 2011-03-09 | 2016-10-27 | Celgene Avilomics Research, Inc. | PI3 kinase inhibitors and uses thereof |
CN103501612B (zh) | 2011-05-04 | 2017-03-29 | 阿里亚德医药股份有限公司 | 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物 |
WO2012154610A1 (fr) * | 2011-05-06 | 2012-11-15 | Intellikine, Llc | Inhibiteurs réactifs de la pi3 kinase et leurs utilisations |
WO2012154608A1 (fr) * | 2011-05-06 | 2012-11-15 | Intellikine, Llc | Inhibiteurs réactifs des mtor et pi3 kinases et leurs utilisations |
US8889716B2 (en) | 2011-05-10 | 2014-11-18 | Chdi Foundation, Inc. | Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof |
WO2013010136A2 (fr) | 2011-07-13 | 2013-01-17 | Pharmacyclics, Inc. | Inhibiteurs de tyrosine kinase de bruton |
MX342326B (es) | 2011-09-27 | 2016-09-26 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
US8377946B1 (en) | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
EP2830615A1 (fr) * | 2012-03-28 | 2015-02-04 | Intervet International B.V. | Composés hétéroaryles à unité de pontage cyclique utilisés dans le traitement d'infections helminthiques |
US20150087628A1 (en) | 2012-04-10 | 2015-03-26 | The Regents Of The University Of California | Compositions and methods for treating cancer |
US9879003B2 (en) | 2012-04-11 | 2018-01-30 | Dana-Farber Cancer Institute, Inc. | Host targeted inhibitors of dengue virus and other viruses |
PL2841075T3 (pl) | 2012-04-26 | 2020-09-21 | The General Hospital Corporation | Środki i sposoby leczenia i zapobiegania rogowaceniu łojotokowemu |
WO2013169401A1 (fr) | 2012-05-05 | 2013-11-14 | Ariad Pharmaceuticals, Inc. | Composés pour inhiber la prolifération cellulaire dans les cancers induits par l'egfr |
WO2013173454A1 (fr) * | 2012-05-15 | 2013-11-21 | New York University | Modulateurs de phosphatidylinositol-3-kinase c2 bêta et leurs procédés d'utilisation |
WO2014012093A1 (fr) * | 2012-07-13 | 2014-01-16 | Wake Forest University Health Sciences | Promédicaments dirigés contre le cancer de la prostate et leurs méthodes d'utilisation |
WO2014022569A1 (fr) * | 2012-08-03 | 2014-02-06 | Principia Biopharma Inc. | Traitement de la sécheresse oculaire |
US11458199B2 (en) | 2012-08-21 | 2022-10-04 | Opko Pharmaceuticals, Llc | Liposome formulations |
KR102177437B1 (ko) * | 2012-08-21 | 2020-11-12 | 옵코 파마슈티칼스, 엘엘씨 | 리포좀 제제 |
DK3181567T3 (da) | 2012-09-10 | 2019-06-11 | Principia Biopharma Inc | Pyrazolopyrimidinforbindelser som kinasehæmmere |
WO2014063054A1 (fr) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Inhibiteurs de kinase moelle osseuse sur chromosome x (bmx) et leurs utilisations |
US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
AU2013364070B2 (en) | 2012-12-21 | 2016-10-27 | Gilead Calistoga Llc | Isoquinolinone or quinazolinone phosphatidylinositol 3-kinase inhibitors |
TW201441216A (zh) | 2012-12-21 | 2014-11-01 | Gilead Calistoga Llc | 肌醇磷酯3-激酶的抑制劑 |
ES2831625T3 (es) * | 2013-02-20 | 2021-06-09 | Kala Pharmaceuticals Inc | Compuestos terapéuticos y sus usos |
ES2665619T3 (es) | 2013-03-14 | 2018-04-26 | Novartis Ag | 3-Pirimidin-4-il-oxazolidin-2-onas como inhibidores de IDH mutante |
DK2970205T3 (da) | 2013-03-14 | 2019-07-29 | Tolero Pharmaceuticals Inc | JAK2- og ALK2-inhibitorer og fremgangsmåder til anvendelse deraf |
US9227978B2 (en) | 2013-03-15 | 2016-01-05 | Araxes Pharma Llc | Covalent inhibitors of Kras G12C |
US9745319B2 (en) | 2013-03-15 | 2017-08-29 | Araxes Pharma Llc | Irreversible covalent inhibitors of the GTPase K-Ras G12C |
WO2014151147A1 (fr) * | 2013-03-15 | 2014-09-25 | Intellikine, Llc | Combinaison d'inhibiteurs de kinase et ses utilisations |
TW201524952A (zh) * | 2013-03-15 | 2015-07-01 | Araxes Pharma Llc | Kras g12c之共價抑制劑 |
JP6378918B2 (ja) * | 2013-04-03 | 2018-08-22 | 株式会社ヤクルト本社 | チアゾリジン誘導体又はその塩を有効成分とするPim阻害剤 |
US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
KR102002265B1 (ko) | 2013-05-01 | 2019-07-19 | 에프. 호프만-라 로슈 아게 | 바이헤테로아릴 화합물 및 이의 용도 |
US10508309B2 (en) * | 2013-05-17 | 2019-12-17 | The General Hospital Corporation | Methods for detecting and treating variants of seborrheic keratoses |
MX347988B (es) | 2013-06-14 | 2017-05-19 | Gilead Sciences Inc | Inhibidores de fosfatidilinositol 3-cinasa. |
UY35675A (es) | 2013-07-24 | 2015-02-27 | Novartis Ag | Derivados sustituidos de quinazolin-4-ona |
CA2925124A1 (fr) | 2013-09-30 | 2015-04-02 | Pharmacyclics Llc | Inhibiteurs de la tyrosine kinase de bruton |
TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Kras g12c之抑制劑 |
SI3057964T1 (sl) | 2013-10-14 | 2020-03-31 | Eisai R&D Management Co., Ltd. | Selektivno substituirane spojine kinolina |
JP6483666B2 (ja) | 2013-10-14 | 2019-03-13 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 選択的に置換されたキノリン化合物 |
ES2676734T3 (es) * | 2013-10-18 | 2018-07-24 | Syros Pharmaceuticals, Inc. | Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas |
EP3072893B1 (fr) * | 2013-11-20 | 2020-03-18 | Beijing Forelandpharma Co. Ltd. | Dérivés cétone d'imidazoles, combinaisons pharmaceutiques desdits dérivés et leur utilisation |
JP6563947B2 (ja) | 2013-12-02 | 2019-08-21 | ケモセントリックス,インコーポレイティド | Ccr6化合物 |
CN112353806A (zh) | 2014-02-21 | 2021-02-12 | 普林斯匹亚生物制药公司 | Btk抑制剂的盐和固体形式 |
JO3556B1 (ar) | 2014-09-18 | 2020-07-05 | Araxes Pharma Llc | علاجات مدمجة لمعالجة السرطان |
US10011600B2 (en) | 2014-09-25 | 2018-07-03 | Araxes Pharma Llc | Methods and compositions for inhibition of Ras |
US9862701B2 (en) | 2014-09-25 | 2018-01-09 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
PT3233103T (pt) | 2014-12-18 | 2021-01-18 | Principia Biopharma Inc | Tratamento de pênfigo |
AU2015370463B2 (en) * | 2014-12-24 | 2020-12-24 | Kither Biotech S.R.L. | Novel PI3K gamma inhibitor peptide for treatment of respiratory system diseases |
EP3280708B1 (fr) | 2015-04-10 | 2021-09-01 | Araxes Pharma LLC | Composés quinazolines substitués et procédés pour leur utilisation |
MX2017013275A (es) | 2015-04-15 | 2018-01-26 | Araxes Pharma Llc | Inhibidores triciclicos fusionados de kras y metodos de uso de los mismos. |
WO2016172952A1 (fr) * | 2015-04-30 | 2016-11-03 | 江苏挪贝肽医药科技有限公司 | Application de la protéine pi4kiiiα et complexe de protéines de membrane associé dans le traitement de la maladie d'alzheimer |
EA201792314A1 (ru) | 2015-05-20 | 2018-05-31 | Новартис Аг | Фармацевтическая комбинация эверолимуса и дактолисиба |
TW201718572A (zh) | 2015-06-24 | 2017-06-01 | 普林斯匹亞生物製藥公司 | 酪胺酸激酶抑制劑 |
US10144724B2 (en) | 2015-07-22 | 2018-12-04 | Araxes Pharma Llc | Substituted quinazoline compounds and methods of use thereof |
EP3356359B1 (fr) | 2015-09-28 | 2021-10-20 | Araxes Pharma LLC | Inhibiteurs de protéines kras portant la mutation g12c |
WO2017058768A1 (fr) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibiteurs de protéines kras portant la mutation g12c |
WO2017058805A1 (fr) * | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibiteurs de protéines kras portant la mutation g12c |
WO2017058915A1 (fr) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibiteurs de protéines mutantes kras g12c |
WO2017058902A1 (fr) | 2015-09-28 | 2017-04-06 | Araxes Pharma Llc | Inhibiteurs de protéines mutantes kras g12c |
US10858343B2 (en) | 2015-09-28 | 2020-12-08 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
US10875842B2 (en) | 2015-09-28 | 2020-12-29 | Araxes Pharma Llc | Inhibitors of KRAS G12C mutant proteins |
WO2017070256A2 (fr) | 2015-10-19 | 2017-04-27 | Araxes Pharma Llc | Méthode de criblage d'inhibiteurs de ras |
CA3005089A1 (fr) | 2015-11-16 | 2017-05-26 | Araxes Pharma Llc | Composes quinazoline substitues en position 2 comprenant un groupe heterocyclique substitue et leur methode d'utilisation |
WO2017100546A1 (fr) | 2015-12-09 | 2017-06-15 | Araxes Pharma Llc | Procédés de préparation de dérivés de quinazoléine |
RU2617409C1 (ru) * | 2015-12-24 | 2017-04-25 | Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) | Амиды акриловой и метакриловой кислот с n-алкилпиперазино-пиперидинами и способ их получения |
RU2617694C1 (ru) * | 2015-12-24 | 2017-04-26 | Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А.Н. Несмеянова Российской академии наук (ИНЭОС РАН) | Амиды акриловой и метакриловой кислот с олигопиперидинами и способ их получения |
GB201602527D0 (en) * | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
WO2017172979A1 (fr) | 2016-03-30 | 2017-10-05 | Araxes Pharma Llc | Composés quinazoline substitués et procédés d'utilisation |
CN109311858B (zh) | 2016-05-26 | 2021-12-03 | 里科瑞尔姆Ip控股有限责任公司 | Egfr抑制剂化合物 |
CA3028169A1 (fr) | 2016-06-29 | 2018-01-04 | Principia Biopharma Inc. | Formulations a liberation modifiee a base de 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidine-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetane-3-yl)piperazin e-1-yl]pent-2-enenitrile |
WO2018002958A1 (fr) | 2016-06-30 | 2018-01-04 | Sun Pharma Advanced Research Company Limited | Nouveaux composés contenant de l'hydrazide utilisés comme inhibiteurs de btk |
US10646488B2 (en) | 2016-07-13 | 2020-05-12 | Araxes Pharma Llc | Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
WO2018064510A1 (fr) | 2016-09-29 | 2018-04-05 | Araxes Pharma Llc | Inhibiteurs de protéines mutantes kras g12c |
US10377743B2 (en) | 2016-10-07 | 2019-08-13 | Araxes Pharma Llc | Inhibitors of RAS and methods of use thereof |
CN110114070A (zh) | 2016-11-23 | 2019-08-09 | 诺华公司 | 使用依维莫司(everolimus)、达托里昔布(dactolisib)或二者增强免疫反应的方法 |
CN106755343A (zh) * | 2016-12-01 | 2017-05-31 | 北京致成生物医学科技有限公司 | 胰腺癌预后诊断分子标记物 |
US11279689B2 (en) | 2017-01-26 | 2022-03-22 | Araxes Pharma Llc | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1 yl)prop-2-en-1-one derivatives and similar compounds as KRAS G12C modulators for treating cancer |
US11274093B2 (en) | 2017-01-26 | 2022-03-15 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
EP3573970A1 (fr) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Dérivés de 1-(6-(3-hydroxynaphtalen-1-yl)quinazolin-2-yl)azétidin-1-yl)prop-2-en-1-one et composés similaires utilisés en tant qu'inhibiteurs de kras g12c pour le traitement du cancer |
EP3573967A1 (fr) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | Composés hétéro-hétéro-bicycliques fusionnés et leurs procédés d'utilisation |
US11358959B2 (en) | 2017-01-26 | 2022-06-14 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
WO2018195649A1 (fr) * | 2017-04-26 | 2018-11-01 | Alberta Research Chemicals Inc. | Dérivés de tétrahydropyridine substitués en tant utiles en tant qu'inhibiteurs d'ido -1 et leurs utilisations |
US11639346B2 (en) | 2017-05-25 | 2023-05-02 | Araxes Pharma Llc | Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS |
JP2020521741A (ja) | 2017-05-25 | 2020-07-27 | アラクセス ファーマ エルエルシー | がんの処置のための化合物およびその使用の方法 |
BR112019024674A2 (pt) | 2017-05-25 | 2020-06-16 | Araxes Pharma Llc | Inibidores covalentes da kras |
US10596165B2 (en) | 2018-02-12 | 2020-03-24 | resTORbio, Inc. | Combination therapies |
KR20210003780A (ko) | 2018-04-05 | 2021-01-12 | 스미토모 다이니폰 파마 온콜로지, 인크. | Axl 키나제 억제제 및 그의 용도 |
EP3774792B1 (fr) * | 2018-04-10 | 2022-09-14 | Neuropore Therapies, Inc. | Dérivés de morpholine en tant qu'inhibiteurs de vps34 |
AU2019251360A1 (en) | 2018-04-10 | 2020-10-08 | Neuropore Therapies, Inc. | Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways |
MX2021000977A (es) | 2018-07-26 | 2021-04-12 | Sumitomo Pharma Oncology Inc | Metodos para tratar enfermedades asociadas con expresion anormal de receptor de activina a tipo 1 (acvr1) e inhibidores de acvr1 para uso en los mismos. |
US20210317127A1 (en) * | 2018-08-01 | 2021-10-14 | Araxes Pharma Llc | Heterocyclic spiro compounds and methods of use thereof for the treatment of cancer |
WO2020053125A1 (fr) * | 2018-09-10 | 2020-03-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés de traitement de la neurofibromatose |
CN113490666A (zh) | 2018-12-19 | 2021-10-08 | 奥瑞生物药品公司 | 作为fgfr酪氨酸激酶的抑制剂的取代的吡唑并[1,5-a]吡啶化合物 |
US20220041579A1 (en) | 2018-12-19 | 2022-02-10 | Array Biopharma Inc. | Substituted quinoxaline compounds as inhibitors of fgfr tyrosine kinases |
WO2021055747A1 (fr) * | 2019-09-19 | 2021-03-25 | Totus Medicines Inc. | Conjugués thérapeutiques |
EP4045485A1 (fr) | 2019-10-18 | 2022-08-24 | The Regents Of The University Of California | Dérivés de 3-phénylsulfonyl-quinoléine en tant qu'agents pour le traitement de troubles des vaisseaux sanguins pathogènes |
EP4087843A1 (fr) * | 2020-01-10 | 2022-11-16 | Incyte Corporation | Composés tricycliques en tant qu'inhibiteurs de kras |
US11530218B2 (en) | 2020-01-20 | 2022-12-20 | Incyte Corporation | Spiro compounds as inhibitors of KRAS |
TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
WO2022047093A1 (fr) | 2020-08-28 | 2022-03-03 | Incyte Corporation | Composés d'imidazole vinylique en tant qu'inhibiteurs de kras |
US11767320B2 (en) | 2020-10-02 | 2023-09-26 | Incyte Corporation | Bicyclic dione compounds as inhibitors of KRAS |
CN113045582B (zh) * | 2021-02-05 | 2022-12-23 | 中国药科大学 | Parp-1/pi3k双靶点抑制剂或其药学上可接受的盐及其制备方法与用途 |
WO2022198024A1 (fr) * | 2021-03-18 | 2022-09-22 | Totus Medicines Inc. | Conjugués thérapeutiques |
US20240208957A1 (en) * | 2021-04-09 | 2024-06-27 | Universität Basel | Triazine derivative as reversible and irreversible covalent inhibitors of pi3k |
EP4323362A1 (fr) | 2021-04-16 | 2024-02-21 | Gilead Sciences, Inc. | Procédés de préparation de carbanucléosides à l'aide d'amides |
WO2023009785A1 (fr) * | 2021-07-29 | 2023-02-02 | Cedilla Therapeutics, Inc. | Inhibiteurs de tead et leurs utilisations |
CN113754680B (zh) * | 2021-09-28 | 2022-07-22 | 云白药征武科技(上海)有限公司 | 一种α氟代酰基哌嗪衍生物及其制备和应用 |
WO2023064857A1 (fr) | 2021-10-14 | 2023-04-20 | Incyte Corporation | Composés de quinoléine utiles en tant qu'inhibiteurs de kras |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
JP4790266B2 (ja) * | 2002-09-30 | 2011-10-12 | バイエル・シエリング・フアーマ・アクチエンゲゼルシヤフト | 縮合アゾールピリミジン誘導体 |
AR046845A1 (es) * | 2003-11-21 | 2005-12-28 | Novartis Ag | Derivados de 1h-imidazo[4,5-c]quinolina para tratamiento de enfermedades dependientes de las proteino-quinasas |
ES2605792T3 (es) * | 2004-05-13 | 2017-03-16 | Icos Corporation | Quinazolinona usada como inhibidor de la fosfatidilinositol 3-quinasa delta humana |
CA2598409A1 (fr) * | 2005-02-17 | 2006-08-24 | Icos Corporation | Procede d'inhibition d'accumulation de leucocytes |
JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
TW200801012A (en) * | 2006-04-26 | 2008-01-01 | Piramed Ltd | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
AU2007243457B2 (en) * | 2006-04-26 | 2012-02-23 | F. Hoffmann-La Roche Ag | Pharmaceutical compounds |
GB0611152D0 (en) * | 2006-06-06 | 2006-07-19 | Ucb Sa | Therapeutic agents |
PT2050749T (pt) * | 2006-08-08 | 2018-01-02 | Chugai Pharmaceutical Co Ltd | Derivado de pirimidina como inibidador de pi3k e sua utilização |
US20080234262A1 (en) * | 2007-03-21 | 2008-09-25 | Wyeth | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors |
PE20090717A1 (es) * | 2007-05-18 | 2009-07-18 | Smithkline Beecham Corp | Derivados de quinolina como inhibidores de la pi3 quinasa |
CA2689989A1 (fr) * | 2007-06-04 | 2008-12-11 | Avila Therapeutics, Inc. | Composes heterocycliques et utilisations de ceux-ci |
US8247397B2 (en) * | 2007-09-12 | 2012-08-21 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
US8354528B2 (en) * | 2007-10-25 | 2013-01-15 | Genentech, Inc. | Process for making thienopyrimidine compounds |
GB0805818D0 (en) * | 2008-03-31 | 2008-04-30 | Ucb Pharma Sa | Therapeutic agents |
EA024252B1 (ru) * | 2009-01-08 | 2016-08-31 | Кьюрис, Инк. | Ингибиторы фосфоинозитид-3-киназ с цинксвязывающей группой |
-
2010
- 2010-09-09 RU RU2012110024/04A patent/RU2595718C2/ru not_active IP Right Cessation
- 2010-09-09 CN CN201080048947XA patent/CN102625708A/zh active Pending
- 2010-09-09 AU AU2010292198A patent/AU2010292198A1/en not_active Abandoned
- 2010-09-09 WO PCT/US2010/048317 patent/WO2011031896A2/fr active Application Filing
- 2010-09-09 JP JP2012528906A patent/JP2013504325A/ja active Pending
- 2010-09-09 EP EP10816104A patent/EP2475375A4/fr not_active Ceased
- 2010-09-09 TW TW099130780A patent/TWI499592B/zh not_active IP Right Cessation
- 2010-09-09 TW TW104118050A patent/TW201609747A/zh unknown
- 2010-09-09 SG SG10201405598QA patent/SG10201405598QA/en unknown
- 2010-09-09 CA CA2773848A patent/CA2773848A1/fr not_active Abandoned
- 2010-09-09 BR BR112012008385A patent/BR112012008385A2/pt not_active IP Right Cessation
- 2010-09-09 US US12/878,965 patent/US20110230476A1/en not_active Abandoned
- 2010-09-09 NZ NZ626650A patent/NZ626650A/en not_active IP Right Cessation
- 2010-09-09 SG SG2012016960A patent/SG179085A1/en unknown
- 2010-09-09 KR KR1020127009074A patent/KR20120063515A/ko not_active Application Discontinuation
- 2010-09-09 NZ NZ598808A patent/NZ598808A/en not_active IP Right Cessation
- 2010-09-09 MX MX2012002972A patent/MX339584B/es active IP Right Grant
-
2012
- 2012-03-08 IL IL218555A patent/IL218555A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2595718C2 (ru) | 2016-08-27 |
NZ626650A (en) | 2015-12-24 |
TW201609747A (zh) | 2016-03-16 |
IL218555A0 (en) | 2012-05-31 |
MX2012002972A (es) | 2012-06-25 |
SG179085A1 (en) | 2012-04-27 |
TW201120047A (en) | 2011-06-16 |
KR20120063515A (ko) | 2012-06-15 |
EP2475375A2 (fr) | 2012-07-18 |
BR112012008385A2 (pt) | 2019-09-24 |
US20110230476A1 (en) | 2011-09-22 |
WO2011031896A3 (fr) | 2011-05-12 |
WO2011031896A2 (fr) | 2011-03-17 |
EP2475375A4 (fr) | 2013-02-20 |
JP2013504325A (ja) | 2013-02-07 |
MX339584B (es) | 2016-06-01 |
NZ598808A (en) | 2014-07-25 |
AU2010292198A1 (en) | 2012-04-05 |
CN102625708A (zh) | 2012-08-01 |
RU2012110024A (ru) | 2013-11-10 |
CA2773848A1 (fr) | 2011-03-17 |
TWI499592B (zh) | 2015-09-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL218555A0 (en) | Pi3 kinase inhibitors and uses thereof | |
HUS2200052I1 (hu) | Imidazotriazinok és imidazopirimidinek mint kinázgátlók | |
HK1257444A1 (zh) | Cdc7激酶抑制劑以及其用途 | |
HK1167862A1 (en) | Inhibitors of pi3 kinase and / or mtor pi3 / mtor | |
IL211549A0 (en) | Aminotriazolopyridines and their use as kinase inhibitors | |
IL219646A0 (en) | Novelnaphthyridine derivatives and the use thereof as kinase inhibitors | |
HK1179477A1 (en) | Kinase inhibitors | |
ZA201203842B (en) | Kinase inhibitors | |
MX315904B (es) | Inhibidores de fosfoinosituro-3 cinasa. | |
IL220212A0 (en) | Aminopyrimidine kinase inhibitors | |
HK1144306A1 (zh) | 激酶抑制劑及其用途 | |
EP2683243A4 (fr) | Inhibiteurs de pi3 kinase et leurs utilisations | |
IL218678A0 (en) | Protein kinase conjugates and inhibitors | |
EP2387572A4 (fr) | Inhibiteurs de la protéine kinase c et leurs utilisations | |
ZA201108622B (en) | Pyrazolopyrimidines and related heterocycles as kinase inhibitors | |
ZA201004942B (en) | Ptrrolopyrazine kinase inhibitors | |
EP2558099A4 (fr) | Inhibiteurs de kinases | |
HK1156026A1 (en) | Pyrazolopyridine kinase inhibitors | |
IL212755A0 (en) | Pyrazinopyrazines and derivatives as kinase inhibitors | |
EP2396004A4 (fr) | Inhibiteurs de kinase sélectifs | |
IL207415A0 (en) | Protein kinase inhibitors and use thereof | |
ZA201003420B (en) | Protein kinase inhibitors and use thereof | |
EP2480076A4 (fr) | Inhibiteurs imidazothiazoliques de kinases | |
EP2379076A4 (fr) | Inhibiteurs de la phosphodiestérase et utilisations de ces derniers | |
EP2432321A4 (fr) | Dérivés de thiazolopyrimidinone comme inhibiteurs de la kinase pi3 |