SE9401727D0 - New compounds I - Google Patents
New compounds IInfo
- Publication number
- SE9401727D0 SE9401727D0 SE9401727A SE9401727A SE9401727D0 SE 9401727 D0 SE9401727 D0 SE 9401727D0 SE 9401727 A SE9401727 A SE 9401727A SE 9401727 A SE9401727 A SE 9401727A SE 9401727 D0 SE9401727 D0 SE 9401727D0
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- hydrogen
- group
- pct
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9401727A SE9401727D0 (sv) | 1994-05-18 | 1994-05-18 | New compounds I |
IL11362795A IL113627A0 (en) | 1994-05-18 | 1995-05-07 | New agonist compounds |
ZA953699A ZA953699B (en) | 1994-05-18 | 1995-05-08 | New agonist compounds |
BR9507656A BR9507656A (pt) | 1994-05-18 | 1995-05-09 | Composto utilização de um composto composição farmacéutica e processos para o tratamento de um paciente que sofre de dor e para a preparação de um composto |
AU25818/95A AU690281B2 (en) | 1994-05-18 | 1995-05-09 | New agonist compounds |
EP95920329A EP0759923A1 (en) | 1994-05-18 | 1995-05-09 | New agonist compounds |
PCT/SE1995/000504 WO1995031464A1 (en) | 1994-05-18 | 1995-05-09 | New agonist compounds |
CA002189139A CA2189139A1 (en) | 1994-05-18 | 1995-05-09 | New agonist compounds |
HU9603171A HU9603171D0 (en) | 1994-05-18 | 1995-05-09 | New agonist compounds |
JP7529554A JPH10500132A (ja) | 1994-05-18 | 1995-05-09 | 新規なアゴニスト化合物 |
PL95317250A PL317250A1 (en) | 1994-05-18 | 1995-05-09 | Novel agonistic compounds |
US08/507,365 US5886001A (en) | 1994-05-18 | 1995-05-09 | Agonist compounds |
CN95194032A CN1152314A (zh) | 1994-05-18 | 1995-05-09 | 新的兴奋剂化合物 |
SK1396-96A SK139696A3 (en) | 1994-05-18 | 1995-05-09 | New agonist compounds |
NZ287177A NZ287177A (en) | 1994-05-18 | 1995-05-09 | Morphinane derivatives; medicaments |
IS4381A IS4381A (is) | 1994-05-18 | 1996-11-08 | Ný gerandefni |
NO964871A NO964871D0 (no) | 1994-05-18 | 1996-11-15 | Nye agonistforbindelser |
FI964576A FI964576A (fi) | 1994-05-18 | 1996-11-15 | Uusia agonistiyhdisteitä |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9401727A SE9401727D0 (sv) | 1994-05-18 | 1994-05-18 | New compounds I |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9401727D0 true SE9401727D0 (sv) | 1994-05-18 |
Family
ID=20394058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9401727A SE9401727D0 (sv) | 1994-05-18 | 1994-05-18 | New compounds I |
Country Status (18)
Country | Link |
---|---|
US (1) | US5886001A (hu) |
EP (1) | EP0759923A1 (hu) |
JP (1) | JPH10500132A (hu) |
CN (1) | CN1152314A (hu) |
AU (1) | AU690281B2 (hu) |
BR (1) | BR9507656A (hu) |
CA (1) | CA2189139A1 (hu) |
FI (1) | FI964576A (hu) |
HU (1) | HU9603171D0 (hu) |
IL (1) | IL113627A0 (hu) |
IS (1) | IS4381A (hu) |
NO (1) | NO964871D0 (hu) |
NZ (1) | NZ287177A (hu) |
PL (1) | PL317250A1 (hu) |
SE (1) | SE9401727D0 (hu) |
SK (1) | SK139696A3 (hu) |
WO (1) | WO1995031464A1 (hu) |
ZA (1) | ZA953699B (hu) |
Families Citing this family (66)
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---|---|---|---|---|
ES2197953T3 (es) * | 1995-09-26 | 2004-01-16 | Toray Industries, Inc. | Derivados de indol y aplicaciones medicas de los mismos. |
JP4110579B2 (ja) * | 1997-01-16 | 2008-07-02 | 東レ株式会社 | インドロモルヒナン誘導体および脳障害治療・予防剤 |
GB9717629D0 (en) * | 1997-08-21 | 1997-10-22 | Johnson Matthey Plc | Removal of residual organic solvents |
WO2000008027A1 (en) * | 1998-08-06 | 2000-02-17 | Regents Of The University Of Minnesota | Kappa (op2) opioid receptor antagonists |
WO2002080919A1 (en) * | 2001-04-06 | 2002-10-17 | Regents Of The University Of Minnesota | Therapeutic compounds and methods |
US7232829B2 (en) | 2001-04-06 | 2007-06-19 | Regents Of The University Of Minnesota | Therapeutic compounds and methods |
DE10229842A1 (de) * | 2002-07-03 | 2004-02-05 | Helmut Prof. Dr. Schmidhammer | Morphinanderivate und deren quartäre Ammoniumsalze substituiert in Position 14, Herstellungsverfahren und Verwendung |
BRPI0415165A (pt) | 2003-10-01 | 2007-01-09 | Adolor Corp | composto heterocìclico espirocìclico, composição farmacêutica, método para ligar receptores opióides, métodos para prevenir ou tratar dor, disfunção gastrointestinal, um distúrbio do trato urogenital, um distúrbio imunomodulatório, um distúrbio inflamatório, um distúrbio de função respiratória, ansiedade, distúrbio do humor, um distúrbio relacionado a estresse, distúrbio do sistema nervoso simpático, tosse, e um distúrbio motor, método para tratar uma lesão traumática ao sistema nervoso central, métodos para prevenir ou tratar acidente vascular, arritmia cardìaca, glaucoma, e disfunção sexual, métodos para tratar uma condição selecionada do grupo consistindo de choque, edema cerebral, isquemia cerebral, déficit cerebral após cirurgia cardìaca (bypass) e enxerto, lupus eritematoso sistêmico, doença de hodgkin, doença de sjogren, epilepsia, e rejeição em transplantes de órgão e enxertos de pele, e para tratar dependência de substáncias, métodos para melhorar a sobrevivência de órgãos e células, e cardioproteção após infarto do miocárdio, métodos para reduzir a necessidade de anestesia, para produzir ou manter um estado anestésico, derivado radiomarcado de um composto, derivado isotopicamente marcado de um composto, composto e método de diagnóstico por imagem |
US7598261B2 (en) | 2005-03-31 | 2009-10-06 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
US7576207B2 (en) | 2006-04-06 | 2009-08-18 | Adolor Corporation | Spirocyclic heterocyclic derivatives and methods of their use |
EP2399577A1 (en) | 2006-09-12 | 2011-12-28 | Adolor Corporation | Use of N-containing spirocompounds for the enhancement of cognitive function |
US9321116B2 (en) * | 2009-03-05 | 2016-04-26 | United Technologies Corporation | Cold metal transfer gas metal arc welding apparatus and method of operation |
EP2340832A1 (en) | 2009-12-23 | 2011-07-06 | Universität Innsbruck | Morphinan-6-one compounds for the treatment or prevention of neurodegenerative diseases |
US8987293B2 (en) | 2010-12-23 | 2015-03-24 | Phoenix Pharmalabs, Inc. | Morphinans useful as analgesics |
WO2014037832A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment of epilepsy and neurological diseases |
WO2013167990A1 (en) | 2012-05-07 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of depression |
CN104603096A (zh) | 2012-05-07 | 2015-05-06 | 塞利克斯比奥私人有限公司 | 用于治疗神经肌肉障碍和神经退行性疾病的组合物和方法 |
SG11201407300VA (en) | 2012-05-07 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for the treatment of neurological disorders |
WO2013167993A1 (en) | 2012-05-08 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of neurological degenerative disorders |
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US9522884B2 (en) | 2012-05-08 | 2016-12-20 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic disorders |
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US9266823B2 (en) | 2012-05-08 | 2016-02-23 | Cellix Bio Private Limited | Compositions and methods for the treatment of parkinson's disease |
WO2013168033A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for treatment of neurologic diseases |
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WO2013168005A2 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of restless leg syndrome and fibromyalgia |
US9346742B2 (en) | 2012-05-10 | 2016-05-24 | Cellix Bio Private Limited | Compositions and methods for the treatment of fibromyalgia pain |
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US9315478B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
US9321775B2 (en) | 2012-05-10 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of moderate to severe pain |
WO2013168000A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of severe pain |
WO2013168012A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of respiratory disorders |
US9499527B2 (en) | 2012-05-10 | 2016-11-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of familial amyloid polyneuropathy |
WO2013168015A1 (en) | 2012-05-10 | 2013-11-14 | Mahesh Kandula | Compositions and methods for the treatment of asthma and allergy |
US9315461B2 (en) | 2012-05-10 | 2016-04-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurologic diseases |
US9273061B2 (en) | 2012-05-10 | 2016-03-01 | Cellix Bio Private Limited | Compositions and methods for the treatment of chronic pain |
WO2013175376A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of local pain |
CN104603100A (zh) | 2012-05-23 | 2015-05-06 | 塞利克斯比奥私人有限公司 | 用于治疗炎症性肠病的组合物和方法 |
CA2873098A1 (en) | 2012-05-23 | 2013-11-28 | Cellixbio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
SG11201407326XA (en) | 2012-05-23 | 2014-12-30 | Cellix Bio Private Ltd | Compositions and methods for treatment of mucositis |
WO2013175344A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of periodontitis and rheumatoid arthritis |
WO2013175347A2 (en) | 2012-05-23 | 2013-11-28 | Mahesh Kandula | Compositions and methods for the treatment of respiratory disorders |
US9108942B1 (en) | 2014-11-05 | 2015-08-18 | Mahesh Kandula | Compositions and methods for the treatment of moderate to severe pain |
US9187427B2 (en) | 2012-08-03 | 2015-11-17 | Cellix Bio Private Limited | N-substituted nicotinamide compounds and compositions for the treatment migraine and neurologic diseases |
WO2014037833A2 (en) | 2012-09-06 | 2014-03-13 | Mahesh Kandula | Compositions and methods for the treatment inflammation and lipid disorders |
US9670153B2 (en) | 2012-09-08 | 2017-06-06 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammation and lipid disorders |
HU231191B1 (hu) | 2013-04-15 | 2021-08-30 | Szegedi Tudományegyetem | Izotóp tartalmú morfin molekulák |
US9333187B1 (en) | 2013-05-15 | 2016-05-10 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammatory bowel disease |
AU2014276346A1 (en) | 2013-06-04 | 2015-12-24 | Cellixbio Private Limited | Compositions and methods for the treatment of diabetes and pre-diabetes |
WO2015082932A1 (en) | 2013-12-05 | 2015-06-11 | The University Of Bath | Novel opioid compounds and their uses |
WO2016110865A1 (en) | 2015-01-06 | 2016-07-14 | Cellix Bio Private Limited | Compositions and methods for the treatment of inflammation and pain |
US9096537B1 (en) | 2014-12-31 | 2015-08-04 | Mahesh Kandula | Compositions and methods for the treatment of mucositis |
WO2016046835A1 (en) | 2014-09-26 | 2016-03-31 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy and neurological disorders |
WO2016051420A1 (en) | 2014-09-29 | 2016-04-07 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
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US9173877B1 (en) | 2014-11-05 | 2015-11-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of local pain |
US9290486B1 (en) | 2014-11-05 | 2016-03-22 | Cellix Bio Private Limited | Compositions and methods for the treatment of epilepsy |
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US9321716B1 (en) | 2014-11-05 | 2016-04-26 | Cellix Bio Private Limited | Compositions and methods for the treatment of metabolic syndrome |
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EP3215154B1 (en) | 2014-11-07 | 2020-01-29 | Regents of the University of Minnesota | Salts and compositions useful for treating disease |
US9932294B2 (en) | 2014-12-01 | 2018-04-03 | Cellix Bio Private Limited | Compositions and methods for the treatment of multiple sclerosis |
US9206111B1 (en) | 2014-12-17 | 2015-12-08 | Cellix Bio Private Limited | Compositions and methods for the treatment of neurological diseases |
WO2017165558A1 (en) | 2016-03-22 | 2017-09-28 | Regents Of The University Of Minnesota | Combination for treating pain |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816586A (en) * | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
JP2906654B2 (ja) * | 1989-11-28 | 1999-06-21 | 東レ株式会社 | 免疫抑制剤及びその製造方法 |
US5225417A (en) * | 1992-01-21 | 1993-07-06 | G. D. Searle & Co. | Opioid agonist compounds |
US5223507A (en) * | 1992-01-21 | 1993-06-29 | G. D. Searle & Co. | Method of using opioid compounds as delta opioid selective agonist analgesics |
NZ246687A (en) * | 1992-01-23 | 1996-12-20 | Toray Industries | Morphinan derivative and pharmaceutical compositions thereof |
EP0614898B1 (en) * | 1992-09-29 | 2003-05-07 | Toray Industries, Inc. | Indole derivative, process for producing the same, and medicinal use thereof |
US5464841A (en) * | 1993-11-08 | 1995-11-07 | Univ Minnesota | Use of delta opioid receptor antagonists to treat immunoregulatory disorders |
US5780479A (en) * | 1997-04-04 | 1998-07-14 | Regents Of The University Of Minnesota | Use of opioid antagonists to treat impulse-control disorders |
-
1994
- 1994-05-18 SE SE9401727A patent/SE9401727D0/xx unknown
-
1995
- 1995-05-07 IL IL11362795A patent/IL113627A0/xx unknown
- 1995-05-08 ZA ZA953699A patent/ZA953699B/xx unknown
- 1995-05-09 HU HU9603171A patent/HU9603171D0/hu unknown
- 1995-05-09 PL PL95317250A patent/PL317250A1/xx unknown
- 1995-05-09 WO PCT/SE1995/000504 patent/WO1995031464A1/en not_active Application Discontinuation
- 1995-05-09 AU AU25818/95A patent/AU690281B2/en not_active Ceased
- 1995-05-09 CN CN95194032A patent/CN1152314A/zh active Pending
- 1995-05-09 EP EP95920329A patent/EP0759923A1/en not_active Withdrawn
- 1995-05-09 JP JP7529554A patent/JPH10500132A/ja not_active Abandoned
- 1995-05-09 SK SK1396-96A patent/SK139696A3/sk unknown
- 1995-05-09 BR BR9507656A patent/BR9507656A/pt not_active Application Discontinuation
- 1995-05-09 NZ NZ287177A patent/NZ287177A/en unknown
- 1995-05-09 CA CA002189139A patent/CA2189139A1/en not_active Abandoned
- 1995-05-09 US US08/507,365 patent/US5886001A/en not_active Expired - Fee Related
-
1996
- 1996-11-08 IS IS4381A patent/IS4381A/is unknown
- 1996-11-15 NO NO964871A patent/NO964871D0/no not_active Application Discontinuation
- 1996-11-15 FI FI964576A patent/FI964576A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
FI964576A0 (fi) | 1996-11-15 |
AU2581895A (en) | 1995-12-05 |
NO964871L (no) | 1996-11-15 |
NO964871D0 (no) | 1996-11-15 |
AU690281B2 (en) | 1998-04-23 |
EP0759923A1 (en) | 1997-03-05 |
CN1152314A (zh) | 1997-06-18 |
PL317250A1 (en) | 1997-04-01 |
US5886001A (en) | 1999-03-23 |
BR9507656A (pt) | 1997-09-23 |
IS4381A (is) | 1996-11-08 |
WO1995031464A1 (en) | 1995-11-23 |
CA2189139A1 (en) | 1995-11-23 |
FI964576A (fi) | 1996-11-15 |
SK139696A3 (en) | 1997-05-07 |
ZA953699B (en) | 1995-11-20 |
HU9603171D0 (en) | 1997-01-28 |
IL113627A0 (en) | 1995-08-31 |
JPH10500132A (ja) | 1998-01-06 |
NZ287177A (en) | 1997-11-24 |
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