SE9001402D0 - PROCESS FOR THE PREPARATION OF QUINAZOLINE DERVATIVES - Google Patents

PROCESS FOR THE PREPARATION OF QUINAZOLINE DERVATIVES

Info

Publication number
SE9001402D0
SE9001402D0 SE9001402A SE9001402A SE9001402D0 SE 9001402 D0 SE9001402 D0 SE 9001402D0 SE 9001402 A SE9001402 A SE 9001402A SE 9001402 A SE9001402 A SE 9001402A SE 9001402 D0 SE9001402 D0 SE 9001402D0
Authority
SE
Sweden
Prior art keywords
general formula
lower alkyl
preparation
group
pharmaceutically acceptable
Prior art date
Application number
SE9001402A
Other languages
Swedish (sv)
Other versions
SE9001402L (en
Inventor
J Reiter
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU193189A external-priority patent/HU203342B/en
Priority claimed from HU193089A external-priority patent/HU203333B/en
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of SE9001402D0 publication Critical patent/SE9001402D0/en
Publication of SE9001402L publication Critical patent/SE9001402L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

PROCESS FOR THE PREPARATION OF QUINAZOLINE DERIVATIVES The invention relates to a process for the preparation of quinazoline derivatives of the general Formula I (I) ¢wherein R1 and R2 may be the same or different and stand for hydrogen or lower alkyl or together form an ethylene (-CH2-CH2-) or trimethylene (-CH2-CH2- -CH2-) group; and n is the integer number 2 or 37 and pharmaceutically acceptable acid addition salts thereof, which comprises a) reacting an isothiourea derivative of the general Formula III (III) ¢wherein R stands for lower alkyl or phenyl-lower alkyl, where the phenyl ring of the latter group may be optionally substituted by one or more lower alkyl group(s) and/or halogen atom(s)! with an amine of the general Formula IV, (IV) (wherein R1, R2 and n are as stated above) at a temperature between 150 .degree.C and 280 .degree.C; or b) cyclising a compound of the general Formula II (II) (wherein R1, R2 and n are as stated above) optionally in the presence of a catalyst; and, if desired, converting a compound of the general Formula I thus obtained into a pharmaceutically acceptable acid addition salt thereof.
SE9001402A 1989-04-21 1990-04-20 PROCEDURES FOR PREPARING CHINAZOLINE DERIVATIVES SE9001402L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU193189A HU203342B (en) 1989-04-21 1989-04-21 Process for producing quinazoline deivatives
HU193089A HU203333B (en) 1989-04-21 1989-04-21 Process for producing n-cyano-carboxamidine derivatives

Publications (2)

Publication Number Publication Date
SE9001402D0 true SE9001402D0 (en) 1990-04-20
SE9001402L SE9001402L (en) 1990-10-22

Family

ID=26317437

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9001402A SE9001402L (en) 1989-04-21 1990-04-20 PROCEDURES FOR PREPARING CHINAZOLINE DERIVATIVES

Country Status (15)

Country Link
JP (1) JPH02292282A (en)
KR (1) KR900016194A (en)
AT (1) AT398075B (en)
CA (2) CA2015066A1 (en)
CH (1) CH681300A5 (en)
DK (1) DK99090A (en)
ES (1) ES2019826A6 (en)
FI (1) FI902002A0 (en)
GB (1) GB2231571B (en)
GR (1) GR900100294A (en)
IT (1) IT1241128B (en)
PL (1) PL162976B1 (en)
RU (1) RU1838309C (en)
SE (1) SE9001402L (en)
YU (1) YU70890A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2077252C (en) * 1992-08-31 2001-04-10 Khashayar Karimian Methods of making ureas and guanidines, and intermediates therefor
ES2096518B1 (en) * 1994-03-28 1997-12-01 Grupo Farmaceutico Almirall S NEW RINGS.
WO2008015525A2 (en) * 2006-07-31 2008-02-07 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of alfuzosin hydrochloride
WO2008152514A2 (en) 2007-05-04 2008-12-18 Actavis Group Ptc Ehf Process for the preparation of alfuzosin and salts thereof
US8716476B2 (en) 2007-08-02 2014-05-06 Cipla Limited Process for the preparation of alfuzosin hydrochloride

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4044135A (en) * 1975-10-14 1977-08-23 Abbott Laboratories Antihypertensive agents
GB1591490A (en) * 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
US4138561A (en) * 1977-09-30 1979-02-06 Bristol-Myers Company Cyanocarboxamidines and quinazoline process
FI56836C (en) * 1977-10-25 1980-04-10 Fermion Oy 4-SUBSTITUTES OF PIPERAZIN-1- (N-ARYL-N'-CYANO) -CARBOXIMIDAMIDER BUTTER OF THE BREAST PREPARATION WITH PHARMACOLOGICAL PROPERTIES 6,7-DIMETOXY-ELLER 6,7,8-TRIMETOXY-2-AMINO -SUBSTITUERADE-Piperazine-1-YL) -KINAZOLINER
FI57751C (en) * 1977-10-25 1980-10-10 Fermion Oy PROCEDURE FOR THE FRAMSTATION OF 6,7-DIMETOXY-ELLER 6,7,8-TRIMETOXY-4-AMINO-2- (4-SUBSTITUTES-PIPERAZIN-1-YL) -KINAZOLINE WITH BLODTRYCKSSAKANDE NETKAN
FR2421888A1 (en) * 1978-02-06 1979-11-02 Synthelabo ALKYLENE DIAMINE AMIDES AND THEIR APPLICATION IN THERAPEUTICS
FI59800C (en) * 1979-01-10 1981-10-12 Fermion Oy PROCEDURE FOR THE FRAMSTATION OF 6,7-DIMETOXY-4-AMINO-2- (4- (FURO-2-YL) -PIPERASIN-1-YL) -QUINAZOLINE
FI67699C (en) * 1979-01-31 1985-05-10 Orion Yhtymae Oy PROCEDURE FOR THE FRAMSTATION OF AV 6,7-DIMETOXY-4-AMINO-2- (4- (2-FUROYL) -1-PIPERAZINYL) QUINAZOLINE HYDROCHLORIDE WITH BLODTRYCKSSAENKANDE VERKAN
ATE32074T1 (en) * 1983-11-22 1988-02-15 Heumann Ludwig & Co Gmbh PROCESS FOR THE PREPARATION OF 4-AMINO-6,7DIMETHOXY-2-(4-(FURO-2-YL)-PIPERAZINE-1-YL)QUINAZOLINE AND ITS PHYSIOLOGICALLY ACCEPTABLE SALTS.

Also Published As

Publication number Publication date
GB2231571A (en) 1990-11-21
IT9020092A0 (en) 1990-04-20
GB2231571B (en) 1992-09-16
DK99090D0 (en) 1990-04-20
DK99090A (en) 1990-10-22
FI902002A0 (en) 1990-04-20
ES2019826A6 (en) 1991-07-01
CH681300A5 (en) 1993-02-26
YU70890A (en) 1992-05-28
PL162976B1 (en) 1994-01-31
JPH02292282A (en) 1990-12-03
GB9008941D0 (en) 1990-06-20
CA2015066A1 (en) 1990-10-21
ATA93190A (en) 1994-01-15
AT398075B (en) 1994-09-26
GR900100294A (en) 1991-09-27
IT9020092A1 (en) 1991-10-20
PL284860A1 (en) 1991-03-11
KR900016194A (en) 1990-11-12
RU1838309C (en) 1993-08-30
CA2028953A1 (en) 1990-10-22
SE9001402L (en) 1990-10-22
IT1241128B (en) 1993-12-29

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