ES2019826A6 - Process for the preparation of quinazoline derivatives - Google Patents
Process for the preparation of quinazoline derivativesInfo
- Publication number
- ES2019826A6 ES2019826A6 ES9001130A ES9001130A ES2019826A6 ES 2019826 A6 ES2019826 A6 ES 2019826A6 ES 9001130 A ES9001130 A ES 9001130A ES 9001130 A ES9001130 A ES 9001130A ES 2019826 A6 ES2019826 A6 ES 2019826A6
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- quinazoline derivatives
- derivative
- procedure
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Procedure for preparation of quinazoline derivatives. The invention is related to a procedure for the preparation of quinazoline derivatives of general formula i, in which rbs1 and rbs2 can be equal or different and represent hydrogen or lower rent, or jointly form a group ethylene or trimethylene, yn is 2 or 3, characterized by the reaction of a 1,2 dimetoxy phenyl 4 istitiourea derivative, with a diamincarboxifuran derivative, eventually substituted, and posterior cyclation, thermal or catalytic, of the compound so obtained. The invention is also related, with the preparation of the intermediate reaction compounds. The compounds object of this invention have interesting properties pharmaceutical as antihypertensive and blockers of si1 receptors. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU193089A HU203333B (en) | 1989-04-21 | 1989-04-21 | Process for producing n-cyano-carboxamidine derivatives |
HU193189A HU203342B (en) | 1989-04-21 | 1989-04-21 | Process for producing quinazoline deivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2019826A6 true ES2019826A6 (en) | 1991-07-01 |
Family
ID=26317437
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9001130A Expired - Lifetime ES2019826A6 (en) | 1989-04-21 | 1990-04-20 | Process for the preparation of quinazoline derivatives |
Country Status (16)
Country | Link |
---|---|
JP (1) | JPH02292282A (en) |
KR (1) | KR900016194A (en) |
AT (1) | AT398075B (en) |
BG (1) | BG91821A (en) |
CA (2) | CA2028953A1 (en) |
CH (1) | CH681300A5 (en) |
DK (1) | DK99090A (en) |
ES (1) | ES2019826A6 (en) |
FI (1) | FI902002A0 (en) |
GB (1) | GB2231571B (en) |
GR (1) | GR900100294A (en) |
IT (1) | IT1241128B (en) |
PL (1) | PL162976B1 (en) |
RU (1) | RU1838309C (en) |
SE (1) | SE9001402L (en) |
YU (1) | YU70890A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2096518A1 (en) * | 1994-03-28 | 1997-03-01 | Almirall Lab | New anilines |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2077252C (en) * | 1992-08-31 | 2001-04-10 | Khashayar Karimian | Methods of making ureas and guanidines, and intermediates therefor |
WO2008015525A2 (en) * | 2006-07-31 | 2008-02-07 | Orchid Chemicals & Pharmaceuticals Limited | An improved process for the preparation of alfuzosin hydrochloride |
US20100174073A1 (en) | 2007-05-04 | 2010-07-08 | Actavis Group Ptc Ehf | Process for the preparation of alfuzosin and salts thereof |
JP2010535185A (en) | 2007-08-02 | 2010-11-18 | シプラ・リミテッド | Method for producing alfuzosin hydrochloride |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4044135A (en) * | 1975-10-14 | 1977-08-23 | Abbott Laboratories | Antihypertensive agents |
US4026894A (en) * | 1975-10-14 | 1977-05-31 | Abbott Laboratories | Antihypertensive agents |
GB1591490A (en) * | 1977-08-04 | 1981-06-24 | Abbott Lab | 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate |
US4138561A (en) * | 1977-09-30 | 1979-02-06 | Bristol-Myers Company | Cyanocarboxamidines and quinazoline process |
FI56836C (en) * | 1977-10-25 | 1980-04-10 | Fermion Oy | 4-SUBSTITUTES OF PIPERAZIN-1- (N-ARYL-N'-CYANO) -CARBOXIMIDAMIDER BUTTER OF THE BREAST PREPARATION WITH PHARMACOLOGICAL PROPERTIES 6,7-DIMETOXY-ELLER 6,7,8-TRIMETOXY-2-AMINO -SUBSTITUERADE-Piperazine-1-YL) -KINAZOLINER |
FI57751C (en) * | 1977-10-25 | 1980-10-10 | Fermion Oy | PROCEDURE FOR THE FRAMSTATION OF 6,7-DIMETOXY-ELLER 6,7,8-TRIMETOXY-4-AMINO-2- (4-SUBSTITUTES-PIPERAZIN-1-YL) -KINAZOLINE WITH BLODTRYCKSSAKANDE NETKAN |
FR2421888A1 (en) * | 1978-02-06 | 1979-11-02 | Synthelabo | ALKYLENE DIAMINE AMIDES AND THEIR APPLICATION IN THERAPEUTICS |
FI59800C (en) * | 1979-01-10 | 1981-10-12 | Fermion Oy | PROCEDURE FOR THE FRAMSTATION OF 6,7-DIMETOXY-4-AMINO-2- (4- (FURO-2-YL) -PIPERASIN-1-YL) -QUINAZOLINE |
FI67699C (en) * | 1979-01-31 | 1985-05-10 | Orion Yhtymae Oy | PROCEDURE FOR THE FRAMSTATION OF AV 6,7-DIMETOXY-4-AMINO-2- (4- (2-FUROYL) -1-PIPERAZINYL) QUINAZOLINE HYDROCHLORIDE WITH BLODTRYCKSSAENKANDE VERKAN |
DE3375395D1 (en) * | 1983-11-22 | 1988-02-25 | Heumann Ludwig & Co Gmbh | Process for the preparation of 4-amino-6,7-dimethoxy-2-(4-(furoyl-2)-piperazin-1-yl)-quinazoline and its physiologically acceptable salt |
-
1990
- 1990-04-11 YU YU00708/90A patent/YU70890A/en unknown
- 1990-04-19 GR GR900100294A patent/GR900100294A/en unknown
- 1990-04-20 CH CH1348/90A patent/CH681300A5/de not_active IP Right Cessation
- 1990-04-20 BG BG091821A patent/BG91821A/en unknown
- 1990-04-20 DK DK099090A patent/DK99090A/en not_active Application Discontinuation
- 1990-04-20 AT AT0093190A patent/AT398075B/en not_active IP Right Cessation
- 1990-04-20 CA CA002028953A patent/CA2028953A1/en not_active Abandoned
- 1990-04-20 IT IT20092A patent/IT1241128B/en active IP Right Grant
- 1990-04-20 GB GB9008941A patent/GB2231571B/en not_active Expired - Lifetime
- 1990-04-20 ES ES9001130A patent/ES2019826A6/en not_active Expired - Lifetime
- 1990-04-20 SE SE9001402A patent/SE9001402L/en not_active Application Discontinuation
- 1990-04-20 CA CA2015066A patent/CA2015066A1/en active Pending
- 1990-04-20 FI FI902002A patent/FI902002A0/en not_active IP Right Cessation
- 1990-04-20 KR KR1019900005608A patent/KR900016194A/en not_active Application Discontinuation
- 1990-04-20 RU SU904743794A patent/RU1838309C/en active
- 1990-04-20 JP JP2103239A patent/JPH02292282A/en active Pending
- 1990-04-20 PL PL28486090A patent/PL162976B1/en unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2096518A1 (en) * | 1994-03-28 | 1997-03-01 | Almirall Lab | New anilines |
Also Published As
Publication number | Publication date |
---|---|
KR900016194A (en) | 1990-11-12 |
BG91821A (en) | 1993-12-24 |
GB9008941D0 (en) | 1990-06-20 |
PL284860A1 (en) | 1991-03-11 |
IT9020092A1 (en) | 1991-10-20 |
DK99090A (en) | 1990-10-22 |
IT9020092A0 (en) | 1990-04-20 |
CA2028953A1 (en) | 1990-10-22 |
JPH02292282A (en) | 1990-12-03 |
GR900100294A (en) | 1991-09-27 |
GB2231571B (en) | 1992-09-16 |
CA2015066A1 (en) | 1990-10-21 |
GB2231571A (en) | 1990-11-21 |
AT398075B (en) | 1994-09-26 |
DK99090D0 (en) | 1990-04-20 |
FI902002A0 (en) | 1990-04-20 |
CH681300A5 (en) | 1993-02-26 |
YU70890A (en) | 1992-05-28 |
SE9001402D0 (en) | 1990-04-20 |
ATA93190A (en) | 1994-01-15 |
IT1241128B (en) | 1993-12-29 |
PL162976B1 (en) | 1994-01-31 |
SE9001402L (en) | 1990-10-22 |
RU1838309C (en) | 1993-08-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990405 |