SE8800207D0 - Nya aminer, deras anvendning och framstellning - Google Patents
Nya aminer, deras anvendning och framstellningInfo
- Publication number
- SE8800207D0 SE8800207D0 SE8800207A SE8800207A SE8800207D0 SE 8800207 D0 SE8800207 D0 SE 8800207D0 SE 8800207 A SE8800207 A SE 8800207A SE 8800207 A SE8800207 A SE 8800207A SE 8800207 D0 SE8800207 D0 SE 8800207D0
- Authority
- SE
- Sweden
- Prior art keywords
- methyl
- preparing
- same
- novel
- manufacturing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Lubricants (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8800207A SE8800207D0 (sv) | 1988-01-22 | 1988-01-22 | Nya aminer, deras anvendning och framstellning |
EP89850017A EP0325571B1 (en) | 1988-01-22 | 1989-01-20 | New amines, their use and preparation |
CA000588821A CA1340223C (en) | 1988-01-22 | 1989-01-20 | 3,3-diphenylpropyl amines and pharmaceutical compositions and cholinergic uses thereof |
DE1998175024 DE19875024I2 (de) | 1988-01-22 | 1989-01-20 | Amine Ihre verwendung und Herstellung |
EP89901611A EP0354234A1 (en) | 1988-01-22 | 1989-01-20 | New amines, their use and preparation |
HU891069A HU212729B (en) | 1988-01-22 | 1989-01-20 | Process for producing 3,3-diphenyl propyl amino derivate and pharmaceutical compositions containing such |
AU29329/89A AU635493B2 (en) | 1988-01-22 | 1989-01-20 | New amines, their use and preparation |
JP1501413A JP2664503B2 (ja) | 1988-01-22 | 1989-01-20 | 新規アミン、その使用及び製法 |
ES89850017T ES2029384T4 (es) | 1988-01-22 | 1989-01-20 | Procedimiento para preparar nuevas 3,3-difenilpropilaminas. |
AT89850017T ATE65990T1 (de) | 1988-01-22 | 1989-01-20 | Amine, ihre verwendung und herstellung. |
DE8989850017T DE68900180D1 (de) | 1988-01-22 | 1989-01-20 | Amine, ihre verwendung und herstellung. |
PCT/SE1989/000016 WO1989006644A1 (en) | 1988-01-22 | 1989-01-20 | New amines, their use and preparation |
NO903085A NO173496C (no) | 1988-01-22 | 1990-07-11 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive 3,3- difenyl-propylaminer |
DK172590A DK172103B1 (da) | 1988-01-22 | 1990-07-19 | Hidtil ukendte 3,3-difenylpropylaminer, farmaceutiske præparater indeholdende disse, deres anvendelse til fremstilling af et anticholinergt lægemiddel samt fremgangsmåde til deres fremstilling |
FI903688A FI109900B (fi) | 1988-01-22 | 1990-07-20 | Menetelmä farmaseuttisesti aktiivisten 3,3-difenyylipropyyliamiinien valmistamiseksi |
GR91401499T GR3002854T3 (en) | 1988-01-22 | 1991-10-08 | New amines, their use and preparation |
US07/810,185 US5382600A (en) | 1988-01-22 | 1991-12-19 | 3,3-diphenylpropylamines and pharmaceutical compositions thereof |
HK64494A HK64494A (en) | 1988-01-22 | 1994-07-07 | New amines, their use and preparation |
HU94P/P00053P HU210603A9 (en) | 1988-01-22 | 1994-12-15 | New amines, their use and preparation |
NL980020C NL980020I2 (nl) | 1988-01-22 | 1998-06-19 | Nieuwe aminen, de toepassing ervan en de bereiding. |
LU90259C LU90259I2 (fr) | 1988-01-22 | 1998-07-03 | N,n-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine et les sels racémates et énantiomères de celle-ci |
NO1998023C NO1998023I1 (no) | 1988-01-22 | 1998-10-20 | Tolterodin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE8800207A SE8800207D0 (sv) | 1988-01-22 | 1988-01-22 | Nya aminer, deras anvendning och framstellning |
Publications (1)
Publication Number | Publication Date |
---|---|
SE8800207D0 true SE8800207D0 (sv) | 1988-01-22 |
Family
ID=20371146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8800207A SE8800207D0 (sv) | 1988-01-22 | 1988-01-22 | Nya aminer, deras anvendning och framstellning |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP0325571B1 (fi) |
JP (1) | JP2664503B2 (fi) |
AT (1) | ATE65990T1 (fi) |
AU (1) | AU635493B2 (fi) |
CA (1) | CA1340223C (fi) |
DE (2) | DE68900180D1 (fi) |
DK (1) | DK172103B1 (fi) |
ES (1) | ES2029384T4 (fi) |
FI (1) | FI109900B (fi) |
GR (1) | GR3002854T3 (fi) |
HK (1) | HK64494A (fi) |
HU (2) | HU212729B (fi) |
LU (1) | LU90259I2 (fi) |
NL (1) | NL980020I2 (fi) |
NO (2) | NO173496C (fi) |
SE (1) | SE8800207D0 (fi) |
WO (1) | WO1989006644A1 (fi) |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9203318D0 (sv) * | 1992-11-06 | 1992-11-06 | Kabi Pharmacia Ab | Novel 3,3-diphenylpropylamines, their use and preparation |
DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
ZA969363B (en) * | 1995-11-08 | 1997-11-18 | Smithkline Beecham Corp | An improved process for preparing aromatic ring-fused cyclopentane derivatives. |
AU728395B2 (en) | 1996-07-19 | 2001-01-11 | Gunnar Aberg | S(-)-tolterodine in the treatment of urinary and gastrointestinal disorders |
KR20000057548A (ko) * | 1996-12-13 | 2000-09-25 | 알프레드 엘. 미첼슨 | 광학적 전송물질 및 결합재 |
SE9701144D0 (sv) * | 1997-03-27 | 1997-03-27 | Pharmacia & Upjohn Ab | Novel compounds, their use and preparation |
EP0957073A1 (en) * | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
EA002720B1 (ru) | 1998-08-27 | 2002-08-29 | Фармациа Энд Апджон Аб | Терапевтическая композиция для введения толтеродина с контролируемым высвобождением и способ лечения мочевого пузыря с её использованием |
DE29923134U1 (de) * | 1999-11-16 | 2000-06-29 | Sanol Arznei Schwarz Gmbh | Stabile Salze neuartiger Derviate von 3,3-Diphenylpropylaminen |
US6566537B2 (en) | 1999-12-30 | 2003-05-20 | Pharmacia Ab | Process and intermediates |
SE9904850D0 (sv) * | 1999-12-30 | 1999-12-30 | Pharmacia & Upjohn Ab | Novel process and intermediates |
DE10028443C1 (de) * | 2000-06-14 | 2002-05-29 | Sanol Arznei Schwarz Gmbh | Verfahren zur Herstellung von 3,3-Diarylpropylaminen, (R,S)- und (R)-4-Phenyl-2-chromanon-6-carbonsäure sowie (R)-4-Phenyl-2-chromanon-carbonsäure-cinchonidinsalz und deren Verwendung zur Herstellung eines rechtsdrehenden Hydroxybenzylalkohols und von pharmazeutischen Zusammensetzungen |
DE10033016A1 (de) * | 2000-07-07 | 2002-01-24 | Sanol Arznei Schwarz Gmbh | Verfahren zur Herstellung von 3,3-Diarylpropylaminen |
CA2464217A1 (en) * | 2001-11-05 | 2003-05-15 | Pharmacia & Upjohn Company | Antimuscarinic aerosol |
US7670612B2 (en) | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
EP1546099B1 (en) | 2002-07-08 | 2008-12-31 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo 3.1.0 hexane derivatives useful as muscarinic receptor antagonists |
DE60226906D1 (de) | 2002-07-31 | 2008-07-10 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo ä3.1.0ühexanderivate, die sich als muscarinrezeptorantagonisten eignen |
AU2002321711A1 (en) * | 2002-08-09 | 2004-02-25 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist |
EP1534675B1 (en) | 2002-08-23 | 2009-02-25 | Ranbaxy Laboratories, Ltd. | Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists |
JP2006518707A (ja) | 2002-12-10 | 2006-08-17 | ランバクシー ラボラトリーズ リミテッド | ムスカリン様受容体アンタゴニストとしての3,6−二置換アザビシクロ[3.1.0]ヘキサン誘導体 |
ES2341240T3 (es) | 2002-12-13 | 2010-06-17 | Warner-Lambert Company Llc | Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior. |
EP1581522B1 (en) | 2002-12-23 | 2008-02-20 | Ranbaxy Laboratories Limited | Flavaxate derivatives as muscarinic receptor antagonists |
AU2002347552A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
ES2324712T5 (es) | 2003-01-22 | 2012-06-08 | Pfizer Health Ab | Dosis reducida de tolterodina para tratar trastornos urinarios |
US7488748B2 (en) | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
CA2517824A1 (en) * | 2003-03-06 | 2004-09-16 | Neela Praveen Kumar | 3,3-diarylpropylamine derivatives and processes for isolation thereof |
AU2003304037A1 (en) | 2003-04-08 | 2004-11-01 | Hetero Drugs Limited | Novel polymorphs of tolterodine tartrate |
DE10315917A1 (de) * | 2003-04-08 | 2004-11-18 | Schwarz Pharma Ag | Hochreine Basen von 3,3-Diphenylpropylaminmonoestern |
EP1618091A1 (en) | 2003-04-09 | 2006-01-25 | Ranbaxy Laboratories, Ltd. | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
US7560479B2 (en) | 2003-04-10 | 2009-07-14 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
US7592359B2 (en) | 2003-04-10 | 2009-09-22 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
NZ542952A (en) | 2003-04-11 | 2008-11-28 | Ranbaxy Lab Ltd | Azabicyclo derivatives as muscarinic receptor antagonists |
EP1620389A1 (en) | 2003-04-25 | 2006-02-01 | Pharmacia & Upjohn Company LLC | Halogen substituted 3,3-diphenylpropylamines (tolterodine) having antimuscarinic activity |
AU2004243005B2 (en) * | 2003-05-23 | 2009-09-03 | Bridge Pharma, Inc. | Smooth muscle spasmolytic agents |
ES2235648B1 (es) * | 2003-12-22 | 2006-11-01 | Ragactives, S.L. | Procedimiento para la obtencion de tolterodina. |
WO2005061432A1 (en) * | 2003-12-24 | 2005-07-07 | Cipla Limited | Tolterodine, compositions and uses thereof, and preparation of the same |
EP1629834A1 (en) | 2004-08-27 | 2006-03-01 | KRKA, D.D., Novo Mesto | Sustained release pharmaceutical composition of tolterodine |
JP4513535B2 (ja) * | 2004-12-03 | 2010-07-28 | 住友化学株式会社 | トルテロジンの製造方法 |
US20080045602A1 (en) * | 2004-12-24 | 2008-02-21 | Casar Renata T | Process for Preparation of 3-(2-Hydroxy-5Methylphenyl)-N, N-Disopropyl-3-Phenylpropylamine |
ITMI20050249A1 (it) | 2005-02-18 | 2006-08-19 | Dipharma Spa | Procedimento per la preparazione di tolterodina |
WO2007039918A1 (en) * | 2005-10-06 | 2007-04-12 | Natco Pharma Limited | Novel process for the preparation of tolterodine |
AU2006305619A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
RU2008120332A (ru) * | 2005-12-20 | 2010-01-27 | Пфайзер Продактс Инк. (Us) | Фармацевтическая композиция для лечения luts, содержащая ингибитор pde5 и мускариновый антагонист |
ITMI20060110A1 (it) * | 2006-01-24 | 2007-07-25 | Dipharma Spa | Procedimento per la purificazione di tolterodina |
CA2643097C (en) | 2006-03-20 | 2012-03-13 | Pfizer Limited | Amine derivatives |
AU2007260267B2 (en) | 2006-06-12 | 2012-09-06 | Ucb Pharma Gmbh | New chiral intermediate, process for producing the same and its use in the manufacture of tolterodine, fesoterodine, or the active metabolite thereof |
BRPI0713314A2 (pt) | 2006-06-20 | 2012-03-06 | Lek Pharmaceuticals D.D. | Processo para a preparação de 3-(2-hidróxi-5-fenil substituído)-n-alquil-3-fenilpropilaminas |
CZ302585B6 (cs) * | 2007-02-26 | 2011-07-20 | Zentiva, A. S. | Krystalická sul 2-[(1R)-3-[bis(1-methylethyl)amino]-1-fenylpropyl]-4-methylfenolu s kyselinou (2R,3R)-2,3-dihydroxybutandiovou |
EA016325B1 (ru) * | 2006-08-09 | 2012-04-30 | Зентива, К.С. | Способ получения кристаллического (r)-толтеродина тартрата |
ITMI20082055A1 (it) * | 2008-11-19 | 2009-02-18 | Dipharma Francis Srl | Procedimento per la preparazione di (r)-tolterodina base libera |
ES2533956T3 (es) * | 2009-05-11 | 2015-04-16 | Ratiopharm Gmbh | Desfesoterodina en forma de una sal de ácido tartárico |
IL210279A0 (en) | 2009-12-25 | 2011-03-31 | Dexcel Pharma Technologies Ltd | Extended release compositions for high solubility, high permeability acdtive pharmaceutical ingredients |
EP2364966A1 (en) | 2010-03-09 | 2011-09-14 | LEK Pharmaceuticals d.d. | Process for preparation of 3-(2-hydroxy-5-substituted phenyl)-3-phenylpropylamines, intermediates for making hydroxytolterodine |
CN102329244A (zh) * | 2010-07-13 | 2012-01-25 | 凯瑞斯德生化(苏州)有限公司 | 一种rs-托特罗定的制备方法及中间体化合物 |
ITMI20110410A1 (it) * | 2011-03-15 | 2012-09-16 | Cambrex Profarmaco Milano Srl | Procedimento per la preparazione di (r)-tolterodina l-tartrato di forma cristallina definita |
ITMI20121232A1 (it) | 2012-07-16 | 2014-01-17 | Cambrex Profarmaco Milano Srl | Procedimento per la preparazione di 2-(3-n,n-diisopropilamino-1-fenilpropil)-4-idrossimetil-fenolo e suoi derivati |
CN110372571B (zh) | 2018-04-12 | 2022-11-15 | 中国科学院大连化学物理研究所 | 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物 |
WO2022256480A1 (en) * | 2021-06-03 | 2022-12-08 | Conagen Inc. | Arylcoumarin synthesis with azeotropic removal of water |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK111894A (fi) * | 1962-11-15 | |||
GB1169945A (en) * | 1966-08-25 | 1969-11-05 | Geistlich Soehne Ag | Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives |
GB1169944A (en) * | 1966-08-25 | 1969-11-05 | Geistlich Soehne Ag | Novel 3,3-Diphenylpropylamines and processes for the preparation thereof |
-
1988
- 1988-01-22 SE SE8800207A patent/SE8800207D0/xx unknown
-
1989
- 1989-01-20 EP EP89850017A patent/EP0325571B1/en not_active Expired - Lifetime
- 1989-01-20 HU HU891069A patent/HU212729B/hu unknown
- 1989-01-20 ES ES89850017T patent/ES2029384T4/es not_active Expired - Lifetime
- 1989-01-20 DE DE8989850017T patent/DE68900180D1/de not_active Expired - Lifetime
- 1989-01-20 EP EP89901611A patent/EP0354234A1/en active Pending
- 1989-01-20 CA CA000588821A patent/CA1340223C/en not_active Expired - Lifetime
- 1989-01-20 WO PCT/SE1989/000016 patent/WO1989006644A1/en active IP Right Grant
- 1989-01-20 AU AU29329/89A patent/AU635493B2/en not_active Expired
- 1989-01-20 JP JP1501413A patent/JP2664503B2/ja not_active Expired - Lifetime
- 1989-01-20 DE DE1998175024 patent/DE19875024I2/de active Active
- 1989-01-20 AT AT89850017T patent/ATE65990T1/de not_active IP Right Cessation
-
1990
- 1990-07-11 NO NO903085A patent/NO173496C/no not_active IP Right Cessation
- 1990-07-19 DK DK172590A patent/DK172103B1/da not_active IP Right Cessation
- 1990-07-20 FI FI903688A patent/FI109900B/fi not_active IP Right Cessation
-
1991
- 1991-10-08 GR GR91401499T patent/GR3002854T3/el unknown
-
1994
- 1994-07-07 HK HK64494A patent/HK64494A/xx not_active IP Right Cessation
- 1994-12-15 HU HU94P/P00053P patent/HU210603A9/hu unknown
-
1998
- 1998-06-19 NL NL980020C patent/NL980020I2/nl unknown
- 1998-07-03 LU LU90259C patent/LU90259I2/fr unknown
- 1998-10-20 NO NO1998023C patent/NO1998023I1/no unknown
Also Published As
Publication number | Publication date |
---|---|
DK172590D0 (da) | 1990-07-19 |
ES2029384T3 (es) | 1992-08-01 |
DE19875024I2 (de) | 2002-09-26 |
ATE65990T1 (de) | 1991-08-15 |
HU891069D0 (en) | 1991-11-28 |
HK64494A (en) | 1994-07-15 |
EP0325571B1 (en) | 1991-08-07 |
NO903085L (no) | 1990-07-11 |
AU635493B2 (en) | 1993-03-25 |
HU210603A9 (en) | 1995-05-29 |
ES2029384T4 (es) | 2011-05-30 |
NO1998023I1 (no) | 1998-10-20 |
CA1340223C (en) | 1998-12-15 |
LU90259I2 (fr) | 1998-09-16 |
JP2664503B2 (ja) | 1997-10-15 |
FI903688A0 (fi) | 1990-07-20 |
DK172590A (da) | 1990-07-19 |
NO903085D0 (no) | 1990-07-11 |
WO1989006644A1 (en) | 1989-07-27 |
FI109900B (fi) | 2002-10-31 |
EP0354234A1 (en) | 1990-02-14 |
EP0325571A1 (en) | 1989-07-26 |
DE68900180D1 (de) | 1991-09-12 |
NL980020I2 (nl) | 1999-02-01 |
NL980020I1 (nl) | 1998-09-01 |
NO173496C (no) | 1993-12-22 |
GR3002854T3 (en) | 1993-01-25 |
DK172103B1 (da) | 1997-10-27 |
HU212729B (en) | 1996-10-28 |
NO173496B (no) | 1993-09-13 |
HUT58040A (en) | 1992-01-28 |
JPH03503163A (ja) | 1991-07-18 |
AU2932989A (en) | 1989-08-11 |
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