SE8704771L - Nya prostacykliner - Google Patents

Nya prostacykliner

Info

Publication number
SE8704771L
SE8704771L SE8704771A SE8704771A SE8704771L SE 8704771 L SE8704771 L SE 8704771L SE 8704771 A SE8704771 A SE 8704771A SE 8704771 A SE8704771 A SE 8704771A SE 8704771 L SE8704771 L SE 8704771L
Authority
SE
Sweden
Prior art keywords
prostacyclines
new
fluoro
agent
schleroderma
Prior art date
Application number
SE8704771A
Other languages
English (en)
Swedish (sv)
Other versions
SE8704771D0 (sv
Inventor
G W Holland
F Lee
H Maag
P Rosen
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SE8704771D0 publication Critical patent/SE8704771D0/xx
Publication of SE8704771L publication Critical patent/SE8704771L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018—Esters of cycloaliphatic acids
SE8704771A 1986-12-01 1987-11-30 Nya prostacykliner SE8704771L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/936,569 US4808734A (en) 1986-12-01 1986-12-01 16-cycloalkyl-7-fluoro-prostacyclins

Publications (2)

Publication Number Publication Date
SE8704771D0 SE8704771D0 (sv) 1987-11-30
SE8704771L true SE8704771L (sv) 1988-06-02

Family

ID=25468824

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8704771A SE8704771L (sv) 1986-12-01 1987-11-30 Nya prostacykliner

Country Status (15)

Country Link
US (1) US4808734A (xx)
JP (1) JPS63145276A (xx)
AT (1) AT392071B (xx)
AU (1) AU604792B2 (xx)
BE (1) BE1001109A3 (xx)
CH (1) CH673650A5 (xx)
DE (1) DE3740596A1 (xx)
DK (1) DK627887A (xx)
FR (1) FR2607500A1 (xx)
GB (1) GB2198131B (xx)
IT (1) IT1223391B (xx)
NL (1) NL8702881A (xx)
NZ (1) NZ222724A (xx)
SE (1) SE8704771L (xx)
ZA (1) ZA878946B (xx)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW208001B (xx) * 1990-09-07 1993-06-21 Asahi Glass Co Ltd

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513913A (en) * 1975-06-20 1978-06-14 Ici Ltd Prostane derivatives
GB2088856B (en) * 1980-10-27 1984-06-27 Chinoin Gyogyszer Es Vegyeszet 7-substituted pg12-derivatives their preparation and pharmaceutical compositions containing them
DE3176313D1 (en) * 1980-12-09 1987-08-20 Teijin Ltd Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof
US4558142A (en) * 1981-03-11 1985-12-10 Hoffmann-La Roche Inc. 7-Fluoro-prostacyclin analogs
CH648556A5 (de) * 1981-03-11 1985-03-29 Hoffmann La Roche Fluorprostacycline.
JPS58150583A (ja) * 1982-03-04 1983-09-07 Teijin Ltd 新規なハロゲン化プロスタサイクリン類、それらの製造法およびそれらを活性成分とする薬学的組成物
JPS59227888A (ja) * 1983-06-10 1984-12-21 Asahi Glass Co Ltd ７−フルオロプロスタグランジン類の製造方法
HU191264B (en) * 1984-01-13 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for production of derivatives of 7-oxo-prostacyclin with selective biological effect
JPS60243079A (ja) * 1984-05-18 1985-12-03 Asahi Glass Co Ltd ７―フルオロプロスタグランジンｉ↓２類を有効成分とする薬剤
US4616034A (en) * 1985-02-28 1986-10-07 G. D. Searle & Co. 15(R)-5-fluoroprostacyclins, pharmaceutical compositions and anti-thrombotic method of use thereof
JPS61289034A (ja) * 1985-06-17 1986-12-19 Teijin Ltd イソカルバサイクリン類脂肪乳剤
FR2583828B1 (fr) * 1985-06-21 1987-08-14 Kley France Sa Appareil moteur fonctionnant par reprises successives
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds

Also Published As

Publication number Publication date
ATA313787A (de) 1990-07-15
CH673650A5 (xx) 1990-03-30
DE3740596A1 (de) 1988-06-16
DK627887D0 (da) 1987-11-30
IT1223391B (it) 1990-09-19
BE1001109A3 (fr) 1989-07-18
AU8190887A (en) 1988-06-02
DK627887A (da) 1988-06-02
SE8704771D0 (sv) 1987-11-30
IT8722815A0 (it) 1987-11-30
AU604792B2 (en) 1991-01-03
US4808734A (en) 1989-02-28
GB2198131A (en) 1988-06-08
GB8727992D0 (en) 1988-01-06
ZA878946B (en) 1988-06-01
GB2198131B (en) 1990-08-08
AT392071B (de) 1991-01-25
NL8702881A (nl) 1988-07-01
JPS63145276A (ja) 1988-06-17
FR2607500A1 (fr) 1988-06-03
NZ222724A (en) 1990-11-27

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Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8704771-8

Effective date: 19910315