SE8201537L - Nya 3,4-dihydro-5h-2,3-bensodiazepinderivat och forfarande for framstellning derav - Google Patents

Nya 3,4-dihydro-5h-2,3-bensodiazepinderivat och forfarande for framstellning derav

Info

Publication number
SE8201537L
SE8201537L SE8201537A SE8201537A SE8201537L SE 8201537 L SE8201537 L SE 8201537L SE 8201537 A SE8201537 A SE 8201537A SE 8201537 A SE8201537 A SE 8201537A SE 8201537 L SE8201537 L SE 8201537L
Authority
SE
Sweden
Prior art keywords
general formula
group
new
dihydro
alkoxy
Prior art date
Application number
SE8201537A
Other languages
English (en)
Swedish (sv)
Inventor
J Korosi
T Lang
F Akdrasi
J Szekely
T Hamori
T Balogh
L Ila
K Goldschmidt
E Sineger
I Moravcsik
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of SE8201537L publication Critical patent/SE8201537L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE8201537A 1981-03-12 1982-03-11 Nya 3,4-dihydro-5h-2,3-bensodiazepinderivat och forfarande for framstellning derav SE8201537L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU81620A HU186760B (en) 1981-03-12 1981-03-12 Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives

Publications (1)

Publication Number Publication Date
SE8201537L true SE8201537L (sv) 1982-09-13

Family

ID=10950496

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8201537A SE8201537L (sv) 1981-03-12 1982-03-11 Nya 3,4-dihydro-5h-2,3-bensodiazepinderivat och forfarande for framstellning derav

Country Status (23)

Country Link
US (1) US4423044A (cs)
JP (1) JPS57159772A (cs)
AT (1) AT383120B (cs)
AU (1) AU550388B2 (cs)
BE (1) BE892395A (cs)
CA (1) CA1178584A (cs)
CH (1) CH648553A5 (cs)
CS (1) CS224646B2 (cs)
DD (1) DD204698A5 (cs)
DE (1) DE3209100A1 (cs)
DK (1) DK106882A (cs)
ES (1) ES510348A0 (cs)
FI (1) FI820839A7 (cs)
FR (1) FR2501686A1 (cs)
GB (1) GB2097387B (cs)
GR (1) GR76111B (cs)
HU (1) HU186760B (cs)
IL (1) IL65076A (cs)
IT (1) IT1190732B (cs)
NL (1) NL8201005A (cs)
NO (1) NO820798L (cs)
SE (1) SE8201537L (cs)
SU (1) SU1151206A3 (cs)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3971179A (en) * 1969-08-13 1976-07-27 Andrew Bodocsi Non-bonded framing system
DE3124013A1 (de) * 1981-06-19 1982-12-30 Kali-Chemie Pharma Gmbh, 3000 Hannover 2-acylaminomethyl-1,4-benzodiazepin-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines
US5204339A (en) * 1986-01-31 1993-04-20 Whitby Research, Inc. Penetration enhancers for transdermal delivery of systemic agents
HU198494B (en) * 1986-08-15 1989-10-30 Gyogyszerkutato Intezet Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
EP0322582A3 (en) * 1987-12-07 1989-09-13 Hoechst-Roussel Pharmaceuticals Incorporated 4-heteroaryl-1,3-benzodiazepines and 2-substituted-alpha-(heteroaryl)benzeneethanamines, a process for their preparation and their use us medicaments
HU206719B (en) * 1990-12-21 1992-12-28 Gyogyszerkutato Intezet Process for producing 1-/4-acylamino-phenyl/-7,8-methylenedioxy-5h-2,3-benzodiazepine derivatives, acid addicional salts and pharmaceutical compositions containing them
HU219778B (hu) * 1990-12-21 2001-07-30 Gyógyszerkutató Intézet Közös Vállalat Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
SK283859B6 (sk) * 1995-02-09 2004-03-02 Egis Gy�Gyszergy�R Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
EP0726256A1 (en) * 1995-02-09 1996-08-14 Egis Gyogyszergyar Rt. 1-Arylvinyl-3,4-dihydro-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
DE19604920A1 (de) * 1996-02-01 1997-08-07 Schering Ag Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
ZA972746B (en) * 1996-04-04 1998-10-09 Egyt Gyogyszervegyeszeti Gyar Novel 2,3-benzodiazepine derivatives
US6080736A (en) * 1999-10-27 2000-06-27 Janus Pharmaceuticals, Inc. Methods and compositions for treating and preventing anxiety and anxiety disorders using optically pure (R) tofisopam
US6649607B2 (en) * 2001-05-18 2003-11-18 Vela Pharmaceuticals, Inc. Compositions and methods for treating or preventing convulsions or seizures
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
AU2003293405A1 (en) * 2002-12-03 2004-06-23 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5h-2,3-benzodiazepine and uses thereof
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
AU2003303312A1 (en) * 2002-12-03 2004-08-30 Vela Pharmaceuticals, Inc. Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5h-2,3-benzodiazepine and uses therof
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
US20070021412A1 (en) * 2003-05-16 2007-01-25 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (S) 2,3-benzodiazepine
CA2525273C (en) * 2003-05-16 2012-04-17 Vela Pharmaceuticals, Inc. Treatment of gastrointestinal dysfunction and related stress with an enantiomerically-pure (r) 2,3-benzodiazepine
US20040254173A1 (en) * 2003-06-13 2004-12-16 Leventer Steven M. Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
US7541355B2 (en) * 2005-05-23 2009-06-02 Vela Acquisition Corporation Conversion process for 2,3-benzodiazepine enantiomers
TW200902024A (en) * 2007-04-02 2009-01-16 Teva Pharma Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
USRE30014E (en) 1966-12-09 1979-05-29 Egyesult Gyogyazer-es Tapozergyar 1-(3,4-Dimethoxy-phenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives

Also Published As

Publication number Publication date
GB2097387B (en) 1984-09-19
DD204698A5 (de) 1983-12-07
FR2501686A1 (fr) 1982-09-17
ES8302671A1 (es) 1983-02-01
AU8130882A (en) 1982-09-16
DK106882A (da) 1982-09-13
SU1151206A3 (ru) 1985-04-15
US4423044A (en) 1983-12-27
AU550388B2 (en) 1986-03-20
CH648553A5 (de) 1985-03-29
AT383120B (de) 1987-05-25
IL65076A (en) 1984-12-31
GR76111B (cs) 1984-08-03
DE3209100A1 (de) 1982-10-28
FR2501686B1 (cs) 1985-03-01
HU186760B (en) 1985-09-30
NL8201005A (nl) 1982-10-01
CS224646B2 (en) 1984-01-16
GB2097387A (en) 1982-11-03
NO820798L (no) 1982-09-13
FI820839L (fi) 1982-09-13
IT8220094A0 (it) 1982-03-11
ES510348A0 (es) 1983-02-01
BE892395A (fr) 1982-09-08
CA1178584A (en) 1984-11-27
FI820839A7 (fi) 1982-09-13
ATA96982A (de) 1986-10-15
JPS57159772A (en) 1982-10-01
IT1190732B (it) 1988-02-24

Similar Documents

Publication Publication Date Title
SE8201537L (sv) Nya 3,4-dihydro-5h-2,3-bensodiazepinderivat och forfarande for framstellning derav
ES8400422A1 (es) "procedimiento de preparacion de eteres triciclicos, asi como de sus sales de adicion con un acido mineral u organico terapeuticamente compatible".
ES8105299A1 (es) Procedimiento para preparar aroilimidazol-2-onas
IL62110A (en) Pharmaceutical compositions containing(substituted)phenyl alkyl imidazole derivatives,some new such compounds and their preparation
ES8706608A1 (es) Un procedimiento para preparar derivados de arilciclobutilalquilamina
SE8603099L (sv) Distamycinderivat och forfarande for deras framstellning
ES8601934A1 (es) Un procedimiento para la preparacion de nuevos derivados de triazina.
SE8603098L (sv) Poly-4-aminopyrrol-2-karboxamidoderivat och forfarande for deras framstellning
ES8400404A1 (es) Un procedimiento para la preparacion de derivados de fenilpiperidina sustituidos.
DK163055C (da) Analogifremgangsmaade til fremstilling af 2-dipropylamino-(5 eller 7)-formylamino-6-hydroxy-1,2,3,4-tetrahydronaphthalen og farmakologisk acceptable syreadditionssalte deraf
ES8203870A1 (es) Procedimiento para preparar difenilbutil-1-acilpiperazinas
ES8801637A1 (es) Un procedimiento para la preparacion de benzimidazoles.
MA19434A1 (fr) Procede de preparation de nouvelles imidazo/i, 2-a/quinoleines et de leurs sels
ES8201977A1 (es) Procedimiento de preparacion de aminoalcoxipirazoles
ES8300776A1 (es) Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina
DE3373302D1 (en) Derivatives of aminopyridinecarboxylic acids, methods for their preparation and pharmaceutical compositions containing them
ES8403130A1 (es) Procedimiento para la preparacion de tienobenzodiazepinonas sustituidas.
SE8406046D0 (sv) New azabiocyclic compounds and a process for the preparation thereof
IL70552A0 (en) Aminoethoxybenzyl alcohol derivatives,their preparation and pharmaceutical compositions containing them
SE8803484L (sv) Nya kinolin- och isokinolinderivat och foerfarande foer framstaellning daerav
ES8205413A1 (es) Procedimiento para preparar nuevas benzotiopirano (2,3-c)pi-ridinas
ES485333A1 (es) Procedimiento para preparar derivados 5,6,7,8-tetrahidro-4 (3h)-quinazolinonicos y sus sales
SE8405332L (sv) 2h-azeto (2,1-a)-isokinolinderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande dem
SE8107493L (sv) Beta-karbolin-3-karboxylsyraderivat
ES8106518A1 (es) Procedimiento de preparacion de un nuevo derivado pirido (3,2-e)-as-triazino o de una sal de adicion acida del mismo, farmaceuticamente aceptable

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8201537-1