SE7902256L - NEW ASSOCIATIONS - Google Patents

NEW ASSOCIATIONS

Info

Publication number
SE7902256L
SE7902256L SE7902256A SE7902256A SE7902256L SE 7902256 L SE7902256 L SE 7902256L SE 7902256 A SE7902256 A SE 7902256A SE 7902256 A SE7902256 A SE 7902256A SE 7902256 L SE7902256 L SE 7902256L
Authority
SE
Sweden
Prior art keywords
carbon atoms
radicals
radical
alkyl radical
group
Prior art date
Application number
SE7902256A
Other languages
Unknown language ( )
Swedish (sv)
Inventor
F Cassidy
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of SE7902256L publication Critical patent/SE7902256L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Pharmaceutically utilisable 3-ketosteroids which are disubstituted in position 16 and have the formula I <IMAGE> in which R3 are alkyl radicals with 1 to 5 carbon atoms, alkenyl or cycloalkyl radicals with 3 to 6 carbon atoms or phenylalkyl radicals with 1 to 3 carbon atoms in the alkyl radical, it being possible for the phenyl radicals to be substituted, R4 is the hydroxyl group or the radical -OR6 where R6 is an acyl radical with 2 to 7 carbon atoms, an alkyl radical with 1 to 4 carbon atoms, or the benzyl group which can be substituted, and R5 is a hydrogen atom or an alkyl radical with 1 to 5 carbon atoms, it also being possible for R4 and R5, together with the carbon atom to which they are bonded, to form the carbonyl group, are obtained by removing the protective group in the compound of the formula I in which the double bond is in the 5,6 position and the 3-carbonyl group is protected by ketal, hemithioketal or thioketal. The double bond rearranges during the elimination and provides the required 4,5 bond in the final product. The prepared compounds are particularly valuable for the treatment of androgen-dependent skin disorders such as acne and seborrhoea and of other androgen-dependent disorders associated with skin and hair glands.
SE7902256A 1975-03-21 1979-03-13 NEW ASSOCIATIONS SE7902256L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB11819/75A GB1538227A (en) 1975-03-21 1975-03-21 16,16-disubstituted steroids of the androstene series

Publications (1)

Publication Number Publication Date
SE7902256L true SE7902256L (en) 1979-03-13

Family

ID=9993275

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7603410A SE7603410L (en) 1975-03-21 1976-03-18 PHARMACEUTICAL ACTIVE ASSOCIATIONS
SE7902256A SE7902256L (en) 1975-03-21 1979-03-13 NEW ASSOCIATIONS

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7603410A SE7603410L (en) 1975-03-21 1976-03-18 PHARMACEUTICAL ACTIVE ASSOCIATIONS

Country Status (15)

Country Link
JP (2) JPS51118756A (en)
AT (1) AT357700B (en)
AU (1) AU501246B2 (en)
BE (1) BE839751A (en)
CA (1) CA1069498A (en)
CH (2) CH621560A5 (en)
DE (1) DE2610497C2 (en)
DK (1) DK143757C (en)
FR (2) FR2304345A1 (en)
GB (1) GB1538227A (en)
IE (1) IE42308B1 (en)
IL (2) IL49132A (en)
NL (1) NL184111C (en)
SE (2) SE7603410L (en)
ZA (1) ZA761324B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1602960A (en) * 1977-05-25 1981-11-18 Beecham Group Ltd Process for preparing 16,16-disubstituted steroids of the androstene series
DE2943778A1 (en) * 1979-10-26 1981-05-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17-Alpha:alkyl-4,15-androstadiene-3-one derivs. - topical antiandrogens effective against acne, seborrhoea, alopecia and hirsutism
DE3514272A1 (en) * 1985-04-17 1986-10-23 Schering AG, 1000 Berlin und 4709 Bergkamen DERMATICA
JPS63300153A (en) * 1987-05-29 1988-12-07 日本碍子株式会社 Building enamel panel
GB9021546D0 (en) * 1990-10-04 1990-11-21 Beecham Group Plc Novel composition
JPH06502161A (en) * 1990-10-31 1994-03-10 ビーチャム・グループ・パブリック・リミテッド・カンパニー Topical compositions containing retinoid penetration enhancers
GB9205194D0 (en) * 1992-03-10 1992-04-22 Smithkline Beecham Plc Novel composition
US20050009797A1 (en) * 2001-12-19 2005-01-13 Mitsuaki Nakamura Androstane derivative having substituent in 7- abd 17--positions
CN108558975B (en) * 2018-04-26 2021-03-02 昆明理工大学 12 beta-hydroxy-androstane 4, 14-diene-16-ketone compound and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853926A (en) * 1973-05-29 1974-12-10 Searle & Co 17{62 -hydroxy-16,16-dimethylester-4-en-3-one

Also Published As

Publication number Publication date
FR2304345B1 (en) 1980-11-07
IL49132A (en) 1980-05-30
NL184111B (en) 1988-11-16
DE2610497C2 (en) 1986-10-16
ZA761324B (en) 1977-02-23
ATA191376A (en) 1979-12-15
DK143757B (en) 1981-10-05
BE839751A (en) 1976-09-20
SE7603410L (en) 1976-09-22
NL184111C (en) 1989-04-17
JPS61178920A (en) 1986-08-11
DK143757C (en) 1982-03-22
FR2304345A1 (en) 1976-10-15
DK123476A (en) 1976-09-22
FR2445340A1 (en) 1980-07-25
FR2445340B1 (en) 1983-02-11
JPS51118756A (en) 1976-10-18
IL49132A0 (en) 1976-05-31
JPS625920B2 (en) 1987-02-07
IL58505A0 (en) 1980-01-31
NL7602949A (en) 1976-09-23
GB1538227A (en) 1979-01-10
AU501246B2 (en) 1979-06-14
IE42308L (en) 1976-09-21
CH631996A5 (en) 1982-09-15
CA1069498A (en) 1980-01-08
CH621560A5 (en) 1981-02-13
IE42308B1 (en) 1980-07-16
AU1220776A (en) 1977-09-22
JPS6355488B2 (en) 1988-11-02
AT357700B (en) 1980-07-25
DE2610497A1 (en) 1976-10-07

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