FR2445340A1 - INTERMEDIATES FOR THE PREPARATION OF STEROID DERIVATIVES HAVING PHARMACEUTICAL ACTIVITY - Google Patents

INTERMEDIATES FOR THE PREPARATION OF STEROID DERIVATIVES HAVING PHARMACEUTICAL ACTIVITY

Info

Publication number
FR2445340A1
FR2445340A1 FR8004184A FR8004184A FR2445340A1 FR 2445340 A1 FR2445340 A1 FR 2445340A1 FR 8004184 A FR8004184 A FR 8004184A FR 8004184 A FR8004184 A FR 8004184A FR 2445340 A1 FR2445340 A1 FR 2445340A1
Authority
FR
France
Prior art keywords
intermediates
preparation
pharmaceutical activity
steroid derivatives
steroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8004184A
Other languages
French (fr)
Other versions
FR2445340B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of FR2445340A1 publication Critical patent/FR2445340A1/en
Application granted granted Critical
Publication of FR2445340B1 publication Critical patent/FR2445340B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Des composés de formule (1) :Compounds of formula (1):

FR8004184A 1975-03-21 1980-02-26 INTERMEDIATES FOR THE PREPARATION OF STEROID DERIVATIVES HAVING PHARMACEUTICAL ACTIVITY Granted FR2445340A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB11819/75A GB1538227A (en) 1975-03-21 1975-03-21 16,16-disubstituted steroids of the androstene series

Publications (2)

Publication Number Publication Date
FR2445340A1 true FR2445340A1 (en) 1980-07-25
FR2445340B1 FR2445340B1 (en) 1983-02-11

Family

ID=9993275

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7607328A Granted FR2304345A1 (en) 1975-03-21 1976-03-15 DERIVATIVES OF STEROIDS
FR8004184A Granted FR2445340A1 (en) 1975-03-21 1980-02-26 INTERMEDIATES FOR THE PREPARATION OF STEROID DERIVATIVES HAVING PHARMACEUTICAL ACTIVITY

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7607328A Granted FR2304345A1 (en) 1975-03-21 1976-03-15 DERIVATIVES OF STEROIDS

Country Status (15)

Country Link
JP (2) JPS51118756A (en)
AT (1) AT357700B (en)
AU (1) AU501246B2 (en)
BE (1) BE839751A (en)
CA (1) CA1069498A (en)
CH (2) CH621560A5 (en)
DE (1) DE2610497C2 (en)
DK (1) DK143757C (en)
FR (2) FR2304345A1 (en)
GB (1) GB1538227A (en)
IE (1) IE42308B1 (en)
IL (2) IL49132A (en)
NL (1) NL184111C (en)
SE (2) SE7603410L (en)
ZA (1) ZA761324B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1602960A (en) * 1977-05-25 1981-11-18 Beecham Group Ltd Process for preparing 16,16-disubstituted steroids of the androstene series
DE2943778A1 (en) * 1979-10-26 1981-05-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17-Alpha:alkyl-4,15-androstadiene-3-one derivs. - topical antiandrogens effective against acne, seborrhoea, alopecia and hirsutism
DE3514272A1 (en) * 1985-04-17 1986-10-23 Schering AG, 1000 Berlin und 4709 Bergkamen DERMATICA
JPS63300153A (en) * 1987-05-29 1988-12-07 日本碍子株式会社 Building enamel panel
GB9021546D0 (en) * 1990-10-04 1990-11-21 Beecham Group Plc Novel composition
JPH06502161A (en) * 1990-10-31 1994-03-10 ビーチャム・グループ・パブリック・リミテッド・カンパニー Topical compositions containing retinoid penetration enhancers
GB9205194D0 (en) * 1992-03-10 1992-04-22 Smithkline Beecham Plc Novel composition
US20050009797A1 (en) * 2001-12-19 2005-01-13 Mitsuaki Nakamura Androstane derivative having substituent in 7- abd 17--positions
CN108558975B (en) * 2018-04-26 2021-03-02 昆明理工大学 12 beta-hydroxy-androstane 4, 14-diene-16-ketone compound and application thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853926A (en) * 1973-05-29 1974-12-10 Searle & Co 17{62 -hydroxy-16,16-dimethylester-4-en-3-one

Also Published As

Publication number Publication date
FR2304345B1 (en) 1980-11-07
IL49132A (en) 1980-05-30
NL184111B (en) 1988-11-16
DE2610497C2 (en) 1986-10-16
ZA761324B (en) 1977-02-23
ATA191376A (en) 1979-12-15
DK143757B (en) 1981-10-05
BE839751A (en) 1976-09-20
SE7603410L (en) 1976-09-22
NL184111C (en) 1989-04-17
JPS61178920A (en) 1986-08-11
DK143757C (en) 1982-03-22
FR2304345A1 (en) 1976-10-15
DK123476A (en) 1976-09-22
FR2445340B1 (en) 1983-02-11
JPS51118756A (en) 1976-10-18
IL49132A0 (en) 1976-05-31
JPS625920B2 (en) 1987-02-07
IL58505A0 (en) 1980-01-31
NL7602949A (en) 1976-09-23
GB1538227A (en) 1979-01-10
AU501246B2 (en) 1979-06-14
IE42308L (en) 1976-09-21
CH631996A5 (en) 1982-09-15
CA1069498A (en) 1980-01-08
CH621560A5 (en) 1981-02-13
IE42308B1 (en) 1980-07-16
AU1220776A (en) 1977-09-22
JPS6355488B2 (en) 1988-11-02
AT357700B (en) 1980-07-25
DE2610497A1 (en) 1976-10-07
SE7902256L (en) 1979-03-13

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