SE503225C2 - Virus-antikroppskomplex för införing av virus i mammalieceller - Google Patents
Virus-antikroppskomplex för införing av virus i mammaliecellerInfo
- Publication number
- SE503225C2 SE503225C2 SE9103183A SE9103183A SE503225C2 SE 503225 C2 SE503225 C2 SE 503225C2 SE 9103183 A SE9103183 A SE 9103183A SE 9103183 A SE9103183 A SE 9103183A SE 503225 C2 SE503225 C2 SE 503225C2
- Authority
- SE
- Sweden
- Prior art keywords
- antibody
- virus
- viral
- complex according
- complex
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title claims abstract description 40
- 210000004962 mammalian cell Anatomy 0.000 title claims abstract description 9
- 210000004027 cell Anatomy 0.000 claims abstract description 46
- 239000000427 antigen Substances 0.000 claims abstract description 19
- 102000036639 antigens Human genes 0.000 claims abstract description 18
- 108091007433 antigens Proteins 0.000 claims abstract description 18
- 230000027455 binding Effects 0.000 claims abstract description 17
- 208000015181 infectious disease Diseases 0.000 claims abstract description 7
- 239000013598 vector Substances 0.000 claims abstract description 7
- 230000002458 infectious effect Effects 0.000 claims abstract description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 29
- 230000003612 virological effect Effects 0.000 claims description 16
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 230000001413 cellular effect Effects 0.000 claims description 8
- 239000003446 ligand Substances 0.000 claims description 5
- 239000000126 substance Substances 0.000 claims description 5
- 230000001225 therapeutic effect Effects 0.000 claims description 5
- 239000003153 chemical reaction reagent Substances 0.000 claims description 4
- 238000010353 genetic engineering Methods 0.000 claims description 4
- 210000000170 cell membrane Anatomy 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 210000000056 organ Anatomy 0.000 claims description 3
- 230000035515 penetration Effects 0.000 claims description 3
- 239000013603 viral vector Substances 0.000 claims description 3
- 230000001588 bifunctional effect Effects 0.000 claims description 2
- 238000010367 cloning Methods 0.000 claims description 2
- 238000001179 sorption measurement Methods 0.000 claims 5
- 108010032595 Antibody Binding Sites Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 210000003462 vein Anatomy 0.000 claims 2
- 108090001008 Avidin Proteins 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 claims 1
- 210000003850 cellular structure Anatomy 0.000 abstract 1
- 101710154606 Hemagglutinin Proteins 0.000 description 6
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 6
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 6
- 101710176177 Protein A56 Proteins 0.000 description 6
- 108070000030 Viral receptors Proteins 0.000 description 6
- 239000000185 hemagglutinin Substances 0.000 description 6
- 230000035931 haemagglutination Effects 0.000 description 5
- 108020003175 receptors Proteins 0.000 description 5
- 102000005962 receptors Human genes 0.000 description 5
- 102000007238 Transferrin Receptors Human genes 0.000 description 3
- 108010033576 Transferrin Receptors Proteins 0.000 description 3
- 208000036142 Viral infection Diseases 0.000 description 3
- 230000021615 conjugation Effects 0.000 description 3
- 238000001415 gene therapy Methods 0.000 description 3
- 229940127121 immunoconjugate Drugs 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000001177 retroviral effect Effects 0.000 description 3
- 241001430294 unidentified retrovirus Species 0.000 description 3
- 230000009385 viral infection Effects 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 206010009944 Colon cancer Diseases 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 208000037797 influenza A Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000004779 membrane envelope Anatomy 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 241000712461 unidentified influenza virus Species 0.000 description 2
- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 description 1
- WDVIDPRACNGFPP-QWRGUYRKSA-N (2s)-2-[[(2s)-6-amino-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid Chemical compound NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O WDVIDPRACNGFPP-QWRGUYRKSA-N 0.000 description 1
- RSRKICWWOYBARZ-UHFFFAOYSA-N (pyridin-2-yldisulfanyl) propanoate Chemical compound CCC(=O)OSSC1=CC=CC=N1 RSRKICWWOYBARZ-UHFFFAOYSA-N 0.000 description 1
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 102100032768 Complement receptor type 2 Human genes 0.000 description 1
- 101710181478 Envelope glycoprotein GP350 Proteins 0.000 description 1
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 1
- 101000941929 Homo sapiens Complement receptor type 2 Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 241001500351 Influenzavirus A Species 0.000 description 1
- 101100293261 Mus musculus Naa15 gene Proteins 0.000 description 1
- -1 N-succinimidyl (2-pyridyldithio) Chemical class 0.000 description 1
- 101150082943 NAT1 gene Proteins 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 102100023105 Sialin Human genes 0.000 description 1
- 101710105284 Sialin Proteins 0.000 description 1
- 239000012505 Superdex™ Substances 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 230000000721 bacterilogical effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000003889 chemical engineering Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 230000003067 hemagglutinative effect Effects 0.000 description 1
- 230000002607 hemopoietic effect Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 210000004754 hybrid cell Anatomy 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000006177 thiolation reaction Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/64—General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9103183A SE503225C2 (sv) | 1991-10-30 | 1991-10-30 | Virus-antikroppskomplex för införing av virus i mammalieceller |
| AT92922980T ATE224442T1 (de) | 1991-10-30 | 1992-10-28 | Zielgerichtetes einbringen eines virus-vektors in säugetierzellen. |
| EP92922980A EP0614486B1 (de) | 1991-10-30 | 1992-10-28 | Zielgerichtetes Einbringen eines Virus-Vektors in Säugetierzellen. |
| ES92922980T ES2180538T3 (es) | 1991-10-30 | 1992-10-28 | Suministro dirigido de vector virico a celulas de mamiferos. |
| PCT/SE1992/000745 WO1993009221A1 (en) | 1991-10-30 | 1992-10-28 | Targeted delivery of virus vector to mammalian cells |
| CA002122613A CA2122613C (en) | 1991-10-30 | 1992-10-28 | Targeted delivery of virus vector to mammalian cells |
| JP5508351A JPH07502026A (ja) | 1991-10-30 | 1992-10-28 | ウイルス抗体複合体 |
| DE69232782T DE69232782T2 (de) | 1991-10-30 | 1992-10-28 | Zielgerichtetes Einbringen eines Virus-Vektors in Säugetierzellen. |
| US08/232,028 US5695991A (en) | 1991-10-30 | 1992-10-28 | Targeted delivery of virus vector to mammalian cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9103183A SE503225C2 (sv) | 1991-10-30 | 1991-10-30 | Virus-antikroppskomplex för införing av virus i mammalieceller |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE9103183D0 SE9103183D0 (sv) | 1991-10-30 |
| SE9103183L SE9103183L (sv) | 1993-05-01 |
| SE503225C2 true SE503225C2 (sv) | 1996-04-22 |
Family
ID=20384166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE9103183A SE503225C2 (sv) | 1991-10-30 | 1991-10-30 | Virus-antikroppskomplex för införing av virus i mammalieceller |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5695991A (de) |
| EP (1) | EP0614486B1 (de) |
| JP (1) | JPH07502026A (de) |
| AT (1) | ATE224442T1 (de) |
| CA (1) | CA2122613C (de) |
| DE (1) | DE69232782T2 (de) |
| ES (1) | ES2180538T3 (de) |
| SE (1) | SE503225C2 (de) |
| WO (1) | WO1993009221A1 (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820157B2 (en) | 1997-04-10 | 2010-10-26 | University Of Southern California | Transgene delivering retrovirus targeting collagen exposed at site of tissue injury |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE503225C2 (sv) * | 1991-10-30 | 1996-04-22 | Leif Lindholm Konsult Ab | Virus-antikroppskomplex för införing av virus i mammalieceller |
| GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| DE4311651A1 (de) * | 1993-04-08 | 1994-10-13 | Boehringer Ingelheim Int | Virus für den Transport von Fremd-DNA in höhere eukaryotische Zellen |
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5753499A (en) * | 1994-12-23 | 1998-05-19 | New York University | Viral vector complexes having adapters of predefined valence |
| US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
| US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| CA2224907A1 (en) | 1995-07-25 | 1997-02-13 | Introgene B.V. | Methods and means for targeted gene delivery |
| KR100353115B1 (ko) | 1995-11-13 | 2003-01-06 | 다카라츠죠 가부시키가이샤 | 레트로바이러스를사용한표적세포내로의유전자도입방법 |
| DE19605279A1 (de) | 1996-02-13 | 1997-08-14 | Hoechst Ag | Zielzellspezifische Vektoren für die Einschleusung von Genen in Zellen, Arzneimittel enthaltend derartige Vektoren und deren Verwendung |
| EP0927044A4 (de) * | 1996-04-16 | 1999-09-08 | Immusol Inc | Gerichtete viral vektoren |
| US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
| US5980898A (en) | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
| US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
| DE19649645A1 (de) * | 1996-11-29 | 1998-06-04 | Hoechst Ag | Mehrfach funktionelles Ligandensystem zur zielzellspezifischen Übertragung von Nukleotidsequenzen |
| US6432699B1 (en) | 1997-03-28 | 2002-08-13 | New York University | Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A |
| AU7127798A (en) * | 1997-04-18 | 1998-11-13 | President And Fellows Of Harvard College | Bifunctional polypeptides for cell-specific viral targeting |
| US6004798A (en) * | 1997-05-14 | 1999-12-21 | University Of Southern California | Retroviral envelopes having modified hypervariable polyproline regions |
| US6287857B1 (en) | 1998-02-09 | 2001-09-11 | Genzyme Corporation | Nucleic acid delivery vehicles |
| AU2662999A (en) * | 1998-02-09 | 1999-08-23 | Genzyme Corporation | Nucleic acid delivery vehicles |
| US20060292121A1 (en) * | 1998-04-29 | 2006-12-28 | Hall Frederick L | Retroviral vectors including modified envelope escort protein |
| US7078483B2 (en) | 1998-04-29 | 2006-07-18 | University Of Southern California | Retroviral vectors including modified envelope escort proteins |
| AU4070499A (en) | 1998-04-30 | 1999-11-16 | Cornell Research Foundation Inc. | Adenoviral vectors with tandem fiber proteins |
| US6060316A (en) * | 1998-06-09 | 2000-05-09 | President And Fellows Of Harvard College | Methods of targeting of viral entry |
| US6455314B1 (en) | 1998-09-11 | 2002-09-24 | Genvec, Inc. | Alternatively targeted adenovirus |
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| WO2001092549A2 (en) * | 2000-05-31 | 2001-12-06 | Genvec, Inc. | Method and composition for targeting an adenoviral vector |
| DK1372708T3 (da) | 2001-02-13 | 2008-10-20 | Us Gov Sec Army | Vaccine til transkutan immunisering mod rejsediarre |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| US11266736B2 (en) | 2008-04-17 | 2022-03-08 | Vin De Bona Trading Company Pte Ltd | Method of painting micro vesicles |
| EP2281033B1 (de) | 2008-04-17 | 2014-10-15 | Vin de Bona Trading Co Pte | Modifizierung viraler hüllen nach deren freisetzung |
| US11826423B2 (en) | 2016-11-16 | 2023-11-28 | Immunomic Therapeutics, Inc. | Nucleic acids for treatment of allergies |
| IL270024B2 (en) | 2017-04-22 | 2025-04-01 | Immunomic Therapeutics Inc | LAMP structures and their use in vaccination |
| KR20200016224A (ko) | 2017-05-02 | 2020-02-14 | 이뮤노믹 쎄라퓨틱스, 인크. | 암 항원을 포함하는 lamp (리소솜 연관 막 단백질) 구축물 |
| EP3793595A1 (de) | 2018-05-15 | 2021-03-24 | Immunomic Therapeutics, Inc. | Verbesserte lamp-konstrukte mit allergenen |
| JP2022551732A (ja) | 2019-10-18 | 2022-12-13 | イミュノミック セラピューティックス, インコーポレイテッド | がん抗原を含む改良lamp構築物 |
| EP4508071A1 (de) | 2022-04-10 | 2025-02-19 | Immunomic Therapeutics, Inc. | Bicistronische lampenkonstrukte mit immunreaktionserhöhenden genen und verfahren zur verwendung davon |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4364934A (en) * | 1979-12-04 | 1982-12-21 | Ortho Pharmaceutical Corporation | Monoclonal antibody to a human early thymocyte antigen and methods for preparing same |
| US5428132A (en) * | 1987-10-11 | 1995-06-27 | United States Of America | Conjugate and method for integration of foreign DNA into cells |
| WO1989007136A2 (en) * | 1988-02-05 | 1989-08-10 | Whitehead Institute For Biomedical Research | Modified hepatocytes and uses therefor |
| JPH04504361A (ja) * | 1989-04-05 | 1992-08-06 | ノバセル コーポレイション | 感染性標的化複製―欠陥ビリオン |
| FR2649119A1 (fr) * | 1989-06-30 | 1991-01-04 | Centre Nat Rech Scient | Procede de pilotage de retrovirus en utilisant des complexes bifonctionnels |
| AU648261B2 (en) * | 1989-08-18 | 1994-04-21 | Novartis Vaccines And Diagnostics, Inc. | Recombinant retroviruses delivering vector constructs to target cells |
| WO1991004753A1 (en) * | 1989-10-02 | 1991-04-18 | Cetus Corporation | Conjugates of antisense oligonucleotides and therapeutic uses thereof |
| CA2092323A1 (en) * | 1990-10-01 | 1992-04-02 | George Y. Wu | Targeting viruses and cells for selective internalization by cells |
| SE503225C2 (sv) * | 1991-10-30 | 1996-04-22 | Leif Lindholm Konsult Ab | Virus-antikroppskomplex för införing av virus i mammalieceller |
-
1991
- 1991-10-30 SE SE9103183A patent/SE503225C2/sv not_active IP Right Cessation
-
1992
- 1992-10-28 US US08/232,028 patent/US5695991A/en not_active Expired - Fee Related
- 1992-10-28 DE DE69232782T patent/DE69232782T2/de not_active Revoked
- 1992-10-28 ES ES92922980T patent/ES2180538T3/es not_active Expired - Lifetime
- 1992-10-28 EP EP92922980A patent/EP0614486B1/de not_active Revoked
- 1992-10-28 WO PCT/SE1992/000745 patent/WO1993009221A1/en not_active Ceased
- 1992-10-28 JP JP5508351A patent/JPH07502026A/ja not_active Ceased
- 1992-10-28 CA CA002122613A patent/CA2122613C/en not_active Expired - Fee Related
- 1992-10-28 AT AT92922980T patent/ATE224442T1/de not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7820157B2 (en) | 1997-04-10 | 2010-10-26 | University Of Southern California | Transgene delivering retrovirus targeting collagen exposed at site of tissue injury |
| US8148509B2 (en) | 1997-04-10 | 2012-04-03 | University Of Southern California | Transgene delivering retrovirus targeting collagen exposed at site of tissue injury |
| US8530441B2 (en) | 1997-04-10 | 2013-09-10 | University Of Southern California | Transgene delivering retrovirus targeting collagen exposed at site of tissue injury |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0614486B1 (de) | 2002-09-18 |
| WO1993009221A1 (en) | 1993-05-13 |
| JPH07502026A (ja) | 1995-03-02 |
| DE69232782D1 (de) | 2002-10-24 |
| SE9103183L (sv) | 1993-05-01 |
| SE9103183D0 (sv) | 1991-10-30 |
| EP0614486A1 (de) | 1994-09-14 |
| US5695991A (en) | 1997-12-09 |
| ES2180538T3 (es) | 2003-02-16 |
| ATE224442T1 (de) | 2002-10-15 |
| CA2122613A1 (en) | 1993-05-13 |
| CA2122613C (en) | 2003-08-19 |
| DE69232782T2 (de) | 2003-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE503225C2 (sv) | Virus-antikroppskomplex för införing av virus i mammalieceller | |
| FI110613B (fi) | Kapsidia muodostava ja kysteiini-modifioitu kimeerinen MS2-vaippaproteiini | |
| US6555367B1 (en) | Complex of biotinylated viral vector and ligand for targeted gene delivery | |
| US5547932A (en) | Composition for introducing nucleic acid complexes into higher eucaryotic cells | |
| JP4716350B2 (ja) | 潜伏期膜タンパク質に対する抗体およびそれらの使用 | |
| Strand et al. | Structural proteins of ribonucleic acid tumor viruses. Purification of envelope, core, and internal components. | |
| US5166050A (en) | Monoclonal antibodies and peptides useful in treating and diagnosing HIV infections | |
| JP2528815B2 (ja) | 多効果免疫性蛋白質 | |
| Singh et al. | Expression of rabies glycoprotein and ricin toxin B chain (RGP–RTB) fusion protein in tomato hairy roots: a step towards Oral vaccination for rabies | |
| US5981273A (en) | Composition comprising an endosomolytic agent for introducing nucleic acid complexes into higher eucaryotic cells | |
| JPH06506583A (ja) | ベクターとして修正された植物ウイルス | |
| BE1000811A4 (fr) | Anticorps monoclonaux, peptides et compositions les contenant, destinees au diagnostic et au traitement des infections par le virus hiv. | |
| SK160391A3 (en) | Recombinant proteine joining complex viral antigen hiv-1 | |
| JPS63501125A (ja) | ヒトレトロウイルス遺伝子を発現する組換えワクチニアウイルス | |
| CN105949316A (zh) | 抗EGFRvIII嵌合抗原受体、编码基因、重组表达载体及其构建方法和应用 | |
| CN102690842B (zh) | 一种表达人抗体全基因的重组腺病毒(rAdv)载体及其方法 | |
| US5364761A (en) | Method for isolating a DNA encoding an autonomously replicating sequence | |
| JPH02142737A (ja) | 擬似狂犬病ウイルスワクチン | |
| CN120518757B (zh) | 一种聚乙二醇化多价抗西尼罗病毒单链抗体 | |
| Rammensee et al. | Targeting cytotoxic T cells to antigen‐specific B lymphocytes | |
| US20030044420A1 (en) | Self antigen vaccines for treating B cell lymphomas and other cancers | |
| Teramoto et al. | Detection of novel murine mammary tumor viruses by interspecies immunoassays | |
| Shinnick et al. | Peptide-elicited protein-reactive antibodies in molecular biology and medicine | |
| RU2217162C2 (ru) | Вакцина против вирусных инфекций | |
| CN120884692A (zh) | 一种具有高效递送能力的复合型核酸类免疫增强物质及其制备方法和应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |