SE464763B - Metod och anordning foer att studera cellers/cellaggregats reaktionsmoenster vid perfusion med ett testmedium - Google Patents
Metod och anordning foer att studera cellers/cellaggregats reaktionsmoenster vid perfusion med ett testmediumInfo
- Publication number
- SE464763B SE464763B SE8903274A SE8903274A SE464763B SE 464763 B SE464763 B SE 464763B SE 8903274 A SE8903274 A SE 8903274A SE 8903274 A SE8903274 A SE 8903274A SE 464763 B SE464763 B SE 464763B
- Authority
- SE
- Sweden
- Prior art keywords
- space
- medium
- cell
- chamber
- intended
- Prior art date
Links
- 230000010412 perfusion Effects 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims abstract description 6
- 230000009087 cell motility Effects 0.000 claims abstract description 4
- 230000030833 cell death Effects 0.000 claims abstract description 3
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 238000000429 assembly Methods 0.000 claims description 5
- 230000000712 assembly Effects 0.000 claims description 5
- 231100000433 cytotoxic Toxicity 0.000 claims description 5
- 230000001472 cytotoxic effect Effects 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 230000033001 locomotion Effects 0.000 claims description 3
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 239000007791 liquid phase Substances 0.000 claims 1
- 230000036647 reaction Effects 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 abstract description 2
- 229940127089 cytotoxic agent Drugs 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 238000005086 pumping Methods 0.000 abstract 2
- 230000005540 biological transmission Effects 0.000 abstract 1
- 238000000386 microscopy Methods 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 description 4
- 238000005273 aeration Methods 0.000 description 2
- 239000000824 cytostatic agent Substances 0.000 description 2
- 230000001085 cytostatic effect Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 208000012661 Dyskinesia Diseases 0.000 description 1
- 241001529742 Rosmarinus Species 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 231100000599 cytotoxic agent Toxicity 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Sustainable Development (AREA)
- Toxicology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8903274A SE464763B (sv) | 1989-10-05 | 1989-10-05 | Metod och anordning foer att studera cellers/cellaggregats reaktionsmoenster vid perfusion med ett testmedium |
| AU65292/90A AU6529290A (en) | 1989-10-05 | 1990-10-05 | Method and apparatus for studying the reaction pattern of cells/cell aggregates during perfusion by a test medium |
| AT90915212T ATE148229T1 (de) | 1989-10-05 | 1990-10-05 | Verfahren und vorrichtung zur untersuchung des reaktionsmusters von zellen/zellaggregaten während der perfusion durch ein testmedium |
| DE69029807T DE69029807T2 (de) | 1989-10-05 | 1990-10-05 | Verfahren und vorrichtung zur untersuchung des reaktionsmusters von zellen/zellaggregaten während der perfusion durch ein testmedium |
| EP90915212A EP0495847B1 (de) | 1989-10-05 | 1990-10-05 | Verfahren und vorrichtung zur untersuchung des reaktionsmusters von zellen/zellaggregaten während der perfusion durch ein testmedium |
| US07/847,053 US5312731A (en) | 1989-10-05 | 1990-10-05 | Method and apparatus for studying a reaction pattern of a cell or cell aggregates during perfusion with different media |
| PCT/SE1990/000638 WO1991005253A1 (en) | 1989-10-05 | 1990-10-05 | Method and apparatus for studying the reaction pattern of cells/cell aggregates during perfusion by a test medium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8903274A SE464763B (sv) | 1989-10-05 | 1989-10-05 | Metod och anordning foer att studera cellers/cellaggregats reaktionsmoenster vid perfusion med ett testmedium |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8903274D0 SE8903274D0 (sv) | 1989-10-05 |
| SE8903274L SE8903274L (sv) | 1991-04-06 |
| SE464763B true SE464763B (sv) | 1991-06-10 |
Family
ID=20377062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8903274A SE464763B (sv) | 1989-10-05 | 1989-10-05 | Metod och anordning foer att studera cellers/cellaggregats reaktionsmoenster vid perfusion med ett testmedium |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5312731A (de) |
| EP (1) | EP0495847B1 (de) |
| AT (1) | ATE148229T1 (de) |
| AU (1) | AU6529290A (de) |
| DE (1) | DE69029807T2 (de) |
| SE (1) | SE464763B (de) |
| WO (1) | WO1991005253A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3067347B2 (ja) * | 1991-10-30 | 2000-07-17 | 株式会社島津製作所 | ゲル状ビーズの選別装置 |
| US5721135A (en) * | 1995-07-06 | 1998-02-24 | Novo Nordisk A/S | Apparatus for identifying biologically active substances by their effect on living cells |
| WO1997014962A1 (en) * | 1995-10-18 | 1997-04-24 | John Hopkins University | Dosage modeling system |
| US5962317A (en) * | 1995-10-18 | 1999-10-05 | The Johns Hopkins University School Of Medicine | Dosage modeling system |
| US6287848B1 (en) | 1995-10-18 | 2001-09-11 | Johns Hopkins University | Dosage modeling system |
| US6762036B2 (en) * | 1995-11-08 | 2004-07-13 | Trustees Of Boston University | Cellular physiology workstations for automated data acquisition and perfusion control |
| WO1997017426A1 (en) * | 1995-11-08 | 1997-05-15 | Trustees Of Boston University | Cellular physiology workstations for automated data acquisition and perfusion control |
| WO1997036166A1 (en) * | 1996-03-25 | 1997-10-02 | Diasys Corporation | Apparatus and method for handling fluid samples of body materials |
| US5942443A (en) * | 1996-06-28 | 1999-08-24 | Caliper Technologies Corporation | High throughput screening assay systems in microscale fluidic devices |
| US20060000722A1 (en) * | 1996-06-28 | 2006-01-05 | Caliper Life Sciences, Inc. | High throughput screening assay systems in microscale fluidic devices |
| CA2258489C (en) * | 1996-06-28 | 2004-01-27 | Caliper Technologies Corporation | High-throughput screening assay systems in microscale fluidic devices |
| CN1310980A (zh) * | 2000-02-29 | 2001-09-05 | 迪亚西斯公司 | 处理各种体液的方法和设备 |
| AU2002230396B2 (en) * | 2000-10-06 | 2012-06-07 | Krstec, Victor | System and method to simulate hemodynamics |
| US6864065B2 (en) * | 2000-11-08 | 2005-03-08 | Surface Logix, Inc. | Assays for monitoring cell motility in real-time |
| US7326563B2 (en) | 2000-11-08 | 2008-02-05 | Surface Logix, Inc. | Device and method for monitoring leukocyte migration |
| US7033819B2 (en) | 2000-11-08 | 2006-04-25 | Surface Logix, Inc. | System for monitoring cell motility in real-time |
| US6893851B2 (en) | 2000-11-08 | 2005-05-17 | Surface Logix, Inc. | Method for arraying biomolecules and for monitoring cell motility in real-time |
| US6699665B1 (en) * | 2000-11-08 | 2004-03-02 | Surface Logix, Inc. | Multiple array system for integrating bioarrays |
| US7374906B2 (en) | 2000-11-08 | 2008-05-20 | Surface Logix, Inc. | Biological assays using gradients formed in microfluidic systems |
| US7033821B2 (en) * | 2000-11-08 | 2006-04-25 | Surface Logix, Inc. | Device for monitoring cell motility in real-time |
| US6844184B2 (en) * | 2000-11-08 | 2005-01-18 | Surface Logix, Inc. | Device for arraying biomolecules and for monitoring cell motility in real-time |
| AU2003228950A1 (en) * | 2002-05-08 | 2003-11-11 | Scion Pharmaceuticals, Inc. | Oocyte recording chamber |
| TWM352684U (en) * | 2008-09-26 | 2009-03-11 | Shanghai Microtek Technology Co Ltd | Inspection apparatus for biological sample |
| KR102291945B1 (ko) | 2017-02-02 | 2021-08-23 | 패스트 코포레이션 | 미생물의 운동성 운동학의 분석 및 사용 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1187970A (en) * | 1912-04-09 | 1916-06-20 | Nathan Augustus Cobb | Mechanical microscope-stage. |
| US2942520A (en) * | 1955-12-20 | 1960-06-28 | George G Rose | Tissue culture device |
| US2940360A (en) * | 1957-05-23 | 1960-06-14 | Jr William H Carter | Perfusion chamber |
| US3031924A (en) * | 1959-03-12 | 1962-05-01 | James C Lamal | Observation slide |
| US3029695A (en) * | 1960-05-02 | 1962-04-17 | Frank E Wolf | Microscope slides |
| US3065669A (en) * | 1960-07-19 | 1962-11-27 | American Cyanamid Co | Tissue culture chamber |
| GB1064244A (en) * | 1965-01-05 | 1967-04-05 | Ici Ltd | Cell culture slides |
| US3620596A (en) * | 1970-09-18 | 1971-11-16 | Aerojet General Co | Microscope slides |
| US3726597A (en) * | 1972-03-09 | 1973-04-10 | Us Health Education & Welfare | Controlled environment culture system for light microscopy |
| FR2178555A5 (de) * | 1972-12-21 | 1973-11-09 | Petroles Cie Francaise | |
| SE448881B (sv) * | 1981-03-12 | 1987-03-23 | Erik Walum | Apparat for genomforandet av perfusionsodling av en eller flera cellkulturer samt forfarande for perfusionsodling av en eller flera cellkulturer |
| US4395492A (en) * | 1981-06-03 | 1983-07-26 | Res-Del Group Ltd. | Perfusion chamber |
| US4435508A (en) * | 1981-11-20 | 1984-03-06 | Gabridge Michael G | Tissue culture vessel |
| US4734372A (en) * | 1983-02-04 | 1988-03-29 | Brown University Research Foundation | Cell culturing methods and apparatus |
| US4559299A (en) * | 1983-02-04 | 1985-12-17 | Brown University Research Foundation Inc. | Cytotoxicity assays in cell culturing devices |
| DE3317551A1 (de) * | 1983-05-13 | 1984-11-15 | Stephan Dipl.-Chem. Dr.rer.nat. 8000 München Nees | Perfusionseinrichtung zum "in vitro"-bespuelen verankerungsabhaengiger biologischer zellsysteme |
| US4647531A (en) * | 1984-02-06 | 1987-03-03 | Ortho Diagnostic Systems, Inc. | Generalized cytometry instrument and methods of use |
| US4748124A (en) * | 1984-10-30 | 1988-05-31 | E. I. Du Pont De Nemours And Company | Compartmentalized cell-culture device and method |
| US4681853A (en) * | 1985-10-23 | 1987-07-21 | Hardy Kenneth J | Perfusion slit chamber for filter-bound sample analyses |
| US4680266A (en) * | 1985-11-21 | 1987-07-14 | Contraves Ag | Cell culture chamber with means for automatic replenishment of nutrient |
-
1989
- 1989-10-05 SE SE8903274A patent/SE464763B/sv not_active IP Right Cessation
-
1990
- 1990-10-05 WO PCT/SE1990/000638 patent/WO1991005253A1/en not_active Ceased
- 1990-10-05 AU AU65292/90A patent/AU6529290A/en not_active Abandoned
- 1990-10-05 DE DE69029807T patent/DE69029807T2/de not_active Expired - Fee Related
- 1990-10-05 US US07/847,053 patent/US5312731A/en not_active Expired - Fee Related
- 1990-10-05 AT AT90915212T patent/ATE148229T1/de not_active IP Right Cessation
- 1990-10-05 EP EP90915212A patent/EP0495847B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU6529290A (en) | 1991-04-28 |
| WO1991005253A1 (en) | 1991-04-18 |
| DE69029807T2 (de) | 1997-05-28 |
| EP0495847A1 (de) | 1992-07-29 |
| US5312731A (en) | 1994-05-17 |
| SE8903274L (sv) | 1991-04-06 |
| ATE148229T1 (de) | 1997-02-15 |
| SE8903274D0 (sv) | 1989-10-05 |
| EP0495847B1 (de) | 1997-01-22 |
| DE69029807D1 (de) | 1997-03-06 |
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