SE455702B - 2 beta-klormetyl-2alfa-metylpenam-3alfa-karboxsylsyrasulfon dess salter och fysiologiskt hydrolyserbara estrar med betalaktamasinhiberande verkan, forfarande for framstellning derav samt farmaceutiska kompositioner dera - Google Patents

2 beta-klormetyl-2alfa-metylpenam-3alfa-karboxsylsyrasulfon dess salter och fysiologiskt hydrolyserbara estrar med betalaktamasinhiberande verkan, forfarande for framstellning derav samt farmaceutiska kompositioner dera

Info

Publication number
SE455702B
SE455702B SE8100339A SE8100339A SE455702B SE 455702 B SE455702 B SE 455702B SE 8100339 A SE8100339 A SE 8100339A SE 8100339 A SE8100339 A SE 8100339A SE 455702 B SE455702 B SE 455702B
Authority
SE
Sweden
Prior art keywords
acid
mixture
solution
added
chloromethyl
Prior art date
Application number
SE8100339A
Other languages
English (en)
Swedish (sv)
Other versions
SE8100339L (sv
Inventor
W J Gottstein
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/214,833 external-priority patent/US4340539A/en
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of SE8100339L publication Critical patent/SE8100339L/xx
Publication of SE455702B publication Critical patent/SE455702B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Cephalosporin Compounds (AREA)
SE8100339A 1980-01-21 1981-01-21 2 beta-klormetyl-2alfa-metylpenam-3alfa-karboxsylsyrasulfon dess salter och fysiologiskt hydrolyserbara estrar med betalaktamasinhiberande verkan, forfarande for framstellning derav samt farmaceutiska kompositioner dera SE455702B (sv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11389480A 1980-01-21 1980-01-21
US21483180A 1980-12-11 1980-12-11
US06/214,833 US4340539A (en) 1980-01-21 1980-12-11 Derivatives of 6-bromo penicillanic acid

Publications (2)

Publication Number Publication Date
SE8100339L SE8100339L (sv) 1981-09-01
SE455702B true SE455702B (sv) 1988-08-01

Family

ID=27381401

Family Applications (5)

Application Number Title Priority Date Filing Date
SE8100339A SE455702B (sv) 1980-01-21 1981-01-21 2 beta-klormetyl-2alfa-metylpenam-3alfa-karboxsylsyrasulfon dess salter och fysiologiskt hydrolyserbara estrar med betalaktamasinhiberande verkan, forfarande for framstellning derav samt farmaceutiska kompositioner dera
SE8502286A SE466203B (sv) 1980-01-21 1985-05-08 Estrar foer framstaellning av en beta-laktamas-inhibitor
SE8502285A SE8502285D0 (sv) 1980-01-21 1985-05-08 Antibakteriell komposition
SE9000189A SE9000189L (sv) 1980-01-21 1990-01-19 Estrar foer framstaellning av en beta-laktamasinhibitor
SE9000190A SE9000190L (sv) 1980-01-21 1990-01-19 Ester foer framstaellning av en beta-laktamasinhibitor

Family Applications After (4)

Application Number Title Priority Date Filing Date
SE8502286A SE466203B (sv) 1980-01-21 1985-05-08 Estrar foer framstaellning av en beta-laktamas-inhibitor
SE8502285A SE8502285D0 (sv) 1980-01-21 1985-05-08 Antibakteriell komposition
SE9000189A SE9000189L (sv) 1980-01-21 1990-01-19 Estrar foer framstaellning av en beta-laktamasinhibitor
SE9000190A SE9000190L (sv) 1980-01-21 1990-01-19 Ester foer framstaellning av en beta-laktamasinhibitor

Country Status (12)

Country Link
KR (1) KR850001066B1 (fr)
CA (1) CA1175807A (fr)
CH (2) CH651571A5 (fr)
DE (1) DE3101527A1 (fr)
DK (3) DK162717C (fr)
GB (1) GB2070592B (fr)
HU (2) HU188606B (fr)
IL (1) IL61880A (fr)
NL (1) NL8100209A (fr)
NO (5) NO160298C (fr)
OA (1) OA06748A (fr)
SE (5) SE455702B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA826687B (en) * 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
EP0134302B1 (fr) * 1983-09-15 1987-06-16 Bristol-Myers Company Compositions pharmaceutiques pour lutter contre les bactéries résistantes, y compris les anaérobies
GB2157286B (en) * 1984-04-12 1987-12-31 Leo Pharm Prod Ltd B-lactam antibiotic potentiators

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN149747B (fr) * 1977-06-07 1982-04-03 Pfizer
DE2912511C2 (de) * 1977-06-07 1982-06-24 Pfizer Inc., 10017 New York, N.Y. Pharmazeutische Zusammensetzung, enthaltend Penicillansäure
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
GB2045236A (en) * 1979-03-26 1980-10-29 Hoechst Uk Ltd Oxapenem derivatives
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide

Also Published As

Publication number Publication date
NO161677C (no) 1989-09-13
NO160298C (no) 1989-04-05
DK162717C (da) 1992-04-21
DK285790A (da) 1990-11-30
DK285890A (da) 1990-11-30
HU188606B (en) 1986-04-28
DK164938B (da) 1992-09-14
DE3101527A1 (de) 1982-02-18
DK164938C (da) 1993-02-01
SE9000189L (sv) 1991-07-20
DK162769C (da) 1992-04-27
NL8100209A (nl) 1981-08-17
SE8502286D0 (sv) 1985-05-08
KR850001066B1 (ko) 1985-07-25
NO853450L (no) 1981-07-22
NO164300C (no) 1990-09-19
SE8502285L (sv) 1985-05-08
DK21881A (da) 1981-07-22
NO161677B (no) 1989-06-05
HU184380B (en) 1984-08-28
NO164298C (no) 1990-09-19
DK285790D0 (da) 1990-11-30
CA1175807A (fr) 1984-10-09
NO861946L (no) 1981-07-22
SE8502285D0 (sv) 1985-05-08
NO861945L (no) 1981-07-22
NO164298B (no) 1990-06-11
SE466203B (sv) 1992-01-13
SE8100339L (sv) 1981-09-01
DK285890D0 (da) 1990-11-30
SE9000189D0 (sv) 1990-01-19
KR850001465A (ko) 1985-03-18
GB2070592B (en) 1983-05-11
OA06748A (fr) 1982-06-30
SE8502286L (sv) 1985-05-08
IL61880A (en) 1984-11-30
NO160298B (no) 1988-12-27
SE9000190D0 (sv) 1990-01-19
GB2070592A (en) 1981-09-09
DK162769B (da) 1991-12-09
NO164299C (no) 1990-09-19
NO164299B (no) 1990-06-11
CH651571A5 (de) 1985-09-30
NO861944L (no) 1981-07-22
SE9000190L (sv) 1991-07-20
NO164300B (no) 1990-06-11
CH649087A5 (de) 1985-04-30
DK162717B (da) 1991-12-02
NO810166L (no) 1981-07-22

Similar Documents

Publication Publication Date Title
US4168314A (en) 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
CA1230113A (fr) Production de composes chimiques
SE449749B (sv) Bis-estrar av metandiol med penicilliner och penicillansyra-1,1-dioxid
EP0061313B1 (fr) Bis-esters de 1,1-alcane-diols avec le 1,1-dioxyde de l'acide 6-béta-hydroxy-méthylpénicillanique et les antibiotiques bêta-lactames
KR920005829B1 (ko) 2β-치환된 티오메틸페니실린 유도체 및 그의 염의 제조방법
CS228919B2 (en) Method of preparing halogenomethylester of 1,1-dioxide of penicillanic acid
FR2579597A1 (fr) Esters d'alceneamidocephalosporines
SE455702B (sv) 2 beta-klormetyl-2alfa-metylpenam-3alfa-karboxsylsyrasulfon dess salter och fysiologiskt hydrolyserbara estrar med betalaktamasinhiberande verkan, forfarande for framstellning derav samt farmaceutiska kompositioner dera
US4340539A (en) Derivatives of 6-bromo penicillanic acid
EP0000645A1 (fr) Isopénicillines, procédés pour leur préparation et compositions qui les contiennent
US4380512A (en) 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone and salts and esters thereof
SE449103B (sv) Sett att framstella penicillansyra-1,1-dioxid samt estrar derav
US5321020A (en) Antibacterial 2-carbapenem derivatives
KR840002214B1 (ko) 2β-클로로메틸-2α-메틸페남-3α-카르복실산 술폰, 염 또는 그의 에스테르의 제조방법
JPS61109791A (ja) ６−（置換）メチレンペニシラン酸および６−（置換）ヒドロキシメチルペニシラン酸およびそれらの誘導体
US4325960A (en) 6-Amidinopenicillanic acid derivatives including the radical of a β-lactamase inhibitor
US3928336A (en) 7-{8 D-({60 -amino{60 -phenyl-, 2-thienyl- and 3-thienyl-acetamido){9 -3-(3-methyl-1,2,5-oxadiazol-4-yl)carbonylthiomethyl-3-cephem-4-carboxylic acids
US3316273A (en) Penicillin aldehydes
JPS63146886A (ja) ６−（２−アミノ−２−フェニルアセタミド）ペニシラン酸１，１−ジオキソペニシラノイルオキシメチル製造のための中間体
CA1175809A (fr) 2.beta.-CHLOROMETHYL-2.alpha.-METHYLPENAM-3.alpha.-ACIDE CARBOXYLIQUE SULFONE ET SELS, AINSI QUE LEURS ESTERS
US4081441A (en) Antibacterial agents
US4502990A (en) Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof
JPS58128387A (ja) 新規β−ラクタム化合物およびその製法と用途
US4444687A (en) 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters
KR830001902B1 (ko) 폐니실란산유도체의 제조방법

Legal Events

Date Code Title Description
NUG Patent has lapsed

Ref document number: 8100339-4

Effective date: 19940810

Format of ref document f/p: F