SE445150B - Forfarande och reagens for immunoanalys varvid kovalent bindning sker via en bryggbildande grupp till svavelatomer i antikropp eller proteinantigen - Google Patents
Forfarande och reagens for immunoanalys varvid kovalent bindning sker via en bryggbildande grupp till svavelatomer i antikropp eller proteinantigenInfo
- Publication number
- SE445150B SE445150B SE7900662A SE7900662A SE445150B SE 445150 B SE445150 B SE 445150B SE 7900662 A SE7900662 A SE 7900662A SE 7900662 A SE7900662 A SE 7900662A SE 445150 B SE445150 B SE 445150B
- Authority
- SE
- Sweden
- Prior art keywords
- antibody
- reagent
- antigen
- reaction
- fragments
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 28
- 238000000034 method Methods 0.000 title claims description 17
- 108090000623 proteins and genes Proteins 0.000 title claims description 13
- 102000004169 proteins and genes Human genes 0.000 title claims description 12
- 238000004458 analytical method Methods 0.000 title description 5
- 102000036639 antigens Human genes 0.000 claims description 40
- 108091007433 antigens Proteins 0.000 claims description 40
- 239000000427 antigen Substances 0.000 claims description 29
- 239000012634 fragment Substances 0.000 claims description 26
- 239000002245 particle Substances 0.000 claims description 26
- 238000006243 chemical reaction Methods 0.000 claims description 19
- 239000004816 latex Substances 0.000 claims description 14
- 229920000126 latex Polymers 0.000 claims description 14
- 239000000203 mixture Substances 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 239000003431 cross linking reagent Substances 0.000 claims description 9
- 238000003018 immunoassay Methods 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 8
- 125000004434 sulfur atom Chemical group 0.000 claims description 8
- 210000002966 serum Anatomy 0.000 claims description 7
- 239000011541 reaction mixture Substances 0.000 claims description 6
- 230000004520 agglutination Effects 0.000 claims description 5
- 150000008064 anhydrides Chemical group 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 125000002668 chloroacetyl group Chemical group ClCC(=O)* 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000011888 foil Substances 0.000 claims description 2
- -1 monochloroacetyl group Chemical group 0.000 claims description 2
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 229940027941 immunoglobulin g Drugs 0.000 claims 2
- 102000014914 Carrier Proteins Human genes 0.000 claims 1
- 108010078791 Carrier Proteins Proteins 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 239000011236 particulate material Substances 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 description 17
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 12
- 229940098773 bovine serum albumin Drugs 0.000 description 12
- 108010088751 Albumins Proteins 0.000 description 10
- 102000009027 Albumins Human genes 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 10
- 125000003277 amino group Chemical group 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- 108060003951 Immunoglobulin Proteins 0.000 description 6
- 239000000872 buffer Substances 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 102000018358 immunoglobulin Human genes 0.000 description 6
- 238000003556 assay Methods 0.000 description 5
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 102000008857 Ferritin Human genes 0.000 description 4
- 108050000784 Ferritin Proteins 0.000 description 4
- 238000008416 Ferritin Methods 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 230000001588 bifunctional effect Effects 0.000 description 3
- 125000000524 functional group Chemical group 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 125000003396 thiol group Chemical group [H]S* 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000007818 agglutination assay Methods 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005206 flow analysis Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- HIZVCIIORGCREW-UHFFFAOYSA-N 1,4-dioxene Chemical compound C1COC=CO1 HIZVCIIORGCREW-UHFFFAOYSA-N 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 description 1
- 235000008206 alpha-amino acids Nutrition 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 125000002228 disulfide group Chemical group 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000005188 flotation Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- JDNTWHVOXJZDSN-UHFFFAOYSA-N iodoacetic acid Chemical compound OC(=O)CI JDNTWHVOXJZDSN-UHFFFAOYSA-N 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
- 238000003127 radioimmunoassay Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000004354 sulfur functional group Chemical group 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/801—Electron dense compounds, e.g. ferritin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Public Health (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB323878 | 1978-01-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7900662L SE7900662L (sv) | 1979-07-27 |
| SE445150B true SE445150B (sv) | 1986-06-02 |
Family
ID=9754562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7900662A SE445150B (sv) | 1978-01-26 | 1979-01-24 | Forfarande och reagens for immunoanalys varvid kovalent bindning sker via en bryggbildande grupp till svavelatomer i antikropp eller proteinantigen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4253844A (en, 2012) |
| JP (1) | JPS54119293A (en, 2012) |
| AU (1) | AU522762B2 (en, 2012) |
| BE (1) | BE873674A (en, 2012) |
| CA (1) | CA1118344A (en, 2012) |
| CH (1) | CH650592A5 (en, 2012) |
| DE (1) | DE2902677A1 (en, 2012) |
| FR (1) | FR2415810A1 (en, 2012) |
| GB (1) | GB2013688B (en, 2012) |
| IT (1) | IT1119258B (en, 2012) |
| NL (1) | NL185798C (en, 2012) |
| SE (1) | SE445150B (en, 2012) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2013211B (en) * | 1978-01-26 | 1982-06-30 | Technicon Instr | Immunoassays using f(ab')2 fragments |
| US4342566A (en) * | 1980-02-22 | 1982-08-03 | Scripps Clinic & Research Foundation | Solid phase anti-C3 assay for detection of immune complexes |
| EP0051985B2 (en) * | 1980-11-07 | 1989-12-27 | International Institute Of Cellular And Molecular Pathology (Icp) | Immunoassay of proteins |
| US4427781A (en) * | 1981-03-16 | 1984-01-24 | International Institute Of Cellular And Molecular Pathology | Particle agglutination immunoassay with agglutinator for determining haptens; PACIA |
| DE3112334A1 (de) * | 1981-03-28 | 1982-10-07 | Behringwerke Ag, 3550 Marburg | "kuenstliche kontroll- und standardseren, verfahren zu ihrer herstellung und ihre verwendung" |
| CA1203164A (en) | 1982-03-09 | 1986-04-15 | Thomas J. Mckearn | Antibody conjugates |
| DE3311889A1 (de) * | 1983-03-31 | 1984-10-11 | Byk-Mallinckrodt Chemische Produkte Gmbh, 6057 Dietzenbach | Verfahren zur irreversiblen bindung von protein an polystyroloberflaechen unter erhaltung der biologischen aktivitaet, so erhaltene polystyroloberflaechen und ihre verwendung |
| EP0140896A1 (en) * | 1983-04-18 | 1985-05-15 | Quidel | Protection of antibody during chemical modification |
| EP0141818A1 (en) * | 1983-04-18 | 1985-05-22 | Quidel | Removal of self-binding and staph a cross-reactivity of anti-strep antibody |
| DE3331627A1 (de) * | 1983-09-01 | 1985-03-21 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zur immunologischen bestimmung fuer proteine in koerperfluessigkeiten, unter verwendung monovalenter antikoerperfragmente |
| US4943636A (en) * | 1984-03-10 | 1990-07-24 | Cetus Corporation | Certain pyridyl-di-sulfide-alkylenecarbonxylate-ortho-nitro-phenylsulfonic acid esters useful for coupling biological materials |
| US4954637A (en) * | 1984-03-10 | 1990-09-04 | Cetus Corporation | Certain maleimide-N-alkylenecarboxylate-ortho-nitrobenzenesulfonic acid esters and derivatives useful for coupling biological materials |
| US5663306A (en) * | 1984-08-09 | 1997-09-02 | Chiron Corporation | Method of conjugating an activated ester to an amine-containing biological material |
| DE3671376D1 (de) * | 1985-07-02 | 1990-06-28 | Cytomed Medizintechnik | Medizinisches geraet, insbesondere filter, kanuele, katheter oder implantat. |
| JPS62132172A (ja) * | 1985-12-04 | 1987-06-15 | Shionogi & Co Ltd | 固相化抗体およびその製造方法 |
| IT1211749B (it) * | 1986-09-24 | 1989-11-03 | Bayer Aktinegesellschaft | Procedimento per la polimerizzazio ne di derivati acrilici |
| DE3638767A1 (de) * | 1986-11-13 | 1988-05-26 | Behringwerke Ag | Laktoferrin enthaltendes inkubationsmedium fuer festphasenimmunometrisches verfahren und seine verwendung |
| JP2565548B2 (ja) * | 1987-09-18 | 1996-12-18 | イーストマン コダック カンパニー | カルバモイルオニウム化合物を用いてポリマー粒子に化合物を結合させる方法 |
| WO1990004178A1 (en) * | 1988-10-11 | 1990-04-19 | Coulter Corporation | Immunoreactant carriers having a novel biocompatible intermediate coating and process of making same |
| US5252496A (en) * | 1989-12-18 | 1993-10-12 | Princeton Biomeditech Corporation | Carbon black immunochemical label |
| US5169754A (en) * | 1990-10-31 | 1992-12-08 | Coulter Corporation | Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes for making same |
| US5639620A (en) * | 1990-10-31 | 1997-06-17 | Coulter Corporation | Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same |
| US5466609A (en) * | 1990-10-31 | 1995-11-14 | Coulter Corporation | Biodegradable gelatin-aminodextran particle coatings of and processes for making same |
| AT402674B (de) * | 1993-01-18 | 1997-07-25 | Waldheim Pharmazeutika Gmbh | Verfahren und mittel zum nachweisen von verfahren und mittel zum nachweisen von antigenen antigenen |
| GB9827845D0 (en) * | 1998-12-17 | 1999-02-10 | Scolab S A | Immunoassay or proteins |
| US6623982B1 (en) * | 1999-07-12 | 2003-09-23 | Immunivest Corporation | Increased separation efficiency via controlled aggregation of magnetic nanoparticles |
| JP5458344B2 (ja) * | 2008-01-30 | 2014-04-02 | 旭化成株式会社 | 抗体固定化担体 |
| CN103328509A (zh) * | 2009-12-25 | 2013-09-25 | 积水医疗株式会社 | 人胰岛素测定法和测定试剂 |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| EP4573366A1 (en) | 2022-08-15 | 2025-06-25 | Solventum Intellectual Properties Company | Functionalized porous substrates and their use for detecting analytes |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3639558A (en) * | 1968-02-19 | 1972-02-01 | Louis Csizmas | Immunological reagent particles having proteinaceous materials covalently bonded thereto |
| FR2184847B1 (en, 2012) * | 1972-05-15 | 1978-05-26 | Biological Developments | |
| US4070246A (en) * | 1976-04-09 | 1978-01-24 | Abbott Laboratories | Reactive matrices |
| US4081244A (en) * | 1976-05-03 | 1978-03-28 | Beckman Instruments, Inc. | Immunoassay procedure employing novel immunochemical composites |
| SE431758B (sv) * | 1977-03-04 | 1984-02-27 | Pharmacia Fine Chemicals Ab | Som tioleringsreagens eller berarmatris for enzymer anvendbart derivat av en sh-grupphaltig polymer |
| US4108976A (en) * | 1977-03-04 | 1978-08-22 | Becton, Dickinson And Company | Automated direct serum radioimmunoassay |
| US4140662A (en) * | 1977-03-25 | 1979-02-20 | Ortho Diagnostics, Inc. | Attachment of proteins to inert particles |
| CA1101330A (en) * | 1977-09-19 | 1981-05-19 | Ernst A. Fischer | Immunological material bonded to carboxylated latex polymer and process for making it |
-
1979
- 1979-01-15 GB GB7901425A patent/GB2013688B/en not_active Expired
- 1979-01-22 FR FR7901538A patent/FR2415810A1/fr active Granted
- 1979-01-22 US US06/005,260 patent/US4253844A/en not_active Expired - Lifetime
- 1979-01-23 AU AU43566/79A patent/AU522762B2/en not_active Ceased
- 1979-01-24 DE DE19792902677 patent/DE2902677A1/de active Granted
- 1979-01-24 SE SE7900662A patent/SE445150B/sv not_active IP Right Cessation
- 1979-01-24 BE BE0/193050A patent/BE873674A/xx not_active IP Right Cessation
- 1979-01-25 NL NLAANVRAGE7900585,A patent/NL185798C/xx not_active IP Right Cessation
- 1979-01-25 CA CA000320277A patent/CA1118344A/en not_active Expired
- 1979-01-25 IT IT67166/79A patent/IT1119258B/it active
- 1979-01-26 JP JP730479A patent/JPS54119293A/ja active Granted
- 1979-01-26 CH CH822/79A patent/CH650592A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL185798C (nl) | 1990-07-16 |
| FR2415810A1 (fr) | 1979-08-24 |
| CA1118344A (en) | 1982-02-16 |
| CH650592A5 (de) | 1985-07-31 |
| US4253844A (en) | 1981-03-03 |
| NL185798B (nl) | 1990-02-16 |
| JPS54119293A (en) | 1979-09-17 |
| IT7967166A0 (it) | 1979-01-25 |
| AU4356679A (en) | 1979-08-02 |
| BE873674A (fr) | 1979-07-24 |
| IT1119258B (it) | 1986-03-10 |
| DE2902677C2 (en, 2012) | 1988-04-21 |
| NL7900585A (nl) | 1979-07-30 |
| AU522762B2 (en) | 1982-06-24 |
| SE7900662L (sv) | 1979-07-27 |
| GB2013688B (en) | 1982-06-30 |
| JPS6338667B2 (en, 2012) | 1988-08-01 |
| FR2415810B1 (en, 2012) | 1984-08-17 |
| DE2902677A1 (de) | 1979-08-09 |
| GB2013688A (en) | 1979-08-15 |
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| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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