SE441752B - Sett att framstella peptider, som innehaller alfa-aminooxisyror och som har gastrinverkan - Google Patents
Sett att framstella peptider, som innehaller alfa-aminooxisyror och som har gastrinverkanInfo
- Publication number
- SE441752B SE441752B SE7714524A SE7714524A SE441752B SE 441752 B SE441752 B SE 441752B SE 7714524 A SE7714524 A SE 7714524A SE 7714524 A SE7714524 A SE 7714524A SE 441752 B SE441752 B SE 441752B
- Authority
- SE
- Sweden
- Prior art keywords
- mmol
- asp
- phe
- solution
- dissolved
- Prior art date
Links
- -1 AMINOXY ACIDS Chemical class 0.000 title claims description 32
- 239000002253 acid Substances 0.000 title claims description 19
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- 102000004196 processed proteins & peptides Human genes 0.000 title claims description 8
- 230000000694 effects Effects 0.000 title description 7
- 150000001875 compounds Chemical class 0.000 claims description 22
- 150000003839 salts Chemical class 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 125000002344 aminooxy group Chemical group [H]N([H])O[*] 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 8
- 125000002252 acyl group Chemical group 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 4
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- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims description 2
- 229910052727 yttrium Inorganic materials 0.000 claims description 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 1
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- 150000004679 hydroxides Chemical class 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 125000001041 indolyl group Chemical group 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
- 125000001557 phthalyl group Chemical group C(=O)(O)C1=C(C(=O)*)C=CC=C1 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000010288 sodium nitrite Nutrition 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- RGYLYUZOGHTBRF-BIHRQFPBSA-N tetragastrin Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C2=CC=CC=C2NC=1)CCSC)C(N)=O)C1=CC=CC=C1 RGYLYUZOGHTBRF-BIHRQFPBSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- UGZADUVQMDAIAO-UHFFFAOYSA-L zinc hydroxide Chemical compound [OH-].[OH-].[Zn+2] UGZADUVQMDAIAO-UHFFFAOYSA-L 0.000 description 1
- 229940007718 zinc hydroxide Drugs 0.000 description 1
- 229910021511 zinc hydroxide Inorganic materials 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU76RI608A HU175152B (hu) | 1976-12-30 | 1976-12-30 | Sposob poluchenija peptidov s gastrin-aktivnost'ju, soderzhahhikh amino-oksi-kisloty |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7714524L SE7714524L (sv) | 1978-07-01 |
| SE441752B true SE441752B (sv) | 1985-11-04 |
Family
ID=11001012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7714524A SE441752B (sv) | 1976-12-30 | 1977-12-20 | Sett att framstella peptider, som innehaller alfa-aminooxisyror och som har gastrinverkan |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4172130A (xx) |
| JP (1) | JPS53111060A (xx) |
| BE (1) | BE862406A (xx) |
| DE (1) | DE2759031A1 (xx) |
| FR (1) | FR2376127A1 (xx) |
| GB (1) | GB1541337A (xx) |
| HU (1) | HU175152B (xx) |
| NL (1) | NL7714582A (xx) |
| SE (1) | SE441752B (xx) |
| SU (1) | SU691082A3 (xx) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5815946A (ja) * | 1981-07-21 | 1983-01-29 | Eisai Co Ltd | 新規ヘプタデカペプタイド |
| CH664560A5 (fr) * | 1982-07-07 | 1988-03-15 | Orgamol Sa | Procede de preparation d'un ester dipeptide d'acide l-aspartique par deblocage reducteur. |
| FR2575164B1 (fr) * | 1984-12-20 | 1987-03-20 | Sanofi Sa | Esters de tri- et tetrapeptides inhibiteurs de la secretion gastrique, procede d'obtention et compositions pharmaceutiques les contenant |
| CN101970015B (zh) * | 2008-01-08 | 2014-05-07 | 兰休斯医疗成像公司 | 作为显像剂的n-烷氧基酰胺共轭物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1042487A (en) * | 1964-06-25 | 1966-09-14 | Ici Ltd | Polypeptide derivatives |
| HU167655B (xx) * | 1972-08-18 | 1975-11-28 |
-
1976
- 1976-12-30 HU HU76RI608A patent/HU175152B/hu not_active IP Right Cessation
-
1977
- 1977-12-20 SE SE7714524A patent/SE441752B/sv not_active IP Right Cessation
- 1977-12-26 FR FR7739181A patent/FR2376127A1/fr active Granted
- 1977-12-26 JP JP15575377A patent/JPS53111060A/ja active Granted
- 1977-12-28 BE BE183910A patent/BE862406A/xx not_active IP Right Cessation
- 1977-12-29 US US05/865,503 patent/US4172130A/en not_active Expired - Lifetime
- 1977-12-29 GB GB54170/77A patent/GB1541337A/en not_active Expired
- 1977-12-29 SU SU772560052A patent/SU691082A3/ru active
- 1977-12-30 NL NL7714582A patent/NL7714582A/xx not_active Application Discontinuation
- 1977-12-30 DE DE19772759031 patent/DE2759031A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6121239B2 (xx) | 1986-05-26 |
| DE2759031A1 (de) | 1978-07-13 |
| HU175152B (hu) | 1980-05-28 |
| US4172130A (en) | 1979-10-23 |
| FR2376127B1 (xx) | 1980-04-04 |
| SU691082A3 (ru) | 1979-10-05 |
| GB1541337A (en) | 1979-02-28 |
| FR2376127A1 (fr) | 1978-07-28 |
| SE7714524L (sv) | 1978-07-01 |
| NL7714582A (nl) | 1978-07-04 |
| DE2759031C2 (xx) | 1988-07-21 |
| BE862406A (fr) | 1978-04-14 |
| JPS53111060A (en) | 1978-09-28 |
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| NUG | Patent has lapsed |
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