SE436357B - Forfarande for framstellning av pyrimido/6,1-a/isokinolin-4-on-derivat - Google Patents

Forfarande for framstellning av pyrimido/6,1-a/isokinolin-4-on-derivat

Info

Publication number
SE436357B
SE436357B SE7712513A SE7712513A SE436357B SE 436357 B SE436357 B SE 436357B SE 7712513 A SE7712513 A SE 7712513A SE 7712513 A SE7712513 A SE 7712513A SE 436357 B SE436357 B SE 436357B
Authority
SE
Sweden
Prior art keywords
alkyl
formula
pyrimido
isoquinolin
dimethoxy
Prior art date
Application number
SE7712513A
Other languages
English (en)
Swedish (sv)
Other versions
SE7712513L (sv
Inventor
B Lal
H Dornauer
B K Bhattacharya
A N Dohadwalla
Souza N J De
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772720085 external-priority patent/DE2720085A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of SE7712513L publication Critical patent/SE7712513L/xx
Publication of SE436357B publication Critical patent/SE436357B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE7712513A 1977-05-05 1977-11-04 Forfarande for framstellning av pyrimido/6,1-a/isokinolin-4-on-derivat SE436357B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772720085 DE2720085A1 (de) 1977-05-05 1977-05-05 Pyrimido(6,1-a)isochinolin-2-on- derivate

Publications (2)

Publication Number Publication Date
SE7712513L SE7712513L (sv) 1978-11-06
SE436357B true SE436357B (sv) 1984-12-03

Family

ID=6008073

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7712513A SE436357B (sv) 1977-05-05 1977-11-04 Forfarande for framstellning av pyrimido/6,1-a/isokinolin-4-on-derivat
SE8206619A SE439307B (sv) 1977-05-05 1982-11-19 Mellanprodukter for framstellning av pyrimido(6,1-a)isokinolin-4-on-derivat och forfarande for framstellning av mellanprodukterna

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE8206619A SE439307B (sv) 1977-05-05 1982-11-19 Mellanprodukter for framstellning av pyrimido(6,1-a)isokinolin-4-on-derivat och forfarande for framstellning av mellanprodukterna

Country Status (18)

Country Link
US (2) US4482556A (en, 2012)
JP (2) JPS53137997A (en, 2012)
AT (1) AT372383B (en, 2012)
BE (1) BE862785A (en, 2012)
CH (2) CH640854A5 (en, 2012)
DK (2) DK158789C (en, 2012)
EG (1) EG12982A (en, 2012)
ES (3) ES464776A1 (en, 2012)
FI (1) FI64370C (en, 2012)
FR (1) FR2389623B1 (en, 2012)
GR (1) GR72114B (en, 2012)
IL (1) IL53336A (en, 2012)
IT (1) IT1192252B (en, 2012)
NL (1) NL185078C (en, 2012)
NO (2) NO148032C (en, 2012)
PT (1) PT67265B (en, 2012)
SE (2) SE436357B (en, 2012)
ZA (1) ZA776706B (en, 2012)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
FR2470130A2 (fr) * 1979-11-21 1981-05-29 Hoechst Ag Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3135831A1 (de) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA1237429A (en) * 1983-05-05 1988-05-31 Frank Kienzle Pyrimidone derivatives
DE3816995A1 (de) * 1988-05-19 1989-11-23 Hoechst Ag Verwendung von pyrimido-(6,1-a)-isochinolin-4-on-derivaten und medizinische zubereitungen auf basis dieser verbindungen
DE68902811D1 (de) * 1988-11-19 1992-10-15 Hoechst Ag Pharmazeutische zusammensetzungen mit einem gehalt an labdan-di-terpenoid-derivaten und pyrimido(6,1-a)isochinolin-4-on-derivaten und ihre anwendung.
BRPI0009446B8 (pt) * 1999-03-31 2021-05-25 Rhinopharma Ltd composto derivado de pirimido [6,1-a] isoquinolin-4-ona, processo para preparar p mesmo, composição, e, uso de um composto
JP2007525475A (ja) * 2003-07-08 2007-09-06 スミスクライン・ビーチャム・コーポレイション 新規化学化合物
CN101671336B (zh) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
US11993596B2 (en) * 2018-07-13 2024-05-28 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Fused tri-cyclic compound as PDE3/PDE4 dual inhibitor
WO2021143841A1 (zh) * 2020-01-15 2021-07-22 正大天晴药业集团股份有限公司 三并环类pde3/pde4双重抑制剂化合物的药物组合物
EP4092022A4 (en) * 2020-01-15 2024-01-24 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. DOUBLE PDE3/PDE4 INHIBITOR CRYSTAL AND USE THEREOF
CA3211820A1 (en) * 2021-04-29 2022-11-03 Zhiya LI Isoquinolone compound and use thereof
GB202202297D0 (en) 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
KR20250095708A (ko) * 2022-10-28 2025-06-26 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 이소퀴놀리논계 화합물의 결정형 및 이의 제조 방법
TW202506117A (zh) 2023-06-26 2025-02-16 英商維羅納製藥Ｐｌｃ公司 顆粒組成物
CN118955496A (zh) * 2023-06-28 2024-11-15 郑州德迈药业有限公司 一种化合物及其应用
CN120136868A (zh) * 2023-12-13 2025-06-13 石家庄以岭药业股份有限公司 三环稠杂环类pde3/4双重抑制剂及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
US3081306A (en) * 1959-11-04 1963-03-12 Pfizer & Co C 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
US3297696A (en) * 1965-05-28 1967-01-10 Sandoz Ag 6-amino-8, 9-dihydro-13bh-isoquinolo-[2, 1-c] quinazolines and intermediates therefor
DE2126148A1 (en) * 1971-05-26 1972-12-07 Farbenfabriken Bayer Ag, 5090 Leverkusen Prepn of uracil derivs - useful as plant - protection agents and their inters
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US5740368A (en) * 1995-06-30 1998-04-14 Canon Kabushiki Kaisha Method and apparatus for providing information on a managed peripheral device to plural agents

Also Published As

Publication number Publication date
DK489477A (da) 1978-11-06
JPS6312871B2 (en, 2012) 1988-03-23
EG12982A (en) 1982-03-31
FI64370B (fi) 1983-07-29
ZA776706B (en) 1978-08-30
NO148032B (no) 1983-04-18
ATA784477A (de) 1983-02-15
BE862785A (fr) 1978-07-10
NL185078C (nl) 1990-01-16
CH642949A5 (de) 1984-05-15
DK158789C (da) 1990-11-26
GR72114B (en, 2012) 1983-09-15
IT1192252B (it) 1988-03-31
FI64370C (fi) 1983-11-10
CH640854A5 (de) 1984-01-31
ES475027A1 (es) 1979-05-16
US4482556A (en) 1984-11-13
AT372383B (de) 1983-09-26
SE7712513L (sv) 1978-11-06
DK158789B (da) 1990-07-16
PT67265B (de) 1981-01-05
IT7822619A0 (it) 1978-04-21
US4598148A (en) 1986-07-01
JPS6225150B2 (en, 2012) 1987-06-01
SE439307B (sv) 1985-06-10
IL53336A (en) 1984-02-29
DK267089A (da) 1989-06-01
PT67265A (de) 1977-12-01
FI773286A7 (fi) 1978-11-06
ES464776A1 (es) 1979-01-01
NO774131L (no) 1978-11-07
SE8206619D0 (sv) 1982-11-19
FR2389623B1 (en, 2012) 1980-10-31
SE8206619L (sv) 1982-11-19
FR2389623A1 (en, 2012) 1978-12-01
IL53336A0 (en) 1978-01-31
NL185078B (nl) 1989-08-16
NO821266L (no) 1978-11-07
DK267089D0 (da) 1989-06-01
NO148032C (no) 1983-07-27
JPS53137997A (en) 1978-12-01
JPS6041677A (ja) 1985-03-05
NL7800149A (nl) 1978-11-07
ES472606A1 (es) 1979-02-16

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