JPS53137997A - Pyrimido*6*11a*isoquinolinee22one derivative - Google Patents

Pyrimido*6*11a*isoquinolinee22one derivative

Info

Publication number
JPS53137997A
JPS53137997A JP13845577A JP13845577A JPS53137997A JP S53137997 A JPS53137997 A JP S53137997A JP 13845577 A JP13845577 A JP 13845577A JP 13845577 A JP13845577 A JP 13845577A JP S53137997 A JPS53137997 A JP S53137997A
Authority
JP
Japan
Prior art keywords
alkyl
substd
opt
isoquinolin
pyrimido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13845577A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6225150B2 (en, 2012
Inventor
Raru Banji
Dorunauaa Horusuto
Kanta Buhatsutachiyaruya Bani
Nomanbuhai Dohado Arifutsusein
Jiyon Do Suuza Noeru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19772720085 external-priority patent/DE2720085A1/de
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of JPS53137997A publication Critical patent/JPS53137997A/ja
Publication of JPS6225150B2 publication Critical patent/JPS6225150B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/650905—Six-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP13845577A 1977-05-05 1977-11-19 Pyrimido*6*11a*isoquinolinee22one derivative Granted JPS53137997A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772720085 DE2720085A1 (de) 1977-05-05 1977-05-05 Pyrimido(6,1-a)isochinolin-2-on- derivate

Publications (2)

Publication Number Publication Date
JPS53137997A true JPS53137997A (en) 1978-12-01
JPS6225150B2 JPS6225150B2 (en, 2012) 1987-06-01

Family

ID=6008073

Family Applications (2)

Application Number Title Priority Date Filing Date
JP13845577A Granted JPS53137997A (en) 1977-05-05 1977-11-19 Pyrimido*6*11a*isoquinolinee22one derivative
JP59123892A Granted JPS6041677A (ja) 1977-05-05 1984-06-18 ピリミド（６，１−ａ）イソキノリン−２，４−ジオン誘導体およびその製法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP59123892A Granted JPS6041677A (ja) 1977-05-05 1984-06-18 ピリミド（６，１−ａ）イソキノリン−２，４−ジオン誘導体およびその製法

Country Status (18)

Country Link
US (2) US4482556A (en, 2012)
JP (2) JPS53137997A (en, 2012)
AT (1) AT372383B (en, 2012)
BE (1) BE862785A (en, 2012)
CH (2) CH640854A5 (en, 2012)
DK (2) DK158789C (en, 2012)
EG (1) EG12982A (en, 2012)
ES (3) ES464776A1 (en, 2012)
FI (1) FI64370C (en, 2012)
FR (1) FR2389623B1 (en, 2012)
GR (1) GR72114B (en, 2012)
IL (1) IL53336A (en, 2012)
IT (1) IT1192252B (en, 2012)
NL (1) NL185078C (en, 2012)
NO (2) NO148032C (en, 2012)
PT (1) PT67265B (en, 2012)
SE (2) SE436357B (en, 2012)
ZA (1) ZA776706B (en, 2012)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0217119A (ja) * 1988-05-19 1990-01-22 Hoechst Ag ピリミド―（６，１―ａ）‐イソキノリン‐４‐オン誘導体
JP2007525475A (ja) * 2003-07-08 2007-09-06 スミスクライン・ビーチャム・コーポレイション 新規化学化合物

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
FR2470130A2 (fr) * 1979-11-21 1981-05-29 Hoechst Ag Derives de pyrimido (6,1-a) isoquinoleine-4-one, leur procede de preparation et leur application en therapeutique
DE3135831A1 (de) * 1981-09-10 1983-04-28 Hoechst Ag, 6230 Frankfurt 9,10-substituierte 2-mesitylimino-3-alkyl-3,4,6,7-tetrahydro-2h-pyrimido(6,1-a)isochinolin-4-one, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
CA1237429A (en) * 1983-05-05 1988-05-31 Frank Kienzle Pyrimidone derivatives
DE68902811D1 (de) * 1988-11-19 1992-10-15 Hoechst Ag Pharmazeutische zusammensetzungen mit einem gehalt an labdan-di-terpenoid-derivaten und pyrimido(6,1-a)isochinolin-4-on-derivaten und ihre anwendung.
BRPI0009446B8 (pt) * 1999-03-31 2021-05-25 Rhinopharma Ltd composto derivado de pirimido [6,1-a] isoquinolin-4-ona, processo para preparar p mesmo, composição, e, uso de um composto
CN101671336B (zh) 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途
GB201613054D0 (en) 2016-07-28 2016-09-14 Verona Pharma Plc New compound and process
US11993596B2 (en) * 2018-07-13 2024-05-28 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Fused tri-cyclic compound as PDE3/PDE4 dual inhibitor
WO2021143841A1 (zh) * 2020-01-15 2021-07-22 正大天晴药业集团股份有限公司 三并环类pde3/pde4双重抑制剂化合物的药物组合物
EP4092022A4 (en) * 2020-01-15 2024-01-24 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. DOUBLE PDE3/PDE4 INHIBITOR CRYSTAL AND USE THEREOF
CA3211820A1 (en) * 2021-04-29 2022-11-03 Zhiya LI Isoquinolone compound and use thereof
GB202202297D0 (en) 2022-02-21 2022-04-06 Verona Pharma Plc Formulation production process
KR20250095708A (ko) * 2022-10-28 2025-06-26 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 이소퀴놀리논계 화합물의 결정형 및 이의 제조 방법
TW202506117A (zh) 2023-06-26 2025-02-16 英商維羅納製藥Ｐｌｃ公司 顆粒組成物
CN118955496A (zh) * 2023-06-28 2024-11-15 郑州德迈药业有限公司 一种化合物及其应用
CN120136868A (zh) * 2023-12-13 2025-06-13 石家庄以岭药业股份有限公司 三环稠杂环类pde3/4双重抑制剂及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3021331A (en) * 1959-07-20 1962-02-13 Pfizer & Co C Azabenzopyridocolines
US3081306A (en) * 1959-11-04 1963-03-12 Pfizer & Co C 2, 4-dioxo-3-aralkylaza-9, 10-di(lower alkoxy)-1, 2, 3, 4, 6, 7-hexahydro-11b-h-benzopyridocolines
US3297696A (en) * 1965-05-28 1967-01-10 Sandoz Ag 6-amino-8, 9-dihydro-13bh-isoquinolo-[2, 1-c] quinazolines and intermediates therefor
DE2126148A1 (en) * 1971-05-26 1972-12-07 Farbenfabriken Bayer Ag, 5090 Leverkusen Prepn of uracil derivs - useful as plant - protection agents and their inters
DE2847693A1 (de) * 1978-11-03 1980-05-22 Hoechst Ag Verfahren zur herstellung von pyrimido-(6,1-a)-isochinolin-2-onen
US5740368A (en) * 1995-06-30 1998-04-14 Canon Kabushiki Kaisha Method and apparatus for providing information on a managed peripheral device to plural agents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0217119A (ja) * 1988-05-19 1990-01-22 Hoechst Ag ピリミド―（６，１―ａ）‐イソキノリン‐４‐オン誘導体
JP2007525475A (ja) * 2003-07-08 2007-09-06 スミスクライン・ビーチャム・コーポレイション 新規化学化合物

Also Published As

Publication number Publication date
DK489477A (da) 1978-11-06
JPS6312871B2 (en, 2012) 1988-03-23
EG12982A (en) 1982-03-31
FI64370B (fi) 1983-07-29
ZA776706B (en) 1978-08-30
NO148032B (no) 1983-04-18
ATA784477A (de) 1983-02-15
BE862785A (fr) 1978-07-10
NL185078C (nl) 1990-01-16
CH642949A5 (de) 1984-05-15
DK158789C (da) 1990-11-26
GR72114B (en, 2012) 1983-09-15
IT1192252B (it) 1988-03-31
FI64370C (fi) 1983-11-10
CH640854A5 (de) 1984-01-31
ES475027A1 (es) 1979-05-16
US4482556A (en) 1984-11-13
AT372383B (de) 1983-09-26
SE7712513L (sv) 1978-11-06
DK158789B (da) 1990-07-16
PT67265B (de) 1981-01-05
IT7822619A0 (it) 1978-04-21
US4598148A (en) 1986-07-01
JPS6225150B2 (en, 2012) 1987-06-01
SE439307B (sv) 1985-06-10
SE436357B (sv) 1984-12-03
IL53336A (en) 1984-02-29
DK267089A (da) 1989-06-01
PT67265A (de) 1977-12-01
FI773286A7 (fi) 1978-11-06
ES464776A1 (es) 1979-01-01
NO774131L (no) 1978-11-07
SE8206619D0 (sv) 1982-11-19
FR2389623B1 (en, 2012) 1980-10-31
SE8206619L (sv) 1982-11-19
FR2389623A1 (en, 2012) 1978-12-01
IL53336A0 (en) 1978-01-31
NL185078B (nl) 1989-08-16
NO821266L (no) 1978-11-07
DK267089D0 (da) 1989-06-01
NO148032C (no) 1983-07-27
JPS6041677A (ja) 1985-03-05
NL7800149A (nl) 1978-11-07
ES472606A1 (es) 1979-02-16

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