SE430983B - Farmaceutiskt aktiva derivat av 1-hydroxi-oktahydrofenantren-9-on, 1,9-dihydroxi-oktahydrofenantren och 1-hydroxi-hexa-hydrofenantren-9-on - Google Patents

Farmaceutiskt aktiva derivat av 1-hydroxi-oktahydrofenantren-9-on, 1,9-dihydroxi-oktahydrofenantren och 1-hydroxi-hexa-hydrofenantren-9-on

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Publication number
SE430983B
SE430983B SE7811653A SE7811653A SE430983B SE 430983 B SE430983 B SE 430983B SE 7811653 A SE7811653 A SE 7811653A SE 7811653 A SE7811653 A SE 7811653A SE 430983 B SE430983 B SE 430983B
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SE
Sweden
Prior art keywords
hydrogen
phenyl
compounds
hydroxy
methyl
Prior art date
Application number
SE7811653A
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English (en)
Swedish (sv)
Other versions
SE7811653L (sv
Inventor
T H Althuis
C A Harbert
M R Johnson
Jr L S Melvin
Original Assignee
Pfizer
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Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE7811653L publication Critical patent/SE7811653L/xx
Publication of SE430983B publication Critical patent/SE430983B/sv

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    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
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SE7811653A 1977-11-14 1978-11-10 Farmaceutiskt aktiva derivat av 1-hydroxi-oktahydrofenantren-9-on, 1,9-dihydroxi-oktahydrofenantren och 1-hydroxi-hexa-hydrofenantren-9-on SE430983B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/851,503 US4188495A (en) 1977-11-14 1977-11-14 1,9-Dihydroxyoctahydrophenanthrenes and intermediates therefor

Publications (2)

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SE7811653L SE7811653L (sv) 1979-05-15
SE430983B true SE430983B (sv) 1983-12-27

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SE7811653A SE430983B (sv) 1977-11-14 1978-11-10 Farmaceutiskt aktiva derivat av 1-hydroxi-oktahydrofenantren-9-on, 1,9-dihydroxi-oktahydrofenantren och 1-hydroxi-hexa-hydrofenantren-9-on

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US (1) US4188495A (it)
JP (1) JPS5484562A (it)
AR (1) AR220158A1 (it)
AT (1) AT358024B (it)
AU (1) AU509680B2 (it)
BE (1) BE871907A (it)
CA (1) CA1097668A (it)
CH (1) CH635813A5 (it)
DE (1) DE2849224C2 (it)
DK (3) DK414778A (it)
ES (1) ES475040A1 (it)
FI (1) FI71120C (it)
FR (2) FR2411821A1 (it)
GB (4) GB2078721B (it)
IE (1) IE47505B1 (it)
IL (1) IL55930A (it)
IT (1) IT1100945B (it)
LU (1) LU80509A1 (it)
NL (1) NL180206C (it)
PH (2) PH14713A (it)
PT (1) PT68775A (it)
SE (1) SE430983B (it)
YU (2) YU40834B (it)

Families Citing this family (32)

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Publication number Priority date Publication date Assignee Title
US4285867A (en) * 1980-09-19 1981-08-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4863934A (en) * 1982-03-16 1989-09-05 Pfizer Inc. Bicyclic benzo fused pyran compounds used for producing analgesia
US4841078A (en) * 1982-03-16 1989-06-20 Pfizer Inc. Benzopyrans
US4476131A (en) * 1982-03-16 1984-10-09 Pfizer Inc. Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyrido[1,2-a]-q
US4576964A (en) * 1982-03-16 1986-03-18 Pfizer Inc. Substituted hexahydrobenzo[e]indene and octahydrophenanthrene CNS agents and pharmaceutical compositions thereof
US4486428A (en) * 1982-03-16 1984-12-04 Pfizer Inc. Bicyclic benzo fused compounds
US4473704A (en) * 1982-03-16 1984-09-25 Pfizer Inc. Substituted dodecahydrotriphenylenes, decahydro-1H-cyclopenta[1]phenanthrenes, decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines as CNS agents
US4870084A (en) * 1982-03-16 1989-09-26 Pfizer Inc. Bicyclic benzo fused pyran compounds used for nausea treatment and prevention
US4920221A (en) * 1982-03-16 1990-04-24 Pfizer Inc. Substituted decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines
US4680404A (en) * 1983-01-13 1987-07-14 Pfizer Inc. Benzopyrans
DK196688A (da) * 1987-04-28 1988-10-29 Fujisawa Pharmaceutical Co Bicykliske forbindelser og fremgangsmaade til fremstilling deraf
CA2340445A1 (en) * 1998-05-04 1999-11-11 The University Of Connecticut Novel analgesic and immunomodulatory cannabinoids
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US6995187B1 (en) 1999-10-18 2006-02-07 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US6943266B1 (en) 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US6900236B1 (en) 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US6340774B1 (en) * 2000-01-31 2002-01-22 The Board Of Trustees Of The Leland Stanford Junior University Non-steroidal estrogen-receptor antagonists
CA2435409A1 (en) * 2001-01-26 2002-08-01 University Of Connecticut Novel cannabimimetic ligands
ATE478670T1 (de) 2001-01-29 2010-09-15 Univ Connecticut Rezeptor-selektive cannabimimetische aminoalkylindole
US7057076B2 (en) * 2001-07-13 2006-06-06 University Of Connecticut Bicyclic and tricyclic cannabinoids
CN1589269A (zh) * 2001-10-26 2005-03-02 康涅狄格大学 杂1,2-二氢化茚:一类新型有效的大麻配体
EP1545502A4 (en) 2002-08-23 2008-12-24 Univ Connecticut KETO CANNABINOIDS WITH THERAPEUTIC INDICATIONS
AU2003287585B2 (en) * 2002-11-12 2009-05-07 Mallinckrodt Inc. Cannabinoid crystalline derivatives and process of cannabinoid purification
CN1884265A (zh) * 2005-06-20 2006-12-27 美时化学制药股份有限公司 治疗糖尿病的阿朴芬及次阿朴芬化合物
US20220317097A1 (en) * 2021-04-05 2022-10-06 Grant Kraus Atmospheric Triphasic Chromatography (ATC) method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3775471A (en) * 1967-05-15 1973-11-27 Syntex Corp Novel phenanthrene-2-carboxylic acids and derivatives thereof
US3833726A (en) * 1971-12-13 1974-09-03 Warner Lambert Co 1-oxo-substituted-tetrahydronaphthalenes (substituted-tetralones)

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US4188495A (en) 1980-02-12
DK463388D0 (da) 1988-08-18
FI71120B (fi) 1986-08-14
FR2411821A1 (fr) 1979-07-13
GB2079269B (en) 1983-02-16
DK463288D0 (da) 1988-08-18
GB2079269A (en) 1982-01-20
NL180206B (nl) 1986-08-18
GB2007665B (en) 1982-08-18
IL55930A0 (en) 1979-01-31
DE2849224A1 (de) 1979-05-17
IT1100945B (it) 1985-09-28
YU261578A (en) 1983-06-30
AU4152178A (en) 1979-05-24
BE871907A (fr) 1979-05-10
YU277282A (en) 1986-04-30
PH14713A (en) 1981-11-13
DK414778A (da) 1979-05-15
NL7811235A (nl) 1979-05-16
DK463388A (da) 1988-08-18
AR220158A1 (es) 1980-10-15
IE47505B1 (en) 1984-04-04
GB2007665A (en) 1979-05-23
AU509680B2 (en) 1980-05-22
IL55930A (en) 1982-11-30
JPS5484562A (en) 1979-07-05
DK463288A (da) 1988-08-18
ES475040A1 (es) 1979-12-01
FR2414035A1 (fr) 1979-08-03
FR2411821B1 (it) 1982-02-05
YU40834B (en) 1986-06-30
FI71120C (fi) 1986-11-24
IT7829727A0 (it) 1978-11-13
GB2078720A (en) 1982-01-13
DE2849224C2 (de) 1984-04-05
CA1097668A (en) 1981-03-17
PT68775A (en) 1978-12-01
GB2078721B (en) 1982-08-11
NL180206C (nl) 1987-01-16
FR2414035B1 (it) 1983-12-09
JPS5757015B2 (it) 1982-12-02
ATA812078A (de) 1980-01-15
PH15429A (en) 1983-01-18
CH635813A5 (fr) 1983-04-29
IE782238L (en) 1979-05-14
AT358024B (de) 1980-08-11
SE7811653L (sv) 1979-05-15
FI783456A (fi) 1979-05-15
LU80509A1 (fr) 1980-06-05
GB2078721A (en) 1982-01-13
GB2078720B (en) 1982-08-11

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