SE7811653L - 1,9-dihydroxioktahydrofenantrener och mellanprodukter for deras framstellning - Google Patents

1,9-dihydroxioktahydrofenantrener och mellanprodukter for deras framstellning

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Publication number
SE7811653L
SE7811653L SE7811653A SE7811653A SE7811653L SE 7811653 L SE7811653 L SE 7811653L SE 7811653 A SE7811653 A SE 7811653A SE 7811653 A SE7811653 A SE 7811653A SE 7811653 L SE7811653 L SE 7811653L
Authority
SE
Sweden
Prior art keywords
dihydroxyoctahydrofenante
trains
preparation
intermediate products
products
Prior art date
Application number
SE7811653A
Other languages
English (en)
Other versions
SE430983B (sv
Inventor
T H Althuis
C A Harbert
M R Johnson
Jr L S Melvin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE7811653L publication Critical patent/SE7811653L/sv
Publication of SE430983B publication Critical patent/SE430983B/sv

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/73—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with hydrogenation
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    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
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    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
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    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/26—Phenanthrenes; Hydrogenated phenanthrenes
SE7811653A 1977-11-14 1978-11-10 Farmaceutiskt aktiva derivat av 1-hydroxi-oktahydrofenantren-9-on, 1,9-dihydroxi-oktahydrofenantren och 1-hydroxi-hexa-hydrofenantren-9-on SE430983B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/851,503 US4188495A (en) 1977-11-14 1977-11-14 1,9-Dihydroxyoctahydrophenanthrenes and intermediates therefor

Publications (2)

Publication Number Publication Date
SE7811653L true SE7811653L (sv) 1979-05-15
SE430983B SE430983B (sv) 1983-12-27

Family

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Family Applications (1)

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SE7811653A SE430983B (sv) 1977-11-14 1978-11-10 Farmaceutiskt aktiva derivat av 1-hydroxi-oktahydrofenantren-9-on, 1,9-dihydroxi-oktahydrofenantren och 1-hydroxi-hexa-hydrofenantren-9-on

Country Status (23)

Country Link
US (1) US4188495A (sv)
JP (1) JPS5484562A (sv)
AR (1) AR220158A1 (sv)
AT (1) AT358024B (sv)
AU (1) AU509680B2 (sv)
BE (1) BE871907A (sv)
CA (1) CA1097668A (sv)
CH (1) CH635813A5 (sv)
DE (1) DE2849224C2 (sv)
DK (3) DK414778A (sv)
ES (1) ES475040A1 (sv)
FI (1) FI71120C (sv)
FR (2) FR2411821A1 (sv)
GB (4) GB2079269B (sv)
IE (1) IE47505B1 (sv)
IL (1) IL55930A (sv)
IT (1) IT1100945B (sv)
LU (1) LU80509A1 (sv)
NL (1) NL180206C (sv)
PH (2) PH14713A (sv)
PT (1) PT68775A (sv)
SE (1) SE430983B (sv)
YU (2) YU40834B (sv)

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US4870084A (en) * 1982-03-16 1989-09-26 Pfizer Inc. Bicyclic benzo fused pyran compounds used for nausea treatment and prevention
US4476131A (en) * 1982-03-16 1984-10-09 Pfizer Inc. Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyrido[1,2-a]-q
US4863934A (en) * 1982-03-16 1989-09-05 Pfizer Inc. Bicyclic benzo fused pyran compounds used for producing analgesia
US4473704A (en) * 1982-03-16 1984-09-25 Pfizer Inc. Substituted dodecahydrotriphenylenes, decahydro-1H-cyclopenta[1]phenanthrenes, decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines as CNS agents
US4576964A (en) * 1982-03-16 1986-03-18 Pfizer Inc. Substituted hexahydrobenzo[e]indene and octahydrophenanthrene CNS agents and pharmaceutical compositions thereof
US4920221A (en) * 1982-03-16 1990-04-24 Pfizer Inc. Substituted decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines
US4841078A (en) * 1982-03-16 1989-06-20 Pfizer Inc. Benzopyrans
US4486428A (en) * 1982-03-16 1984-12-04 Pfizer Inc. Bicyclic benzo fused compounds
US4680404A (en) * 1983-01-13 1987-07-14 Pfizer Inc. Benzopyrans
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DE2849224A1 (de) 1979-05-17
FI71120B (fi) 1986-08-14
GB2078721A (en) 1982-01-13
IT7829727A0 (it) 1978-11-13
YU261578A (en) 1983-06-30
FR2411821A1 (fr) 1979-07-13
GB2007665B (en) 1982-08-18
AU4152178A (en) 1979-05-24
NL180206C (nl) 1987-01-16
GB2078720B (en) 1982-08-11
FR2414035B1 (sv) 1983-12-09
AU509680B2 (en) 1980-05-22
DE2849224C2 (de) 1984-04-05
LU80509A1 (fr) 1980-06-05
US4188495A (en) 1980-02-12
JPS5484562A (en) 1979-07-05
GB2079269A (en) 1982-01-20
DK463388D0 (da) 1988-08-18
YU40834B (en) 1986-06-30
AR220158A1 (es) 1980-10-15
ATA812078A (de) 1980-01-15
FI783456A (fi) 1979-05-15
ES475040A1 (es) 1979-12-01
NL7811235A (nl) 1979-05-16
AT358024B (de) 1980-08-11
BE871907A (fr) 1979-05-10
DK414778A (da) 1979-05-15
SE430983B (sv) 1983-12-27
YU277282A (en) 1986-04-30
GB2078721B (en) 1982-08-11
FR2411821B1 (sv) 1982-02-05
GB2079269B (en) 1983-02-16
IE782238L (en) 1979-05-14
CA1097668A (en) 1981-03-17
DK463388A (da) 1988-08-18
FR2414035A1 (fr) 1979-08-03
JPS5757015B2 (sv) 1982-12-02
FI71120C (fi) 1986-11-24
IL55930A0 (en) 1979-01-31
DK463288D0 (da) 1988-08-18
IE47505B1 (en) 1984-04-04
IT1100945B (it) 1985-09-28
PT68775A (en) 1978-12-01
GB2078720A (en) 1982-01-13
IL55930A (en) 1982-11-30
PH15429A (en) 1983-01-18
CH635813A5 (fr) 1983-04-29
DK463288A (da) 1988-08-18
PH14713A (en) 1981-11-13
NL180206B (nl) 1986-08-18
GB2007665A (en) 1979-05-23

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