SE420199B - Forfarande for framstellning av 16-oxiderade prostansyraderivat - Google Patents

Forfarande for framstellning av 16-oxiderade prostansyraderivat

Info

Publication number
SE420199B
SE420199B SE7503431A SE7503431A SE420199B SE 420199 B SE420199 B SE 420199B SE 7503431 A SE7503431 A SE 7503431A SE 7503431 A SE7503431 A SE 7503431A SE 420199 B SE420199 B SE 420199B
Authority
SE
Sweden
Prior art keywords
oxidated
preparing
procedure
acid derivatives
prostanic acid
Prior art date
Application number
SE7503431A
Other languages
English (en)
Swedish (sv)
Other versions
SE7503431L (nl
Inventor
R Pappo
P W Collins
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of SE7503431L publication Critical patent/SE7503431L/xx
Publication of SE420199B publication Critical patent/SE420199B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
SE7503431A 1974-03-26 1975-03-25 Forfarande for framstellning av 16-oxiderade prostansyraderivat SE420199B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/454,913 US3965143A (en) 1974-03-26 1974-03-26 16-Oxygenated prostanoic acid derivatives

Publications (2)

Publication Number Publication Date
SE7503431L SE7503431L (nl) 1975-09-29
SE420199B true SE420199B (sv) 1981-09-21

Family

ID=23806587

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7503431A SE420199B (sv) 1974-03-26 1975-03-25 Forfarande for framstellning av 16-oxiderade prostansyraderivat

Country Status (25)

Country Link
US (1) US3965143A (nl)
JP (1) JPS5855142B2 (nl)
AR (1) AR207355A1 (nl)
AT (1) AT351684B (nl)
BE (1) BE827127A (nl)
CA (1) CA1040197A (nl)
CH (1) CH613443A5 (nl)
DE (1) DE2513212C2 (nl)
DK (1) DK128075A (nl)
EG (1) EG12063A (nl)
ES (1) ES436043A1 (nl)
FI (1) FI63747C (nl)
FR (1) FR2274289A1 (nl)
GB (1) GB1492426A (nl)
HU (1) HU174973B (nl)
IE (1) IE41328B1 (nl)
IL (1) IL46919A (nl)
NL (2) NL183294B (nl)
NO (1) NO146200C (nl)
OA (1) OA04910A (nl)
PH (1) PH16276A (nl)
PL (1) PL100838B1 (nl)
SE (1) SE420199B (nl)
YU (1) YU39735B (nl)
ZA (1) ZA751391B (nl)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4113723A (en) * 1972-07-13 1978-09-12 Pfizer Inc. 15-Substituted-ω-pentanorprostaglandins
US4293704A (en) * 1975-09-25 1981-10-06 American Cyanamid Company Novel 2-substituted-3,4-epoxycyclopentan-1-ones, 2-substituted-3,4-epoxycyclopentan-1-ols, and various 2-substituted-cyclopentenones
US4107441A (en) * 1973-06-15 1978-08-15 American Cyanamid Company Novel 16 hydroxy 15-deoxy-5-cis-prostenoic acids and esters
US4060691A (en) * 1974-03-26 1977-11-29 G. D. Searle & Co. 7-{3-Hydroxy-2-[4-hydroxy-4-(lower alkyl)-trans-1-octen-1-yl]-5-oxocyclopent-1-yl}heptanoic acids and esters
US4730065A (en) * 1976-07-19 1988-03-08 American Cyanamid Company 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners
US4328358A (en) * 1976-07-19 1982-05-04 American Cyanamid Company 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners
US4190596A (en) * 1976-07-19 1980-02-26 American Cyanamid Company Various 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins
US4192950A (en) * 1976-07-19 1980-03-11 American Cyanamid Company 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners
US4191699A (en) * 1976-07-19 1980-03-04 American Cyanamid Company Various- 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins
US4061670A (en) * 1976-07-19 1977-12-06 American Cyanamid Company 15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic acids and congeners
US4429148A (en) 1976-07-19 1984-01-31 American Cyanamid Company 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners
AU3437478A (en) * 1977-03-30 1979-09-27 American Cyanamid Co Prostanoic acids and congeners
US4281153A (en) * 1977-08-01 1981-07-28 American Cyanamid 15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners
GB2006186A (en) * 1977-08-29 1979-05-02 American Cyanamid Co 15-Deoxy-16-substituted prostanoic acids
GB2009162A (en) * 1977-12-05 1979-06-13 American Cyanamid Co Prostanoic acids and congeners
AU529836B2 (en) * 1977-12-05 1983-06-23 American Cyanamid Company Prostaglandin analog
US4132738A (en) * 1978-02-23 1979-01-02 Miles Laboratories, Inc. Preparation of 15-deoxy-16-hydroxyprostaglandins
US4833157A (en) * 1978-02-23 1989-05-23 Miles Inc. Methods of inhibitng gastric secretion with prostaglandin derivatives
US4742080A (en) * 1978-02-23 1988-05-03 Miles Laboratories, Inc. Therapeutic method for producing bronchodilation by administration of 15-deoxy-16-hydroxy prostaglandin esters
US4239899A (en) * 1979-09-13 1980-12-16 American Cyanamid Company Various 15-deoxy-16-hydroxy-16-ethynyl and 16-ethynylsubstituted prostaglandins
US4322543A (en) * 1979-11-28 1982-03-30 G. D. Searle & Co. 4,5-Unsaturated prostanoic acid derivatives
US4271314A (en) * 1979-11-28 1981-06-02 G. D. Searle & Co. 4,5-Unsaturated prostanoic acid derivatives
US4291174A (en) * 1980-04-03 1981-09-22 American Cyanamid Company 1-Hydroxymethyl-15-hydroxy-prosten-1-ol derivatives
US4288630A (en) * 1980-04-03 1981-09-08 American Cyanamid Company 1-Hydroxymethyl-11,15-dihydroxy-prosten-1-ol-derivatives
US4288633A (en) * 1980-04-03 1981-09-08 American Cyanamid Company 1-Hydroxymethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives
US4310700A (en) * 1980-04-03 1982-01-12 American Cyanamid Company 1-Hydroxylmethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives
US4289910A (en) * 1980-04-03 1981-09-15 American Cyanamid Company 1-Hydroxymethyl-prosten-1-ol derivatives
US4288632A (en) * 1980-04-03 1981-09-08 American Cyanamid Company 1-Hydroxymethyl-11,16-dihydroxy-prosten-1-ol derivatives
US4288629A (en) * 1980-04-03 1981-09-08 American Cyanamid Company 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives
US4291175A (en) * 1980-04-03 1981-09-22 American Cyanamid Company 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives
US4301146A (en) * 1980-07-29 1981-11-17 G. D. Searle & Co. Stabilization of 16-oxygenated prostanoic acid derivatives
US4399290A (en) * 1980-09-22 1983-08-16 E. I. Du Pont De Nemours And Company Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl)heptanoates
US4459310A (en) * 1983-06-27 1984-07-10 G.D. Searle & Co. Method for cholesterol lowering
US4499296A (en) * 1983-11-14 1985-02-12 G. D. Searle & Co. Omega cycloalkyl prostaglandins
US4754059A (en) * 1984-11-07 1988-06-28 G. D. Searle & Co. Omega cycloalkyl prostaglandins
US4820728A (en) * 1985-11-25 1989-04-11 G. D. Searle & Co. Tetraenyl prostaglandins
US4847293A (en) * 1985-11-25 1989-07-11 G. D. Searle & Co. Tetraenyl prostaglandins
US4683328A (en) * 1985-11-25 1987-07-28 G. D. Searle & Co. Tetraenyl prostaglandins
US4785124A (en) * 1987-06-08 1988-11-15 G. D. Searle & Co. Process for preparing higher order cuprate complexes
US5011958A (en) * 1987-06-08 1991-04-30 G. D. Searle & Co. Process for preparing higher order cuprate complexes
US4777275A (en) * 1987-06-09 1988-10-11 G. D. Searle & Co. Process of preparing higher order cuprate complexes
US5055604A (en) * 1990-04-17 1991-10-08 G. D. Searle & Co. Process for preparing prostaglandin analogs using organozirconium compounds
US5252763A (en) * 1990-04-17 1993-10-12 G. D. Searle & Co. Process for preparing prostaglandin analogs
AU7793791A (en) * 1990-05-03 1991-11-27 G.D. Searle & Co. Pharmaceutical composition for use in treating pain
US5232704A (en) * 1990-12-19 1993-08-03 G. D. Searle & Co. Sustained release, bilayer buoyant dosage form
US5157052A (en) * 1990-12-27 1992-10-20 Monsanto Company Method for inhibiting ige production
US5218139A (en) * 1990-12-27 1993-06-08 G. D. Searle & Co. Method for inhibiting IgE production
US5324746A (en) * 1993-02-12 1994-06-28 Mckee Rex N Method of treating damaged mucosal and epithelial tissues with misoprostol
US5684177A (en) * 1996-05-17 1997-11-04 Torcan Chemical Ltd. Misoprostol
DE69720587D1 (de) * 1996-05-17 2003-05-15 Torcan Chemical Ltd Misoprostol, Verfahren zur deren Herstellung mit Verwendung eines Organometall-Kupferkomplexes
WO1997045114A1 (en) * 1996-05-30 1997-12-04 Lysis Corporation The treatment of vascular disease with prostaglandins via a sustained-release dermal patch
US5994399A (en) * 1997-03-27 1999-11-30 Mckee; Rex N. Method of regenerating collagen-containing tissues with misoprostol
US6030959A (en) * 1997-04-04 2000-02-29 Monsanto Company Gastro-specific prodrugs
US6103765A (en) 1997-07-09 2000-08-15 Androsolutions, Inc. Methods for treating male erectile dysfunction
CA2295595A1 (en) 1997-07-09 1999-01-21 Androsolutions, Inc. Improved methods and compositions for treating male erectile dysfunction
EP0896823B1 (en) * 1997-07-15 2002-09-25 Development Center For Biotechnology Improved stabilization of Misoprostol
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
AU2003272962A1 (en) * 2002-10-10 2004-05-04 Shuh Narumiya Remedies for allergic diseases
TW200413000A (en) 2002-10-10 2004-08-01 Ono Pharmaceutical Co Intrinsic repair factor producing accelerator
WO2005009468A1 (ja) 2003-07-25 2005-02-03 Ono Pharmaceutical Co., Ltd. 軟骨関連疾患治療剤
US7241746B2 (en) * 2003-08-06 2007-07-10 Regena Therapeutics, Lc Method and composition for treating periodontal disease
US8735394B2 (en) 2005-02-18 2014-05-27 Abraxis Bioscience, Llc Combinations and modes of administration of therapeutic agents and combination therapy
WO2007146795A2 (en) * 2006-06-12 2007-12-21 Ironwood Pharmaceuticals, Inc. Pharmaceutical formulation for parenteral administration
JP6400479B2 (ja) 2012-10-29 2018-10-03 株式会社カルディオ 肺疾患特異的治療剤
US9968716B2 (en) 2013-10-15 2018-05-15 Ono Pharmaceutical Co., Ltd. Drug-eluting stent graft
HU231185B1 (hu) 2017-07-11 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás Misoprostol előállítására és tisztítására
CN108753898A (zh) * 2018-04-09 2018-11-06 深圳市祥根生物科技有限公司 一种米索前列醇酸的制备方法及其用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3812172A (en) * 1970-05-04 1974-05-21 Upjohn Co 15-methyl and 15-ethyl dihydro-pge1
CA927836A (en) * 1971-03-11 1973-06-05 The Upjohn Company Analogs of prostaglandins
CA1045131A (en) * 1972-07-24 1978-12-26 Middleton B. Floyd (Jr.) Derivatives of 9-hydroxy-13-trans-prostenoic acid

Also Published As

Publication number Publication date
ATA227375A (de) 1979-01-15
YU39735B (en) 1985-04-30
CH613443A5 (nl) 1979-09-28
HU174973B (hu) 1980-04-28
GB1492426A (en) 1977-11-16
EG12063A (en) 1978-09-30
JPS5855142B2 (ja) 1983-12-08
ES436043A1 (es) 1977-01-16
OA04910A (fr) 1980-10-31
JPS50135059A (nl) 1975-10-25
FI750899A (nl) 1975-09-27
ZA751391B (en) 1976-10-27
AR207355A1 (es) 1976-09-30
NL930058I2 (nl) 1994-02-16
IE41328B1 (en) 1979-12-05
FR2274289B1 (nl) 1979-06-29
NO146200C (no) 1982-08-18
BE827127A (fr) 1975-09-25
DK128075A (nl) 1975-09-27
AT351684B (de) 1979-08-10
PL100838B1 (pl) 1978-11-30
CA1040197A (en) 1978-10-10
SE7503431L (nl) 1975-09-29
IL46919A (en) 1979-12-30
DE2513212C2 (de) 1986-03-27
YU73575A (en) 1982-02-28
AU7947175A (en) 1976-09-30
FR2274289A1 (fr) 1976-01-09
DE2513212A1 (de) 1975-10-09
PH16276A (en) 1983-08-26
FI63747B (fi) 1983-04-29
NO146200B (no) 1982-05-10
NO751039L (nl) 1975-09-29
NL183294B (nl) 1988-04-18
NL930058I1 (nl) 1993-09-01
NL7503553A (nl) 1975-09-30
IL46919A0 (en) 1975-05-22
IE41328L (en) 1975-09-26
FI63747C (fi) 1983-08-10
US3965143A (en) 1976-06-22

Similar Documents

Publication Publication Date Title
SE420199B (sv) Forfarande for framstellning av 16-oxiderade prostansyraderivat
SE442295B (sv) Forfarande for framstellning av 4-amino-5-en-hexansyra
SE428562C (sv) Forfarande for framstellning av purinderivat
SE423633B (sv) Forfarande for framstellning av 4-demetoxi-daunomycin
DK552377A (da) Fremgangsmaade til fremstilling af alfa-beskyttede oxyimino-beta-oxo-gamma-halogen-smoersyrederivater
SE434394B (sv) Analogiforfarande for framstellning av kinolonalkansyraderivat
SE431652B (sv) Forfarande for framstellning av 7beta-amino-3cefem-3ol-4-karboxylsyraderivat
SE412066B (sv) Forfarande for framstellning av famakologiskt verksamma tienodiazinderivat
SE431211B (sv) Forfarande for framstellning av n-acylamino-alfa-arylacetamido-cefalosporiner
SE411752B (sv) Forfarande for framstellning av substituerade aminobensoesyraderivat
SE421612B (sv) Forfarande for framstellning av alfa-6-deoxi-5-hydroxitetracyklin
SE422052B (sv) Forfarande for framstellning av vissa angivna 1-fenoxi-2-hydroxi-3-aminofenyl-propylderivat
SE418292B (sv) Forfarande for framstellning av 5-aryl-2-furamidiner
SE422800B (sv) Forfarande for framstellning av 6-d-(-)-alfa-amino-alfa(p-acetoxifenylacetamido) penicillansyra
NO141050C (no) Fremgangsmaate ved fremstilling av 5-fluor-2-methyl-1-(p-methylsulfinylbenzyliden)-ind-2-en-3-yl-eddiksyre
BE828925A (nl) 13-thiaprostaanzuurderivaten
SE425739B (sv) Forfarande for framstellning av vissa angivna tetrazolyl-bensopyranopyridinderivat
SE400960B (sv) Forfarande for framstellning av alhŸ3 (poŸ4)Ÿ2 3hŸ2o
SE416725B (sv) Forfarande for framstellning av p-nitrobensoesyra
SE414926B (sv) Forfarande for framstellning av 1-alkyl-2-(fenoximetyl)-5-nitroimidazoler
AR203228A1 (es) Procedimiento para preparar derivados de acidos naftil-carbonolamino-alquil fenoxialquilcarboxilicos
SE422202B (sv) Forfarande for framstellning av amidoximderivat
SE404364B (sv) Forfarande for framstellning av vissa angivna 5-sulfonylfenyl-tetrazolderivat
SE421310B (sv) Forfarande for framstellning av substituerade bensoylpyridiner
SE418177B (sv) Forfarande for framstellning av 2-metyl-(2-isopropylindan-5-yl)-ettiksyra

Legal Events

Date Code Title Description
SPCF Application for supplementary protection certificate filed

Free format text: 7503431

SPCG Supplementary protection certificate granted

Free format text: 7503431, EXPIRES: 20000325

NAL Patent in force

Ref document number: 7503431-4

Format of ref document f/p: F

NUG Patent has lapsed

Ref document number: 7503431-4

Format of ref document f/p: F