SE406198B - Sett att framstella 6-(alfa-aminobensyl-alfa-penicilloylamino)-kapronsyra - Google Patents
Sett att framstella 6-(alfa-aminobensyl-alfa-penicilloylamino)-kapronsyraInfo
- Publication number
- SE406198B SE406198B SE7203125A SE312572A SE406198B SE 406198 B SE406198 B SE 406198B SE 7203125 A SE7203125 A SE 7203125A SE 312572 A SE312572 A SE 312572A SE 406198 B SE406198 B SE 406198B
- Authority
- SE
- Sweden
- Prior art keywords
- alfa
- penicilloylamino
- preparing
- cooh
- aminobensyl
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 claims description 7
- 206010020751 Hypersensitivity Diseases 0.000 claims description 3
- 239000007795 chemical reaction product Substances 0.000 claims description 2
- ROFNJLCLYMMXCT-UHFFFAOYSA-N 4-aminohexanoic acid Chemical compound CCC(N)CCC(O)=O ROFNJLCLYMMXCT-UHFFFAOYSA-N 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- SLXKOJJOQWFEFD-UHFFFAOYSA-N 6-aminohexanoic acid Chemical compound NCCCCCC(O)=O SLXKOJJOQWFEFD-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229960002684 aminocaproic acid Drugs 0.000 description 3
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 3
- 239000000427 antigen Substances 0.000 description 3
- 102000036639 antigens Human genes 0.000 description 3
- 108091007433 antigens Proteins 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000700199 Cavia porcellus Species 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229930182555 Penicillin Natural products 0.000 description 2
- 229960000723 ampicillin Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 2
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- OPEGYZAATHKDEM-HCWXCVPCSA-N (2r,4s)-2-[(r)-carboxy(formamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid Chemical class CC1(C)S[C@H]([C@H](NC=O)C(O)=O)N[C@H]1C(O)=O OPEGYZAATHKDEM-HCWXCVPCSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 206010040914 Skin reaction Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 229960003311 ampicillin trihydrate Drugs 0.000 description 1
- 125000000926 ampicilloyl group Chemical group [H]N([H])[C@@]([H])(C(=O)N([H])[C@]1([H])C(=O)N2[C@]1([H])SC(C([H])([H])[H])(C([H])([H])[H])[C@]2([H])C(*)=O)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 150000002960 penicillins Chemical class 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000004460 silage Substances 0.000 description 1
- 230000035483 skin reaction Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000002568 urticarial effect Effects 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH355871 | 1971-03-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE406198B true SE406198B (sv) | 1979-01-29 |
Family
ID=4258572
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7203125A SE406198B (sv) | 1971-03-11 | 1972-03-10 | Sett att framstella 6-(alfa-aminobensyl-alfa-penicilloylamino)-kapronsyra |
| SE7513807A SE7513807L (sv) | 1971-03-11 | 1975-12-08 | Penicilloinsyraderivat |
| SE7514031A SE7514031L (sv) | 1971-03-11 | 1975-12-11 | Farmaceutiskt preparat |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7513807A SE7513807L (sv) | 1971-03-11 | 1975-12-08 | Penicilloinsyraderivat |
| SE7514031A SE7514031L (sv) | 1971-03-11 | 1975-12-11 | Farmaceutiskt preparat |
Country Status (21)
| Country | Link |
|---|---|
| AT (2) | AT331389B (https=) |
| AU (1) | AU461136B2 (https=) |
| BE (2) | BE780472A (https=) |
| CA (1) | CA972759A (https=) |
| CH (1) | CH546783A (https=) |
| DE (2) | DE2211419A1 (https=) |
| DK (1) | DK136977B (https=) |
| ES (2) | ES400623A1 (https=) |
| FI (1) | FI52345C (https=) |
| FR (2) | FR2128823B1 (https=) |
| GB (2) | GB1333524A (https=) |
| HK (1) | HK14676A (https=) |
| HU (2) | HU165203B (https=) |
| IE (2) | IE36204B1 (https=) |
| IL (2) | IL38865A (https=) |
| NL (2) | NL7202772A (https=) |
| NO (1) | NO138142C (https=) |
| PH (2) | PH12264A (https=) |
| SE (3) | SE406198B (https=) |
| YU (1) | YU35011B (https=) |
| ZA (2) | ZA721364B (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4316882A (en) * | 1978-04-20 | 1982-02-23 | Levine Bernard B | Compositions for testing to predict and/or diagnose allergy to penicillins |
| CA1209477A (en) * | 1981-03-26 | 1986-08-12 | Bruce E. Haeger | Composition of matter comprising a lyophilized preparation of a penicillin derivative |
-
1971
- 1971-03-11 CH CH355871A patent/CH546783A/xx not_active IP Right Cessation
-
1972
- 1972-03-01 ZA ZA721364A patent/ZA721364B/xx unknown
- 1972-03-01 ZA ZA721363A patent/ZA721363B/xx unknown
- 1972-03-01 IL IL38865A patent/IL38865A/xx unknown
- 1972-03-01 IL IL38864A patent/IL38864A/xx unknown
- 1972-03-02 AU AU39571/72A patent/AU461136B2/en not_active Expired
- 1972-03-02 NL NL7202772A patent/NL7202772A/xx unknown
- 1972-03-02 PH PH13316A patent/PH12264A/en unknown
- 1972-03-02 NL NL7202771A patent/NL7202771A/xx not_active Application Discontinuation
- 1972-03-03 PH PH13315*UA patent/PH9295A/en unknown
- 1972-03-06 CA CA136,277A patent/CA972759A/en not_active Expired
- 1972-03-07 AT AT188672A patent/AT331389B/de not_active IP Right Cessation
- 1972-03-07 IE IE282/72A patent/IE36204B1/xx unknown
- 1972-03-07 IE IE281/72A patent/IE36203B1/xx unknown
- 1972-03-07 AT AT188772A patent/AT312802B/de not_active IP Right Cessation
- 1972-03-08 FI FI720618A patent/FI52345C/fi active
- 1972-03-09 DE DE19722211419 patent/DE2211419A1/de active Pending
- 1972-03-09 DE DE19722211420 patent/DE2211420A1/de active Pending
- 1972-03-10 HU HUHO1460A patent/HU165203B/hu unknown
- 1972-03-10 YU YU625/72A patent/YU35011B/xx unknown
- 1972-03-10 DK DK112072AA patent/DK136977B/da unknown
- 1972-03-10 BE BE780472A patent/BE780472A/xx unknown
- 1972-03-10 HU HUHO1459A patent/HU166712B/hu unknown
- 1972-03-10 NO NO790/72A patent/NO138142C/no unknown
- 1972-03-10 ES ES400623A patent/ES400623A1/es not_active Expired
- 1972-03-10 FR FR7208434A patent/FR2128823B1/fr not_active Expired
- 1972-03-10 BE BE780471A patent/BE780471A/xx unknown
- 1972-03-10 SE SE7203125A patent/SE406198B/sv unknown
- 1972-03-10 ES ES400624A patent/ES400624A1/es not_active Expired
- 1972-03-10 FR FR7208435A patent/FR2128824B1/fr not_active Expired
- 1972-03-10 GB GB1135272A patent/GB1333524A/en not_active Expired
- 1972-03-10 GB GB1135172A patent/GB1322149A/en not_active Expired
-
1975
- 1975-12-08 SE SE7513807A patent/SE7513807L/xx unknown
- 1975-12-11 SE SE7514031A patent/SE7514031L/xx unknown
-
1976
- 1976-03-18 HK HK146/76*UA patent/HK14676A/xx unknown
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