SE400777B - Forfarande for framstellning av 2,4-diamino-5-bensylpyrimidiner med antibakteriell verkan - Google Patents

Forfarande for framstellning av 2,4-diamino-5-bensylpyrimidiner med antibakteriell verkan

Info

Publication number
SE400777B
SE400777B SE7006713A SE671370A SE400777B SE 400777 B SE400777 B SE 400777B SE 7006713 A SE7006713 A SE 7006713A SE 671370 A SE671370 A SE 671370A SE 400777 B SE400777 B SE 400777B
Authority
SE
Sweden
Prior art keywords
benzylpyrimidines
diamino
procedure
preparation
antibacterial effect
Prior art date
Application number
SE7006713A
Other languages
English (en)
Swedish (sv)
Inventor
R M Cresswell
J W Mentha
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of SE400777B publication Critical patent/SE400777B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • C07D239/49Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SE7006713A 1969-05-16 1970-05-15 Forfarande for framstellning av 2,4-diamino-5-bensylpyrimidiner med antibakteriell verkan SE400777B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2517169 1969-05-16

Publications (1)

Publication Number Publication Date
SE400777B true SE400777B (sv) 1978-04-10

Family

ID=10223379

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7006713A SE400777B (sv) 1969-05-16 1970-05-15 Forfarande for framstellning av 2,4-diamino-5-bensylpyrimidiner med antibakteriell verkan
SE7308030A SE398878B (sv) 1969-05-16 1973-06-07 Forfarande for framstellning av substituerade 2,4-diamino-5-bensylpyrimidiner

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE7308030A SE398878B (sv) 1969-05-16 1973-06-07 Forfarande for framstellning av substituerade 2,4-diamino-5-bensylpyrimidiner

Country Status (14)

Country Link
JP (1) JPS505184B1 (es)
AT (1) AT308082B (es)
BR (1) BR6915082D0 (es)
CA (1) CA994812A (es)
CH (1) CH544071A (es)
DE (1) DE2023977C2 (es)
ES (3) ES379700A1 (es)
FI (1) FI56375C (es)
FR (1) FR2070070A1 (es)
IL (1) IL34433A (es)
IT (1) IT1021507B (es)
NL (2) NL173395C (es)
PL (1) PL92440B1 (es)
SE (2) SE400777B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1469521A (en) * 1973-01-05 1977-04-06 Wellcome Found Antimicrobial preparations
US4687861A (en) * 1984-11-28 1987-08-18 Ciba-Geigy Corporation Microbicidal compositions
KR100822530B1 (ko) * 2004-03-05 2008-04-16 에프. 호프만-라 로슈 아게 P2x3 및 p2x2/3 길항물질로서의 다이아미노피리미딘

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049544A (en) * 1962-08-14 Method for the preparation of
DE1103931B (de) 1957-02-21 1961-04-06 Wellcome Found Verfahren zur Herstellung von 2, 4-Diamino-5-benzylpyrimidinderivaten
DE1303727B (de) 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-Arylidensubstituierte Propioni-Irile
NL122146C (es) * 1960-09-02
DE1620729A1 (de) 1965-07-08 1970-08-20 Wellcome Found Verfahren zur Herstellung von substituierten Benzylpyrimidinen
GB1261455A (en) 1969-03-06 1972-01-26 Burroughs Wellcome Co Improvements in or relating to substituted acrylonitriles

Also Published As

Publication number Publication date
FR2070070B1 (es) 1974-10-11
FI56375C (fi) 1980-01-10
NL8004796A (nl) 1980-11-28
PL92440B1 (en) 1977-04-30
NL173395C (nl) 1984-01-16
JPS505184B1 (es) 1975-02-28
AT308082B (de) 1973-06-25
CA994812A (en) 1976-08-10
BR6915082D0 (pt) 1973-03-08
ES406725A1 (es) 1975-10-01
DE2023977A1 (de) 1971-02-18
IL34433A0 (en) 1970-07-19
IL34433A (en) 1971-10-20
NL173395B (nl) 1983-08-16
ES406726A1 (es) 1975-10-01
IT1021507B (it) 1978-02-20
FR2070070A1 (en) 1971-09-10
ES379700A1 (es) 1973-01-16
SE398878B (sv) 1978-01-23
DE2023977C2 (de) 1984-03-15
FI56375B (fi) 1979-09-28
NL7007108A (es) 1970-11-18
CH544071A (de) 1973-11-15

Similar Documents

Publication Publication Date Title
SE382459B (sv) Forfarande for framstellning av xantonderivat.
SE384211B (sv) Forfarande for framstellning av 2-substituerade-4-amino-6,7,8-trialkoxikinazoliner
BE758910A (fr) Preparation de dimethyl-2, 2-propanediol-1, 3
SE390969B (sv) Forfarande for framstellning av 1,2,3,4-tetrahydro-7-halogen-6-sulfamyl-4-kinazolinoner
SE399427B (sv) Forfarande for framstellning av 2,4 diamino-bensylpyrimidiner
SE388617B (sv) Analogiforfarande for framstellning av bensimidazo (2,1-b)kinazolin-12(6h)-oner
SE393374B (sv) Forfarande for framstellning av 2-alkyl-2-dialkylamino-2, '6'-acetoxylidider med lokalestetisk effekt
SE384368B (sv) Forfarande for framstellning av 6-substituerade - 4 - amino- 1,2 - dihydro - 1 - hydroxi - 2 - iminopyrimidiner
SE387115B (sv) Sett att framstella nitro-imidazoler med antimikrobiell verkan
SE390303B (sv) Forfarande for framstellning av isotiokarbamider med h?712-blockerande effekt
IT1031002B (it) Procedimento per la preparazione de bromonitroalcooli
SE402451B (sv) Forfarande for framstellning av 14-desoxi-14-acetoximutilin
SE7511680L (sv) Forfarande for framstellning av furanderivat
SE384685B (sv) Forfarande for framstellning av linkomycinderivat
FI55204B (fi) Foerfarande foer framstaellning av antibakterisk oxofurylester av 6-(alfa-aminofenylacetamido)penicillansyra
SE416201B (sv) Foerfarande foer framstaellning av 1,4-bensodiazepinderivat
SE397971B (sv) Forfarande for framstellning av halogenmetyl-1,3-polyhalogen-2-propyletrar
BE747236A (fr) Derives de la pyridazone
SE373364B (sv) Forfarande for framstellning av bis-karboxikromonylforeningar med farmakologisk verkan
SE380796B (sv) Forfarande for framstellning av cyklopentanderivat
SE400777B (sv) Forfarande for framstellning av 2,4-diamino-5-bensylpyrimidiner med antibakteriell verkan
SE394668B (sv) Forfarande for framstellning av 2-etylhexan-1-al
SE383738B (sv) Forfarande for framstellning av sulfamoyl-bensensulfonamider med terapeutiska egenskaper
SE384363B (sv) Forfarande for framstellning av osymmetriska, substituerade difenyletener vilka uppvisar farmakolisk verkan
FI56387B (fi) Foerfarande foer framstaellning av alkansulfonsyraestrar av 1,3,2-oxazafosforinfoereningar med immunitetssaenkande verkan