SE392038B - Forfarande for isolering av antitrombin ur blod eller blodprodukter - Google Patents

Forfarande for isolering av antitrombin ur blod eller blodprodukter

Info

Publication number
SE392038B
SE392038B SE7111350A SE1135071A SE392038B SE 392038 B SE392038 B SE 392038B SE 7111350 A SE7111350 A SE 7111350A SE 1135071 A SE1135071 A SE 1135071A SE 392038 B SE392038 B SE 392038B
Authority
SE
Sweden
Prior art keywords
blood
antitrombin
insulation
procedure
products
Prior art date
Application number
SE7111350A
Other languages
English (en)
Swedish (sv)
Inventor
S-O Andersson
M Miller-Andersson
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Priority to SE7111350A priority Critical patent/SE392038B/xx
Priority to IL39982A priority patent/IL39982A/xx
Priority to FI722094A priority patent/FI50583C/fi
Priority to BE787284A priority patent/BE787284A/xx
Priority to SU1818160A priority patent/SU447876A1/ru
Priority to JP8439172A priority patent/JPS5545528B2/ja
Priority to CS7906A priority patent/CS172957B2/cs
Priority to ES406199A priority patent/ES406199A1/es
Priority to DK430972AA priority patent/DK131128B/da
Priority to NL727211953A priority patent/NL154118B/xx
Priority to ZA726024A priority patent/ZA726024B/xx
Priority to IE1211/72A priority patent/IE36670B1/xx
Priority to DE2243688A priority patent/DE2243688C3/de
Priority to PL1972157623A priority patent/PL83490B1/pl
Priority to US00286732A priority patent/US3842061A/en
Priority to CA151,075A priority patent/CA979805A/en
Priority to AU46373/72A priority patent/AU461865B2/en
Priority to NO3184/72A priority patent/NO135302C/no
Priority to GB4158872A priority patent/GB1356229A/en
Priority to AT768872A priority patent/AT324549B/de
Priority to CH1324072A priority patent/CH577829A5/xx
Priority to FR7231896A priority patent/FR2154483B1/fr
Priority to HUKA1355A priority patent/HU165070B/hu
Publication of SE392038B publication Critical patent/SE392038B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y10S530/831—Cohn fractions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
SE7111350A 1971-09-08 1971-09-08 Forfarande for isolering av antitrombin ur blod eller blodprodukter SE392038B (sv)

Priority Applications (23)

Application Number Priority Date Filing Date Title
SE7111350A SE392038B (sv) 1971-09-08 1971-09-08 Forfarande for isolering av antitrombin ur blod eller blodprodukter
IL39982A IL39982A (en) 1971-09-08 1972-07-24 The isolation of antithrombin from animal material
FI722094A FI50583C (fi) 1971-09-08 1972-07-26 Menetelmä antitrombiinin eristämiseksi verestä tai verituotteista adso rboimalla sulfatoidulle polysakkaridille
BE787284A BE787284A (fr) 1971-09-08 1972-08-07 Procede d'isolation d'antithrombine a partir d'un materiel animal par adsorption sur un carbohydrate sulfate
SU1818160A SU447876A1 (ru) 1972-08-08 Способ выделени антитромбина
JP8439172A JPS5545528B2 (da) 1971-09-08 1972-08-23
CS7906A CS172957B2 (da) 1971-09-08 1972-08-28
ES406199A ES406199A1 (es) 1971-09-08 1972-08-30 Un metodo de aislar antitrombina a partir de material ani- mal.
DK430972AA DK131128B (da) 1971-09-08 1972-08-31 Fremgangsmåde til udvinding af antitrombin fra blod eller blodprodukter ved adsorption.
NL727211953A NL154118B (nl) 1971-09-08 1972-09-01 Werkwijze voor het isoleren van antitrombine uit dierlijk materiaal door adsorptie aan een ionenuitwisselende gel.
ZA726024A ZA726024B (en) 1971-09-08 1972-09-01 Method for isolation of antithrombin from animal material by adsorption on sulphated carbohydrate
IE1211/72A IE36670B1 (en) 1971-09-08 1972-09-06 Method for isolation of antithrombin from animal material
DE2243688A DE2243688C3 (de) 1971-09-08 1972-09-06 Verfahren zur Isolierung von Antithrombin
PL1972157623A PL83490B1 (da) 1971-09-08 1972-09-06
US00286732A US3842061A (en) 1971-09-08 1972-09-06 Method for isolation of antithrombin from animal tissue materials by adsorption on sulfated carbohydrate gel
CA151,075A CA979805A (en) 1971-09-08 1972-09-06 Method for isolation of antithrombin from animal tissue material by adsorption on sulfated carbohydrate gel
AU46373/72A AU461865B2 (en) 1971-09-08 1972-09-06 Method for isolation of antithrombin from animal material
NO3184/72A NO135302C (da) 1971-09-08 1972-09-07
GB4158872A GB1356229A (en) 1971-09-08 1972-09-07 Method for isolation of antithrombin from animal material
AT768872A AT324549B (de) 1971-09-08 1972-09-07 Verfahren zur isolierung von antithrombin aus blutplasma oder plasmaprotein
CH1324072A CH577829A5 (da) 1971-09-08 1972-09-08
FR7231896A FR2154483B1 (da) 1971-09-08 1972-09-08
HUKA1355A HU165070B (da) 1971-09-08 1972-09-08

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7111350A SE392038B (sv) 1971-09-08 1971-09-08 Forfarande for isolering av antitrombin ur blod eller blodprodukter

Publications (1)

Publication Number Publication Date
SE392038B true SE392038B (sv) 1977-03-14

Family

ID=20293800

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7111350A SE392038B (sv) 1971-09-08 1971-09-08 Forfarande for isolering av antitrombin ur blod eller blodprodukter

Country Status (22)

Country Link
US (1) US3842061A (da)
JP (1) JPS5545528B2 (da)
AT (1) AT324549B (da)
AU (1) AU461865B2 (da)
BE (1) BE787284A (da)
CA (1) CA979805A (da)
CH (1) CH577829A5 (da)
CS (1) CS172957B2 (da)
DE (1) DE2243688C3 (da)
DK (1) DK131128B (da)
ES (1) ES406199A1 (da)
FI (1) FI50583C (da)
FR (1) FR2154483B1 (da)
GB (1) GB1356229A (da)
HU (1) HU165070B (da)
IE (1) IE36670B1 (da)
IL (1) IL39982A (da)
NL (1) NL154118B (da)
NO (1) NO135302C (da)
PL (1) PL83490B1 (da)
SE (1) SE392038B (da)
ZA (1) ZA726024B (da)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040601B1 (en) * 1979-08-22 1984-03-14 I.R.D. Biomaterial Aktiebolag Method for detecting proteolytic enzymes in blood

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920625A (en) * 1973-06-19 1975-11-18 Kabi Ab Isolation of coagulation factors from biological material using cross linked sulfated, sulfonated carbohydrates
US4022758A (en) * 1973-06-19 1977-05-10 Ab Kabi Isolation of coagulation factors I and VIII from biological material
US4054557A (en) * 1974-05-15 1977-10-18 Ab Kabi Growth promoting polypeptides and preparation method
US4103685A (en) * 1976-01-05 1978-08-01 Lupien Paul J Method and apparatus for extravascular treatment of blood
NZ180199A (en) * 1976-03-04 1978-11-13 New Zealand Dev Finance Method of testing for the presence of elevated plasma liprotein concentration
NZ187246A (en) * 1976-03-04 1980-05-27 New Zealand Dev Finance Hydrophilic hydroxy c2-c4 alkylated crosslinked regenerated cellulose
US4087415A (en) * 1976-06-09 1978-05-02 William L. Wilson Antithrombin III
JPS597693B2 (ja) * 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4278594A (en) * 1979-06-19 1981-07-14 David Amrani Process for separation and isolation of AHF, von Willebrand's ristocetin cofactor (VWF:RCF) and fibronectin from blood plasma
US4210580A (en) * 1979-06-19 1980-07-01 David Amrani Process for separation and isolation of AHF and fibronectin from blood plasma
US4386025A (en) * 1980-09-30 1983-05-31 Cutter Laboratories, Inc. Method of preparing antithrombin
US4446314A (en) * 1980-09-30 1984-05-01 Cutter Laboratories, Inc. Fractionation of heparin
DE3038163A1 (de) * 1980-10-09 1982-05-06 Boehringer Mannheim Gmbh, 6800 Mannheim Thrombininhibitor, seine herstellung und verwendung
FR2527222A1 (fr) * 1982-05-19 1983-11-25 Christine Fougnot Procede de separation et de purification des proteases et des antiproteases de la coagulation sanguine, ainsi que du complexe protease/antiprotease
US4632981A (en) * 1982-07-30 1986-12-30 Genentech, Inc. Human antithrombin III
CA1221307A (en) * 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent and process for preparing the same
US4515714A (en) * 1983-03-09 1985-05-07 Juridicial Foundation, The Chemo-Semo-Sero-Therapeutic Research Institute Method for purification of hepatitis B virus surface antigen
AT379510B (de) * 1983-05-20 1986-01-27 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf) -haeltigen praeparation
AT379310B (de) * 1983-05-20 1985-12-27 Immuno Ag Verfahren zur herstellung eines antithrombin iii-heparin- bzw. antithrombin iii-heparinoidkonzentrates
AU571078B2 (en) * 1984-04-14 1988-03-31 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Purification of filamentous hemagglutinin
GB8505882D0 (en) * 1985-03-07 1985-04-11 Central Blood Lab Authority Purification of blood coagulation factor viii
DE3519011A1 (de) * 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III
AT399095B (de) * 1986-03-27 1995-03-27 Vukovich Thomas Dr Verfahren zur auftrennung von proteinen mittels gradientenelution und vorrichtung zur durchführung des verfahrens
US4749783A (en) * 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins
CA1341379C (en) 1988-04-28 2002-07-23 Welfide Corporation Purified antithrombin-iii and methods of producing the same
US5110907A (en) * 1989-08-01 1992-05-05 Alpha Therapeutic Corporation Factor viii complex purification using heparin affinity chromatography
US6562781B1 (en) 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6491965B1 (en) * 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
US5989593A (en) * 1996-11-20 1999-11-23 Yoshitomi Pharmaceutical Industries, Ltd. Method for producing antithrombin-III, method for purifying it, and preparation containing it
AT405739B (de) 1997-09-19 1999-11-25 Immuno Ag Verfahren zur reinigung von antithrombin iii
US8563693B2 (en) * 2001-01-26 2013-10-22 Acceleration Biopharmaceuticals, Inc. Method of treating human immunodeficiency virus infection in a mammal comprising administering heparin-activated antithrombin III
ATE377657T1 (de) * 2001-01-26 2007-11-15 Gen Hospital Corp Serpin-arzneistoffe zur behandlung einer hiv- infektion und verfahren zu deren verwendung
SE0203770D0 (sv) * 2002-12-19 2002-12-19 Biovitrum Ab Method of separation
JP4970260B2 (ja) 2004-08-20 2012-07-04 プロメティック バイオサイエンシズ，リミテッド 親和性クロマトグラフィーによるタンパク質の逐次的単離および精製スキーム

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE366760B (da) * 1967-12-18 1974-05-06 J Sjoevall
DE1907738A1 (de) * 1969-02-15 1970-08-13 Bayer Ag Verfahren zur Abtrennung des Trypsin-Plasmin-Inhibitors vom Thrombin-Inhibitor in handelsueblichen Hirudinpraeparaten und in Hirudinrohpraeparaten

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040601B1 (en) * 1979-08-22 1984-03-14 I.R.D. Biomaterial Aktiebolag Method for detecting proteolytic enzymes in blood

Also Published As

Publication number Publication date
US3842061A (en) 1974-10-15
NO135302C (da) 1977-03-23
NO135302B (da) 1976-12-13
ZA726024B (en) 1973-05-30
JPS4835017A (da) 1973-05-23
DK131128C (da) 1975-11-03
FR2154483B1 (da) 1977-01-14
GB1356229A (en) 1974-06-12
FI50583B (da) 1976-02-02
IE36670L (en) 1973-03-08
SU447876A3 (ru) 1974-10-25
AT324549B (de) 1975-09-10
BE787284A (fr) 1972-12-01
JPS5545528B2 (da) 1980-11-18
CA979805A (en) 1975-12-16
DE2243688C3 (de) 1984-05-10
FI50583C (fi) 1976-05-10
FR2154483A1 (da) 1973-05-11
CS172957B2 (da) 1977-01-28
NL154118B (nl) 1977-08-15
DE2243688A1 (de) 1973-03-22
AU461865B2 (en) 1975-06-05
CH577829A5 (da) 1976-07-30
IE36670B1 (en) 1977-01-19
DK131128B (da) 1975-06-02
AU4637372A (en) 1974-03-14
IL39982A0 (en) 1972-09-28
NL7211953A (da) 1973-03-12
ES406199A1 (es) 1975-07-01
IL39982A (en) 1974-11-29
DE2243688B2 (de) 1978-06-15
PL83490B1 (da) 1975-12-31
HU165070B (da) 1974-06-28

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