BE787284A - Procede d'isolation d'antithrombine a partir d'un materiel animal par adsorption sur un carbohydrate sulfate - Google Patents

Procede d'isolation d'antithrombine a partir d'un materiel animal par adsorption sur un carbohydrate sulfate

Info

Publication number
BE787284A
BE787284A BE787284A BE787284A BE787284A BE 787284 A BE787284 A BE 787284A BE 787284 A BE787284 A BE 787284A BE 787284 A BE787284 A BE 787284A BE 787284 A BE787284 A BE 787284A
Authority
BE
Belgium
Prior art keywords
antithrombin
carbohydrate
sulphate
adsorption
isolation process
Prior art date
Application number
BE787284A
Other languages
English (en)
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of BE787284A publication Critical patent/BE787284A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y10S530/831—Cohn fractions
BE787284A 1971-09-08 1972-08-07 Procede d'isolation d'antithrombine a partir d'un materiel animal par adsorption sur un carbohydrate sulfate BE787284A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7111350A SE392038B (sv) 1971-09-08 1971-09-08 Forfarande for isolering av antitrombin ur blod eller blodprodukter

Publications (1)

Publication Number Publication Date
BE787284A true BE787284A (fr) 1972-12-01

Family

ID=20293800

Family Applications (1)

Application Number Title Priority Date Filing Date
BE787284A BE787284A (fr) 1971-09-08 1972-08-07 Procede d'isolation d'antithrombine a partir d'un materiel animal par adsorption sur un carbohydrate sulfate

Country Status (22)

Country Link
US (1) US3842061A (fr)
JP (1) JPS5545528B2 (fr)
AT (1) AT324549B (fr)
AU (1) AU461865B2 (fr)
BE (1) BE787284A (fr)
CA (1) CA979805A (fr)
CH (1) CH577829A5 (fr)
CS (1) CS172957B2 (fr)
DE (1) DE2243688C3 (fr)
DK (1) DK131128B (fr)
ES (1) ES406199A1 (fr)
FI (1) FI50583C (fr)
FR (1) FR2154483B1 (fr)
GB (1) GB1356229A (fr)
HU (1) HU165070B (fr)
IE (1) IE36670B1 (fr)
IL (1) IL39982A (fr)
NL (1) NL154118B (fr)
NO (1) NO135302C (fr)
PL (1) PL83490B1 (fr)
SE (1) SE392038B (fr)
ZA (1) ZA726024B (fr)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022758A (en) * 1973-06-19 1977-05-10 Ab Kabi Isolation of coagulation factors I and VIII from biological material
US3920625A (en) * 1973-06-19 1975-11-18 Kabi Ab Isolation of coagulation factors from biological material using cross linked sulfated, sulfonated carbohydrates
US4054557A (en) * 1974-05-15 1977-10-18 Ab Kabi Growth promoting polypeptides and preparation method
US4103685A (en) * 1976-01-05 1978-08-01 Lupien Paul J Method and apparatus for extravascular treatment of blood
NZ180199A (en) * 1976-03-04 1978-11-13 New Zealand Dev Finance Method of testing for the presence of elevated plasma liprotein concentration
NZ180198A (en) * 1976-03-04 1978-11-13 New Zealand Dev Finance Cationic ion exchanger with a cross-linked carbohydrate marix
US4087415A (en) * 1976-06-09 1978-05-02 William L. Wilson Antithrombin III
JPS597693B2 (ja) * 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4278594A (en) * 1979-06-19 1981-07-14 David Amrani Process for separation and isolation of AHF, von Willebrand's ristocetin cofactor (VWF:RCF) and fibronectin from blood plasma
US4210580A (en) * 1979-06-19 1980-07-01 David Amrani Process for separation and isolation of AHF and fibronectin from blood plasma
SE422081B (sv) * 1979-08-22 1982-02-15 Ird Biomaterial Ab Sett att pavisa proteolytiska enzymer
US4446314A (en) * 1980-09-30 1984-05-01 Cutter Laboratories, Inc. Fractionation of heparin
US4386025A (en) * 1980-09-30 1983-05-31 Cutter Laboratories, Inc. Method of preparing antithrombin
DE3038163A1 (de) * 1980-10-09 1982-05-06 Boehringer Mannheim Gmbh, 6800 Mannheim Thrombininhibitor, seine herstellung und verwendung
FR2527222A1 (fr) * 1982-05-19 1983-11-25 Christine Fougnot Procede de separation et de purification des proteases et des antiproteases de la coagulation sanguine, ainsi que du complexe protease/antiprotease
US4632981A (en) * 1982-07-30 1986-12-30 Genentech, Inc. Human antithrombin III
CA1221307A (fr) * 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent en methode de preparation
US4515714A (en) * 1983-03-09 1985-05-07 Juridicial Foundation, The Chemo-Semo-Sero-Therapeutic Research Institute Method for purification of hepatitis B virus surface antigen
AT379310B (de) * 1983-05-20 1985-12-27 Immuno Ag Verfahren zur herstellung eines antithrombin iii-heparin- bzw. antithrombin iii-heparinoidkonzentrates
AT379510B (de) * 1983-05-20 1986-01-27 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf) -haeltigen praeparation
US4563303A (en) * 1984-04-14 1986-01-07 Judicial Foundation The Chemosero-Therapeutic Research Institute Method for purification of filamentous hemagglutinin
GB8505882D0 (en) * 1985-03-07 1985-04-11 Central Blood Lab Authority Purification of blood coagulation factor viii
DE3519011A1 (de) * 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III
AT399095B (de) * 1986-03-27 1995-03-27 Vukovich Thomas Dr Verfahren zur auftrennung von proteinen mittels gradientenelution und vorrichtung zur durchführung des verfahrens
US4749783A (en) * 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins
CA1341379C (fr) 1988-04-28 2002-07-23 Welfide Corporation Antithrombine iii purifiee et leur methode de preparation
US5110907A (en) * 1989-08-01 1992-05-05 Alpha Therapeutic Corporation Factor viii complex purification using heparin affinity chromatography
US6491965B1 (en) * 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
US6562781B1 (en) 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
EP0844254A3 (fr) * 1996-11-20 1999-05-12 The Green Cross Corporation Procédé de production de l'antithrombine-III, son procédé de purification, et préparation la contenant
AT405739B (de) 1997-09-19 1999-11-25 Immuno Ag Verfahren zur reinigung von antithrombin iii
ES2296914T3 (es) * 2001-01-26 2008-05-01 The General Hospital Corporation Farmacos de serpina para el tratamiento de la infeccion por vih y metodo de uso de los mismos.
US8563693B2 (en) * 2001-01-26 2013-10-22 Acceleration Biopharmaceuticals, Inc. Method of treating human immunodeficiency virus infection in a mammal comprising administering heparin-activated antithrombin III
SE0203770D0 (sv) * 2002-12-19 2002-12-19 Biovitrum Ab Method of separation
CN101035439B (zh) 2004-08-20 2013-02-06 普洛麦提生命科学有限公司 通过亲和色谱法进行的连续蛋白质分离和提纯方案

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE366760B (fr) * 1967-12-18 1974-05-06 J Sjoevall
DE1907738A1 (de) * 1969-02-15 1970-08-13 Bayer Ag Verfahren zur Abtrennung des Trypsin-Plasmin-Inhibitors vom Thrombin-Inhibitor in handelsueblichen Hirudinpraeparaten und in Hirudinrohpraeparaten

Also Published As

Publication number Publication date
HU165070B (fr) 1974-06-28
CS172957B2 (fr) 1977-01-28
FI50583B (fr) 1976-02-02
DK131128B (da) 1975-06-02
PL83490B1 (fr) 1975-12-31
SU447876A3 (ru) 1974-10-25
NO135302B (fr) 1976-12-13
CA979805A (en) 1975-12-16
ZA726024B (en) 1973-05-30
IL39982A0 (en) 1972-09-28
AU4637372A (en) 1974-03-14
AT324549B (de) 1975-09-10
ES406199A1 (es) 1975-07-01
GB1356229A (en) 1974-06-12
FR2154483B1 (fr) 1977-01-14
NL7211953A (fr) 1973-03-12
DE2243688C3 (de) 1984-05-10
FR2154483A1 (fr) 1973-05-11
DE2243688B2 (de) 1978-06-15
JPS5545528B2 (fr) 1980-11-18
CH577829A5 (fr) 1976-07-30
DK131128C (fr) 1975-11-03
SE392038B (sv) 1977-03-14
DE2243688A1 (de) 1973-03-22
IE36670L (en) 1973-03-08
US3842061A (en) 1974-10-15
IE36670B1 (en) 1977-01-19
AU461865B2 (en) 1975-06-05
JPS4835017A (fr) 1973-05-23
NL154118B (nl) 1977-08-15
NO135302C (fr) 1977-03-23
FI50583C (fi) 1976-05-10
IL39982A (en) 1974-11-29

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: KABI A.B.

Effective date: 19920807