AT324549B - Verfahren zur isolierung von antithrombin aus blutplasma oder plasmaprotein - Google Patents

Verfahren zur isolierung von antithrombin aus blutplasma oder plasmaprotein

Info

Publication number
AT324549B
AT324549B AT768872A AT768872A AT324549B AT 324549 B AT324549 B AT 324549B AT 768872 A AT768872 A AT 768872A AT 768872 A AT768872 A AT 768872A AT 324549 B AT324549 B AT 324549B
Authority
AT
Austria
Prior art keywords
plasma
antithrombin
isolation
protein
blood plasma
Prior art date
Application number
AT768872A
Other languages
English (en)
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kabi Ab filed Critical Kabi Ab
Application granted granted Critical
Publication of AT324549B publication Critical patent/AT324549B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum
    • Y10S530/831—Cohn fractions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT768872A 1971-09-08 1972-09-07 Verfahren zur isolierung von antithrombin aus blutplasma oder plasmaprotein AT324549B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7111350A SE392038B (sv) 1971-09-08 1971-09-08 Forfarande for isolering av antitrombin ur blod eller blodprodukter

Publications (1)

Publication Number Publication Date
AT324549B true AT324549B (de) 1975-09-10

Family

ID=20293800

Family Applications (1)

Application Number Title Priority Date Filing Date
AT768872A AT324549B (de) 1971-09-08 1972-09-07 Verfahren zur isolierung von antithrombin aus blutplasma oder plasmaprotein

Country Status (23)

Country Link
US (1) US3842061A (de)
JP (1) JPS5545528B2 (de)
AT (1) AT324549B (de)
AU (1) AU461865B2 (de)
BE (1) BE787284A (de)
CA (1) CA979805A (de)
CH (1) CH577829A5 (de)
CS (1) CS172957B2 (de)
DE (1) DE2243688C3 (de)
DK (1) DK131128B (de)
ES (1) ES406199A1 (de)
FI (1) FI50583C (de)
FR (1) FR2154483B1 (de)
GB (1) GB1356229A (de)
HU (1) HU165070B (de)
IE (1) IE36670B1 (de)
IL (1) IL39982A (de)
NL (1) NL154118B (de)
NO (1) NO135302C (de)
PL (1) PL83490B1 (de)
SE (1) SE392038B (de)
SU (1) SU447876A3 (de)
ZA (1) ZA726024B (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399095B (de) * 1986-03-27 1995-03-27 Vukovich Thomas Dr Verfahren zur auftrennung von proteinen mittels gradientenelution und vorrichtung zur durchführung des verfahrens

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3920625A (en) * 1973-06-19 1975-11-18 Kabi Ab Isolation of coagulation factors from biological material using cross linked sulfated, sulfonated carbohydrates
US4022758A (en) * 1973-06-19 1977-05-10 Ab Kabi Isolation of coagulation factors I and VIII from biological material
US4054557A (en) * 1974-05-15 1977-10-18 Ab Kabi Growth promoting polypeptides and preparation method
US4103685A (en) * 1976-01-05 1978-08-01 Lupien Paul J Method and apparatus for extravascular treatment of blood
NZ180198A (en) * 1976-03-04 1978-11-13 New Zealand Dev Finance Cationic ion exchanger with a cross-linked carbohydrate marix
NZ180199A (en) * 1976-03-04 1978-11-13 New Zealand Dev Finance Method of testing for the presence of elevated plasma liprotein concentration
US4087415A (en) * 1976-06-09 1978-05-02 William L. Wilson Antithrombin III
JPS597693B2 (ja) * 1978-01-07 1984-02-20 株式会社ミドリ十字 抗トロンビン製剤及びその製法
DE2916711A1 (de) 1979-04-25 1980-11-06 Behringwerke Ag Blutgerinnungsfaktoren und verfahren zu ihrer herstellung
US4210580A (en) * 1979-06-19 1980-07-01 David Amrani Process for separation and isolation of AHF and fibronectin from blood plasma
US4278594A (en) * 1979-06-19 1981-07-14 David Amrani Process for separation and isolation of AHF, von Willebrand's ristocetin cofactor (VWF:RCF) and fibronectin from blood plasma
SE422081B (sv) * 1979-08-22 1982-02-15 Ird Biomaterial Ab Sett att pavisa proteolytiska enzymer
US4446314A (en) * 1980-09-30 1984-05-01 Cutter Laboratories, Inc. Fractionation of heparin
US4386025A (en) * 1980-09-30 1983-05-31 Cutter Laboratories, Inc. Method of preparing antithrombin
DE3038163A1 (de) * 1980-10-09 1982-05-06 Boehringer Mannheim Gmbh, 6800 Mannheim Thrombininhibitor, seine herstellung und verwendung
FR2527222A1 (fr) * 1982-05-19 1983-11-25 Christine Fougnot Procede de separation et de purification des proteases et des antiproteases de la coagulation sanguine, ainsi que du complexe protease/antiprotease
US4632981A (en) * 1982-07-30 1986-12-30 Genentech, Inc. Human antithrombin III
CA1221307A (en) * 1982-12-02 1987-05-05 Nobutaka Tani Adsorbent and process for preparing the same
US4515714A (en) * 1983-03-09 1985-05-07 Juridicial Foundation, The Chemo-Semo-Sero-Therapeutic Research Institute Method for purification of hepatitis B virus surface antigen
AT379510B (de) * 1983-05-20 1986-01-27 Immuno Ag Verfahren zur herstellung einer faktor viii (ahf) -haeltigen praeparation
AT379310B (de) * 1983-05-20 1985-12-27 Immuno Ag Verfahren zur herstellung eines antithrombin iii-heparin- bzw. antithrombin iii-heparinoidkonzentrates
AU571078B2 (en) * 1984-04-14 1988-03-31 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Purification of filamentous hemagglutinin
GB8505882D0 (en) * 1985-03-07 1985-04-11 Central Blood Lab Authority Purification of blood coagulation factor viii
DE3519011A1 (de) * 1985-05-25 1986-11-27 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung eines materials zur affinitaetschromatographie
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III
US4749783A (en) * 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins
CA1341379C (en) 1988-04-28 2002-07-23 Welfide Corporation Purified antithrombin-iii and methods of producing the same
US5110907A (en) * 1989-08-01 1992-05-05 Alpha Therapeutic Corporation Factor viii complex purification using heparin affinity chromatography
US7045585B2 (en) * 1995-11-30 2006-05-16 Hamilton Civic Hospital Research Development Inc. Methods of coating a device using anti-thrombin heparin
US6491965B1 (en) 1995-11-30 2002-12-10 Hamilton Civic Hospitals Research Development, Inc. Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
US6562781B1 (en) * 1995-11-30 2003-05-13 Hamilton Civic Hospitals Research Development Inc. Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates
EP0844254A3 (de) * 1996-11-20 1999-05-12 The Green Cross Corporation Methode zur Herstellung von Antithrombin-III, Methode zu dessen Reinigung, und diese enthaltende Zusammensetzung
AT405739B (de) 1997-09-19 1999-11-25 Immuno Ag Verfahren zur reinigung von antithrombin iii
US8563693B2 (en) * 2001-01-26 2013-10-22 Acceleration Biopharmaceuticals, Inc. Method of treating human immunodeficiency virus infection in a mammal comprising administering heparin-activated antithrombin III
EP1362127B1 (de) * 2001-01-26 2007-11-07 The General Hospital Corporation Serpin-arzneistoffe zur behandlung einer hiv-infektion und verfahren zu deren verwendung
SE0203770D0 (sv) * 2002-12-19 2002-12-19 Biovitrum Ab Method of separation
MX2007002085A (es) 2004-08-20 2007-07-19 Prometic Biosciences Ltd Esquemas de aislamiento y purificacion consecutivos de proteinas mediante cromatografia de afinidad.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE366760B (de) * 1967-12-18 1974-05-06 J Sjoevall
DE1907738A1 (de) * 1969-02-15 1970-08-13 Bayer Ag Verfahren zur Abtrennung des Trypsin-Plasmin-Inhibitors vom Thrombin-Inhibitor in handelsueblichen Hirudinpraeparaten und in Hirudinrohpraeparaten

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT399095B (de) * 1986-03-27 1995-03-27 Vukovich Thomas Dr Verfahren zur auftrennung von proteinen mittels gradientenelution und vorrichtung zur durchführung des verfahrens

Also Published As

Publication number Publication date
NO135302B (de) 1976-12-13
IE36670L (en) 1973-03-08
IE36670B1 (en) 1977-01-19
DK131128B (da) 1975-06-02
CH577829A5 (de) 1976-07-30
ZA726024B (en) 1973-05-30
NL154118B (nl) 1977-08-15
GB1356229A (en) 1974-06-12
NL7211953A (de) 1973-03-12
DE2243688C3 (de) 1984-05-10
NO135302C (de) 1977-03-23
IL39982A0 (en) 1972-09-28
SU447876A3 (ru) 1974-10-25
AU4637372A (en) 1974-03-14
BE787284A (fr) 1972-12-01
AU461865B2 (en) 1975-06-05
SE392038B (sv) 1977-03-14
FR2154483A1 (de) 1973-05-11
DK131128C (de) 1975-11-03
HU165070B (de) 1974-06-28
ES406199A1 (es) 1975-07-01
PL83490B1 (de) 1975-12-31
JPS5545528B2 (de) 1980-11-18
FR2154483B1 (de) 1977-01-14
JPS4835017A (de) 1973-05-23
US3842061A (en) 1974-10-15
DE2243688A1 (de) 1973-03-22
DE2243688B2 (de) 1978-06-15
IL39982A (en) 1974-11-29
CA979805A (en) 1975-12-16
CS172957B2 (de) 1977-01-28
FI50583B (de) 1976-02-02
FI50583C (fi) 1976-05-10

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Legal Events

Date Code Title Description
ELA Expired due to lapse of time