SE378109B - - Google Patents

Info

Publication number
SE378109B
SE378109B SE7206644A SE664472A SE378109B SE 378109 B SE378109 B SE 378109B SE 7206644 A SE7206644 A SE 7206644A SE 664472 A SE664472 A SE 664472A SE 378109 B SE378109 B SE 378109B
Authority
SE
Sweden
Application number
SE7206644A
Inventor
R L Brattsand
K G Claeson
Af Ekenstam B Thuresson
B A Thalen
Original Assignee
Bofors Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20269234&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SE378109(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to SE7206644A priority Critical patent/SE378109B/xx
Application filed by Bofors Ab filed Critical Bofors Ab
Priority to ZA732955A priority patent/ZA732955B/xx
Priority to IL42155A priority patent/IL42155A/en
Priority to AU55253/73A priority patent/AU487812B2/en
Priority to CY1013A priority patent/CY1013A/xx
Priority to DE2323215A priority patent/DE2323215C3/de
Priority to GB2219473A priority patent/GB1429922A/en
Priority to ES414673A priority patent/ES414673A1/es
Priority to US360051A priority patent/US3929768A/en
Priority to FI731542A priority patent/FI50631C/fi
Priority to YU1291/73A priority patent/YU35896B/xx
Priority to CH699973A priority patent/CH595400A5/xx
Priority to DK277273AA priority patent/DK134783B/da
Priority to DD170888A priority patent/DD104295A5/xx
Priority to BE131270A priority patent/BE799727A/xx
Priority to FR7318125A priority patent/FR2185405B1/fr
Priority to NO2059/73A priority patent/NO139640C/no
Priority to CS3590A priority patent/CS178129B2/cs
Priority to NLAANVRAGE7306978,A priority patent/NL177493C/xx
Priority to HUBO1438A priority patent/HU166680B/hu
Priority to AT436573A priority patent/AT328630B/de
Priority to SU1923451A priority patent/SU470954A3/ru
Priority to PL1973162650A priority patent/PL87765B1/pl
Priority to CA171,785A priority patent/CA1002938A/en
Priority to JP5623373A priority patent/JPS5521760B2/ja
Publication of SE378109B publication Critical patent/SE378109B/xx
Priority to US05/629,389 priority patent/US3983233A/en
Priority to KE2970A priority patent/KE2970A/xx
Priority to HK491/79A priority patent/HK49179A/xx
Priority to NL930025C priority patent/NL930025I1/nl
Priority to NO1994013C priority patent/NO1994013I1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE7206644A 1972-05-19 1972-05-19 SE378109B (en:Method)

Priority Applications (30)

Application Number Priority Date Filing Date Title
SE7206644A SE378109B (en:Method) 1972-05-19 1972-05-19
ZA732955A ZA732955B (en) 1972-05-19 1973-05-01 New steroids,processes for their manufacture and preparations containing same
IL42155A IL42155A (en) 1972-05-19 1973-05-01 16alpha,17alpha-alkylidenedioxy-11beta,21-dihydroxy-pregna-1,4-diene-3,20-diones their manufacture and preparations containing same
AU55253/73A AU487812B2 (en) 1972-05-19 1973-05-04 New Steroids, processes for their manufacture and preparations containing same
CY1013A CY1013A (en) 1972-05-19 1973-05-09 Steroid acetals, processes for their manufacture and preparations containing them
DE2323215A DE2323215C3 (de) 1972-05-19 1973-05-09 Pregna-l,4-dien-ll-ol-3,20-dione, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel
GB2219473A GB1429922A (en) 1972-05-19 1973-05-09 Steroid acetals processes for their manufacture and preparations containing them
ES414673A ES414673A1 (es) 1972-05-19 1973-05-11 Procedimiento para preparar esteroides.
FI731542A FI50631C (fi) 1972-05-19 1973-05-14 Menetelmä pregnadieenijohdannaisten valmistamiseksi.
US360051A US3929768A (en) 1972-05-19 1973-05-14 Steroids, processes for their manufacture and preparations containing same
YU1291/73A YU35896B (en) 1972-05-19 1973-05-16 Process for obtaining steroids
CH699973A CH595400A5 (en:Method) 1972-05-19 1973-05-16
DK277273AA DK134783B (da) 1972-05-19 1973-05-17 Analogifremgangsmåde til fremstilling af 16alfa,17alfa-alkylidendioxypregna-1,4-dien-11beta,21-diol-3,20-dioner.
DD170888A DD104295A5 (en:Method) 1972-05-19 1973-05-17
FR7318125A FR2185405B1 (en:Method) 1972-05-19 1973-05-18
BE131270A BE799727A (fr) 1972-05-19 1973-05-18 Nouveaux steroides physiologiquement actifs, et procede pour leur preparation.
CA171,785A CA1002938A (en) 1972-05-19 1973-05-18 Steroids, processes for their manufacture and preparations containing same
NO2059/73A NO139640C (no) 1972-05-19 1973-05-18 Analogifremgangsmaate for fremstilling av fysiologisk virksomme 16alfa,17alfa-alkylidendioksypregna-1,4-dien-3,20-dioner
CS3590A CS178129B2 (en:Method) 1972-05-19 1973-05-18
NLAANVRAGE7306978,A NL177493C (nl) 1972-05-19 1973-05-18 Werkwijze voor de bereiding van steroiden en werkwijze ter bereiding van een farmaceutisch preparaat tegen ontstekingen.
HUBO1438A HU166680B (en:Method) 1972-05-19 1973-05-18
AT436573A AT328630B (de) 1972-05-19 1973-05-18 Verfahren zur herstellung neuer steroide
SU1923451A SU470954A3 (ru) 1972-05-19 1973-05-18 Способ получени производных кортикостероидов
PL1973162650A PL87765B1 (en:Method) 1972-05-19 1973-05-18
JP5623373A JPS5521760B2 (en:Method) 1972-05-19 1973-05-19
US05/629,389 US3983233A (en) 1972-05-19 1975-11-06 Compositions and method of treating with stereoisomeric mixtures of 2-unsymmetrical 16,17-methylenedioxy steroids
KE2970A KE2970A (en) 1972-05-19 1979-06-20 New steriod acetals, process for their manufacture and preparations containing them
HK491/79A HK49179A (en) 1972-05-19 1979-07-19 New steroid acetals, processes for their manufacture and preparations containing them
NL930025C NL930025I1 (nl) 1972-05-19 1993-04-13 Werkwijze voor de bereiding van steroïden en werkwijze ter bereiding van een farmaceutisch preparaattegen ontstekingen
NO1994013C NO1994013I1 (no) 1972-05-19 1994-08-31 Budenosid/ 16¿, 17¿-alkyldendioksypregna-1,4-dien-3,20-dioner

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7206644A SE378109B (en:Method) 1972-05-19 1972-05-19

Publications (1)

Publication Number Publication Date
SE378109B true SE378109B (en:Method) 1975-08-18

Family

ID=20269234

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7206644A SE378109B (en:Method) 1972-05-19 1972-05-19

Country Status (26)

Country Link
US (2) US3929768A (en:Method)
JP (1) JPS5521760B2 (en:Method)
AT (1) AT328630B (en:Method)
BE (1) BE799727A (en:Method)
CA (1) CA1002938A (en:Method)
CH (1) CH595400A5 (en:Method)
CS (1) CS178129B2 (en:Method)
CY (1) CY1013A (en:Method)
DD (1) DD104295A5 (en:Method)
DE (1) DE2323215C3 (en:Method)
DK (1) DK134783B (en:Method)
ES (1) ES414673A1 (en:Method)
FI (1) FI50631C (en:Method)
FR (1) FR2185405B1 (en:Method)
GB (1) GB1429922A (en:Method)
HK (1) HK49179A (en:Method)
HU (1) HU166680B (en:Method)
IL (1) IL42155A (en:Method)
KE (1) KE2970A (en:Method)
NL (2) NL177493C (en:Method)
NO (2) NO139640C (en:Method)
PL (1) PL87765B1 (en:Method)
SE (1) SE378109B (en:Method)
SU (1) SU470954A3 (en:Method)
YU (1) YU35896B (en:Method)
ZA (1) ZA732955B (en:Method)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0197018A1 (en) * 1985-04-04 1986-10-08 Aktiebolaget Draco 16,17-Acetal-substituted androstane-17-beta-carboxylic-acid esters, process for their preparation and pharmaceutical compound containing them
EP0170642A3 (en) * 1984-07-30 1986-10-29 Aktiebolaget Draco Liposomes containing steroid esters
EP0232690A1 (en) * 1985-12-19 1987-08-19 Aktiebolaget Draco Novel 16,17-acetalsubstituted pregnane-21-oic acid derivatives, process for the preparation thereof and pharmaceutical preparation containing them
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8004580L (sv) * 1980-06-19 1981-12-20 Draco Ab Farmaceutisk beredning
SE8008524L (sv) * 1980-12-04 1982-06-05 Draco Ab 4-pregnen-derivat, ett forfarande for deras framstellning, beredning och metod for behandling av inflammatoriska tillstand
IT1196142B (it) * 1984-06-11 1988-11-10 Sicor Spa Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) * 1986-09-25 1986-09-25 Astra Pharma Prod A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
LV5274A3 (lv) * 1988-02-29 1993-10-10 Richter Gedeon Vegyeszet 22(R,S)-11 beta,21-dihidroksi-16 alpha,17-butilidenbisoksipregna-1,4-dien-3,20-diona iegusanas panemiens
HU203769B (en) * 1989-03-09 1991-09-30 Richter Gedeon Vegyeszet Process for producing new steroide derivatives and pharmaceutical compositions containing them
SE8903219D0 (sv) * 1989-10-02 1989-10-02 Astra Ab Process for the manufacture of budesonide
SE8903914D0 (sv) 1989-11-22 1989-11-22 Draco Ab Oral composition for the treatment of inflammatory bowel diseases
US5643602A (en) * 1989-11-22 1997-07-01 Astra Aktiebolag Oral composition for the treatment of inflammatory bowel disease
GR1001529B (el) * 1990-09-07 1994-03-31 Elmuquimica Farm Sl Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης.
SE9100341D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroids
SE9100342D0 (sv) * 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
US5888995A (en) * 1991-02-04 1999-03-30 Astra Aktiebolag Steroid esters
IE67345B1 (en) * 1991-03-12 1996-03-20 Akzo Nv Low dose dry pharmaceutical preparations
FR2675146A1 (fr) * 1991-04-10 1992-10-16 Roussel Uclaf Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
MD24C2 (ro) * 1991-07-09 1994-05-31 Fabrica De Parfumerii Si Cosmetica "Viorica" Compoziţie de substanţe odorante
LT3695B (en) 1991-11-18 1996-02-26 Dineika Raimundas Arnas Folded roof
HU0004452D0 (en:Method) * 1991-12-18 2001-01-29 Astra Ab
ES2107806T3 (es) * 1992-12-24 1997-12-01 Rhone Poulenc Rorer Ltd Nuevos esteroides.
CA2152374A1 (en) * 1993-01-08 1994-07-21 Ralph Lennart Brattsand Novel colon- or ileum-specific steroid derivatives
JP3333210B2 (ja) 1993-04-02 2002-10-15 ビイク グルデン ロンベルク ヒェーミッシェ ファブリーク ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規プレドニソロン誘導体および該化合物を含有する薬剤
GB9423919D0 (en) * 1994-11-26 1995-01-11 Rhone Poulenc Rorer Ltd Chemical process
US6166024A (en) 1995-03-30 2000-12-26 Mayo Foundation For Medical Education And Research Use of topical azathioprine and thioguanine to treat colorectal adenomas
FR2756739B1 (fr) * 1996-12-05 2000-04-28 Astra Ab Nouvelle formulation de budesonide
IT1291288B1 (it) 1997-04-30 1999-01-07 Farmabios Srl Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.
DE29717252U1 (de) * 1997-09-26 1998-02-19 Dr. Falk Pharma GmbH, 79108 Freiburg Arzneimittelkit aus einem Budesonid-haltigen und einem Ursodesoxycholsäure-haltigen Arzneimittel zur Behandlung von cholestatischen Lebererkrankungen
US6266556B1 (en) 1998-04-27 2001-07-24 Beth Israel Deaconess Medical Center, Inc. Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation
US6667299B1 (en) * 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
PT1175433E (pt) 1999-05-04 2005-11-30 Strakan Int Ltd Glicosidos androgenos e sua actividade androgenica
GB0009583D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory formulations
GB0009584D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Pharmaceutical compositions
GB0009613D0 (en) * 2000-04-18 2000-06-07 Glaxo Group Ltd Pharmaceutical compositions
AR028948A1 (es) * 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
US20030055026A1 (en) * 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US6667344B2 (en) 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
IL144900A (en) 2001-08-14 2013-12-31 Neurim Pharma 1991 Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs
US20040235811A1 (en) * 2002-10-08 2004-11-25 Sepracor Inc. Fatty acid modified forms of glucocorticoids
EP1620083A2 (en) * 2003-04-18 2006-02-01 Pharmacia & Upjohn Company LLC Combination therapies
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
BRPI0413330A (pt) * 2003-08-29 2006-10-10 Ranbaxy Lab Ltd inibidores de fosfodiesterase do tipo iv, composição farmacêutica contendo os mesmos e processo para sua preparação
EP1694655A2 (en) * 2003-11-26 2006-08-30 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
US7750151B2 (en) 2004-04-09 2010-07-06 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
ES2382814T3 (es) 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
ES2265276B1 (es) 2005-05-20 2008-02-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
TW200738634A (en) 2005-08-02 2007-10-16 Astrazeneca Ab New salt
TW200744612A (en) * 2005-08-26 2007-12-16 Astrazeneca Ab New combination
EP1934219A1 (en) 2005-09-16 2008-06-25 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
US20090054382A1 (en) * 2005-10-19 2009-02-26 Abhijit Ray Compositions of phosphodiesterase type iv inhibitors
AU2006305619A1 (en) 2005-10-19 2007-04-26 Ranbaxy Laboratories Limited Pharmaceutical compositions of muscarinic receptor antagonists
WO2007056181A2 (en) * 2005-11-02 2007-05-18 Sicor, Inc. Process for the preparation of ciclesonide
TWI374147B (en) 2006-01-27 2012-10-11 Sun Pharma Advance Res Company Ltd Novel 11β-hydroxyandrosta-4-ene-3-ones
US20070232578A1 (en) * 2006-02-15 2007-10-04 Pierluigi Rossetto Crystalline forms of ciclesonide
ES2296516B1 (es) * 2006-04-27 2009-04-01 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
EA016567B1 (ru) * 2006-08-22 2012-05-30 Ранбакси Лабораториз Лимитед Ингибиторы матриксных металлопротеиназ
WO2008035316A2 (en) * 2006-09-22 2008-03-27 Ranbaxy Laboratories Limited Phosphodiesterase inhibitors
EA200900472A1 (ru) * 2006-09-22 2009-10-30 Ранбакси Лабораторис Лимитед Ингибиторы фосфодиэстеразы iv типа
ES2302447B1 (es) * 2006-10-20 2009-06-12 Laboratorios Almirall S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor beta2 adrenergico.
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
CA2674084C (en) 2006-12-26 2013-05-14 Pharmacyclics, Inc. Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
CA2674436C (en) 2007-01-10 2012-07-17 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
GB0702456D0 (en) 2007-02-08 2007-03-21 Astrazeneca Ab New combination
ES2306595B1 (es) * 2007-02-09 2009-09-11 Laboratorios Almirall S.A. Sal de napadisilato de 5-(2-((6-(2,2-difluoro-2-feniletoxi)hexil)amino)-1-hidroxietil)-8-hidroxiquinolin-2(1h)-ona como agonista del receptor adrenergico beta2.
US10201490B2 (en) 2007-02-14 2019-02-12 Polichem Sa Use of chitosans for the treatment of nail inflammatory diseases
EP1958639A1 (en) 2007-02-14 2008-08-20 Polichem S.A. Use of chitosans for the treatment of nail inflammatory diseases
US20080207659A1 (en) * 2007-02-15 2008-08-28 Asit Kumar Chakraborti Inhibitors of phosphodiesterase type 4
KR101568884B1 (ko) * 2007-03-14 2015-11-12 랜박시 래보러터리스 리미티드 포스포디에스테라제 저해제로서 피라졸로 (３,４-ｂ) 피리딘 유도체
WO2008111009A1 (en) * 2007-03-14 2008-09-18 Ranbaxy Laboratories Limited Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors
EP3103791B1 (en) 2007-06-27 2018-01-31 Merck Sharp & Dohme Corp. 4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US20090082319A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched budesonide
WO2009045539A2 (en) * 2007-10-05 2009-04-09 Nektar Therapeutics Al, Corporation Oligomer-corticosteroid conjugates
ES2320961B1 (es) * 2007-11-28 2010-03-17 Laboratorios Almirall, S.A. Derivados de 4-(2-amino-1-hidroxietil)fenol como agonistas del receptor adrenergico beta2.
EP2096105A1 (en) * 2008-02-28 2009-09-02 Laboratorios Almirall, S.A. Derivatives of 4-(2-amino-1-hydroxyethyl)phenol as agonists of the b2 adrenergic receptor
EP2262823B1 (en) * 2008-03-13 2013-01-23 Farmabios S.p.A. Process for the preparation of pregnane derivatives
ITMI20080645A1 (it) 2008-04-11 2009-10-12 Ind Chimica Srl Procedimento per la preparazione di budesonide
EP2111861A1 (en) 2008-04-21 2009-10-28 Ranbaxy Laboratories Limited Compositions of phosphodiesterase type IV inhibitors
CN101279997B (zh) * 2008-05-29 2011-08-24 鲁南制药集团股份有限公司 布地奈德的一种制备方法
UY32297A (es) 2008-12-22 2010-05-31 Almirall Sa Sal mesilato de 5-(2-{[6-(2,2-difluoro-2-fenilitoxi) hexil]amino}-1-hidroxietil)-8-hidroxiquinolin-2( 1h)-ona como agonista del receptor b(beta)2 acrenérgico
GB0900484D0 (en) 2009-01-13 2009-02-11 Angeletti P Ist Richerche Bio Therapeutic agent
EP2228368A1 (en) 2009-03-12 2010-09-15 Almirall, S.A. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one
EP2413932A4 (en) 2009-04-01 2012-09-19 Merck Sharp & Dohme INHIBITORS OF AKT ACTIVITY
US8603521B2 (en) 2009-04-17 2013-12-10 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor and uses thereof
US8815258B2 (en) 2009-05-29 2014-08-26 Pearl Therapeutics, Inc. Compositions, methods and systems for respiratory delivery of two or more active agents
SMT202000108T1 (it) 2009-05-29 2020-03-13 Pearl Therapeutics Inc Composizioni, metodi & sistemi per il rilascio respiratorio di due o più agenti attivi
GB0916608D0 (en) 2009-09-22 2009-11-04 Angeletti P Ist Richerche Bio Therapeutic compounds
CN107252488A (zh) 2009-10-01 2017-10-17 艾戴尔医药公司 口服给予的皮质类固醇组合物
US8859776B2 (en) 2009-10-14 2014-10-14 Merck Sharp & Dohme Corp. Substituted piperidines that increase p53 activity and the uses thereof
WO2011073662A1 (en) 2009-12-17 2011-06-23 Astrazeneca Ab Combination of a benzoxazinone and a further agent for treating respiratory diseases
WO2011093812A2 (en) 2010-01-28 2011-08-04 Mahmut Bilgic Pharmaceutical formulation comprising tiotropium and budesonide in dry powder form
WO2011097594A2 (en) 2010-02-08 2011-08-11 Kinagen, Inc. Therapeutic methods and compositions involving allosteric kinase inhibition
CN101863952B (zh) * 2010-04-30 2013-04-17 湖北葛店人福药业有限责任公司 布地奈德的制备方法
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
AU2011285909B2 (en) 2010-08-02 2016-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
US9029341B2 (en) 2010-08-17 2015-05-12 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en) 2010-09-01 2016-11-02 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
US9242981B2 (en) 2010-09-16 2016-01-26 Merck Sharp & Dohme Corp. Fused pyrazole derivatives as novel ERK inhibitors
ES2663009T3 (es) 2010-10-29 2018-04-10 Sirna Therapeutics, Inc. Inhibición de la expresión génica mediada por interferencia por ARN utilizando ácidos nucleicos de interferencia cortos (ANic)
EP2654748B1 (en) 2010-12-21 2016-07-27 Merck Sharp & Dohme Corp. Indazole derivatives useful as erk inhibitors
AU2012245455A1 (en) 2011-04-21 2013-10-31 Merck Sharp & Dohme Corp. Insulin-Like Growth Factor-1 Receptor inhibitors
CA2845806C (en) 2011-09-13 2019-06-11 Pharmacyclics, Inc. Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2770987B1 (en) 2011-10-27 2018-04-04 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
WO2013109214A1 (en) 2012-01-16 2013-07-25 Mahmut Bilgic Process for the preparation of dry powder formulations
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
US20150299696A1 (en) 2012-05-02 2015-10-22 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
CN103421075B (zh) * 2012-05-16 2017-07-28 上海特化医药科技有限公司 孕烷衍生物16,17‑缩醛(酮)的制备方法
US20150224197A1 (en) 2012-07-05 2015-08-13 Arven Ilac Sanayi Ve Ticaret A.S. Inhalation compositions
US10105316B2 (en) 2012-07-05 2018-10-23 Arven llac Sanayi Ve Ticaret A.S. Inhalation compositions comprising muscarinic receptor antagonist
US10111957B2 (en) 2012-07-05 2018-10-30 Arven Ilac Snayi ve Ticaret A.S. Inhalation compositions comprising glucose anhydrous
WO2014007770A2 (en) 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions comprising corticosteroid and sorbitol
BR112015003729A2 (pt) 2012-08-24 2018-06-05 Univ Texas composto de fórmula estrutural i; composição farmacêutica; método de tratamento de uma doença mediada por caminho do hif; método de tratamento de uma doença causada por proliferação anormal de células; e método para alcançar um efeito em um paciente
RU2660429C2 (ru) 2012-09-28 2018-07-06 Мерк Шарп И Доум Корп. Новые соединения, которые являются ингибиторами erk
CA2892361A1 (en) 2012-11-28 2014-06-05 Merck Sharp & Dohme Corp. Use of a wee1 inhibitor for treating a cancer characterized by low pkmyt1 expression levels
EP2935263B1 (en) 2012-12-20 2018-12-05 Merck Sharp & Dohme Corp. Substituted imidazopyridines as hdm2 inhibitors
US9540377B2 (en) 2013-01-30 2017-01-10 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as HDM2 inhibitors
CA2905542C (en) 2013-03-15 2022-05-03 Pearl Therapeutics, Inc. Methods and systems for conditioning of particulate crystalline materials
HK1221653A1 (zh) 2013-05-22 2017-06-09 Pearl Therapeutics, Inc. 用於呼吸递送三种或更多种活性剂的组合物、方法和系统
WO2015034925A1 (en) 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
WO2015034678A2 (en) 2013-09-06 2015-03-12 Aptalis Pharmatech, Inc. Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis
CA2902911C (en) 2014-10-31 2017-06-27 Purdue Pharma Methods and compositions particularly for treatment of attention deficit disorder
EP3250211B1 (en) 2015-01-30 2021-12-22 Coral Drugs Pvt. Ltd. Novel process for preparation of glucocorticoid steroids
WO2017222951A1 (en) 2016-06-23 2017-12-28 Merck Sharp & Dohme Corp. 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors
TWI728172B (zh) 2016-08-18 2021-05-21 美商愛戴爾製藥股份有限公司 治療嗜伊紅性食道炎之方法
WO2018071283A1 (en) 2016-10-12 2018-04-19 Merck Sharp & Dohme Corp. Kdm5 inhibitors
BR112019009019A2 (pt) 2016-11-08 2019-07-09 Regeneron Pharma esteroides e conjugados de proteínas dos mesmos
CA3063871A1 (en) 2017-05-18 2018-11-22 Regeneron Pharmaceuticals, Inc. Cyclodextrin protein drug conjugates
WO2019094395A2 (en) 2017-11-07 2019-05-16 Regeneron Pharmaceuticals, Inc. Hydrophilic linkers for antibody drug conjugates
US11098059B2 (en) 2017-11-08 2021-08-24 Merck Sharp & Dohme Corp. PRMT5 inhibitors
CN118955604A (zh) 2018-01-08 2024-11-15 里珍纳龙药品有限公司 类固醇类化合物及其抗体偶联物
MX2020011546A (es) 2018-05-09 2021-01-29 Regeneron Pharma Anticuerpos anti-msr1 y metodos de uso de los mismos.
EP3833667B1 (en) 2018-08-07 2024-03-13 Merck Sharp & Dohme LLC Prmt5 inhibitors
CA3108388A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
US11993602B2 (en) 2018-08-07 2024-05-28 Merck Sharp & Dohme Llc PRMT5 inhibitors
US10722473B2 (en) 2018-11-19 2020-07-28 Purdue Pharma L.P. Methods and compositions particularly for treatment of attention deficit disorder
JP7589247B2 (ja) 2019-12-17 2024-11-25 メルク・シャープ・アンド・ドーム・エルエルシー Ｐｒｍｔ５阻害剤
HUE067547T2 (hu) 2021-07-09 2024-10-28 Astrazeneca Pharmaceuticals Lp Készítmények, eljárások és rendszerek aeroszol gyógyszerbevitelre
US20250057764A1 (en) 2021-12-20 2025-02-20 Astrazeneca Ab Compositions, methods and systems for aerosol drug delivery
CR20250070A (es) 2022-09-02 2025-04-10 Merck Sharp & Dohme Llc Inhibidores de topoisomerasa-1 derivados de exatecán composiciones farmacéuticas y sus usos.
KR20250079227A (ko) 2022-10-25 2025-06-04 머크 샤프 앤드 돔 엘엘씨 엑사테칸-유래 adc 링커-페이로드, 제약 조성물, 및 그의 용도
AU2023397331A1 (en) 2022-12-14 2025-06-26 Merck Sharp & Dohme Llc Auristatin linker-payloads, pharmaceutical compositions, and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126375A (en) * 1964-03-24 Chioacyl
US3133940A (en) * 1956-04-10 1964-05-19 Glaxo Group Ltd Process for the separation of delta-1, 4-3-keto steroid compounds from mixtures thereof with other 3-keto steroids
US2990401A (en) * 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
US3197469A (en) * 1958-08-06 1965-07-27 Pharmaceutical Res Products In 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
US3128238A (en) * 1962-09-14 1964-04-07 Lilly Co Eli delta1-dehydrogenation of steroids by fermentation with actinoplanaceae
JPS4843910A (en:Method) * 1971-10-08 1973-06-25

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0170642A3 (en) * 1984-07-30 1986-10-29 Aktiebolaget Draco Liposomes containing steroid esters
US4693999A (en) * 1984-07-30 1987-09-15 Aktiebolaget Draco Liposomes containing steroid esters
EP0197018A1 (en) * 1985-04-04 1986-10-08 Aktiebolaget Draco 16,17-Acetal-substituted androstane-17-beta-carboxylic-acid esters, process for their preparation and pharmaceutical compound containing them
EP0355859A1 (en) * 1985-04-04 1990-02-28 Aktiebolaget Draco Process for the preparation of intermediates for 11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-3,20-dione 16-alpha,17-alpha-acetals and 21-esters thereof
US4950659A (en) * 1985-04-04 1990-08-21 Aktiebolaget Draco 16,17-acetalsubstituted androstane-17β-carboxylic acid esters prossessing high binding affinity to the glucocorticosteroid receptor
EP0232690A1 (en) * 1985-12-19 1987-08-19 Aktiebolaget Draco Novel 16,17-acetalsubstituted pregnane-21-oic acid derivatives, process for the preparation thereof and pharmaceutical preparation containing them
US5215979A (en) * 1985-12-19 1993-06-01 Aktiebolaget Draco 16,17-acetalsubstituted pregnane 21-oic acid derivatives

Also Published As

Publication number Publication date
DE2323215A1 (de) 1973-11-29
DE2323215B2 (de) 1977-08-11
CS178129B2 (en:Method) 1977-08-31
CY1013A (en) 1979-11-23
FR2185405B1 (en:Method) 1976-12-31
DK134783B (da) 1977-01-17
GB1429922A (en) 1976-03-31
IL42155A0 (en) 1973-07-30
NO1994013I1 (no) 1994-08-31
FI50631B (en:Method) 1976-02-02
PL87765B1 (en:Method) 1976-07-31
YU129173A (en) 1981-02-28
FI50631C (fi) 1976-05-10
US3929768A (en) 1975-12-30
ATA436573A (de) 1975-06-15
HK49179A (en) 1979-07-27
YU35896B (en) 1981-08-31
NO139640C (no) 1979-04-18
US3983233A (en) 1976-09-28
DD104295A5 (en:Method) 1974-03-05
NL930025I1 (nl) 1993-06-01
JPS5521760B2 (en:Method) 1980-06-12
ZA732955B (en) 1974-04-24
NL7306978A (en:Method) 1973-11-21
JPS4941378A (en:Method) 1974-04-18
NL177493B (nl) 1985-05-01
NL177493C (nl) 1985-10-01
NO139640B (no) 1979-01-08
FR2185405A1 (en:Method) 1974-01-04
ES414673A1 (es) 1976-07-01
IL42155A (en) 1977-06-30
CA1002938A (en) 1977-01-04
KE2970A (en) 1979-07-20
DK134783C (en:Method) 1977-06-06
AT328630B (de) 1976-03-25
BE799727A (fr) 1973-09-17
DE2323215C3 (de) 1978-03-30
SU470954A3 (ru) 1975-05-15
AU5525373A (en) 1974-11-07
CH595400A5 (en:Method) 1978-02-15
HU166680B (en:Method) 1975-05-28

Similar Documents

Publication Publication Date Title
DK134783C (en:Method)
FR2223065A2 (en:Method)
FR2202125B1 (en:Method)
JPS48103611A (en:Method)
FR2212389A1 (en:Method)
FR2208732A1 (en:Method)
JPS4921271A (en:Method)
JPS5251787Y2 (en:Method)
JPS497952U (en:Method)
JPS499985U (en:Method)
JPS5143954B2 (en:Method)
JPS5145086B2 (en:Method)
JPS4940784U (en:Method)
JPS5634915B2 (en:Method)
JPS4955924U (en:Method)
JPS4954395U (en:Method)
CS153164B1 (en:Method)
DD110748A5 (en:Method)
CH592046A5 (en:Method)
DD105120A5 (en:Method)
NL7315752A (en:Method)
CH590182A5 (en:Method)
CH602566A5 (en:Method)
CH599679A5 (en:Method)
CH592748A5 (en:Method)