SE367200B - - Google Patents

Info

Publication number
SE367200B
SE367200B SE10572/70A SE1057270A SE367200B SE 367200 B SE367200 B SE 367200B SE 10572/70 A SE10572/70 A SE 10572/70A SE 1057270 A SE1057270 A SE 1057270A SE 367200 B SE367200 B SE 367200B
Authority
SE
Sweden
Application number
SE10572/70A
Inventor
K Ueno
T Ohmura
R Moroi
A Akashi
M Arimoto
A Kasahara
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP3060169A external-priority patent/JPS471928B1/ja
Priority claimed from JP4221369A external-priority patent/JPS4834749B1/ja
Priority claimed from JP5286869A external-priority patent/JPS4828437B1/ja
Priority claimed from JP6454269A external-priority patent/JPS505195B1/ja
Priority claimed from DE19702017060 external-priority patent/DE2017060C3/de
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of SE367200B publication Critical patent/SE367200B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D243/00Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/141,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/161,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/181,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24Oxygen atoms
    • C07D243/30Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE10572/70A 1969-04-18 1970-07-31 SE367200B (fi)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
JP3060669 1969-04-18
JP3060169A JPS471928B1 (fi) 1969-04-18 1969-04-18
JP3060369 1969-04-18
JP3222069 1969-04-24
JP4187369 1969-05-28
JP4221369A JPS4834749B1 (fi) 1969-05-29 1969-05-29
JP5286869A JPS4828437B1 (fi) 1969-07-03 1969-07-03
JP6121869 1969-08-02
JP5454269 1969-08-15
JP6454269A JPS505195B1 (fi) 1969-08-15 1969-08-15
JP6510669 1969-08-18
DE19702017060 DE2017060C3 (de) 1969-04-18 1970-04-09 Verfahren zur Herstellung von 1,3-Dihydro-2H-1,4-benzodiazepinon-(2)derivaten
DE19702065290 DE2065290C3 (de) 1970-04-09 1 -(beta-Alkenyk>xy*Uiyl)-5-phenyl-7-chlor-1,3-dlhydro-2H-1,4-benzodiazepin-2-on-Oerivate und ihre Salze, Verfahren zu Ihrer Herstellung und Arzneimittel
GB1797470 1970-04-15
BE749136 1970-04-17
FR707014027A FR2042345B1 (fi) 1969-04-18 1970-04-17
NL7005566A NL7005566A (fi) 1969-04-18 1970-04-17

Publications (1)

Publication Number Publication Date
SE367200B true SE367200B (fi) 1974-05-20

Family

ID=27585847

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7005303A SE385701B (sv) 1969-04-18 1970-04-17 Sett att framstella 1,4-bensodiazepinderivat
SE10572/70A SE367200B (fi) 1969-04-18 1970-07-31

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SE7005303A SE385701B (sv) 1969-04-18 1970-04-17 Sett att framstella 1,4-bensodiazepinderivat

Country Status (9)

Country Link
US (2) US3778433A (fi)
AT (1) AT303043B (fi)
BE (1) BE749136A (fi)
CH (3) CH549029A (fi)
DE (2) DE2065675A1 (fi)
FR (2) FR2042345B1 (fi)
GB (2) GB1309947A (fi)
NL (2) NL7005566A (fi)
SE (2) SE385701B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU162330B (fi) * 1970-03-11 1973-01-29
GB1307144A (en) * 1970-04-23 1973-02-14 Sumitomo Chemical Co Benzodiazepine derivatives processes for producing them and compo sitions containing them
ES412186A1 (es) * 1973-02-28 1976-01-01 Made Labor Sa Un procedimiento para la preparacion de derivados de tieno-diazepinona.
US4208327A (en) * 1979-04-03 1980-06-17 G. D. Searle & Co. 5-Aryl-1-(2-oxazolin-2-yl)-1H-1,4-benzodiazepines and related compounds
US4405743A (en) * 1979-08-31 1983-09-20 Hokko Chemical Industry Co., Ltd. Pyrazolylpyrimidine derivatives
CA1332410C (en) * 1984-06-26 1994-10-11 Roger M. Freidinger Benzodiazepine analogs
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US5141735A (en) * 1990-06-18 1992-08-25 Hoffman-La Roche, Inc. Substituted amino-benzodiazepines having anitviral activity
TW312694B (fi) * 1994-09-26 1997-08-11 Daiichi Seiyaku Co
US7842693B2 (en) * 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
DK1531822T3 (da) 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
AU2003288352A1 (en) * 2002-10-30 2004-06-07 Centre National De La Recherche Scientifique (Cnrs) Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses
FR2846653B1 (fr) * 2002-10-30 2007-04-20 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
FR2850379B1 (fr) * 2003-01-28 2006-11-17 Aventis Pharma Sa Produits n-aryl-heteroaromatiques, compositions les contenant et utilisation
JP4845873B2 (ja) * 2004-03-03 2011-12-28 ケモセントリックス インコーポレーティッド 二環式および架橋した窒素複素環
US7435831B2 (en) * 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US8022061B2 (en) * 2006-10-10 2011-09-20 Amgen Inc. N-aryl pyrazole compounds, compositions, and methods for their use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1510315A (fr) * 1966-02-03 1968-01-19 Ciba Geigy Procédé pour la préparation de 4-diaza-cyclo-alcano-pyrazoles substitués en position 1 par des restes hétérocycliques bicycliques
CH535777A (de) * 1967-03-01 1973-04-15 Ciba Geigy Ag Verfahren zur Herstellung neuer azacycloaliphatischer Verbindungen

Also Published As

Publication number Publication date
AT303043B (de) 1972-11-10
DE2065675A1 (de) 1974-11-21
FR2060076A1 (fi) 1971-06-11
CH536310A (de) 1973-04-30
DE2017060A1 (de) 1970-10-29
DE2065290B2 (de) 1976-09-09
DE2038503A1 (de) 1971-02-25
FR2042345B1 (fi) 1974-06-14
SE385701B (sv) 1976-07-19
US3723433A (en) 1973-03-27
BE749136A (fr) 1970-10-01
FR2060076B1 (fi) 1974-08-30
NL7005566A (fi) 1970-10-20
CH539642A (de) 1973-09-14
CH549029A (de) 1974-05-15
US3778433A (en) 1973-12-11
FR2042345A1 (fi) 1971-02-12
DE2017060B2 (de) 1975-08-21
GB1287659A (en) 1972-09-06
NL7011354A (fi) 1971-02-04
GB1309947A (en) 1973-03-14
DE2065290A1 (de) 1973-04-26

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