SE0400886D0 - Process of purification - Google Patents

Process of purification

Info

Publication number
SE0400886D0
SE0400886D0 SE0400886A SE0400886A SE0400886D0 SE 0400886 D0 SE0400886 D0 SE 0400886D0 SE 0400886 A SE0400886 A SE 0400886A SE 0400886 A SE0400886 A SE 0400886A SE 0400886 D0 SE0400886 D0 SE 0400886D0
Authority
SE
Sweden
Prior art keywords
chromatography matrix
target compound
ionic polyether
peg
isolating
Prior art date
Application number
SE0400886A
Other languages
English (en)
Swedish (sv)
Inventor
James Van Alstine
Anders Ljungloef
Hamid Houshmand
Per-Mikael Aaberg
Original Assignee
Amersham Biosciences Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences Ab filed Critical Amersham Biosciences Ab
Priority to SE0400886A priority Critical patent/SE0400886D0/xx
Publication of SE0400886D0 publication Critical patent/SE0400886D0/xx
Priority to JP2007506111A priority patent/JP4831697B2/ja
Priority to CA002560012A priority patent/CA2560012A1/en
Priority to AU2005228834A priority patent/AU2005228834A1/en
Priority to EP05722292A priority patent/EP1729867B1/en
Priority to US10/594,187 priority patent/US20070213513A1/en
Priority to AT05722292T priority patent/ATE485880T1/de
Priority to DE602005024373T priority patent/DE602005024373D1/de
Priority to PCT/SE2005/000467 priority patent/WO2005094960A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
SE0400886A 2004-04-02 2004-04-02 Process of purification SE0400886D0 (sv)

Priority Applications (9)

Application Number Priority Date Filing Date Title
SE0400886A SE0400886D0 (sv) 2004-04-02 2004-04-02 Process of purification
JP2007506111A JP4831697B2 (ja) 2004-04-02 2005-03-31 精製方法
CA002560012A CA2560012A1 (en) 2004-04-02 2005-03-31 A method for chromatographic purification
AU2005228834A AU2005228834A1 (en) 2004-04-02 2005-03-31 A method for chromatographic purification
EP05722292A EP1729867B1 (en) 2004-04-02 2005-03-31 A method for chromatographic purification
US10/594,187 US20070213513A1 (en) 2004-04-02 2005-03-31 Method for Chromatographic Purification
AT05722292T ATE485880T1 (de) 2004-04-02 2005-03-31 Verfahren zur chromatographischen reinigung
DE602005024373T DE602005024373D1 (de) 2004-04-02 2005-03-31 Verfahren zur chromatographischen reinigung
PCT/SE2005/000467 WO2005094960A1 (en) 2004-04-02 2005-03-31 A method for chromatographic purification

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0400886A SE0400886D0 (sv) 2004-04-02 2004-04-02 Process of purification

Publications (1)

Publication Number Publication Date
SE0400886D0 true SE0400886D0 (sv) 2004-04-02

Family

ID=32173667

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0400886A SE0400886D0 (sv) 2004-04-02 2004-04-02 Process of purification

Country Status (9)

Country Link
US (1) US20070213513A1 (https=)
EP (1) EP1729867B1 (https=)
JP (1) JP4831697B2 (https=)
AT (1) ATE485880T1 (https=)
AU (1) AU2005228834A1 (https=)
CA (1) CA2560012A1 (https=)
DE (1) DE602005024373D1 (https=)
SE (1) SE0400886D0 (https=)
WO (1) WO2005094960A1 (https=)

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TWI456062B (zh) 2006-09-13 2014-10-11 Abbvie Inc 細胞培養改良
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
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WO2009090056A2 (en) 2008-01-18 2009-07-23 F. Hoffmann-La Roche Ag Purification of not-glycosylated polypeptides
WO2009099375A1 (en) * 2008-02-05 2009-08-13 Ge Healthcare Bio-Sciences Ab Method for production of separation media
FR2930780B1 (fr) 2008-04-30 2010-08-20 Moet & Chandon Procede de degorgement de vins mousseux
CN102119168A (zh) * 2008-06-03 2011-07-06 帕特里有限公司 抗体纯化工艺
MX2011004201A (es) 2008-10-20 2011-05-24 Abbott Lab Desactivacion viral durante purificacion de anticuerpos.
AU2009347206C1 (en) 2008-10-20 2016-12-08 Abbvie Inc. Isolation and purification of antibodies using Protein A affinity chromatography
EP3318571B1 (en) 2011-03-16 2021-02-17 F. Hoffmann-La Roche AG Ion exchange chromatography with improved selectivity for the separation of polypeptide monomers, aggregates and fragments by modulation of the mobile phase
KR102058254B1 (ko) 2011-03-29 2019-12-20 글락소스미스클라인 엘엘씨 단백질 정제용 완충제 시스템
SG195306A1 (en) * 2011-06-08 2013-12-30 Agency Science Tech & Res Purification of biological products by constrained cohydration chromatography
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
JPWO2015041218A1 (ja) * 2013-09-17 2017-03-02 株式会社カネカ 新規抗体精製方法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎＭｅｔｈｏｄａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ）、並びに陽イオン交換基を用いた新規抗体精製法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎｍｅｔｈｏｄｕｓｉｎｇＣａｔｉｏｎＥｘｃｈａｎｇｅｒａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ）
TW201628649A (zh) 2014-10-09 2016-08-16 再生元醫藥公司 減少醫藥調配物中微可見顆粒之方法
KR102369014B1 (ko) 2016-08-16 2022-03-02 리제너론 파아마슈티컬스, 인크. 혼합물로부터 개별 항체들을 정량하는 방법
EA201990986A1 (ru) 2016-10-25 2019-09-30 Ридженерон Фармасьютикалз, Инк. Способы и системы анализа хроматографических данных
WO2019060062A1 (en) 2017-09-19 2019-03-28 Regeneron Pharmaceuticals Inc. METHODS OF REDUCING PARTICLE FORMATION AND COMPOSITIONS FORMED THEREFROM
CN108152104B (zh) * 2017-12-25 2020-08-11 上海微谱化工技术服务有限公司 超支化水性聚氨酯中二氧化硅填料的分离及定量方法
CN111902720B (zh) 2018-03-21 2025-02-07 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
WO2019237100A1 (en) * 2018-06-08 2019-12-12 Board Of Regents, The University Of Texas System Systems and methods for separation of olefins from mixtures that contain reducing agents
TWI853823B (zh) 2018-07-02 2024-09-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法
EA202192422A1 (ru) 2019-03-05 2021-12-09 Ридженерон Фармасьютикалз, Инк. Человеческий сывороточный альбумин в составах
JP2022550837A (ja) * 2019-10-04 2022-12-05 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング プロテインａアフィニティークロマトグラフィーにおけるモノクローナル抗体の溶離

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Also Published As

Publication number Publication date
CA2560012A1 (en) 2005-10-13
DE602005024373D1 (de) 2010-12-09
JP2007530971A (ja) 2007-11-01
ATE485880T1 (de) 2010-11-15
JP4831697B2 (ja) 2011-12-07
US20070213513A1 (en) 2007-09-13
WO2005094960A1 (en) 2005-10-13
EP1729867B1 (en) 2010-10-27
EP1729867A1 (en) 2006-12-13
AU2005228834A1 (en) 2005-10-13

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