SE0400850D0 - Novel Compounds - Google Patents

Novel Compounds

Info

Publication number
SE0400850D0
SE0400850D0 SE0400850A SE0400850A SE0400850D0 SE 0400850 D0 SE0400850 D0 SE 0400850D0 SE 0400850 A SE0400850 A SE 0400850A SE 0400850 A SE0400850 A SE 0400850A SE 0400850 D0 SE0400850 D0 SE 0400850D0
Authority
SE
Sweden
Prior art keywords
novel compounds
compounds
metalloproteinase
mmp
inhibitors
Prior art date
Application number
SE0400850A
Other languages
English (en)
Swedish (sv)
Inventor
Anders Eriksson
Matti Lepistoe
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0400850A priority Critical patent/SE0400850D0/xx
Publication of SE0400850D0 publication Critical patent/SE0400850D0/xx
Priority to PCT/SE2005/000448 priority patent/WO2005095362A1/en
Priority to DE602005012811T priority patent/DE602005012811D1/de
Priority to EP05722275A priority patent/EP1732903B1/en
Priority to ES05722275T priority patent/ES2320679T3/es
Priority to US10/593,543 priority patent/US20070219217A1/en
Priority to AT05722275T priority patent/ATE423105T1/de
Priority to JP2007506108A priority patent/JP2007530672A/ja
Priority to CNA2005800176722A priority patent/CN1960979A/zh
Priority to HK07105624.6A priority patent/HK1099751A1/xx
Priority to US12/538,522 priority patent/US20090299066A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SE0400850A 2004-03-30 2004-03-30 Novel Compounds SE0400850D0 (sv)

Priority Applications (11)

Application Number Priority Date Filing Date Title
SE0400850A SE0400850D0 (sv) 2004-03-30 2004-03-30 Novel Compounds
CNA2005800176722A CN1960979A (zh) 2004-03-30 2005-03-29 作为mmp抑制剂用于治疗哮喘和慢性阻塞性肺病的三唑酮衍生物
ES05722275T ES2320679T3 (es) 2004-03-30 2005-03-29 Derivados de triazolona como inhibidores de mmp para el tratamiento del asma y epoc.
DE602005012811T DE602005012811D1 (de) 2004-03-30 2005-03-29 Triazolonderivate als mmp-inhibitoren zur behandlung von asthma und copd
EP05722275A EP1732903B1 (en) 2004-03-30 2005-03-29 Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd
PCT/SE2005/000448 WO2005095362A1 (en) 2004-03-30 2005-03-29 Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd
US10/593,543 US20070219217A1 (en) 2004-03-30 2005-03-29 Triazolone Derivatives as Mmp Inhibitors for the Treatment of Asthma and Copd
AT05722275T ATE423105T1 (de) 2004-03-30 2005-03-29 Triazolonderivate als mmp-inhibitoren zur behandlung von asthma und copd
JP2007506108A JP2007530672A (ja) 2004-03-30 2005-03-29 喘息およびｃｏｐｄの処置のためのｍｍｐ阻害剤としてのトリアゾロン誘導体
HK07105624.6A HK1099751A1 (en) 2004-03-30 2007-05-29 Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd
US12/538,522 US20090299066A1 (en) 2004-03-30 2009-08-10 Triazolone derivatives as mmp inhibitors for the treatment of asthma and copd

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0400850A SE0400850D0 (sv) 2004-03-30 2004-03-30 Novel Compounds

Publications (1)

Publication Number Publication Date
SE0400850D0 true SE0400850D0 (sv) 2004-03-31

Family

ID=32105805

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0400850A SE0400850D0 (sv) 2004-03-30 2004-03-30 Novel Compounds

Country Status (10)

Country Link
US (2) US20070219217A1 (xx)
EP (1) EP1732903B1 (xx)
JP (1) JP2007530672A (xx)
CN (1) CN1960979A (xx)
AT (1) ATE423105T1 (xx)
DE (1) DE602005012811D1 (xx)
ES (1) ES2320679T3 (xx)
HK (1) HK1099751A1 (xx)
SE (1) SE0400850D0 (xx)
WO (1) WO2005095362A1 (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0613597A2 (pt) 2005-06-28 2011-01-18 Sanofi Aventis derivado de isoquinolina como inibidores de rho-quinase
PT1910333E (pt) 2005-07-26 2013-08-01 Sanofi Sa Derivados de isoquinolona substituída com piperidinilo como inibidores da rho-cinase
BRPI0614063A2 (pt) 2005-07-26 2011-03-09 Sanofi Aventis derivados de cicloexilamina isoquinolona
ATE490243T1 (de) 2006-12-27 2010-12-15 Sanofi Aventis Cycloalkylaminsubstituierte isochinolin- und isochinolinonderivate
MY150746A (en) 2006-12-27 2014-02-28 Sanofi Aventis Substituted isoquinoline and isoquinolinone derivatives as inhibitors of rho-kinase
KR20090092303A (ko) 2006-12-27 2009-08-31 사노피-아벤티스 사이클로알킬아민 치환된 이소퀴놀린 유도체
CN101595094B (zh) 2006-12-27 2013-02-20 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹诺酮衍生物
MX2009006517A (es) 2006-12-27 2009-06-26 Sanofi Aventis Nuevos derivados de isoquinolina e isoquinolinona sustituidos.
JP5313919B2 (ja) 2006-12-27 2013-10-09 サノフイ 新規な置換イソキノリン及びイソキノリノン誘導体
CA2722658C (en) 2008-04-28 2018-09-18 Richard L. Watson Compositions and methods for treating multiple sclerosis
SI2303845T1 (sl) 2008-06-24 2013-12-31 Sanofi Bi- in policiklični substituirani izokinolin in izokinolinski derivati kot inhibitorji rho-kinaze
MY157330A (en) 2008-06-24 2016-05-31 Sanofi Aventis Substituted isoquinolinones as rho kinase inhibitors
JP5714485B2 (ja) 2008-06-24 2015-05-07 サノフイ ６−置換イソキノリン類及びイソキノリノン類
GB0813144D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
GB0813142D0 (en) 2008-07-17 2008-08-27 Glaxo Group Ltd Novel compounds
CN102858175A (zh) 2010-02-22 2013-01-02 葛兰素史密斯克莱有限责任公司 作为脂肪酸合成酶抑制剂的三唑酮
US9045445B2 (en) 2010-06-04 2015-06-02 Albany Molecular Research, Inc. Glycine transporter-1 inhibitors, methods of making them, and uses thereof
WO2013134562A1 (en) 2012-03-09 2013-09-12 Inception 2, Inc. Triazolone compounds and uses thereof
CA2894281C (en) 2012-12-20 2021-04-20 Inception 2, Inc. Triazolone compounds and uses thereof
PE20160880A1 (es) 2013-09-06 2016-09-22 Inception 2 Inc Compuestos de triazolona y usos de los mismos
CN104876917B (zh) * 2015-06-16 2017-09-19 上海皓元医药股份有限公司 用作脂肪酸合成酶抑制剂的三唑酮的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19504627A1 (de) * 1995-02-13 1996-08-14 Bayer Ag Verfahren und neue Zwischenprodukte zur Herstellung von Triazolinonen
WO2000074679A1 (en) * 1999-06-04 2000-12-14 Merck & Co., Inc. Substituted piperidines as melanocortin-4 receptor agonists
US6420119B1 (en) * 1999-10-12 2002-07-16 The Board Of Trustees Of The Leland Stanford Jr. University Methods of diagnosing and treating urinary incontinence relating to collagen proteolysis in pelvic supporting tissue
EP1110958A1 (en) * 1999-12-20 2001-06-27 Ucb, S.A. Alpha-arylethylpiperazine derivatives as neurokinin antagonists
BR0109469A (pt) * 2000-03-17 2003-04-29 Bristol Myers Squibb Co Compostos derivados de b-aminoácidos, composição farmacêutica, método para o tratamento ou prevenção de disfunções inflamatórias, método para o tratamento de condições ou doenças mediadas por mmps, tnf, aggrecanase ou uma combinação destes em mamìferos e uso do composto
GB0203412D0 (en) * 2002-02-13 2002-04-03 Pharmagene Lab Ltd 5-HT 2B receptor antagonists
PE20040682A1 (es) * 2002-03-13 2004-10-07 Schering Corp Derivados de ciclobutano como antagonistas de nk1
AR039625A1 (es) * 2002-04-18 2005-03-02 Merck & Co Inc Proceso para la preparacion de 5-((2(r)--(1(r)- (3,5-bis (trifluormetil) fenil)etoxi-3 (s) - (4-fluorfenil) -4-morfolinil) metil) -1,2-dihidro-3h-1,2,4-triazol-3-ona
US20040010010A1 (en) * 2002-04-30 2004-01-15 Ebetino Frank Hallock Melanocortin receptor ligands
BR0311425A (pt) * 2002-05-31 2005-03-15 Takeda Pharmaceutical Composto, pró-droga, método para preparar o composto, álcool oticamente ativo, e amina oticamemte ativa, e para prevenir e/ou tratar anormalidades ou doenças, medicamento, e, uso do composto ou de uma pró-droga deste
SE0202539D0 (sv) * 2002-08-27 2002-08-27 Astrazeneca Ab Compounds
KR20060106106A (ko) * 2005-04-06 2006-10-12 삼성전자주식회사 고속 레벨 쉬프터

Also Published As

Publication number Publication date
CN1960979A (zh) 2007-05-09
HK1099751A1 (en) 2007-08-24
DE602005012811D1 (de) 2009-04-02
JP2007530672A (ja) 2007-11-01
US20070219217A1 (en) 2007-09-20
EP1732903B1 (en) 2009-02-18
US20090299066A1 (en) 2009-12-03
ES2320679T3 (es) 2009-05-27
EP1732903A1 (en) 2006-12-20
ATE423105T1 (de) 2009-03-15
WO2005095362A1 (en) 2005-10-13

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