SE0102300D0 - Compounds - Google Patents
CompoundsInfo
- Publication number
- SE0102300D0 SE0102300D0 SE0102300A SE0102300A SE0102300D0 SE 0102300 D0 SE0102300 D0 SE 0102300D0 SE 0102300 A SE0102300 A SE 0102300A SE 0102300 A SE0102300 A SE 0102300A SE 0102300 D0 SE0102300 D0 SE 0102300D0
- Authority
- SE
- Sweden
- Prior art keywords
- sup
- compounds
- glucokinase
- formula
- treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000030595 Glucokinase Human genes 0.000 abstract 3
- 108010021582 Glucokinase Proteins 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0102300A SE0102300D0 (sv) | 2001-06-26 | 2001-06-26 | Compounds |
JP2003506912A JP2005500312A (ja) | 2001-06-26 | 2002-06-24 | グルコキナーゼ(glk)モジュレーターとしてのアミノニコチネート誘導体 |
KR10-2003-7016791A KR20040029324A (ko) | 2001-06-26 | 2002-06-24 | 글루코키나제(glk) 조절제로서 아미노 니코티네이트유도체 |
MXPA03012004A MXPA03012004A (es) | 2001-06-26 | 2002-06-24 | Derivados de aminonicotinato como moduladores de glucocinasa (glk). |
IL15940302A IL159403A0 (en) | 2001-06-26 | 2002-06-24 | Amino nicotinate derivatives as glucokinase (glk) modulators |
BR0210711-2A BR0210711A (pt) | 2001-06-26 | 2002-06-24 | Uso de um composto, composição farmacêutica, composto, e, processo para a preparação de um composto |
NZ530203A NZ530203A (en) | 2001-06-26 | 2002-06-24 | Amino nicotinate derivatives as glucokinase (GLK) modulators |
AU2002314330A AU2002314330B2 (en) | 2001-06-26 | 2002-06-24 | Amino nicotinate derivatives as glucokinase (GLK) modulators |
US10/482,572 US20040214868A1 (en) | 2001-06-26 | 2002-06-24 | Amino nicotinate derivatives as glucokinase (GLK) modulators |
PCT/GB2002/002873 WO2003000267A1 (en) | 2001-06-26 | 2002-06-24 | Amino nicotinate derivatives as glucokinase (glk) modulators |
CA002451249A CA2451249A1 (en) | 2001-06-26 | 2002-06-24 | Amino nicotinate derivatives as glucokinase (glk) modulators |
CNA028129458A CN1520296A (zh) | 2001-06-26 | 2002-06-24 | 作为葡糖激酶(glk)调制剂的氨基烟酸盐衍生物 |
EP02740900A EP1404335A1 (en) | 2001-06-26 | 2002-06-24 | Amino nicotinate derivatives as glucokinase (glk) modulators |
ARP020102403A AR037996A1 (es) | 2001-06-26 | 2002-06-26 | Compuesto derivado de amino nicotinato, composicion farmaceutica; proceso para su preparacion y su uso como medicamento |
NO20035766A NO20035766L (no) | 2001-06-26 | 2003-12-22 | Aminonikotinatderivater som glukokinase (GLK) modulatorer |
ZA200309979A ZA200309979B (en) | 2001-06-26 | 2003-12-23 | Amino nicotinate derivatives as glucokinase (GLK) modulators. |
US11/634,966 US20070112040A1 (en) | 2001-06-26 | 2006-12-07 | Amino nicotinate derivatives as glucokinase (GLK) modulators |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0102300A SE0102300D0 (sv) | 2001-06-26 | 2001-06-26 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0102300D0 true SE0102300D0 (sv) | 2001-06-26 |
Family
ID=20284652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0102300A SE0102300D0 (sv) | 2001-06-26 | 2001-06-26 | Compounds |
Country Status (16)
Country | Link |
---|---|
US (2) | US20040214868A1 (es) |
EP (1) | EP1404335A1 (es) |
JP (1) | JP2005500312A (es) |
KR (1) | KR20040029324A (es) |
CN (1) | CN1520296A (es) |
AR (1) | AR037996A1 (es) |
AU (1) | AU2002314330B2 (es) |
BR (1) | BR0210711A (es) |
CA (1) | CA2451249A1 (es) |
IL (1) | IL159403A0 (es) |
MX (1) | MXPA03012004A (es) |
NO (1) | NO20035766L (es) |
NZ (1) | NZ530203A (es) |
SE (1) | SE0102300D0 (es) |
WO (1) | WO2003000267A1 (es) |
ZA (1) | ZA200309979B (es) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2233014T3 (es) | 1999-12-22 | 2005-06-01 | Soremartec S.A. | Metodo para envolver un producto alimentario y articulo obtenido. |
SE0102299D0 (sv) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
WO2004022525A1 (en) * | 2002-09-05 | 2004-03-18 | Neurosearch A/S | Amide derivatives and their use as chloride channel blockers |
GB0226930D0 (en) * | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
GB0226931D0 (en) | 2002-11-19 | 2002-12-24 | Astrazeneca Ab | Chemical compounds |
PL378117A1 (pl) | 2003-02-11 | 2006-03-06 | Prosidion Limited | Tricyklopodstawione związki amidowe |
JP4400563B2 (ja) | 2003-02-13 | 2010-01-20 | 萬有製薬株式会社 | 新規2−ピリジンカルボキサミド誘導体 |
BRPI0407810A (pt) | 2003-02-26 | 2006-03-01 | Banyu Pharma Co Ltd | composto, composição farmacêutica, ativador da glicocinase, e, medicamento |
GB0325402D0 (en) * | 2003-10-31 | 2003-12-03 | Astrazeneca Ab | Compounds |
GB0327761D0 (en) * | 2003-11-29 | 2003-12-31 | Astrazeneca Ab | Compounds |
GB0327760D0 (en) * | 2003-11-29 | 2003-12-31 | Astrazeneca Ab | Compounds |
GB0328178D0 (en) * | 2003-12-05 | 2004-01-07 | Astrazeneca Ab | Compounds |
EP2048137A1 (en) * | 2004-02-18 | 2009-04-15 | AstraZeneca AB | Benzamide derivatives and their use as glucokinase activating agents. |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
GB0423043D0 (en) * | 2004-10-16 | 2004-11-17 | Astrazeneca Ab | Compounds |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
EP1902052B1 (en) | 2005-07-09 | 2012-11-28 | AstraZeneca AB | Heteroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
WO2007007040A1 (en) * | 2005-07-09 | 2007-01-18 | Astrazeneca Ab | 2 -heterocyclyloxybenzoyl amino heterocyclyl compounds as modulators of glucokinase for the treatment of type 2 diabetes |
EP1910317B1 (en) | 2005-07-20 | 2013-07-03 | Eli Lilly And Company | 1-amino linked compounds |
JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
CN101272784A (zh) | 2005-09-29 | 2008-09-24 | 塞诺菲-安万特股份有限公司 | 苯基-和吡啶基-1,2,4-噁二唑酮衍生物、它们的制备方法和它们作为药物的用途 |
CN101312940B (zh) | 2005-11-17 | 2012-11-14 | 伊莱利利公司 | 胰高血糖素受体拮抗剂、制备和治疗用途 |
JP5302012B2 (ja) | 2006-03-08 | 2013-10-02 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤 |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
EP2049518B1 (en) | 2006-05-31 | 2011-08-31 | Takeda San Diego, Inc. | Indazole and isoindole derivatives as glucokinase activating agents. |
WO2008024456A2 (en) | 2006-08-24 | 2008-02-28 | University Of Tennessee Research Foundation | Substituted acylanilides and methods of use thereof |
AR063028A1 (es) | 2006-10-06 | 2008-12-23 | Banyu Pharma Co Ltd | Derivados heterociclicos de piridin-2-carboxamida activadores de glucoquinasas, utiles para el tratamiento de diabetes y obesidad y composiciones farmaceuticas que los contienen. |
CL2007003061A1 (es) * | 2006-10-26 | 2008-08-01 | Astrazeneca Ab | Compuestos derivados de 3,5-dioxi-benzamida; proceso de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar una enfermedad mediada a traves de glk, tal como la diabetes tipo 2. |
WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
KR20090089868A (ko) * | 2006-12-15 | 2009-08-24 | 글락소 그룹 리미티드 | Ep4 수용체 작동제로서 벤즈아미드 유도체 |
EP2091947A2 (en) | 2006-12-20 | 2009-08-26 | Takeda San Diego, Inc. | Glucokinase activators |
US8173645B2 (en) | 2007-03-21 | 2012-05-08 | Takeda San Diego, Inc. | Glucokinase activators |
JP2010138073A (ja) * | 2007-03-30 | 2010-06-24 | Taisho Pharmaceutical Co Ltd | ピコリン酸アミド化合物 |
US20100190777A1 (en) | 2007-07-17 | 2010-07-29 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
AU2009278929B2 (en) | 2008-08-04 | 2012-07-05 | Astrazeneca Ab | Pyrazolo [3,4] pyrimidin-4-yl derivatives and their uses to treat diabetes and obesity |
EP2344458A1 (en) | 2008-09-11 | 2011-07-20 | Pfizer Inc. | Heteroaryls amide derivatives and their use as glucokinase activators |
GB0902406D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
GB0902434D0 (en) * | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Chemical process |
BRPI1013246B1 (pt) * | 2009-03-11 | 2019-10-01 | Pfizer, Inc. | Derivados de benzofuranila, suas composições farmacêuticas e seus usos |
EP2414356B1 (en) | 2009-04-03 | 2015-09-02 | F.Hoffmann-La Roche Ag | Propane-i-sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof |
WO2010116176A1 (en) | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity |
AR076220A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivados de pirazol [4,5 - e] pirimidina |
AU2010276215A1 (en) * | 2009-07-21 | 2012-02-16 | Auckland Uniservices Limited | Heteroaryl benzamides, compositions and methods of use |
WO2011081280A2 (en) * | 2009-09-22 | 2011-07-07 | Yuhan Corporation | Novel glucokinase activators and processes for the preparation thereof |
CN106220623A (zh) | 2009-11-06 | 2016-12-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
EA028821B9 (ru) | 2011-02-07 | 2018-10-31 | Плексксикон, Инк. | Соединения и способы для модуляции киназ, а также показания к их применению |
AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
CN102786468A (zh) * | 2011-05-18 | 2012-11-21 | 中国医学科学院药物研究所 | Gk和ppar双重激动活性的烟酸类衍生物 |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
US10258596B2 (en) | 2012-07-13 | 2019-04-16 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
US9969683B2 (en) | 2012-07-13 | 2018-05-15 | Gtx, Inc. | Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS) |
US10987334B2 (en) | 2012-07-13 | 2021-04-27 | University Of Tennessee Research Foundation | Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs) |
US9622992B2 (en) | 2012-07-13 | 2017-04-18 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
US10314807B2 (en) | 2012-07-13 | 2019-06-11 | Gtx, Inc. | Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS) |
EP3733170A1 (en) | 2012-07-13 | 2020-11-04 | Oncternal Therapeutics, Inc. | A method of treating androgen receptor (ar) -positive breast cancers with selective androgen receptor modulator (sarms) |
US9744149B2 (en) | 2012-07-13 | 2017-08-29 | Gtx, Inc. | Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs) |
KR20140092696A (ko) * | 2013-01-16 | 2014-07-24 | 주식회사유한양행 | 신규의 페닐에티닐 벤즈아마이드 글루코키나제 활성화제 및 그의 제조방법 |
GB201714777D0 (en) | 2017-09-14 | 2017-11-01 | Univ London Queen Mary | Agent |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1400540A (en) * | 1972-12-06 | 1975-07-16 | Smith Kline French Lab | Salicylamides and compositions thereof |
GB1561350A (en) * | 1976-11-05 | 1980-02-20 | May & Baker Ltd | Benzamide derivatives |
US5849735A (en) * | 1995-01-17 | 1998-12-15 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
JPH08301760A (ja) * | 1995-05-10 | 1996-11-19 | Shiseido Co Ltd | 皮膚外用剤 |
ES2226811T3 (es) * | 1999-03-29 | 2005-04-01 | F. Hoffmann-La Roche Ag | Activadores de glucoquinasa. |
US6353111B1 (en) * | 1999-12-15 | 2002-03-05 | Hoffmann-La Roche Inc. | Trans olefinic glucokinase activators |
KR100502033B1 (ko) * | 2000-05-03 | 2005-07-25 | 에프. 호프만-라 로슈 아게 | 알키닐 페닐 헤테로방향족 글루코키나제 활성제 |
SE0102764D0 (sv) * | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
GB0325402D0 (en) * | 2003-10-31 | 2003-12-03 | Astrazeneca Ab | Compounds |
-
2001
- 2001-06-26 SE SE0102300A patent/SE0102300D0/xx unknown
-
2002
- 2002-06-24 US US10/482,572 patent/US20040214868A1/en active Granted
- 2002-06-24 JP JP2003506912A patent/JP2005500312A/ja not_active Withdrawn
- 2002-06-24 BR BR0210711-2A patent/BR0210711A/pt not_active IP Right Cessation
- 2002-06-24 EP EP02740900A patent/EP1404335A1/en not_active Ceased
- 2002-06-24 NZ NZ530203A patent/NZ530203A/en unknown
- 2002-06-24 KR KR10-2003-7016791A patent/KR20040029324A/ko not_active Application Discontinuation
- 2002-06-24 AU AU2002314330A patent/AU2002314330B2/en not_active Ceased
- 2002-06-24 CA CA002451249A patent/CA2451249A1/en not_active Abandoned
- 2002-06-24 CN CNA028129458A patent/CN1520296A/zh active Pending
- 2002-06-24 IL IL15940302A patent/IL159403A0/xx unknown
- 2002-06-24 WO PCT/GB2002/002873 patent/WO2003000267A1/en active IP Right Grant
- 2002-06-24 MX MXPA03012004A patent/MXPA03012004A/es active IP Right Grant
- 2002-06-26 AR ARP020102403A patent/AR037996A1/es not_active Application Discontinuation
-
2003
- 2003-12-22 NO NO20035766A patent/NO20035766L/no not_active Application Discontinuation
- 2003-12-23 ZA ZA200309979A patent/ZA200309979B/en unknown
-
2006
- 2006-12-07 US US11/634,966 patent/US20070112040A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA03012004A (es) | 2004-03-26 |
IL159403A0 (en) | 2004-06-01 |
NZ530203A (en) | 2005-06-24 |
WO2003000267A1 (en) | 2003-01-03 |
EP1404335A1 (en) | 2004-04-07 |
KR20040029324A (ko) | 2004-04-06 |
US20070112040A1 (en) | 2007-05-17 |
NO20035766L (no) | 2004-02-04 |
JP2005500312A (ja) | 2005-01-06 |
AR037996A1 (es) | 2004-12-22 |
AU2002314330B2 (en) | 2007-08-09 |
BR0210711A (pt) | 2004-07-20 |
ZA200309979B (en) | 2005-03-23 |
CA2451249A1 (en) | 2003-01-03 |
CN1520296A (zh) | 2004-08-11 |
US20040214868A1 (en) | 2004-10-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE0102299D0 (sv) | Compounds | |
SE0102300D0 (sv) | Compounds | |
MXPA04001500A (es) | Compuestos que tienen un efecto sobre la glucocinasa. | |
MY136034A (en) | New medicaments for the treatment of chronic obstructive pulmonary disease | |
EA200401114A2 (ru) | Замещённые гидроксиэтиламины | |
BRPI0412851A (pt) | benzamidazóis de n-metila-substituìdos | |
TR200401029T4 (tr) | Asilfenil-üre türevleri, imalat yöntemleri ve ilaç maddesi olarak kullanımları | |
DE602004024375D1 (de) | Carboxamidderivate | |
SE0104140D0 (sv) | Novel Compounds | |
JO2353B1 (en) | New derivatives of mixed-ring fluoroglycosides and drugs containing these compounds and their use | |
SE0104340D0 (sv) | New compounds | |
SE0103836D0 (sv) | Novel compounds | |
EA200701324A1 (ru) | Соединения пиридина для лечения заболеваний, опосредованных действием простагландина | |
DE602004028150D1 (de) | Aminopyrazolderivate als gsk-3-inhibitoren | |
WO2005037798A3 (en) | Amide or thiomide derivatives and their use in the treatment of pain | |
SE0302192D0 (sv) | Novel compounds | |
GB0112348D0 (en) | Compounds | |
UA83691C2 (ru) | Применение замещенных 2-аминотетралинов для упреждающего лечения болезни паркинсона | |
SE0201544D0 (sv) | Novel compounds and thier use | |
ATE386725T1 (de) | Heterocyclylverbindungen | |
ATE409480T1 (de) | Pyrazoloä3,4-büpyridin-6-one als gsk-3 inhibitoren | |
TW200716152A (en) | Substituted 1,2-ethylendiamines, medicaments comprising said compound, their use and their method of manufacture | |
DE602004008959D1 (de) | Benzoäbüä1,4üdioxepinderivate | |
ATE403428T1 (de) | Pyrazoloä3,4-büpyridin-6-one als gsk-3 inhibitoren | |
IL166057A0 (en) | Urea-substituted and urethane-substituted acylureas methods for the production thereof and their useas medicaments |