SE0002793D0 - Ny kristallin form av 6-hydroxi-3-(4-§2-(piperidin-1-yl)-etoxi¤fenoxi)-2-(4-metoxifenyl)benso§b¤tiofen-hydroklorid - Google Patents
Ny kristallin form av 6-hydroxi-3-(4-§2-(piperidin-1-yl)-etoxi¤fenoxi)-2-(4-metoxifenyl)benso§b¤tiofen-hydrokloridInfo
- Publication number
- SE0002793D0 SE0002793D0 SE0002793A SE0002793A SE0002793D0 SE 0002793 D0 SE0002793 D0 SE 0002793D0 SE 0002793 A SE0002793 A SE 0002793A SE 0002793 A SE0002793 A SE 0002793A SE 0002793 D0 SE0002793 D0 SE 0002793D0
- Authority
- SE
- Sweden
- Prior art keywords
- piperidin
- benzo
- methoxyphenyl
- hydroxy
- cancer
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Cell Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14618499P | 1999-07-29 | 1999-07-29 | |
US14764299P | 1999-08-06 | 1999-08-06 | |
US14982099P | 1999-08-19 | 1999-08-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
SE0002793D0 true SE0002793D0 (sv) | 2000-07-28 |
SE0002793L SE0002793L (sv) | 2001-01-30 |
Family
ID=27386367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0002793A SE0002793L (sv) | 1999-07-29 | 2000-07-28 | Ny kristallin form av 6-hydroxi-3-(4-§2-(piperidin-1-yl)- etoxi fenoxi)-2-(4-metoxifenyl)benso§b tiofen-hydroklorid |
Country Status (45)
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7122203B2 (en) | 2000-05-08 | 2006-10-17 | Eli Lilly And Company | Stabilized formulations of 6-hydroxy-3-(-4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene and salts thereof |
AU2005200809B2 (en) * | 2000-05-08 | 2006-05-11 | Eli Lilly And Company | Stabilized Formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl) Ethoxy]phenoxy)-2-(4-methoxyphenyl) Benzo[b]thiophene and Salts Thereof |
BR0110620A (pt) * | 2000-05-08 | 2003-04-01 | Lilly Co Eli | Formulações estabilizadas de 6-hidróxi-3-(4-[2-(piperidin-1-il)etóxi]fenóxi)-2-(4-metoxi fenil)benzo[b]tiofeno e de sais do mesmo |
EP1757291A3 (en) * | 2000-05-08 | 2009-07-15 | Eli Lilly & Company | Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-YL)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof |
KR20030037690A (ko) * | 2000-10-20 | 2003-05-14 | 일라이 릴리 앤드 캄파니 | 6-히드록시-3-(4-[2-(피페리딘-1-일)에톡시]페녹시)-2-(4-메톡시페닐)벤조[b]티오펜 히드로클로라이드의 신규 결정형 |
US6921827B2 (en) | 2000-11-27 | 2005-07-26 | Eli Lilly And Company | Process for preparing 3-aryl-benzo{b} thiophenes |
PL1773811T3 (pl) * | 2004-07-22 | 2011-02-28 | Lilly Co Eli | Krystaliczny zmienny hydrat soli hemibursztynianowej (s)-6-(4-(2-((3(9h-karbazol-4-iloksy)-2-hydroksypropylo)amino)-2-metylopropylo)fenoksy)-3-pirydynokarboksy amidu |
JP2008525439A (ja) * | 2004-12-23 | 2008-07-17 | ボイジャー・ファーマシューティカル・コーポレーション | アルツハイマー病の治療のための酢酸ロイプロリド及びアセチルコリンエステラーゼインヒビターまたはnmdaレセプターアゴニスト |
WO2006088648A1 (en) * | 2005-02-11 | 2006-08-24 | Eli Lilly And Company | Compositions and methods for treating dyslipidemia |
DE102008057230A1 (de) * | 2008-11-11 | 2010-05-12 | Bayer Schering Pharma Aktiengesellschaft | Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin |
CN113325183B (zh) * | 2021-06-01 | 2022-11-15 | 中国医学科学院北京协和医院 | 一种用于鉴别诊断em/fem的试剂盒 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE44597A1 (es) * | 1995-02-28 | 1997-10-13 | Lilly Co Eli | Compuestos de benzotiofeno, productos intermedios, composiciones y procedimientos |
US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
ZA982877B (en) * | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Treatment of central nervous system disorders with selective estrogen receptor modulators. |
WO2001009116A2 (en) * | 1999-07-29 | 2001-02-08 | Eli Lilly And Company | A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3- (4-[2-(PIPERIDIN-1-YL) ETHOXY]PHENOXY)- 2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE |
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2000
- 2000-07-17 AT AT00950222T patent/ATE251151T1/de not_active IP Right Cessation
- 2000-07-17 ES ES00950222T patent/ES2208384T3/es not_active Expired - Lifetime
- 2000-07-17 DE DE60005693T patent/DE60005693T2/de not_active Expired - Fee Related
- 2000-07-17 AU AU63355/00A patent/AU6335500A/en not_active Abandoned
- 2000-07-17 EP EP00950222A patent/EP1204655B1/en not_active Expired - Lifetime
- 2000-07-17 WO PCT/US2000/016332 patent/WO2001009115A2/en active IP Right Grant
- 2000-07-18 LV LVP-00-95A patent/LV12733B/lv unknown
- 2000-07-24 ID IDP20000630A patent/ID26679A/id unknown
- 2000-07-24 CZ CZ20002717A patent/CZ300356B6/cs not_active IP Right Cessation
- 2000-07-25 HR HR20000502A patent/HRP20000502B1/xx not_active IP Right Cessation
- 2000-07-26 EG EG20000954A patent/EG24196A/xx active
- 2000-07-27 NL NL1015822A patent/NL1015822C2/nl not_active IP Right Cessation
- 2000-07-27 CO CO00056522A patent/CO5180572A1/es not_active Application Discontinuation
- 2000-07-27 IL IL137552A patent/IL137552A/en not_active IP Right Cessation
- 2000-07-27 TR TR2000/02205A patent/TR200002205A2/xx unknown
- 2000-07-28 MY MYPI20003448A patent/MY120393A/en unknown
- 2000-07-28 BE BE2000/0477A patent/BE1013410A3/fr not_active IP Right Cessation
- 2000-07-28 DE DE10036855A patent/DE10036855A1/de not_active Withdrawn
- 2000-07-28 SI SI200000173A patent/SI20427B/sl not_active IP Right Cessation
- 2000-07-28 GR GR20000100264A patent/GR20000100264A/el not_active IP Right Cessation
- 2000-07-28 CA CA002314685A patent/CA2314685C/en not_active Expired - Fee Related
- 2000-07-28 DK DK200001150A patent/DK176771B1/da not_active IP Right Cessation
- 2000-07-28 TW TW089115152A patent/TWI271403B/zh not_active IP Right Cessation
- 2000-07-28 NO NO20003876A patent/NO325594B1/no not_active IP Right Cessation
- 2000-07-28 FR FR0009972A patent/FR2798384B1/fr not_active Expired - Fee Related
- 2000-07-28 IT IT2000MI001758A patent/IT1318659B1/it active
- 2000-07-28 MD MDA20000161A patent/MD2335G2/ro not_active IP Right Cessation
- 2000-07-28 PT PT102501A patent/PT102501A/pt not_active IP Right Cessation
- 2000-07-28 KR KR1020000043586A patent/KR100733094B1/ko not_active IP Right Cessation
- 2000-07-28 SV SV2000000134A patent/SV2002000134A/es unknown
- 2000-07-28 LU LU90616A patent/LU90616B1/fr active
- 2000-07-28 GB GB0018636A patent/GB2352716A/en not_active Withdrawn
- 2000-07-28 SE SE0002793A patent/SE0002793L/sv unknown
- 2000-07-28 JP JP2000228949A patent/JP2001048880A/ja active Pending
- 2000-07-28 NZ NZ506045A patent/NZ506045A/en unknown
- 2000-07-28 AT AT0132300A patent/AT502317A1/de not_active Application Discontinuation
- 2000-07-28 AU AU48911/00A patent/AU779559B2/en not_active Ceased
- 2000-07-28 SG SG200004287A patent/SG90737A1/en unknown
- 2000-07-28 BR BR0003211-5A patent/BR0003211A/pt not_active Application Discontinuation
- 2000-07-28 HU HU0003005A patent/HUP0003005A2/hu unknown
- 2000-07-28 LT LT2000075A patent/LT4789B/lt not_active IP Right Cessation
- 2000-07-28 FI FI20001721A patent/FI20001721A/sv not_active Application Discontinuation
- 2000-07-28 PL PL00341748A patent/PL341748A1/xx not_active Application Discontinuation
- 2000-07-28 AR ARP000103929A patent/AR029176A1/es not_active Application Discontinuation
- 2000-07-28 CN CNB001222406A patent/CN1138771C/zh not_active Expired - Fee Related
- 2000-07-28 MX MXPA00007462A patent/MXPA00007462A/es active IP Right Grant
- 2000-07-31 PE PE2000000758A patent/PE20010383A1/es not_active Application Discontinuation
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2001
- 2001-08-08 HK HK01105511A patent/HK1034962A1/xx not_active IP Right Cessation
Also Published As
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SE0002792D0 (sv) | Ny kristallin form av 6-hydroxi-3-(4-§2-(piperidin-1-yl)-etoxi¤fenoxi)-2-(4-metoxifenyl)benso§b¤tiofen-hydroklorid | |
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