CO5180572A1 - Una nueva forma cristalina de clorhidrato de 6-hidroxi-3- (4-[2-(piperidin-1-il)etoxi]fenoxi)-2-(4-metoxifenil)benzo [b]tiofeno - Google Patents

Una nueva forma cristalina de clorhidrato de 6-hidroxi-3- (4-[2-(piperidin-1-il)etoxi]fenoxi)-2-(4-metoxifenil)benzo [b]tiofeno

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Publication number
CO5180572A1
CO5180572A1 CO00056522A CO00056522A CO5180572A1 CO 5180572 A1 CO5180572 A1 CO 5180572A1 CO 00056522 A CO00056522 A CO 00056522A CO 00056522 A CO00056522 A CO 00056522A CO 5180572 A1 CO5180572 A1 CO 5180572A1
Authority
CO
Colombia
Prior art keywords
piperidin
benzo
phenoxi
etoxi
metoxyphenyl
Prior art date
Application number
CO00056522A
Other languages
English (en)
Inventor
Julie Kay Bush
Charles Conrad Preston
Gerard Flom Merlyn
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO5180572A1 publication Critical patent/CO5180572A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P19/00—Drugs for skeletal disorders
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Abstract

El hidrato cristalino del clorhidrato de 6-hidroxi-3-(4-[2-(piperidin-1il)etoxi]fenoxi)-2-(4-metoxifenil)benzo[b]tiofeno (F-III) de fórmula<EMI FILE="00056522_1" ID="1" IMF=JPEG >que tiene un modelo de difracción de rayos X que comprende los siguientes picos:4,6 ± 0,2, 7,8 ± 0,2, 9,3 ± 0,2,14,0 ± 0,2, 17,6 ± 0,2, 20,8 ± 0,2 y 24,3 ± 0,2° en 2T ;cuando se obtiene a 25 ± 2°C y 35 ± 10% de humedad relativa a partir de una fuente de radiación de cobre.
CO00056522A 1999-07-29 2000-07-27 Una nueva forma cristalina de clorhidrato de 6-hidroxi-3- (4-[2-(piperidin-1-il)etoxi]fenoxi)-2-(4-metoxifenil)benzo [b]tiofeno CO5180572A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14618499P 1999-07-29 1999-07-29
US14764299P 1999-08-06 1999-08-06
US14982099P 1999-08-19 1999-08-19

Publications (1)

Publication Number Publication Date
CO5180572A1 true CO5180572A1 (es) 2002-07-30

Family

ID=27386367

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00056522A CO5180572A1 (es) 1999-07-29 2000-07-27 Una nueva forma cristalina de clorhidrato de 6-hidroxi-3- (4-[2-(piperidin-1-il)etoxi]fenoxi)-2-(4-metoxifenil)benzo [b]tiofeno

Country Status (45)

Country Link
EP (1) EP1204655B1 (es)
JP (1) JP2001048880A (es)
KR (1) KR100733094B1 (es)
CN (1) CN1138771C (es)
AR (1) AR029176A1 (es)
AT (2) ATE251151T1 (es)
AU (2) AU6335500A (es)
BE (1) BE1013410A3 (es)
BR (1) BR0003211A (es)
CA (1) CA2314685C (es)
CO (1) CO5180572A1 (es)
CZ (1) CZ300356B6 (es)
DE (2) DE60005693T2 (es)
DK (1) DK176771B1 (es)
EG (1) EG24196A (es)
ES (1) ES2208384T3 (es)
FI (1) FI20001721A (es)
FR (1) FR2798384B1 (es)
GB (1) GB2352716A (es)
GR (1) GR20000100264A (es)
HK (1) HK1034962A1 (es)
HR (1) HRP20000502B1 (es)
HU (1) HUP0003005A2 (es)
ID (1) ID26679A (es)
IL (1) IL137552A (es)
IT (1) IT1318659B1 (es)
LT (1) LT4789B (es)
LU (1) LU90616B1 (es)
LV (1) LV12733B (es)
MD (1) MD2335G2 (es)
MX (1) MXPA00007462A (es)
MY (1) MY120393A (es)
NL (1) NL1015822C2 (es)
NO (1) NO325594B1 (es)
NZ (1) NZ506045A (es)
PE (1) PE20010383A1 (es)
PL (1) PL341748A1 (es)
PT (1) PT102501A (es)
SE (1) SE0002793L (es)
SG (1) SG90737A1 (es)
SI (1) SI20427B (es)
SV (1) SV2002000134A (es)
TR (1) TR200002205A2 (es)
TW (1) TWI271403B (es)
WO (1) WO2001009115A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122203B2 (en) 2000-05-08 2006-10-17 Eli Lilly And Company Stabilized formulations of 6-hydroxy-3-(-4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene and salts thereof
CZ20023651A3 (cs) * 2000-05-08 2003-02-12 Eli Lilly And Company Stabilizované přípravky 6-hydroxy-3-(4-[2-(piperidin-1-yl)-ethoxy]fenoxy)-2-(4-methoxyfenyl)benzo[b]thiofen a jejich sole
AU2005200809B2 (en) * 2000-05-08 2006-05-11 Eli Lilly And Company Stabilized Formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl) Ethoxy]phenoxy)-2-(4-methoxyphenyl) Benzo[b]thiophene and Salts Thereof
EP1757291A3 (en) * 2000-05-08 2009-07-15 Eli Lilly &amp; Company Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-YL)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof
PL360946A1 (en) * 2000-10-20 2004-09-20 Eli Lilly And Company A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene hydrochloride
WO2002042289A2 (en) 2000-11-27 2002-05-30 Eli Lilly And Company Process for preparing 3-aryl-benzo[b]thiophenes
PT1773811E (pt) * 2004-07-22 2010-10-19 Lilly Co Eli Um hidrato cristalino variável de sal de hemissuccinato de (s)-6-(4-(2-((3-(9h-carbazol-4-iloxi)-2- hidroxipropil)amino)-2-metilpropil)fenoxi)-3-piridinicarbox amida
WO2006071274A2 (en) * 2004-12-23 2006-07-06 Voyager Pharmaceutical Corporation Leuprolide acetate and acetylcholinesterase inhibitors or nmda receptor antagonists for the treatment of alzheimer’s disease
EP1853263A1 (en) * 2005-02-11 2007-11-14 Eli Lilly And Company Compositions and methods for treating dyslipidemia
DE102008057230A1 (de) * 2008-11-11 2010-05-12 Bayer Schering Pharma Aktiengesellschaft Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin
CN113325183B (zh) * 2021-06-01 2022-11-15 中国医学科学院北京协和医院 一种用于鉴别诊断em/fem的试剂盒

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3989569B2 (ja) * 1995-02-28 2007-10-10 イーライ リリー アンド カンパニー ベンゾチオフェン化合物、中間体、組成物および方法
US5510357A (en) * 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
ZA982877B (en) * 1997-04-09 1999-10-04 Lilly Co Eli Treatment of central nervous system disorders with selective estrogen receptor modulators.
EP1204656A2 (en) * 1999-07-29 2002-05-15 Eli Lilly And Company A crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl) ethoxy] phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene hydrochloride

Also Published As

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IE20000604A1 (en) 2001-04-04
SE0002793D0 (sv) 2000-07-28
EG24196A (en) 2008-10-14
WO2001009115A2 (en) 2001-02-08
AU4891100A (en) 2001-02-01
NO20003876D0 (no) 2000-07-28
JP2001048880A (ja) 2001-02-20
HRP20000502B1 (en) 2008-04-30
HU0003005D0 (en) 2000-10-28
KR20010049911A (ko) 2001-06-15
AR029176A1 (es) 2003-06-18
ITMI20001758A1 (it) 2002-01-28
CN1138771C (zh) 2004-02-18
EP1204655A2 (en) 2002-05-15
SI20427B (sl) 2009-04-30
PT102501A (pt) 2001-01-31
CZ20002717A3 (en) 2001-05-16
PL341748A1 (en) 2001-02-12
NL1015822A1 (nl) 2001-01-30
HUP0003005A2 (hu) 2002-04-29
MD20000161A (en) 2001-04-30
NZ506045A (en) 2002-02-01
TR200002205A2 (tr) 2001-03-21
IL137552A0 (en) 2001-07-24
GR20000100264A (el) 2001-03-30
GB2352716A (en) 2001-02-07
TWI271403B (en) 2007-01-21
LT4789B (lt) 2001-05-25
NO325594B1 (no) 2008-06-23
FR2798384B1 (fr) 2004-09-24
EP1204655B1 (en) 2003-10-01
DK200001150A (da) 2001-01-30
DK176771B1 (da) 2009-08-03
HRP20000502A2 (en) 2001-06-30
FI20001721A0 (fi) 2000-07-28
CA2314685A1 (en) 2001-01-29
LT2000075A (lt) 2001-02-26
ITMI20001758A0 (it) 2000-07-28
IL137552A (en) 2009-06-15
MD2335G2 (ro) 2004-06-30
SE0002793L (sv) 2001-01-30
GB0018636D0 (en) 2000-09-13
IT1318659B1 (it) 2003-08-27
SV2002000134A (es) 2002-06-07
LU90616B1 (fr) 2007-06-08
DE60005693D1 (de) 2003-11-06
DE60005693T2 (de) 2004-07-29
AU779559B2 (en) 2005-01-27
LV12733A (lv) 2001-10-20
KR100733094B1 (ko) 2007-06-27
BE1013410A3 (fr) 2001-12-04
MXPA00007462A (es) 2002-06-04
HK1034962A1 (en) 2001-11-09
AT502317A1 (de) 2007-02-15
FI20001721A (fi) 2001-01-30
WO2001009115A3 (en) 2001-08-16
MD2335F2 (en) 2003-12-31
ES2208384T3 (es) 2004-06-16
LV12733B (lv) 2002-02-20
CN1283622A (zh) 2001-02-14
CZ300356B6 (cs) 2009-04-29
ID26679A (id) 2001-02-01
PE20010383A1 (es) 2001-04-05
NL1015822C2 (nl) 2004-08-04
MY120393A (en) 2005-10-31
SI20427A (sl) 2001-06-30
CA2314685C (en) 2009-10-20
FR2798384A1 (fr) 2001-03-16
ATE251151T1 (de) 2003-10-15
SG90737A1 (en) 2002-08-20
AU6335500A (en) 2001-02-19
BR0003211A (pt) 2001-03-13
DE10036855A1 (de) 2001-03-22
NO20003876L (no) 2001-01-30

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