LT4789B - Nauja 6-hidroksi-3(4-[2-(piperidin-1-il)-etoksi]fenoksi)-2-(4-metoksifenil)benzo[b]tiofeno hidrochlorido kristalinė forma - Google Patents

Nauja 6-hidroksi-3(4-[2-(piperidin-1-il)-etoksi]fenoksi)-2-(4-metoksifenil)benzo[b]tiofeno hidrochlorido kristalinė forma Download PDF

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Publication number
LT4789B
LT4789B LT2000075A LT2000075A LT4789B LT 4789 B LT4789 B LT 4789B LT 2000075 A LT2000075 A LT 2000075A LT 2000075 A LT2000075 A LT 2000075A LT 4789 B LT4789 B LT 4789B
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LT
Lithuania
Prior art keywords
iii
estrogen
pharmaceutical composition
water
compound according
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Application number
LT2000075A
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English (en)
Lithuanian (lt)
Other versions
LT2000075A (lt
Inventor
Julie Kay Bush
Preston Charles Conrad
Merlyn Gerard Flom
Original Assignee
Eli Lilly And Company An Indiana Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company An Indiana Corporation filed Critical Eli Lilly And Company An Indiana Corporation
Publication of LT2000075A publication Critical patent/LT2000075A/xx
Publication of LT4789B publication Critical patent/LT4789B/lt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biotechnology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
LT2000075A 1999-07-29 2000-07-28 Nauja 6-hidroksi-3(4-[2-(piperidin-1-il)-etoksi]fenoksi)-2-(4-metoksifenil)benzo[b]tiofeno hidrochlorido kristalinė forma LT4789B (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14618499P 1999-07-29 1999-07-29
US14764299P 1999-08-06 1999-08-06
US14982099P 1999-08-19 1999-08-19

Publications (2)

Publication Number Publication Date
LT2000075A LT2000075A (lt) 2001-02-26
LT4789B true LT4789B (lt) 2001-05-25

Family

ID=27386367

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2000075A LT4789B (lt) 1999-07-29 2000-07-28 Nauja 6-hidroksi-3(4-[2-(piperidin-1-il)-etoksi]fenoksi)-2-(4-metoksifenil)benzo[b]tiofeno hidrochlorido kristalinė forma

Country Status (45)

Country Link
EP (1) EP1204655B1 (es)
JP (1) JP2001048880A (es)
KR (1) KR100733094B1 (es)
CN (1) CN1138771C (es)
AR (1) AR029176A1 (es)
AT (2) ATE251151T1 (es)
AU (2) AU6335500A (es)
BE (1) BE1013410A3 (es)
BR (1) BR0003211A (es)
CA (1) CA2314685C (es)
CO (1) CO5180572A1 (es)
CZ (1) CZ300356B6 (es)
DE (2) DE60005693T2 (es)
DK (1) DK176771B1 (es)
EG (1) EG24196A (es)
ES (1) ES2208384T3 (es)
FI (1) FI20001721A (es)
FR (1) FR2798384B1 (es)
GB (1) GB2352716A (es)
GR (1) GR20000100264A (es)
HK (1) HK1034962A1 (es)
HR (1) HRP20000502B1 (es)
HU (1) HUP0003005A2 (es)
ID (1) ID26679A (es)
IL (1) IL137552A (es)
IT (1) IT1318659B1 (es)
LT (1) LT4789B (es)
LU (1) LU90616B1 (es)
LV (1) LV12733B (es)
MD (1) MD2335G2 (es)
MX (1) MXPA00007462A (es)
MY (1) MY120393A (es)
NL (1) NL1015822C2 (es)
NO (1) NO325594B1 (es)
NZ (1) NZ506045A (es)
PE (1) PE20010383A1 (es)
PL (1) PL341748A1 (es)
PT (1) PT102501A (es)
SE (1) SE0002793L (es)
SG (1) SG90737A1 (es)
SI (1) SI20427B (es)
SV (1) SV2002000134A (es)
TR (1) TR200002205A2 (es)
TW (1) TWI271403B (es)
WO (1) WO2001009115A2 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152699A0 (en) * 2000-05-08 2003-06-24 Lilly Co Eli STABILIZED FORMULATIONS OF 6-HYDROXY-3-(4-[2-(PIPERIDIN-1-YL)ETHOXY]PHENOXY)-2-(4-METHOXYPHENYL) BENZO [b] THIOPHENE AND SALTS THEREOF
EP1757291A3 (en) * 2000-05-08 2009-07-15 Eli Lilly & Company Stabilized formulations of 6-hydroxy-3-(4-[2-(piperidin-1-YL)ethoxy]phenoxy)-2-(4-methoxyphenyl)benzo[b]thiophene and salts thereof
AU2005200809B2 (en) * 2000-05-08 2006-05-11 Eli Lilly And Company Stabilized Formulations of 6-hydroxy-3-(4-[2-(piperidin-1-yl) Ethoxy]phenoxy)-2-(4-methoxyphenyl) Benzo[b]thiophene and Salts Thereof
US7122203B2 (en) 2000-05-08 2006-10-17 Eli Lilly And Company Stabilized formulations of 6-hydroxy-3-(-4-[2-(piperidin-1-yl) ethoxy]phenoxy)-2-(4-methoxyphenyl) benzo[b]thiophene and salts thereof
MXPA03003432A (es) * 2000-10-20 2003-08-07 Lilly Co Eli Nueva forma cristalina de clorhidrato de 6-hidroxi -3-(4 -(2 -(piperidin-1- il)etoxi)fenoxi) -2-(4-metoxifenil) benzo (b) tiofeno.
WO2002042289A2 (en) 2000-11-27 2002-05-30 Eli Lilly And Company Process for preparing 3-aryl-benzo[b]thiophenes
US7834187B2 (en) * 2004-07-22 2010-11-16 Eli Lilly And Company Crystalline variable hydrate of (S)-6-(4-(2-((3-9H-carbazol-4-yloxy)-2-hydroxypropyl)amino)-2-methylpropyl)phenoxy)-3-pyridinecarbox amide hemisuccinate salt
EP2425846A1 (en) * 2004-12-23 2012-03-07 Voyager Pharmaceutical Corporation Acetylcholinesterase Inhibitors and leuprolide acetate for the treatment of Alzheimer's disease
WO2006088648A1 (en) * 2005-02-11 2006-08-24 Eli Lilly And Company Compositions and methods for treating dyslipidemia
DE102008057230A1 (de) * 2008-11-11 2010-05-12 Bayer Schering Pharma Aktiengesellschaft Synergistische pharmazeutische Kombination mit einem Estrogenrezeptorantagonisten und einem Progestin
CN113325183B (zh) * 2021-06-01 2022-11-15 中国医学科学院北京协和医院 一种用于鉴别诊断em/fem的试剂盒

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510357A (en) 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
EP0729956A1 (en) 1995-02-28 1996-09-04 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA982877B (en) * 1997-04-09 1999-10-04 Lilly Co Eli Treatment of central nervous system disorders with selective estrogen receptor modulators.
WO2001009116A2 (en) * 1999-07-29 2001-02-08 Eli Lilly And Company A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3- (4-[2-(PIPERIDIN-1-YL) ETHOXY]PHENOXY)- 2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5510357A (en) 1995-02-28 1996-04-23 Eli Lilly And Company Benzothiophene compounds as anti-estrogenic agents
EP0729956A1 (en) 1995-02-28 1996-09-04 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods
US5723474A (en) 1995-02-28 1998-03-03 Eli Lilly And Company Benzothiophene compounds, intermediates, compositions, and methods

Also Published As

Publication number Publication date
EP1204655A2 (en) 2002-05-15
LV12733A (lv) 2001-10-20
IL137552A (en) 2009-06-15
LV12733B (lv) 2002-02-20
ITMI20001758A0 (it) 2000-07-28
AU4891100A (en) 2001-02-01
IT1318659B1 (it) 2003-08-27
MY120393A (en) 2005-10-31
FR2798384A1 (fr) 2001-03-16
ITMI20001758A1 (it) 2002-01-28
HRP20000502B1 (en) 2008-04-30
SG90737A1 (en) 2002-08-20
NL1015822C2 (nl) 2004-08-04
AU6335500A (en) 2001-02-19
PE20010383A1 (es) 2001-04-05
ES2208384T3 (es) 2004-06-16
FR2798384B1 (fr) 2004-09-24
IE20000604A1 (en) 2001-04-04
DK200001150A (da) 2001-01-30
AR029176A1 (es) 2003-06-18
SV2002000134A (es) 2002-06-07
MD2335F2 (en) 2003-12-31
LT2000075A (lt) 2001-02-26
FI20001721A0 (fi) 2000-07-28
SI20427B (sl) 2009-04-30
CZ20002717A3 (en) 2001-05-16
NO325594B1 (no) 2008-06-23
PT102501A (pt) 2001-01-31
WO2001009115A2 (en) 2001-02-08
FI20001721A (fi) 2001-01-30
SI20427A (sl) 2001-06-30
HUP0003005A2 (hu) 2002-04-29
PL341748A1 (en) 2001-02-12
DE60005693D1 (de) 2003-11-06
CN1138771C (zh) 2004-02-18
MD2335G2 (ro) 2004-06-30
ATE251151T1 (de) 2003-10-15
KR100733094B1 (ko) 2007-06-27
NO20003876D0 (no) 2000-07-28
GR20000100264A (el) 2001-03-30
MD20000161A (en) 2001-04-30
WO2001009115A3 (en) 2001-08-16
BR0003211A (pt) 2001-03-13
TWI271403B (en) 2007-01-21
IL137552A0 (en) 2001-07-24
CA2314685A1 (en) 2001-01-29
DK176771B1 (da) 2009-08-03
DE60005693T2 (de) 2004-07-29
SE0002793L (sv) 2001-01-30
EP1204655B1 (en) 2003-10-01
HK1034962A1 (en) 2001-11-09
MXPA00007462A (es) 2002-06-04
KR20010049911A (ko) 2001-06-15
CA2314685C (en) 2009-10-20
CO5180572A1 (es) 2002-07-30
NL1015822A1 (nl) 2001-01-30
NZ506045A (en) 2002-02-01
SE0002793D0 (sv) 2000-07-28
DE10036855A1 (de) 2001-03-22
NO20003876L (no) 2001-01-30
LU90616B1 (fr) 2007-06-08
GB0018636D0 (en) 2000-09-13
AT502317A1 (de) 2007-02-15
AU779559B2 (en) 2005-01-27
CZ300356B6 (cs) 2009-04-29
HRP20000502A2 (en) 2001-06-30
TR200002205A2 (tr) 2001-03-21
GB2352716A (en) 2001-02-07
CN1283622A (zh) 2001-02-14
BE1013410A3 (fr) 2001-12-04
HU0003005D0 (en) 2000-10-28
EG24196A (en) 2008-10-14
JP2001048880A (ja) 2001-02-20
ID26679A (id) 2001-02-01

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