SA520411120B1 - مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركبات - Google Patents
مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركباتInfo
- Publication number
- SA520411120B1 SA520411120B1 SA520411120A SA520411120A SA520411120B1 SA 520411120 B1 SA520411120 B1 SA 520411120B1 SA 520411120 A SA520411120 A SA 520411120A SA 520411120 A SA520411120 A SA 520411120A SA 520411120 B1 SA520411120 B1 SA 520411120B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- preparing
- same
- aminopyrimidine derivatives
- intermediates useful
- novel intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Health & Medical Sciences (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
Abstract
يوفر الاختراع الحالي عملية محسّنة لتحضير مشتقات أمينو بيريميدين أو أملاح منه مقبولة صيدلانيًا تتميز بنشاط تثبيطي انتقائي ضد كينازات البروتين، وخاصة ضد كينازات البروتين لمستقبلات عوامل النمو البشروية الطافرة. ويوفر الاختراع الحالي أيضًا مركبات وسيطة جديدة مفيدة للعملية المذكورة ولعمليات من أجل تحضيرها.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170096220 | 2017-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA520411120B1 true SA520411120B1 (ar) | 2022-08-25 |
Family
ID=65040817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA520411120A SA520411120B1 (ar) | 2017-07-28 | 2020-01-22 | مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركبات |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10858353B2 (ar) |
| EP (1) | EP3658553B1 (ar) |
| JP (1) | JP7216704B2 (ar) |
| KR (1) | KR102684954B1 (ar) |
| CN (1) | CN111032650A (ar) |
| AU (1) | AU2018308039B2 (ar) |
| BR (1) | BR112020001396A2 (ar) |
| CA (1) | CA3069408A1 (ar) |
| CO (1) | CO2020000595A2 (ar) |
| DK (1) | DK3658553T3 (ar) |
| EA (1) | EA038856B1 (ar) |
| ES (1) | ES2923278T3 (ar) |
| HR (1) | HRP20220848T1 (ar) |
| HU (1) | HUE059501T2 (ar) |
| IL (1) | IL271974B (ar) |
| LT (1) | LT3658553T (ar) |
| MA (1) | MA49703A (ar) |
| PH (1) | PH12020500070A1 (ar) |
| PL (1) | PL3658553T3 (ar) |
| PT (1) | PT3658553T (ar) |
| RS (1) | RS63497B1 (ar) |
| SA (1) | SA520411120B1 (ar) |
| SG (1) | SG11201913520YA (ar) |
| SI (1) | SI3658553T1 (ar) |
| UA (1) | UA125664C2 (ar) |
| WO (1) | WO2019022486A1 (ar) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020230091A1 (en) | 2019-05-14 | 2020-11-19 | Janssen Biotech, Inc. | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102811619B (zh) | 2009-11-13 | 2015-04-22 | 金纳斯克公司 | 激酶抑制剂 |
| CN105461695B (zh) * | 2014-09-29 | 2018-03-27 | 齐鲁制药有限公司 | 嘧啶或三嗪衍生物及其制备方法和用途 |
| PL3207035T3 (pl) * | 2014-10-13 | 2020-06-01 | Yuhan Corporation | Związki i kompozycje do modulowania aktywności zmutowanych kinaz EGFR |
| CN104788427B (zh) * | 2015-02-05 | 2017-05-31 | 上海泓博智源医药股份有限公司 | 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用 |
| CN107973791B (zh) * | 2015-04-29 | 2020-04-07 | 南京圣和药业股份有限公司 | 稠环或三环芳基嘧啶化合物用作激酶抑制剂 |
| WO2017027768A1 (en) * | 2015-08-13 | 2017-02-16 | The Broad Institute, Inc. | Compositions and methods for treating tuberculosis |
| BR112020001457A2 (pt) | 2017-07-28 | 2020-07-28 | Yuhan Corporation | intermediários úteis para a síntese de um inibidor seletivo contra proteína quinase e processos para preparar os mesmos |
-
2018
- 2018-07-25 ES ES18838173T patent/ES2923278T3/es active Active
- 2018-07-25 KR KR1020180086377A patent/KR102684954B1/ko active IP Right Grant
- 2018-07-25 HR HRP20220848TT patent/HRP20220848T1/hr unknown
- 2018-07-25 UA UAA202001305A patent/UA125664C2/uk unknown
- 2018-07-25 WO PCT/KR2018/008381 patent/WO2019022486A1/en active Application Filing
- 2018-07-25 PT PT188381735T patent/PT3658553T/pt unknown
- 2018-07-25 AU AU2018308039A patent/AU2018308039B2/en active Active
- 2018-07-25 LT LTEPPCT/KR2018/008381T patent/LT3658553T/lt unknown
- 2018-07-25 MA MA049703A patent/MA49703A/fr unknown
- 2018-07-25 RS RS20220706A patent/RS63497B1/sr unknown
- 2018-07-25 CA CA3069408A patent/CA3069408A1/en active Pending
- 2018-07-25 DK DK18838173.5T patent/DK3658553T3/da active
- 2018-07-25 SI SI201830722T patent/SI3658553T1/sl unknown
- 2018-07-25 IL IL271974A patent/IL271974B/en unknown
- 2018-07-25 US US16/633,695 patent/US10858353B2/en active Active
- 2018-07-25 EP EP18838173.5A patent/EP3658553B1/en active Active
- 2018-07-25 JP JP2020503944A patent/JP7216704B2/ja active Active
- 2018-07-25 CN CN201880049025.7A patent/CN111032650A/zh active Pending
- 2018-07-25 BR BR112020001396-0A patent/BR112020001396A2/pt unknown
- 2018-07-25 HU HUE18838173A patent/HUE059501T2/hu unknown
- 2018-07-25 EA EA202090385A patent/EA038856B1/ru unknown
- 2018-07-25 PL PL18838173.5T patent/PL3658553T3/pl unknown
- 2018-07-25 SG SG11201913520YA patent/SG11201913520YA/en unknown
-
2020
- 2020-01-09 PH PH12020500070A patent/PH12020500070A1/en unknown
- 2020-01-20 CO CONC2020/0000595A patent/CO2020000595A2/es unknown
- 2020-01-22 SA SA520411120A patent/SA520411120B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US10858353B2 (en) | 2020-12-08 |
| CO2020000595A2 (es) | 2020-05-05 |
| UA125664C2 (uk) | 2022-05-11 |
| PL3658553T3 (pl) | 2022-10-10 |
| EP3658553B1 (en) | 2022-06-15 |
| KR20190013554A (ko) | 2019-02-11 |
| EP3658553A4 (en) | 2021-04-21 |
| CN111032650A (zh) | 2020-04-17 |
| PH12020500070A1 (en) | 2020-12-07 |
| JP2020528437A (ja) | 2020-09-24 |
| LT3658553T (lt) | 2022-09-12 |
| IL271974A (en) | 2020-02-27 |
| BR112020001396A2 (pt) | 2020-08-11 |
| US20200207750A1 (en) | 2020-07-02 |
| WO2019022486A1 (en) | 2019-01-31 |
| ES2923278T3 (es) | 2022-09-26 |
| AU2018308039A1 (en) | 2020-01-30 |
| MA49703A (fr) | 2021-04-21 |
| RS63497B1 (sr) | 2022-09-30 |
| JP7216704B2 (ja) | 2023-02-01 |
| PT3658553T (pt) | 2022-09-23 |
| EP3658553A1 (en) | 2020-06-03 |
| IL271974B (en) | 2022-08-01 |
| HRP20220848T1 (hr) | 2022-10-14 |
| SG11201913520YA (en) | 2020-02-27 |
| HUE059501T2 (hu) | 2022-11-28 |
| SI3658553T1 (sl) | 2022-10-28 |
| KR102684954B1 (ko) | 2024-07-15 |
| EA038856B1 (ru) | 2021-10-28 |
| DK3658553T3 (da) | 2022-07-25 |
| AU2018308039B2 (en) | 2022-04-14 |
| EA202090385A1 (ru) | 2020-09-09 |
| CA3069408A1 (en) | 2019-01-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SA520411112B1 (ar) | عملية محسّنة لتحضير مشتقات أمينو بيريميدين | |
| PH12020500093A1 (en) | Intermediates useful for the synthesis of a selective inhibitor against protein kinase and processes for preparing the same | |
| ZA202202097B (en) | Amino pyrimidine ssao inhibitors | |
| WO2017108723A3 (en) | PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS | |
| MX2019009501A (es) | Compuestos de amino piridina utiles como inhibidores de ssao. | |
| SG10201902206QA (en) | Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof | |
| SG11201906435SA (en) | Pyrimidine compound and pharmaceutical use thereof | |
| NZ745349A (en) | Urea compound, preparation method therefor and medical use thereof | |
| PH12017550004B1 (en) | Heterocyclic derivatives and use thereof | |
| MX2019000536A (es) | Nuevas pirimidinas carboxamidas como inhibidores de enzima vanina-1. | |
| EP4234547A3 (en) | Pharmaceutical salts of pyrimidine derivatives and method of treating disorders | |
| MX2021007247A (es) | Derivados de rapamicina. | |
| SA520411120B1 (ar) | مركبات وسيطة مبتكرة مفيدة لتركيب مشتقات الأمينوبيريميدين، وعملية لتحضير هذه المركبات الوسيطة، وعملية لتحضير مشتقات الأمينوبيريميدين باستخدام هذه المركبات | |
| EP3560931A4 (en) | METHOD FOR PRODUCING A 7H-PYRROLO [2,3-D] PYRIMIDINE DERIVATIVE, AND CO-CRYSTAL OF SAID DERIVATIVE | |
| MX2020002010A (es) | Procesos para la preparacion de 4,5-diamino-5-oxopentanoato de (s)-terc-butilo. | |
| AU2018375456A1 (en) | Thieno(3,2-d)pyrimidine compound having inhibitory activity for protein kinase | |
| WO2018075598A8 (en) | SYNTHESIS OF EZH2 INHIBITORS | |
| WO2018229796A3 (en) | PROCESS FOR THE PREPARATION OF BETRIXABAN CHLORHYDRATE AND BETRIXABAN MALEATE SALT | |
| AU2019248350A8 (en) | Process for making sarecycline hydrochloride | |
| EP3377470A4 (en) | PROCESS FOR THE SYNTHESIS OF INTERMEDIATES USEFUL FOR THE PREPARATION OF 1,3,4-TRIAZINE DERIVATIVES |