CO2020000595A2 - Intermedios novedosos útiles para la síntesis de derivados de aminopirimidina, proceso para prepararlos, y proceso para preparar derivados de aminopirimidina usando estos - Google Patents
Intermedios novedosos útiles para la síntesis de derivados de aminopirimidina, proceso para prepararlos, y proceso para preparar derivados de aminopirimidina usando estosInfo
- Publication number
- CO2020000595A2 CO2020000595A2 CONC2020/0000595A CO2020000595A CO2020000595A2 CO 2020000595 A2 CO2020000595 A2 CO 2020000595A2 CO 2020000595 A CO2020000595 A CO 2020000595A CO 2020000595 A2 CO2020000595 A2 CO 2020000595A2
- Authority
- CO
- Colombia
- Prior art keywords
- preparing
- aminopyrimidine derivatives
- intermediates useful
- novel intermediates
- synthesis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Abstract
La presente invención proporciona un proceso novedoso para preparar un derivado de aminopirimidina o sal farmacéuticamente aceptable de este que tiene una actividad inhibidora selectiva contra proteínas quinasas, especialmente contra las proteínas quinasas para receptores del factor de crecimiento epidérmico mutantes. Además, la presente invención proporciona intermedios novedosos útiles para el proceso y procesos para prepararlos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20170096220 | 2017-07-28 | ||
| PCT/KR2018/008381 WO2019022486A1 (en) | 2017-07-28 | 2018-07-25 | NOVEL INTERMEDIATES USEFUL FOR SYNTHESIZING AMINOPYRIMIDINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES THEREWITH |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2020000595A2 true CO2020000595A2 (es) | 2020-05-05 |
Family
ID=65040817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2020/0000595A CO2020000595A2 (es) | 2017-07-28 | 2020-01-20 | Intermedios novedosos útiles para la síntesis de derivados de aminopirimidina, proceso para prepararlos, y proceso para preparar derivados de aminopirimidina usando estos |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10858353B2 (es) |
| EP (1) | EP3658553B1 (es) |
| JP (1) | JP7216704B2 (es) |
| KR (1) | KR20190013554A (es) |
| CN (1) | CN111032650A (es) |
| AU (1) | AU2018308039B2 (es) |
| BR (1) | BR112020001396A2 (es) |
| CA (1) | CA3069408A1 (es) |
| CO (1) | CO2020000595A2 (es) |
| DK (1) | DK3658553T3 (es) |
| EA (1) | EA038856B1 (es) |
| ES (1) | ES2923278T3 (es) |
| HR (1) | HRP20220848T1 (es) |
| HU (1) | HUE059501T2 (es) |
| IL (1) | IL271974B (es) |
| LT (1) | LT3658553T (es) |
| MA (1) | MA49703A (es) |
| PH (1) | PH12020500070A1 (es) |
| PL (1) | PL3658553T3 (es) |
| PT (1) | PT3658553T (es) |
| RS (1) | RS63497B1 (es) |
| SA (1) | SA520411120B1 (es) |
| SG (1) | SG11201913520YA (es) |
| SI (1) | SI3658553T1 (es) |
| UA (1) | UA125664C2 (es) |
| WO (1) | WO2019022486A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020230091A1 (en) | 2019-05-14 | 2020-11-19 | Janssen Biotech, Inc. | Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors |
| US11850248B2 (en) | 2019-05-14 | 2023-12-26 | Yuhan Corporation | Therapies with 3rd generation EGFR tyrosine kinase inhibitors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102811619B (zh) * | 2009-11-13 | 2015-04-22 | 金纳斯克公司 | 激酶抑制剂 |
| CN105461695B (zh) * | 2014-09-29 | 2018-03-27 | 齐鲁制药有限公司 | 嘧啶或三嗪衍生物及其制备方法和用途 |
| SG11201701960XA (en) * | 2014-10-13 | 2017-04-27 | Yuhan Corp | Compounds and compositions for modulating egfr mutant kinase activities |
| CN104788427B (zh) * | 2015-02-05 | 2017-05-31 | 上海泓博智源医药股份有限公司 | 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用 |
| CN107614503B (zh) | 2015-04-29 | 2020-03-10 | 广东众生药业股份有限公司 | 稠环或三环芳基嘧啶化合物用作激酶抑制剂 |
| WO2017027768A1 (en) * | 2015-08-13 | 2017-02-16 | The Broad Institute, Inc. | Compositions and methods for treating tuberculosis |
| PL3658547T3 (pl) | 2017-07-28 | 2024-01-03 | Yuhan Corporation | Sposób wytwarzania n-(5-(4-(4-formylo-3-fenylo-1h-pirazol-1-ilo)pirymidyn-2-yloamino)-4-metoksy-2-morfolinofenylo)akrylamidu |
-
2018
- 2018-07-25 LT LTEPPCT/KR2018/008381T patent/LT3658553T/lt unknown
- 2018-07-25 PL PL18838173.5T patent/PL3658553T3/pl unknown
- 2018-07-25 EA EA202090385A patent/EA038856B1/ru unknown
- 2018-07-25 US US16/633,695 patent/US10858353B2/en active Active
- 2018-07-25 CA CA3069408A patent/CA3069408A1/en active Pending
- 2018-07-25 MA MA049703A patent/MA49703A/fr unknown
- 2018-07-25 JP JP2020503944A patent/JP7216704B2/ja active Active
- 2018-07-25 EP EP18838173.5A patent/EP3658553B1/en active Active
- 2018-07-25 HR HRP20220848TT patent/HRP20220848T1/hr unknown
- 2018-07-25 RS RS20220706A patent/RS63497B1/sr unknown
- 2018-07-25 HU HUE18838173A patent/HUE059501T2/hu unknown
- 2018-07-25 CN CN201880049025.7A patent/CN111032650A/zh active Pending
- 2018-07-25 DK DK18838173.5T patent/DK3658553T3/da active
- 2018-07-25 WO PCT/KR2018/008381 patent/WO2019022486A1/en active Application Filing
- 2018-07-25 PT PT188381735T patent/PT3658553T/pt unknown
- 2018-07-25 IL IL271974A patent/IL271974B/en unknown
- 2018-07-25 UA UAA202001305A patent/UA125664C2/uk unknown
- 2018-07-25 ES ES18838173T patent/ES2923278T3/es active Active
- 2018-07-25 AU AU2018308039A patent/AU2018308039B2/en active Active
- 2018-07-25 BR BR112020001396-0A patent/BR112020001396A2/pt unknown
- 2018-07-25 SG SG11201913520YA patent/SG11201913520YA/en unknown
- 2018-07-25 KR KR1020180086377A patent/KR20190013554A/ko active IP Right Grant
- 2018-07-25 SI SI201830722T patent/SI3658553T1/sl unknown
-
2020
- 2020-01-09 PH PH12020500070A patent/PH12020500070A1/en unknown
- 2020-01-20 CO CONC2020/0000595A patent/CO2020000595A2/es unknown
- 2020-01-22 SA SA520411120A patent/SA520411120B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3658553B1 (en) | 2022-06-15 |
| PL3658553T3 (pl) | 2022-10-10 |
| PT3658553T (pt) | 2022-09-23 |
| AU2018308039A1 (en) | 2020-01-30 |
| CA3069408A1 (en) | 2019-01-31 |
| HRP20220848T1 (hr) | 2022-10-14 |
| US20200207750A1 (en) | 2020-07-02 |
| EA038856B1 (ru) | 2021-10-28 |
| BR112020001396A2 (pt) | 2020-08-11 |
| EP3658553A1 (en) | 2020-06-03 |
| IL271974B (en) | 2022-08-01 |
| RS63497B1 (sr) | 2022-09-30 |
| AU2018308039B2 (en) | 2022-04-14 |
| SA520411120B1 (ar) | 2022-08-25 |
| SI3658553T1 (sl) | 2022-10-28 |
| ES2923278T3 (es) | 2022-09-26 |
| JP2020528437A (ja) | 2020-09-24 |
| EA202090385A1 (ru) | 2020-09-09 |
| EP3658553A4 (en) | 2021-04-21 |
| KR20190013554A (ko) | 2019-02-11 |
| DK3658553T3 (da) | 2022-07-25 |
| JP7216704B2 (ja) | 2023-02-01 |
| IL271974A (en) | 2020-02-27 |
| US10858353B2 (en) | 2020-12-08 |
| WO2019022486A1 (en) | 2019-01-31 |
| MA49703A (fr) | 2021-04-21 |
| UA125664C2 (uk) | 2022-05-11 |
| CN111032650A (zh) | 2020-04-17 |
| PH12020500070A1 (en) | 2020-12-07 |
| SG11201913520YA (en) | 2020-02-27 |
| HUE059501T2 (hu) | 2022-11-28 |
| LT3658553T (lt) | 2022-09-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA202202097B (en) | Amino pyrimidine ssao inhibitors | |
| CO2020000371A2 (es) | Intermedios útiles para la síntesis de un inhibidor selectivo contra proteín cinasas y procesos para preparar los mismos | |
| CO2020000374A2 (es) | Proceso mejorado para preparar derivados de aminopirimidina | |
| CU20180006A7 (es) | Compuestos de indazaol y azaindazol como inhibidores de irak-4 | |
| BR112017024917A2 (pt) | síntese de compostos heterocíclicos | |
| CL2020000886A1 (es) | Derivados de 1-benzil-2-imino-4-fenil-5-oxoimidazolidina como inhibidores de la proteasa del vih. | |
| BR112018072168A2 (pt) | compostos derivados da pirimidina como inibidores da quinase jak | |
| PH12017550004B1 (en) | Heterocyclic derivatives and use thereof | |
| TW201613859A (en) | Analogs of PRIDOPIDINE, their preparation and use | |
| CL2021000514A1 (es) | Dimetilaminoazetidinaminas como inhibidores de jak | |
| AR113803A1 (es) | Compuesto de pirimidina como inhibidor de jak quinasas | |
| MX2016013812A (es) | Derivados de amino-pirazina como inhibidores de fosfatidil-inositol-3-cinasa. | |
| MX2015015168A (es) | Derivados heterociclicos y sus usos. | |
| EA202193015A1 (ru) | Ингибиторы cdk | |
| CO2020000595A2 (es) | Intermedios novedosos útiles para la síntesis de derivados de aminopirimidina, proceso para prepararlos, y proceso para preparar derivados de aminopirimidina usando estos | |
| CL2021001198A1 (es) | Compuestos heteroaromáticos como inhibidores de vanina | |
| UY38233A (es) | Agentes inhibidores para la tirosina cinasa de bruton | |
| CO2019005514A2 (es) | Derivado de pirido[3,4–d]pirimidina y su sal farmacéuticamente aceptable | |
| MX2016013981A (es) | Derivados de amino-piridina como inhibidores de fosfatidil-inositol-3-cinasa. | |
| JOP20190163B1 (ar) | منشط nrf2 | |
| EA201990313A1 (ru) | Производное триазолопиразинона, пригодное в качестве ингибитора фдэ1 человека | |
| SG10201810263QA (en) | Nampt inhibitors and methods | |
| WO2018075598A8 (en) | SYNTHESIS OF EZH2 INHIBITORS | |
| CO2021003412A2 (es) | Nuevos derivados de tiazol y sus sales farmacéuticamente aceptables | |
| CY1123076T1 (el) | Ενωσεις βενζο-ν-υδροξυ αμιδιου που εχουν αντικαρκινικη δραστikothta |