CO2020000595A2 - Intermedios novedosos útiles para la síntesis de derivados de aminopirimidina, proceso para prepararlos, y proceso para preparar derivados de aminopirimidina usando estos - Google Patents

Intermedios novedosos útiles para la síntesis de derivados de aminopirimidina, proceso para prepararlos, y proceso para preparar derivados de aminopirimidina usando estos

Info

Publication number
CO2020000595A2
CO2020000595A2 CONC2020/0000595A CO2020000595A CO2020000595A2 CO 2020000595 A2 CO2020000595 A2 CO 2020000595A2 CO 2020000595 A CO2020000595 A CO 2020000595A CO 2020000595 A2 CO2020000595 A2 CO 2020000595A2
Authority
CO
Colombia
Prior art keywords
preparing
aminopyrimidine derivatives
intermediates useful
novel intermediates
synthesis
Prior art date
Application number
CONC2020/0000595A
Other languages
English (en)
Inventor
Sang Ho Oh
Woo Seob Shin
Hyun Ju
Ja-Heouk Khoo
Jong-Chul Lim
Doo-Byung Lee
Jung-Ae Lee
Jun-Sup Lee
Sang-Seol Jeon
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of CO2020000595A2 publication Critical patent/CO2020000595A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Health & Medical Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)

Abstract

La presente invención proporciona un proceso novedoso para preparar un derivado de aminopirimidina o sal farmacéuticamente aceptable de este que tiene una actividad inhibidora selectiva contra proteínas quinasas, especialmente contra las proteínas quinasas para receptores del factor de crecimiento epidérmico mutantes. Además, la presente invención proporciona intermedios novedosos útiles para el proceso y procesos para prepararlos.
CONC2020/0000595A 2017-07-28 2020-01-20 Intermedios novedosos útiles para la síntesis de derivados de aminopirimidina, proceso para prepararlos, y proceso para preparar derivados de aminopirimidina usando estos CO2020000595A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170096220 2017-07-28
PCT/KR2018/008381 WO2019022486A1 (en) 2017-07-28 2018-07-25 NOVEL INTERMEDIATES USEFUL FOR SYNTHESIZING AMINOPYRIMIDINE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES THEREWITH

Publications (1)

Publication Number Publication Date
CO2020000595A2 true CO2020000595A2 (es) 2020-05-05

Family

ID=65040817

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2020/0000595A CO2020000595A2 (es) 2017-07-28 2020-01-20 Intermedios novedosos útiles para la síntesis de derivados de aminopirimidina, proceso para prepararlos, y proceso para preparar derivados de aminopirimidina usando estos

Country Status (26)

Country Link
US (1) US10858353B2 (es)
EP (1) EP3658553B1 (es)
JP (1) JP7216704B2 (es)
KR (1) KR102684954B1 (es)
CN (1) CN111032650A (es)
AU (1) AU2018308039B2 (es)
BR (1) BR112020001396A2 (es)
CA (1) CA3069408A1 (es)
CO (1) CO2020000595A2 (es)
DK (1) DK3658553T3 (es)
EA (1) EA038856B1 (es)
ES (1) ES2923278T3 (es)
HR (1) HRP20220848T1 (es)
HU (1) HUE059501T2 (es)
IL (1) IL271974B (es)
LT (1) LT3658553T (es)
MA (1) MA49703A (es)
PH (1) PH12020500070A1 (es)
PL (1) PL3658553T3 (es)
PT (1) PT3658553T (es)
RS (1) RS63497B1 (es)
SA (1) SA520411120B1 (es)
SG (1) SG11201913520YA (es)
SI (1) SI3658553T1 (es)
UA (1) UA125664C2 (es)
WO (1) WO2019022486A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020230091A1 (en) 2019-05-14 2020-11-19 Janssen Biotech, Inc. Combination therapies with bispecific anti-egfr/c-met antibodies and third generation egfr tyrosine kinase inhibitors
US11850248B2 (en) 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101663637B1 (ko) * 2009-11-13 2016-10-07 제노스코 키나아제 억제제
CN105461695B (zh) * 2014-09-29 2018-03-27 齐鲁制药有限公司 嘧啶或三嗪衍生物及其制备方法和用途
BR112017007769B1 (pt) * 2014-10-13 2023-10-10 Yuhan Corporation Compostos derivados de aminopirimidina, composição farmacêutica que compreende os ditos compostos e uso terapêutico dos mesmos
CN104788427B (zh) * 2015-02-05 2017-05-31 上海泓博智源医药股份有限公司 3‑(2‑嘧啶氨基)苯基丙烯酰胺类化合物及其应用
EP3312179B1 (en) * 2015-04-29 2019-07-10 Nanjing Sanhome Pharmaceutical Co., Ltd. Fused-ring or tricyclic aryl pyrimidine compound used as kinase inhibitor
WO2017027768A1 (en) * 2015-08-13 2017-02-16 The Broad Institute, Inc. Compositions and methods for treating tuberculosis
KR102671396B1 (ko) * 2017-07-28 2024-05-31 주식회사유한양행 프로테인 카이네이즈에 대한 선택적 억제제의 합성에 유용한 중간체 및 이의 제조방법

Also Published As

Publication number Publication date
EP3658553A4 (en) 2021-04-21
EP3658553B1 (en) 2022-06-15
HRP20220848T1 (hr) 2022-10-14
SG11201913520YA (en) 2020-02-27
CN111032650A (zh) 2020-04-17
PT3658553T (pt) 2022-09-23
PL3658553T3 (pl) 2022-10-10
SI3658553T1 (sl) 2022-10-28
HUE059501T2 (hu) 2022-11-28
SA520411120B1 (ar) 2022-08-25
AU2018308039B2 (en) 2022-04-14
IL271974B (en) 2022-08-01
WO2019022486A1 (en) 2019-01-31
RS63497B1 (sr) 2022-09-30
PH12020500070A1 (en) 2020-12-07
US20200207750A1 (en) 2020-07-02
KR102684954B1 (ko) 2024-07-15
AU2018308039A1 (en) 2020-01-30
EP3658553A1 (en) 2020-06-03
MA49703A (fr) 2021-04-21
IL271974A (en) 2020-02-27
EA202090385A1 (ru) 2020-09-09
US10858353B2 (en) 2020-12-08
DK3658553T3 (da) 2022-07-25
EA038856B1 (ru) 2021-10-28
KR20190013554A (ko) 2019-02-11
ES2923278T3 (es) 2022-09-26
UA125664C2 (uk) 2022-05-11
JP2020528437A (ja) 2020-09-24
JP7216704B2 (ja) 2023-02-01
BR112020001396A2 (pt) 2020-08-11
CA3069408A1 (en) 2019-01-31
LT3658553T (lt) 2022-09-12

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