WO2018229796A3 - A process for the preparation of betrixaban hydrochloride - Google Patents

A process for the preparation of betrixaban hydrochloride Download PDF

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Publication number
WO2018229796A3
WO2018229796A3 PCT/IN2018/050387 IN2018050387W WO2018229796A3 WO 2018229796 A3 WO2018229796 A3 WO 2018229796A3 IN 2018050387 W IN2018050387 W IN 2018050387W WO 2018229796 A3 WO2018229796 A3 WO 2018229796A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
betrixaban
betrixaban hydrochloride
hydrochloride
disclosed
Prior art date
Application number
PCT/IN2018/050387
Other languages
French (fr)
Other versions
WO2018229796A2 (en
Inventor
Sureshbabu JAYACHANDRA
Vipin Kumar Kaushik
Bhaskar Kumar TELAGAMSETTY
Pudi Giri Jagannadham NAIDU
Madhuresh Sethi
Original Assignee
Mylan Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mylan Laboratories Limited filed Critical Mylan Laboratories Limited
Publication of WO2018229796A2 publication Critical patent/WO2018229796A2/en
Publication of WO2018229796A3 publication Critical patent/WO2018229796A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Disclosed herein is a process for the preparation of betrixaban hydrochloride and a process for the preparation of betrixaban maleate from betrixaban hydrochloride salt.
PCT/IN2018/050387 2017-06-14 2018-06-13 A process for betrixaban hydrochloride and betrixaban maleate salt WO2018229796A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201741020808 2017-06-14
IN201741020808 2017-06-14
IN201741035801 2017-10-09
IN201741035801 2017-10-09

Publications (2)

Publication Number Publication Date
WO2018229796A2 WO2018229796A2 (en) 2018-12-20
WO2018229796A3 true WO2018229796A3 (en) 2019-01-24

Family

ID=62976103

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2018/050387 WO2018229796A2 (en) 2017-06-14 2018-06-13 A process for betrixaban hydrochloride and betrixaban maleate salt

Country Status (1)

Country Link
WO (1) WO2018229796A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113845465A (en) * 2021-10-29 2021-12-28 河北维达康生物科技有限公司 Method for synthesizing 5-hydroxytryptamine adipate

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008057972A1 (en) * 2006-11-02 2008-05-15 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
EP2431358A1 (en) * 2005-11-08 2012-03-21 Millennium Pharmaceuticals, Inc. Method of preparing a factor XA inhibitor
CN104693114A (en) * 2013-12-10 2015-06-10 四川海思科制药有限公司 Improved method for preparing betrixaban

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6376515B2 (en) 2000-02-29 2002-04-23 Cor Therapeutics, Inc. Benzamides and related inhibitors of factor Xa

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2431358A1 (en) * 2005-11-08 2012-03-21 Millennium Pharmaceuticals, Inc. Method of preparing a factor XA inhibitor
WO2008057972A1 (en) * 2006-11-02 2008-05-15 Millennium Pharmaceuticals, Inc. Methods of synthesizing pharmaceutical salts of a factor xa inhibitor
CN104693114A (en) * 2013-12-10 2015-06-10 四川海思科制药有限公司 Improved method for preparing betrixaban

Also Published As

Publication number Publication date
WO2018229796A2 (en) 2018-12-20

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