SA518391470B1 - مركبات تثبيط كيناز لعائلة جانيس من الكينازات لمعالجة مرض تنفسي - Google Patents

مركبات تثبيط كيناز لعائلة جانيس من الكينازات لمعالجة مرض تنفسي Download PDF

Info

Publication number
SA518391470B1
SA518391470B1 SA518391470A SA518391470A SA518391470B1 SA 518391470 B1 SA518391470 B1 SA 518391470B1 SA 518391470 A SA518391470 A SA 518391470A SA 518391470 A SA518391470 A SA 518391470A SA 518391470 B1 SA518391470 B1 SA 518391470B1
Authority
SA
Saudi Arabia
Prior art keywords
imidazo
ethyl
tetrahydro
fluoro
compound
Prior art date
Application number
SA518391470A
Other languages
Arabic (ar)
English (en)
Inventor
مارتا بابروس
جارى اى. ال براندت
نوا بينجامين
انى – مارى بيوسليل
فينكات ار ثالادى
جون ار جاكوبسين
لان جينج
ميروسلاف رابتا
كاميرون سميث
ستيفن دى. اى سوليفان
بول ار فاثير
جين تيموثى فاس
اوردين لورى جين فان
ميليسا فليورى
بير- جين كولسون
Original Assignee
ثيرافانس بيوفارما ار اند دى اى بى ، ال ال سى
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ثيرافانس بيوفارما ار اند دى اى بى ، ال ال سى filed Critical ثيرافانس بيوفارما ار اند دى اى بى ، ال ال سى
Publication of SA518391470B1 publication Critical patent/SA518391470B1/ar

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SA518391470A 2015-11-03 2018-04-30 مركبات تثبيط كيناز لعائلة جانيس من الكينازات لمعالجة مرض تنفسي SA518391470B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

Publications (1)

Publication Number Publication Date
SA518391470B1 true SA518391470B1 (ar) 2021-03-31

Family

ID=57442794

Family Applications (1)

Application Number Title Priority Date Filing Date
SA518391470A SA518391470B1 (ar) 2015-11-03 2018-04-30 مركبات تثبيط كيناز لعائلة جانيس من الكينازات لمعالجة مرض تنفسي

Country Status (22)

Country Link
US (6) US10100049B2 (enExample)
EP (1) EP3371186A1 (enExample)
JP (1) JP6800969B2 (enExample)
KR (1) KR20180073687A (enExample)
CN (1) CN108349972B (enExample)
AU (1) AU2016350816B2 (enExample)
BR (1) BR112018008966B1 (enExample)
CA (1) CA3001542C (enExample)
CL (1) CL2018001145A1 (enExample)
CO (1) CO2018005640A2 (enExample)
EA (1) EA034914B1 (enExample)
HK (1) HK1252685A1 (enExample)
IL (1) IL258772B (enExample)
MX (1) MX374605B (enExample)
MY (1) MY195427A (enExample)
NZ (1) NZ741737A (enExample)
PH (1) PH12018500828B1 (enExample)
SA (1) SA518391470B1 (enExample)
TW (1) TWI710560B (enExample)
UA (1) UA123633C2 (enExample)
WO (1) WO2017079205A1 (enExample)
ZA (1) ZA201802496B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017079205A1 (en) 2015-11-03 2017-05-11 Theravance Biopharma R&D Ip, Llc Jak kinase inhibitor compounds for treatment of respiratory disease
EP3712152B1 (en) 2015-11-03 2021-01-13 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
WO2017077288A1 (en) 2015-11-03 2017-05-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
JP6974487B2 (ja) 2017-03-09 2021-12-01 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー 4員ヘテロ環式アミドを含むjak阻害剤
US10406148B2 (en) * 2017-05-01 2019-09-10 Theravance Biopharma R&D Ip, Llc Methods of treatment using a JAK inhibitor compound
TWI808083B (zh) * 2017-05-01 2023-07-11 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶型式
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
EP3713545A1 (en) 2017-11-22 2020-09-30 Dauntless 1, Inc. Therapeutic compound formulations
US12171764B2 (en) 2018-06-20 2024-12-24 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor
SG11202101751XA (en) 2018-09-04 2021-03-30 Theravance Biopharma R&D Ip Llc 5 to 7 membered heterocyclic amides as jak inhibitors
BR112021004052A2 (pt) 2018-09-04 2021-05-25 Theravance Biopharma R&D Ip, Llc amidas de dimetil-amino azetidina como inibidores de jak
WO2020051135A1 (en) 2018-09-04 2020-03-12 Theravance Biopharma R&D Ip, Llc Process for preparing jak inhibitors and intermediates thereof
MX2021004582A (es) * 2018-10-29 2021-06-15 Theravance Biopharma R&D Ip Llc Compuesto 2-azabiciclo hexano inhibidor de jak.
US12209092B2 (en) 2018-11-19 2025-01-28 New York University Inhibitors of GLI1 as therapeutic agents
MX2021010242A (es) 2019-02-25 2021-09-21 Henan Medinno Pharmaceutical Tech Co Ltd Compuesto inhibidor de jak y uso del mismo.
CN114075200A (zh) * 2020-08-14 2022-02-22 河南迈英诺医药科技有限公司 用于治疗重症肺炎的jak抑制剂化合物
JP2022524997A (ja) 2019-03-05 2022-05-11 インサイト・コーポレイション 慢性肺同種移植片機能不全の治療のためのjak1経路阻害剤
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
CN113121509B (zh) * 2019-12-30 2024-04-26 河南迈英诺医药科技有限公司 Jak抑制剂化合物及其用途
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
TW202144343A (zh) 2020-03-02 2021-12-01 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶水合物
WO2022178215A1 (en) * 2021-02-19 2022-08-25 Theravance Biopharma R&D Ip, Llc Amino amide tetrahydro imidazo pyridines as jak inhibitors
CN117083273A (zh) 2021-03-26 2023-11-17 施万生物制药研发Ip有限责任公司 Jak抑制剂化合物的二盐酸盐的晶型
TW202317550A (zh) 2021-06-25 2023-05-01 美商施萬生物製藥研發 Ip有限責任公司 作為jak抑制劑之咪唑吲唑化合物
CN114181055A (zh) * 2021-12-21 2022-03-15 苏州楚凯药业有限公司 1-苄氧基-4-溴-5-乙基-2-氟苯的制备方法
JP2025515078A (ja) 2022-05-05 2025-05-13 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー 噴霧経口吸入による送達のためのネズルシチニブ

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
US7872014B2 (en) 2003-07-23 2011-01-18 Exelixis, Inc. Anaplastic lymphoma kinase modulators and methods of use
US20050090529A1 (en) 2003-07-31 2005-04-28 Pfizer Inc 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
US7884109B2 (en) 2005-04-05 2011-02-08 Wyeth Llc Purine and imidazopyridine derivatives for immunosuppression
WO2008049123A2 (en) 2006-10-19 2008-04-24 Rigel Pharmaceuticals, Inc. 2,4-pyrimidinediamine derivatives as inhibitors of jak kinases for the treatment of autoimmune diseases
US8648069B2 (en) 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
CA2727036C (en) 2008-06-20 2017-03-21 Genentech, Inc. Triazolopyridine jak inhibitor compounds and methods
US20110184013A1 (en) 2008-10-01 2011-07-28 Shelley Allen Imidazo[1,2-a]Pyridine Compounds As Receptor Tyrosine Kinase Inhibitors
CL2009001884A1 (es) * 2008-10-02 2010-05-14 Incyte Holdings Corp Uso de 3-ciclopentil-3-[4-(7h-pirrolo[2,3-d]pirimidin-4-il)-1h-pirazol-1-il)propanonitrilo, inhibidor de janus quinasa, y uso de una composición que lo comprende para el tratamiento del ojo seco.
JP2010111624A (ja) 2008-11-06 2010-05-20 Shionogi & Co Ltd Ttk阻害作用を有するインダゾール誘導体
US20120029190A1 (en) 2009-04-03 2012-02-02 Douglas Burdi Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
CN102470135A (zh) 2009-07-28 2012-05-23 里格尔药品股份有限公司 抑制jak途径的组合物和方法
LT3001903T (lt) * 2009-12-21 2018-01-10 Samumed, Llc 1h-pirazolo[3,4-b]piridinai ir jų terapinis panaudojimas
EP2338888A1 (en) 2009-12-24 2011-06-29 Almirall, S.A. Imidazopyridine derivatives as JAK inhibitors
CN103476770B (zh) 2010-11-25 2017-02-15 拉蒂欧制药有限责任公司 阿法替尼盐和多晶型物
US8575336B2 (en) * 2011-07-27 2013-11-05 Pfizer Limited Indazoles
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
TW201513861A (zh) * 2013-01-17 2015-04-16 Galapagos Nv 用於治療退化性及發炎疾病之新穎化合物
MD4649C1 (ro) 2013-12-05 2020-04-30 Pfizer Inc. Pirol[2,3-d]pirimidinil, pirol[2,3-b]pirazinil şi pirol[2,3-d]piridinil acrilamide
PE20161475A1 (es) 2014-05-14 2017-01-08 Pfizer Pirazolopiridinas y pirazolopirimidinas
WO2016026078A1 (en) 2014-08-19 2016-02-25 Changzhou Jiekai Pharmatech Co., Ltd. Heterocyclic compounds as erk inhibitors
KR101663277B1 (ko) 2015-03-30 2016-10-06 주식회사 녹십자 TNIK, IKKε 및 TBK1 억제제로서의 피라졸계 유도체 및 이를 포함하는 약학적 조성물
WO2017077288A1 (en) 2015-11-03 2017-05-11 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
EP3712152B1 (en) 2015-11-03 2021-01-13 Topivert Pharma Limited 4,5,6,7-tetrahydro-1h-imidazo[4,5-c]pyridine and 1,4,5,6,7,8-hexahydroimidazo[4,5-d]azepine derivatives as janus kinase inhibitors
WO2017079205A1 (en) 2015-11-03 2017-05-11 Theravance Biopharma R&D Ip, Llc Jak kinase inhibitor compounds for treatment of respiratory disease
JP6974487B2 (ja) 2017-03-09 2021-12-01 セラヴァンス バイオファーマ アール&ディー アイピー, エルエルシー 4員ヘテロ環式アミドを含むjak阻害剤
US10406148B2 (en) 2017-05-01 2019-09-10 Theravance Biopharma R&D Ip, Llc Methods of treatment using a JAK inhibitor compound
AR111495A1 (es) 2017-05-01 2019-07-17 Theravance Biopharma R&D Ip Llc Compuestos de imidazo-piperidina fusionada como inhibidores de jak
TWI808083B (zh) 2017-05-01 2023-07-11 美商施萬生物製藥研發 Ip有限責任公司 Jak抑制劑化合物之結晶型式
SG11202101751XA (en) 2018-09-04 2021-03-30 Theravance Biopharma R&D Ip Llc 5 to 7 membered heterocyclic amides as jak inhibitors
WO2020051135A1 (en) 2018-09-04 2020-03-12 Theravance Biopharma R&D Ip, Llc Process for preparing jak inhibitors and intermediates thereof
BR112021004052A2 (pt) 2018-09-04 2021-05-25 Theravance Biopharma R&D Ip, Llc amidas de dimetil-amino azetidina como inibidores de jak
MX2021004582A (es) 2018-10-29 2021-06-15 Theravance Biopharma R&D Ip Llc Compuesto 2-azabiciclo hexano inhibidor de jak.
CN117083273A (zh) 2021-03-26 2023-11-17 施万生物制药研发Ip有限责任公司 Jak抑制剂化合物的二盐酸盐的晶型

Also Published As

Publication number Publication date
CN108349972A (zh) 2018-07-31
WO2017079205A1 (en) 2017-05-11
BR112018008966A2 (pt) 2018-11-27
AU2016350816A1 (en) 2018-05-17
CL2018001145A1 (es) 2018-07-06
EP3371186A1 (en) 2018-09-12
PH12018500828B1 (en) 2023-06-30
US11718616B2 (en) 2023-08-08
EA201891091A1 (ru) 2018-12-28
US20170121327A1 (en) 2017-05-04
TWI710560B (zh) 2020-11-21
TW201726673A (zh) 2017-08-01
KR20180073687A (ko) 2018-07-02
JP6800969B2 (ja) 2020-12-16
JP2018531982A (ja) 2018-11-01
BR112018008966B1 (pt) 2023-05-02
PH12018500828A1 (en) 2018-10-29
NZ741737A (en) 2023-11-24
US20200087303A1 (en) 2020-03-19
HK1252685A1 (zh) 2019-05-31
CN108349972B (zh) 2021-06-08
US20220306624A1 (en) 2022-09-29
US20190106420A1 (en) 2019-04-11
EA034914B1 (ru) 2020-04-06
IL258772A (en) 2018-06-28
US11299492B2 (en) 2022-04-12
UA123633C2 (uk) 2021-05-05
US10100049B2 (en) 2018-10-16
CO2018005640A2 (es) 2018-05-31
IL258772B (en) 2021-01-31
AU2016350816B2 (en) 2020-06-25
ZA201802496B (en) 2025-01-29
US10526330B2 (en) 2020-01-07
US10913740B2 (en) 2021-02-09
MX374605B (es) 2025-03-06
MX2018005446A (es) 2018-08-01
US20210130351A1 (en) 2021-05-06
US20180319796A1 (en) 2018-11-08
US10183942B2 (en) 2019-01-22
MY195427A (en) 2023-01-20
CA3001542A1 (en) 2017-05-11
CA3001542C (en) 2021-02-16

Similar Documents

Publication Publication Date Title
SA518391470B1 (ar) مركبات تثبيط كيناز لعائلة جانيس من الكينازات لمعالجة مرض تنفسي
US8563565B2 (en) Pyrazoloquinoline derivatives
JP7098716B2 (ja) Jakキナーゼ阻害剤としてのピラゾロおよびトリアゾロ二環式化合物
TWI764392B (zh) Pi3k抑制劑之鹽及製備方法
US20240279224A1 (en) Quinolines and azaquinolines as inhibitors of cd38
US20060235013A1 (en) Tricyclic azole derivatives
CN114751899A (zh) 一种二芳基脲类mTOR激酶抑制剂及其药物组合物和应用
HK40077703A (en) Piperidin-4-yl azetidine derivatives as jak1 inhibitors
HK40077703B (en) Piperidin-4-yl azetidine derivatives as jak1 inhibitors
HK40084227A (zh) 哒嗪基噻唑甲醯胺类化合物
HK40036913B (en) Piperidin-4-yl azetidine derivatives as jak1 inhibitors
NZ621991B2 (en) Heterocyclylamines as pi3k inhibitors