JP6800969B2 - 呼吸器疾患の処置のためのｊａｋキナーゼ阻害剤化合物 - Google Patents

呼吸器疾患の処置のためのｊａｋキナーゼ阻害剤化合物 Download PDF

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JP6800969B2
JP6800969B2 JP2018522556A JP2018522556A JP6800969B2 JP 6800969 B2 JP6800969 B2 JP 6800969B2 JP 2018522556 A JP2018522556 A JP 2018522556A JP 2018522556 A JP2018522556 A JP 2018522556A JP 6800969 B2 JP6800969 B2 JP 6800969B2
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alkyl
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ethyl
formula
hydrogen
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JP2018531982A5 (enExample
JP2018531982A (ja
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ポール アール． ファザリー，
ポール アール． ファザリー，
ジョン アール． ヤコブセン，
ジョン アール． ヤコブセン，
アン−マリー ボーソレイユ，
アン−マリー ボーソレイユ，
ゲイリー イー．エル． ブラント，
ゲイリー イー．エル． ブラント，
メリッサ フルーリー，
メリッサ フルーリー，
ラン ジアン，
ラン ジアン，
キャメロン スミス，
キャメロン スミス，
スティーブン ディー．イー． サリバン，
スティーブン ディー．イー． サリバン，
オーデン， ロリ ジーン バン
オーデン， ロリ ジーン バン
ピエール−ジャン コルソン，
ピエール−ジャン コルソン，
ジーン ティモシー ファス，
ジーン ティモシー ファス，
ミロスラブ ラプタ，
ミロスラブ ラプタ，
ノア ベンジャミン，
ノア ベンジャミン，
マータ ダブロス，
マータ ダブロス，
ヴェンカット アール． サラディー，
ヴェンカット アール． サラディー，
Original Assignee
セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー
セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2018522556A 2015-11-03 2016-11-02 呼吸器疾患の処置のためのｊａｋキナーゼ阻害剤化合物 Expired - Fee Related JP6800969B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562250113P 2015-11-03 2015-11-03
US62/250,113 2015-11-03
PCT/US2016/059999 WO2017079205A1 (en) 2015-11-03 2016-11-02 Jak kinase inhibitor compounds for treatment of respiratory disease

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JP2018531982A JP2018531982A (ja) 2018-11-01
JP2018531982A5 JP2018531982A5 (enExample) 2019-09-26
JP6800969B2 true JP6800969B2 (ja) 2020-12-16

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US (6) US10100049B2 (enExample)
EP (1) EP3371186A1 (enExample)
JP (1) JP6800969B2 (enExample)
KR (1) KR20180073687A (enExample)
CN (1) CN108349972B (enExample)
AU (1) AU2016350816B2 (enExample)
BR (1) BR112018008966B1 (enExample)
CA (1) CA3001542C (enExample)
CL (1) CL2018001145A1 (enExample)
CO (1) CO2018005640A2 (enExample)
EA (1) EA034914B1 (enExample)
HK (1) HK1252685A1 (enExample)
IL (1) IL258772B (enExample)
MX (1) MX374605B (enExample)
MY (1) MY195427A (enExample)
NZ (1) NZ741737A (enExample)
PH (1) PH12018500828B1 (enExample)
SA (1) SA518391470B1 (enExample)
TW (1) TWI710560B (enExample)
UA (1) UA123633C2 (enExample)
WO (1) WO2017079205A1 (enExample)
ZA (1) ZA201802496B (enExample)

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KR102568333B1 (ko) 2017-05-01 2023-08-18 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Jak 저해제 화합물을 사용하는 치료 방법
JP7383696B2 (ja) 2018-09-04 2023-11-20 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Ｊａｋ阻害剤としての５員～７員の複素環アミド
EP3837253B1 (en) 2018-09-04 2023-06-07 Theravance Biopharma R&D IP, LLC Process for preparing jak inhibitors and intermediates thereof
DK3837258T3 (da) 2018-09-04 2024-07-22 Theravance Biopharma R&D Ip Llc Dimethyl amino azetidine amides as jak inhibitors
SG11202103042XA (en) 2018-10-29 2021-04-29 Theravance Biopharma R&D Ip Llc 2-azabicyclo hexane compound as jak inhibitor
CN117083273A (zh) 2021-03-26 2023-11-17 施万生物制药研发Ip有限责任公司 Jak抑制剂化合物的二盐酸盐的晶型

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TW201726673A (zh) 2017-08-01
US20220306624A1 (en) 2022-09-29
KR20180073687A (ko) 2018-07-02
MY195427A (en) 2023-01-20
NZ741737A (en) 2023-11-24
US11718616B2 (en) 2023-08-08
US20210130351A1 (en) 2021-05-06
WO2017079205A1 (en) 2017-05-11
US20170121327A1 (en) 2017-05-04
UA123633C2 (uk) 2021-05-05
CN108349972B (zh) 2021-06-08
CN108349972A (zh) 2018-07-31
HK1252685A1 (zh) 2019-05-31
US10100049B2 (en) 2018-10-16
US10913740B2 (en) 2021-02-09
CL2018001145A1 (es) 2018-07-06
AU2016350816A1 (en) 2018-05-17
PH12018500828B1 (en) 2023-06-30
US20190106420A1 (en) 2019-04-11
AU2016350816B2 (en) 2020-06-25
BR112018008966B1 (pt) 2023-05-02
EA034914B1 (ru) 2020-04-06
PH12018500828A1 (en) 2018-10-29
IL258772B (en) 2021-01-31
US10526330B2 (en) 2020-01-07
MX2018005446A (es) 2018-08-01
CA3001542A1 (en) 2017-05-11
TWI710560B (zh) 2020-11-21
CA3001542C (en) 2021-02-16
US11299492B2 (en) 2022-04-12
US20200087303A1 (en) 2020-03-19
SA518391470B1 (ar) 2021-03-31
CO2018005640A2 (es) 2018-05-31
US20180319796A1 (en) 2018-11-08
IL258772A (en) 2018-06-28
BR112018008966A2 (pt) 2018-11-27
JP2018531982A (ja) 2018-11-01
EA201891091A1 (ru) 2018-12-28
EP3371186A1 (en) 2018-09-12
MX374605B (es) 2025-03-06
ZA201802496B (en) 2025-01-29
US10183942B2 (en) 2019-01-22

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