SA517390330B1 - التحكم في عملية تنقية مستمرة لمحاليل بروتينية - Google Patents
التحكم في عملية تنقية مستمرة لمحاليل بروتينية Download PDFInfo
- Publication number
- SA517390330B1 SA517390330B1 SA517390330A SA517390330A SA517390330B1 SA 517390330 B1 SA517390330 B1 SA 517390330B1 SA 517390330 A SA517390330 A SA 517390330A SA 517390330 A SA517390330 A SA 517390330A SA 517390330 B1 SA517390330 B1 SA 517390330B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- unit
- units
- buffer space
- control
- buffer
- Prior art date
Links
- 238000000746 purification Methods 0.000 title description 3
- 239000012460 protein solution Substances 0.000 title description 2
- 238000000034 method Methods 0.000 claims abstract description 54
- 238000004519 manufacturing process Methods 0.000 claims abstract description 44
- 230000008569 process Effects 0.000 claims abstract description 32
- 229960000074 biopharmaceutical Drugs 0.000 claims abstract description 6
- 239000000523 sample Substances 0.000 claims description 27
- 230000009471 action Effects 0.000 claims description 12
- 238000010924 continuous production Methods 0.000 claims description 10
- 238000005259 measurement Methods 0.000 claims description 8
- 238000012544 monitoring process Methods 0.000 claims description 7
- 230000033228 biological regulation Effects 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 4
- 230000008901 benefit Effects 0.000 claims description 3
- 230000001447 compensatory effect Effects 0.000 claims description 3
- 238000013461 design Methods 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 238000003860 storage Methods 0.000 claims description 3
- 238000012546 transfer Methods 0.000 claims description 3
- 230000002518 glial effect Effects 0.000 claims description 2
- 101100495256 Caenorhabditis elegans mat-3 gene Proteins 0.000 claims 1
- 239000011800 void material Substances 0.000 claims 1
- 238000012545 processing Methods 0.000 abstract description 7
- 102000004169 proteins and genes Human genes 0.000 abstract description 4
- 108090000623 proteins and genes Proteins 0.000 abstract description 4
- 108020004707 nucleic acids Proteins 0.000 abstract description 3
- 102000039446 nucleic acids Human genes 0.000 abstract description 3
- 150000007523 nucleic acids Chemical class 0.000 abstract description 3
- 229960005486 vaccine Drugs 0.000 abstract description 3
- 239000013612 plasmid Substances 0.000 abstract description 2
- 238000004587 chromatography analysis Methods 0.000 description 21
- 241000700605 Viruses Species 0.000 description 19
- 230000002779 inactivation Effects 0.000 description 15
- 238000009776 industrial production Methods 0.000 description 13
- 238000000855 fermentation Methods 0.000 description 9
- 230000004151 fermentation Effects 0.000 description 9
- 230000001419 dependent effect Effects 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 8
- 238000001914 filtration Methods 0.000 description 7
- 238000004886 process control Methods 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 6
- 230000008859 change Effects 0.000 description 6
- 230000001105 regulatory effect Effects 0.000 description 6
- 230000001276 controlling effect Effects 0.000 description 5
- 238000011049 filling Methods 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 238000011100 viral filtration Methods 0.000 description 5
- 235000019800 disodium phosphate Nutrition 0.000 description 4
- 230000003750 conditioning effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- 238000011210 chromatographic step Methods 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000011221 initial treatment Methods 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000010412 perfusion Effects 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 240000008415 Lactuca sativa Species 0.000 description 1
- 241001103596 Lelia Species 0.000 description 1
- 241000234435 Lilium Species 0.000 description 1
- 229920002145 PharMed Polymers 0.000 description 1
- 241001474791 Proboscis Species 0.000 description 1
- 244000292604 Salvia columbariae Species 0.000 description 1
- 235000012377 Salvia columbariae var. columbariae Nutrition 0.000 description 1
- 235000001498 Salvia hispanica Nutrition 0.000 description 1
- -1 Sse Proteins 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000013452 biotechnological production Methods 0.000 description 1
- 235000014167 chia Nutrition 0.000 description 1
- 238000011097 chromatography purification Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000011143 downstream manufacturing Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000011093 media selection Methods 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229920002578 polythiourethane polymer Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 229920002477 rna polymer Polymers 0.000 description 1
- 235000012045 salad Nutrition 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 230000026676 system process Effects 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/44—Multiple separable units; Modules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/58—Reaction vessels connected in series or in parallel
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/10—Perfusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/48—Automatic or computerized control
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B11/00—Automatic controllers
- G05B11/01—Automatic controllers electric
- G05B11/36—Automatic controllers electric with provision for obtaining particular characteristics, e.g. proportional, integral, differential
- G05B11/42—Automatic controllers electric with provision for obtaining particular characteristics, e.g. proportional, integral, differential for obtaining a characteristic which is both proportional and time-dependent, e.g. P. I., P. I. D.
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
- G05B13/00—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion
- G05B13/02—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
- G05B13/0265—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric the criterion being a learning criterion
- G05B13/0275—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric the criterion being a learning criterion using fuzzy logic only
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D7/00—Control of flow
- G05D7/06—Control of flow characterised by the use of electric means
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Computer Hardware Design (AREA)
- General Physics & Mathematics (AREA)
- Automation & Control Theory (AREA)
- Artificial Intelligence (AREA)
- Software Systems (AREA)
- Mathematical Physics (AREA)
- Fuzzy Systems (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Evolutionary Computation (AREA)
- Medical Informatics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Feedback Control In General (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Testing And Monitoring For Control Systems (AREA)
- Flow Control (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15167538.6A EP3093335A1 (de) | 2015-05-13 | 2015-05-13 | Prozessleitsystem zur regelung und steuerung einer modular aufgebauten anlage zur produktion von biopharmazeutischen und biologischen makromolekularen produkten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA517390330B1 true SA517390330B1 (ar) | 2021-09-22 |
Family
ID=53177195
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA517390330A SA517390330B1 (ar) | 2015-05-13 | 2017-11-13 | التحكم في عملية تنقية مستمرة لمحاليل بروتينية |
Country Status (21)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3431173A1 (en) | 2017-07-19 | 2019-01-23 | Bayer Pharma Aktiengesellschaft | Continuous manufacture of guidance molecule drug conjugates |
| AU2019335063A1 (en) * | 2018-09-05 | 2021-01-07 | Commonwealth Scientific And Industrial Research Organisation | "a monitor for a multi-parameter manufacturing process" |
| EP3699697A1 (en) | 2019-02-25 | 2020-08-26 | Bayer Aktiengesellschaft | Automated simultaneous process control |
| JP7604486B2 (ja) * | 2020-05-29 | 2024-12-23 | 株式会社ダイセル | 異常変調原因特定装置、異常変調原因特定方法及び異常変調原因特定プログラム |
| DE102022208467A1 (de) | 2022-06-24 | 2024-01-04 | Bilfinger Life Science Gmbh | Modulare Vorrichtung und Verfahren zur kontinuierlichen Herstellung von biotechnologischen Produkten |
| WO2023247798A1 (de) | 2022-06-24 | 2023-12-28 | Bilfinger Life Science Gmbh | Modulare vorrichtung und verfahren zur kontinuierlichen herstellung von biotechnologischen produkten |
| EP4711439A1 (en) | 2024-09-16 | 2026-03-18 | Sartorius Stedim Biotech GmbH | Flow system with recirculation loop |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5546594A (en) * | 1992-11-06 | 1994-06-08 | Abbott Laboratories | Process control system for biological fluid testing |
| JP2004198123A (ja) * | 2002-12-16 | 2004-07-15 | Shimadzu Corp | 分取液体クロマトグラフ質量分析装置 |
| JP3823092B2 (ja) * | 2003-03-11 | 2006-09-20 | 株式会社日立ハイテクノロジーズ | 分離分析装置 |
| JP2006018711A (ja) * | 2004-07-05 | 2006-01-19 | Earekkusu:Kk | 液体除染剤供給システム |
| CN102794109B (zh) | 2004-09-30 | 2015-10-07 | 拜耳医药保健有限公司 | 用于集成连续生产生物分子的装置和方法 |
| JP2008539738A (ja) * | 2005-05-09 | 2008-11-20 | サクソニア バイオテック ゲーエムベーハー | 細胞培養モジュール用供給システム |
| US9103814B2 (en) * | 2006-03-17 | 2015-08-11 | Waters Technologies Corporation | Solvent delivery system for liquid chromatography that maintains fluid integrity and pre-forms gradients |
| JP4831480B2 (ja) * | 2006-06-21 | 2011-12-07 | 三浦工業株式会社 | 膜濾過システム |
| US9891157B2 (en) * | 2010-12-03 | 2018-02-13 | Cellply S.R.L. | Microanalysis of cellular function |
| CN103562145B (zh) * | 2010-12-06 | 2016-09-21 | 颇尔公司 | 生物制品的连续加工方法 |
| CN103243026B (zh) * | 2012-02-14 | 2014-09-03 | 常州医凌生命科技有限公司 | 多功能全自动细胞及溶液处理仪 |
| EP2682168A1 (en) * | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| US10203308B2 (en) * | 2013-01-18 | 2019-02-12 | Shimadzu Corporation | Sample concentration device |
| AU2014226126B2 (en) | 2013-03-08 | 2019-02-14 | Genzyme Corporation | Continuous purification of therapeutic proteins |
| DE102013212540A1 (de) * | 2013-06-27 | 2014-12-31 | Agilent Technologies Inc. | Konditionieren eines nachfolgenden Probenpakets in einer Probentrennstufe während Prozessierens eines vorangehenden Probenpakets in einer Probenweiterverarbeitungsstufe |
| EP3186355A4 (en) * | 2014-07-31 | 2018-03-21 | Govind Rao | Microscale bioprocessing system and method for protein manufacturing from human blood |
-
2015
- 2015-05-13 EP EP15167538.6A patent/EP3093335A1/de not_active Withdrawn
-
2016
- 2016-05-06 AR ARP160101310A patent/AR104554A1/es not_active Application Discontinuation
- 2016-05-10 WO PCT/EP2016/060369 patent/WO2016180798A1/de not_active Ceased
- 2016-05-10 JP JP2017559064A patent/JP6833721B2/ja not_active Expired - Fee Related
- 2016-05-10 CN CN201680040972.0A patent/CN107849506B/zh not_active Expired - Fee Related
- 2016-05-10 AU AU2016259746A patent/AU2016259746B2/en not_active Ceased
- 2016-05-10 CA CA2985678A patent/CA2985678A1/en active Pending
- 2016-05-10 BR BR112017024373-3A patent/BR112017024373B1/pt not_active IP Right Cessation
- 2016-05-10 MX MX2017014527A patent/MX380681B/es unknown
- 2016-05-10 RU RU2017143437A patent/RU2724495C2/ru active
- 2016-05-10 KR KR1020177035436A patent/KR20180005225A/ko not_active Ceased
- 2016-05-10 PL PL16722163T patent/PL3294856T3/pl unknown
- 2016-05-10 PT PT167221639T patent/PT3294856T/pt unknown
- 2016-05-10 SG SG11201709329YA patent/SG11201709329YA/en unknown
- 2016-05-10 EP EP16722163.9A patent/EP3294856B1/de not_active Revoked
- 2016-05-10 DK DK16722163T patent/DK3294856T3/da active
- 2016-05-10 ES ES16722163T patent/ES2760468T3/es active Active
- 2016-05-10 US US15/573,148 patent/US20180127461A1/en not_active Abandoned
- 2016-05-11 TW TW105114507A patent/TWI689303B/zh not_active IP Right Cessation
-
2017
- 2017-11-09 IL IL255556A patent/IL255556B/en unknown
- 2017-11-13 SA SA517390330A patent/SA517390330B1/ar unknown
- 2017-12-12 ZA ZA2017/08418A patent/ZA201708418B/en unknown
-
2021
- 2021-03-04 US US17/192,384 patent/US20210221842A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2724495C2 (ru) | Система контроля технологического процесса для регулирования и управления модульной установкой, предназначенной для производства биофармацевтических и биологических макромолекулярных продуктов | |
| Feidl et al. | Process‐wide control and automation of an integrated continuous manufacturing platform for antibodies | |
| CN113490738B (zh) | 用于生产治疗性蛋白质的自动化集成连续系统和生物工艺 | |
| AU2016259745B2 (en) | Method for the continuous elution of a product from chromatography columns | |
| US20250290027A1 (en) | Facilities and processes to produce biotherapeutics | |
| KR20190093572A (ko) | 세포 및/또는 세포 생성물의 생산을 위한 시스템 | |
| EP3701704B1 (en) | Cloud-controlled manufacturing execution system (clo-cmes) for use in pharmaceutical manufacturing process control, methods, and systems thereof | |
| Lozano Aviles et al. | Methodology for energy optimization in wastewater treatment plants. Phase iii: Implementation of an integral control system for the aeration stage in the biological process of activated sludge and the membrane biological reactor | |
| Thakur et al. | Process analytical technology in continuous processing: Model-based real time control of pH between capture chromatography and viral inactivation for monoclonal antibody production | |
| EP3931642B1 (en) | Automated simultaneous process control | |
| US9604186B1 (en) | Automated multichannel media dispenser | |
| Taylor et al. | Use of live digital twin (shadow) soft sensor to monitor membrane degradation in continuous manufacturing single pass tangential flow filtration | |
| Nowak et al. | ADRC-based habituating control of double-heater heat source | |
| Nasukawa-Morimoto et al. | From Failures to Insights: The Role of Surge Tanks in Integrated and Continuous Bioprocessing for Antibody Production | |
| Junior et al. | Avoiding buffer tank overflow in an iron ore dewatering system with integrated control system | |
| Peuker et al. | Equipment design and facility layout for flexible biomanufacturing processes | |
| Bazolana et al. | Optimum Water Network Design for Multipurpose Batch Plants with a Detailed Electrodialysis Regeneration Model | |
| HK1252939B (en) | Process control system for regulating and controlling a modular plant for manufacturing biopharmaceutical and biological macromolecular products | |
| Dey et al. | Fermenter balancing for semi-continuous, multi-tank mammalian cell culture processes | |
| Sarkis et al. | Emerging Challenges and Opportunities in Pharmaceutical Manufacturing and Distribution. Processes 2021, 9, 457 | |
| Romeu | Development of biotechnology control systems | |
| HK40053110A (en) | Automated simultaneous process control | |
| WO2021197249A1 (zh) | 一种用于靶分子连续纯化的系统和方法 | |
| Hamers | Manufacturing of BioPharmaceuticals |