SA517381232B1 - تركيبات وأطقم للإنضار الإنزيمي وطرق لاستخدامها - Google Patents

تركيبات وأطقم للإنضار الإنزيمي وطرق لاستخدامها

Info

Publication number
SA517381232B1
SA517381232B1 SA517381232A SA517381232A SA517381232B1 SA 517381232 B1 SA517381232 B1 SA 517381232B1 SA 517381232 A SA517381232 A SA 517381232A SA 517381232 A SA517381232 A SA 517381232A SA 517381232 B1 SA517381232 B1 SA 517381232B1
Authority
SA
Saudi Arabia
Prior art keywords
amylase
kits
compositions
methods
same
Prior art date
Application number
SA517381232A
Other languages
English (en)
Inventor
بيال سالاموني آن
تشارلز سالاموني جوزيف
إليزابيث ريلي كاتيلين
زياويو - شين ليونج كيلي
Original Assignee
روتشال إندستريـز، ال ال سي
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by روتشال إندستريـز، ال ال سي filed Critical روتشال إندستريـز، ال ال سي
Publication of SA517381232B1 publication Critical patent/SA517381232B1/ar

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/38Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061Use of materials characterised by their function or physical properties
    • A61L26/0066Medicaments; Biocides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01001Alpha-amylase (3.2.1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01002Beta-amylase (3.2.1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01003Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22Cysteine endopeptidases (3.4.22)
    • C12Y304/22032Stem bromelain (3.4.22.32)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24Metalloendopeptidases (3.4.24)
    • C12Y304/24007Interstitial collagenase (3.4.24.7), i.e. matrix metalloprotease 1 or MMP1
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/206Biguanides, e.g. chlorohexidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254Enzymes, proenzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402Anaestetics, analgesics, e.g. lidocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45Mixtures of two or more drugs, e.g. synergistic mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

يتعلق الاختراع الحالي بإنزيم إنضار لنسيج نخري debridement enzyme for necrotic tissue غير معتمد على النشاط الإنزيمي المُفكك للبروتين proteolytic enzymatic activity ولكنه يستخدم بدلًا من ذلك فصيلة الأميلاز amylase من الإنزيمات. الأميلازات amylases (ألفا، بيتا، جاما-أميلاز) (α-, ß-, γ-amylase) معروفة بانشطار روابط α-الجليكوسيدية α-glycosidic bonds لمتعددات السكاريد polysaccharides ، منتجة شظايا كربوهيدرات/سكر carbohydrate/sugar fragments منخفضة الوزن الجزيئي. وجد الآن أن ألفا- أميلاز α-amylase فعال في إنضار النسيج الذي يفتقر إلى الحيوية debridement of devitalized tissue. شكل 1.
SA517381232A 2014-10-10 2017-04-03 تركيبات وأطقم للإنضار الإنزيمي وطرق لاستخدامها SA517381232B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/511,912 US9592280B2 (en) 2014-10-10 2014-10-10 Compositions and kits for enzymatic debridement and methods of using the same
PCT/US2015/054682 WO2016057788A1 (en) 2014-10-10 2015-10-08 Compositions and kits for enzymatic debridement and methods of using the same

Publications (1)

Publication Number Publication Date
SA517381232B1 true SA517381232B1 (ar) 2022-08-29

Family

ID=55653768

Family Applications (1)

Application Number Title Priority Date Filing Date
SA517381232A SA517381232B1 (ar) 2014-10-10 2017-04-03 تركيبات وأطقم للإنضار الإنزيمي وطرق لاستخدامها

Country Status (20)

Country Link
US (1) US9592280B2 (ar)
EP (1) EP3204037B1 (ar)
JP (1) JP6710862B2 (ar)
KR (2) KR20170065551A (ar)
CN (1) CN107106663B (ar)
AU (1) AU2015330888B2 (ar)
BR (1) BR112017006939B1 (ar)
CA (1) CA2963811A1 (ar)
CO (1) CO2017003290A2 (ar)
DK (1) DK3204037T3 (ar)
ES (1) ES2938202T3 (ar)
FI (1) FI3204037T3 (ar)
IL (1) IL251546A (ar)
MX (1) MX2017004199A (ar)
PH (1) PH12017500663A1 (ar)
PT (1) PT3204037T (ar)
SA (1) SA517381232B1 (ar)
SG (1) SG11201702871WA (ar)
UA (1) UA126367C2 (ar)
WO (1) WO2016057788A1 (ar)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017130204A1 (en) 2016-01-31 2017-08-03 Mediwound Ltd. Debriding composition for treating wounds
AU2018375567A1 (en) * 2017-11-30 2020-05-28 Hollister Incorporated Wound debridement composition and method for treating wounds
FI3533458T3 (fi) 2018-03-02 2023-07-20 Upm Kymmene Corp Lääketieteellinen tuote, joka käsittää bioaktiivisen molekyylin, joka on kiinnitetty paikoilleen nanofibrilliselluloosaan, sekä menetelmä sen valmistamiseksi
EP4295869A3 (en) * 2019-06-03 2024-03-20 Convatec Limited Methods and devices to disrupt and contain pathogens
KR20240028210A (ko) * 2022-08-24 2024-03-05 주식회사 티앤알바이오팹 단백질 추출물을 포함하는 하이드로겔 기반의 국소 창상 피복재
CN115671369B (zh) * 2022-11-09 2023-10-27 华东理工大学 一种按需可拆的水凝胶组织粘合剂及其制备方法

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA733072A (en) * 1966-04-26 J. Beckhorn Edward Debridement agent
US2120667A (en) 1937-12-01 1938-06-14 Lakeland Foundation Therapeutic agent for use in the treatment of infection
US2917433A (en) 1956-04-02 1959-12-15 Rystan Company Stable aqueous papain topical compositions
US3003917A (en) * 1959-01-14 1961-10-10 Nat Drug Co Wound healing composition
US3409719A (en) 1967-05-23 1968-11-05 Baxter Laboratories Inc Debridement agent
US3681197A (en) * 1969-01-02 1972-08-01 Clarence T Smith Method and solution for maintaining biological activity in enzymes
US4652524A (en) 1980-10-02 1987-03-24 Ivan E. Modrovich Soluble stabilized enzymes
EP0133438A1 (en) 1983-01-21 1985-02-27 Advanced Drug Technology Corporation Enzyme ointment
US4719235A (en) 1984-10-16 1988-01-12 Gerald N. Kern Methods and compositions for treating viral infection
US4668228A (en) 1985-03-12 1987-05-26 Johnson & Johnson Products, Inc. Debriding tape
US4885310A (en) 1985-05-09 1989-12-05 Gerald N. Kern Anti-fungal methods and agent
US4717737A (en) 1985-06-05 1988-01-05 Gerald N. Kern Anti-bacterial methods and agent
US4772465A (en) 1986-10-27 1988-09-20 Miles Laboratories, Inc. Method of treating polymicrobial burn wound sepsis with a combination therapy of ciprofloxacin and pseudomonas immune globulin
US5206026A (en) 1988-05-24 1993-04-27 Sharik Clyde L Instantaneous delivery film
US5120656A (en) 1989-08-18 1992-06-09 Osteotech, Inc. Process for debriding bone
DE4140473C2 (de) 1991-12-09 1995-12-21 Schuelke & Mayr Gmbh Hautantiseptikum und Händedesinfektionsmittel
US5543149A (en) 1995-03-01 1996-08-06 Rubin; Stan M. Treatment for insect bites
US5670142A (en) 1996-07-08 1997-09-23 Donald Neudecker Treatment for itch of chicken pox
WO1999046368A2 (en) 1998-03-13 1999-09-16 Biomarin Pharmaceuticals Carbohydrate-modifying enzymes for burn and wound debridement and methods for treatment
AU2001268953A1 (en) 2000-07-21 2002-02-05 Novozymes A/S Antimicrobial compositions
US6548556B2 (en) 2000-12-27 2003-04-15 Healthpoint, Ltd. Stable enzymatic wound debrider
US7223386B2 (en) * 2002-03-11 2007-05-29 Dow Corning Corporation Preparations for topical skin use and treatment
US20040076671A1 (en) * 2002-10-21 2004-04-22 Aletha Tippett Methods and compositions for topical wound treatment
US20070237812A1 (en) * 2006-04-11 2007-10-11 Tyco Healthcare Group Multi-layer wound dressings
AU2003213273A1 (en) * 2003-02-26 2004-09-28 Genencor International, Inc. Amylases producing an altered immunogenic response and methods of making and using the same
WO2005035010A1 (en) 2003-10-10 2005-04-21 Coloplast A/S Wound dressing containing proteolytic enzymes
IL165334A0 (en) 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
WO2008063229A2 (en) 2006-05-12 2008-05-29 Livingston James A Enzymatic debridement therapy for abnormal cell proliferation
US7629158B2 (en) 2006-06-16 2009-12-08 The Procter & Gamble Company Cleaning and/or treatment compositions
JP2007262099A (ja) * 2007-07-19 2007-10-11 Yamachu:Kk 紫外線対抗化粧用組成物
WO2010004367A1 (en) 2008-07-10 2010-01-14 Life Science Investments Ltd Use of a mixture of superoxide dismutase and catalase for treating pruritus and alleviating its symptoms
JP5684725B2 (ja) * 2009-01-06 2015-03-18 キュレロン リミテッド ライアビリティ カンパニー 黄色ブドウ球菌感染の治療または予防のための組成物および方法ならびに表面上にいる黄色ブドウ球菌の根絶または低減のための組成物および方法
US8486664B2 (en) 2010-07-29 2013-07-16 Basf Se Enzymatic production of an ethylenically unsaturated glycoside using polysaccharides
ES2482610T3 (es) 2010-07-29 2014-08-04 Basf Se Procedimiento de producción de glucósidos de derivados de acrilato que emplean polisacáridos y glicosidasas o glicosiltransferasas
CN103687610A (zh) 2011-05-12 2014-03-26 史密夫和内修整形外科股份公司 含有蜂蜜曲霉蛋白酶的伤口清创组合物和使用其治疗伤口的方法
US20140194803A1 (en) * 2011-07-28 2014-07-10 Regents Of The University Of Minnestoa Wound-healing compositions and method of use
EP2809341B1 (en) * 2012-02-02 2020-12-30 Galenagen, LLC Enzyme compositions and use thereof for wound healing
WO2013155476A1 (en) 2012-04-12 2013-10-17 Integrative Enzymatics, Inc. Composition and method for modulating inflammatory molecules with amylase
US20150086529A1 (en) 2013-09-26 2015-03-26 Barbara Ann Hillenbrand Therapeutic Burn Gel
US20160101166A1 (en) * 2014-10-10 2016-04-14 Rochal Industries, Llp Compositions and kits for treating pruritus and methods of using the same

Also Published As

Publication number Publication date
PT3204037T (pt) 2023-01-31
WO2016057788A1 (en) 2016-04-14
EP3204037A1 (en) 2017-08-16
DK3204037T3 (da) 2023-01-23
IL251546A (en) 2017-11-30
IL251546A0 (en) 2017-05-29
MX2017004199A (es) 2017-07-19
US20160101165A1 (en) 2016-04-14
ES2938202T3 (es) 2023-04-05
BR112017006939B1 (pt) 2023-11-28
CN107106663B (zh) 2022-12-06
AU2015330888A1 (en) 2017-04-27
UA126367C2 (uk) 2022-09-28
AU2015330888B2 (en) 2021-04-01
BR112017006939A2 (pt) 2018-01-09
CO2017003290A2 (es) 2017-06-30
JP6710862B2 (ja) 2020-06-17
SG11201702871WA (en) 2017-05-30
US9592280B2 (en) 2017-03-14
JP2017530165A (ja) 2017-10-12
EP3204037A4 (en) 2018-05-30
KR20170065551A (ko) 2017-06-13
FI3204037T3 (fi) 2023-03-01
CN107106663A (zh) 2017-08-29
KR20230075529A (ko) 2023-05-31
CA2963811A1 (en) 2016-04-14
EP3204037B1 (en) 2022-12-07
PH12017500663A1 (en) 2017-10-02

Similar Documents

Publication Publication Date Title
SA517381232B1 (ar) تركيبات وأطقم للإنضار الإنزيمي وطرق لاستخدامها
MX2018014890A (es) Composiciones de limpieza que comprenden enzimas.
NZ730769A (en) Compositions and kits for treating pruritus and methods of using the same
CO2019014682A2 (es) Composiciones y métodos para enzimas de internalización
EP3957711A3 (en) Detergent composition comprising amylase and protease variants
PH12019502279A1 (en) Cleaning compositions and uses thereof
MX2023002841A (es) Composiciones detergentes y sus usos.
WO2020070063A3 (en) Detergent compositions and uses thereof
MY202018A (en) Anti-cd39 antibodies, compositions comprising anti-cd39 antibodies and methods of using anti-cd39 antibodies
WO2018229236A3 (en) COMPOSITIONS COMPRISING BACTERIAL STRAINS
EP4234693A3 (en) Bacillus gibsonii-clade serine proteases
MX2019006421A (es) Composiciones de limpieza que incluyen enzimas.
MX2016006489A (es) Alfa-amilasas variantes que tienen susceptibilidad reducida a la escision por proteasas y metodos de uso.
MX2016001315A (es) Variantes de enzimas.
MX2016014807A (es) Singenes de alfa(1,2)fucosiltransferasa para su utilizacion en la produccion de oligosacaridos fucosilados.
MX2019009229A (es) Novedosas variantes enzimaticas que degradan la nicotina.
MY189867A (en) Solubilization of msw with blend enzymes
EP4242294A3 (en) B. amyloliquefaciens strain and therapeutic use
MX2019006422A (es) Composiciones de limpieza que incluyen enzimas.
MY202423A (en) Biosynthetic production of steviol glycoside rebaudioside d4 from rebaudioside e
NZ767856A (en) Solid enzymatic detergent compositions and methods of use and manufacture
MX2021005157A (es) Composiciones, metodos para hacer y utilizar extracto de salvado de arroz.
WO2017058003A3 (en) Method of isolating mesenchymal stromal cells and applications for tissue engineering
WO2020109233A3 (en) Trmt2a inhibitors for use in the treatment of polyglutamine diseases
UY38035A (es) Cebada con actividad enzimática hidrolitica incrementada