RU98103394A - MAGNETIC POLYMER PARTICLES BASED ON POLYVINYL ALCOHOL, METHODS FOR PRODUCING AND APPLICATION - Google Patents

MAGNETIC POLYMER PARTICLES BASED ON POLYVINYL ALCOHOL, METHODS FOR PRODUCING AND APPLICATION

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Publication number
RU98103394A
RU98103394A RU98103394/04A RU98103394A RU98103394A RU 98103394 A RU98103394 A RU 98103394A RU 98103394/04 A RU98103394/04 A RU 98103394/04A RU 98103394 A RU98103394 A RU 98103394A RU 98103394 A RU98103394 A RU 98103394A
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RU
Russia
Prior art keywords
polyvinyl alcohol
particles
polymer
phase
magnetic
Prior art date
Application number
RU98103394/04A
Other languages
Russian (ru)
Other versions
RU2160154C2 (en
Inventor
Мюллер-Шульте Детлеф
Original Assignee
Мюллер-Шульте Детлеф
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from DE19528029A external-priority patent/DE19528029B4/en
Application filed by Мюллер-Шульте Детлеф filed Critical Мюллер-Шульте Детлеф
Publication of RU98103394A publication Critical patent/RU98103394A/en
Application granted granted Critical
Publication of RU2160154C2 publication Critical patent/RU2160154C2/en

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Claims (1)

1. Способ получения гранулообразных или шарообразных частиц из поливинилового спирта, отличающийся тем, что водный раствор поливинилового спирта, в котором диспергирован магнитный коллоид, суспендируют при комнатной температуре при перемешивании в не смешивающейся с полимерной фазой органической фазе, которая содержит, по меньшей мере, два эмульгатора, и во время суспензионного процесса осуществляют сшивание добавлением водорастворимого, реагирующего с гидроксильными группами агента.1. A method of producing granular or spherical particles from polyvinyl alcohol, characterized in that the aqueous solution of polyvinyl alcohol in which the magnetic colloid is dispersed is suspended at room temperature with stirring in an organic phase which is not miscible with the polymer phase and contains at least two emulsifier, and during the suspension process, crosslinking is carried out by adding a water-soluble, hydroxyl-reactive agent. 2. Способ по п. 1, отличающийся тем, что в органической фазе растворяют 2 - 6 об.% смеси эмульгаторов, состоящей, по меньшей мере, из двух различных компонентов, из которых, по меньшей мере, один компонент является частично водорастворимым. 2. The method according to p. 1, characterized in that 2 to 6 vol.% A mixture of emulsifiers consisting of at least two different components, of which at least one component is partially water-soluble, is dissolved in the organic phase. 3. Способ по п. 1, отличающийся тем, что в полимерной фазе растворяют 0,01 - 2 вес.% одного или нескольких эмульгаторов. 3. The method according to p. 1, characterized in that 0.01 to 2 wt.% Of one or more emulsifiers are dissolved in the polymer phase. 4. Способ по п. 3, отличающийся тем, что эмульгаторы представляют собой протеины, производные целлюлозы, производные сульфокислоты, поливинилпирролидон или полиэтиленгликоли или их смеси. 4. The method according to p. 3, characterized in that the emulsifiers are proteins, cellulose derivatives, sulfonic acid derivatives, polyvinylpyrrolidone or polyethylene glycols, or mixtures thereof. 5. Способ по п. 1, отличающийся тем, что раствор полимера содержит 2,5 -12,5 вес.% поливинилового спирта. 5. The method according to p. 1, characterized in that the polymer solution contains 2.5 to 12.5 wt.% Polyvinyl alcohol. 6. Способ по пп. 1-5, отличающийся тем, что к полимерной фазе примешивают магнитный коллоид в виде ферромагнитных или суперпарамагнитных веществ. ?
7. Способ по пп. 1-6, отличающийся тем, что добавляют 2 - 7 об.% раствора сшивающего агента, в расчете на полимерную фазу.6. The method according to PP. 1-5, characterized in that the magnetic phase is mixed with a magnetic colloid in the form of ferromagnetic or superparamagnetic substances. ?
7. The method according to PP. 1-6, characterized in that add 2 to 7 vol.% Solution of a crosslinking agent, calculated on the polymer phase. 8. Способ по пп. 1-7, отличающийся тем, что сшивающий агент вводят путем добавления водорастворимых диаминов. 8. The method according to PP. 1-7, characterized in that the crosslinking agent is introduced by adding water-soluble diamines. 9. Способ по пп. 1-7, отличающийся тем, что сшивание проводят при помощи диальдегидов при добавлении 20 - 50 об.% кислоты, в расчете на полимерную фазу. 9. The method according to PP. 1-7, characterized in that the crosslinking is carried out using dialdehydes with the addition of 20 to 50 vol.% Acid, based on the polymer phase. 10. Гранулообразные или шарообразные магнитные частицы поливинилового спирта с размерами частиц 1 - 10 мкм, получаемые согласно способу по пп. 1 - 9. 10. Granular or spherical magnetic particles of polyvinyl alcohol with a particle size of 1 to 10 microns, obtained according to the method according to PP. 19. 11. Гранулообразные или шарообразные полимерные частицы по п. 10, поверхности которых имеют химически связанные полимерные цепи, отличающиеся тем, что образующие полимерные цепи виниловые мономеры содержат карбоксильные, гидроксильные, амино-, альдегидо- или оксирановые группы. 11. Granular or spherical polymer particles according to claim 10, the surfaces of which have chemically bonded polymer chains, characterized in that the vinyl chain-forming polymer monomers contain carboxyl, hydroxyl, amino, aldehyde or oxirane groups. 12. Магнитные частицы по пп. 10 и 11, отличающиеся тем, что на поверхности полимерных частиц имеются реактивные группы, связывающиеся с биомолекулами. 12. Magnetic particles according to claims. 10 and 11, characterized in that on the surface of the polymer particles there are reactive groups that bind to biomolecules. 13. Гранулообразные частицы поливинилового спирта по п. 12, отличающиеся тем, что связывающиеся группы вводятся во взаимодействие с антителами, пептидами, протеинами, энзимами, стрептавидином, авидином, олигонуклеотидами или ДНК-фрагментами. 13. The granular particles of polyvinyl alcohol according to claim 12, characterized in that the binding groups are introduced into interaction with antibodies, peptides, proteins, enzymes, streptavidin, avidin, oligonucleotides or DNA fragments. 14. Применение частиц поливинилового спирта по пп. 10-13 для фракционирования клеток, нуклеиновых кислот, протеинов, вирусов или бактерий. 14. The use of particles of polyvinyl alcohol according to paragraphs. 10-13 for fractionating cells, nucleic acids, proteins, viruses or bacteria. 15. Применение частиц поливинилового спирта по пп. 10-13 для иммуноанализа, для ДНК-последовательности или ДНК-синтеза. 15. The use of particles of polyvinyl alcohol according to paragraphs. 10-13 for immunoassay, for DNA sequence or DNA synthesis.
RU98103394/04A 1995-07-31 1996-06-03 Magnetic polymer particle based on polyvinyl alcohol, and method of preparing thereof RU2160154C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19528029A DE19528029B4 (en) 1995-07-31 1995-07-31 Magnetic polymer particles based on polyvinyl alcohol, process for their preparation and use
DE19528029.6 1995-07-31

Publications (2)

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RU98103394A true RU98103394A (en) 2000-01-27
RU2160154C2 RU2160154C2 (en) 2000-12-10

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US (2) US6204033B1 (en)
EP (1) EP0843591B1 (en)
JP (1) JP3164585B2 (en)
KR (1) KR100355006B1 (en)
CN (1) CN1104276C (en)
AT (1) ATE199503T1 (en)
AU (1) AU717433B2 (en)
CA (1) CA2227608C (en)
DE (2) DE19528029B4 (en)
DK (1) DK0843591T3 (en)
ES (1) ES2157443T3 (en)
GR (1) GR3035993T3 (en)
IL (1) IL123061A (en)
PT (1) PT843591E (en)
RU (1) RU2160154C2 (en)
WO (1) WO1997004862A1 (en)

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