RU98102450A - Способ эпидурального введения терапевтических соединений с поддерживаемой скоростью высвобождения, способ уменьшения угнетения дыхания - Google Patents
Способ эпидурального введения терапевтических соединений с поддерживаемой скоростью высвобождения, способ уменьшения угнетения дыханияInfo
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- RU98102450A RU98102450A RU98102450/14A RU98102450A RU98102450A RU 98102450 A RU98102450 A RU 98102450A RU 98102450/14 A RU98102450/14 A RU 98102450/14A RU 98102450 A RU98102450 A RU 98102450A RU 98102450 A RU98102450 A RU 98102450A
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- delivery system
- drug delivery
- therapeutic compound
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- compound
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Links
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- 230000001225 therapeutic Effects 0.000 title claims 10
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- 239000002552 dosage form Substances 0.000 claims 5
- 239000002502 liposome Substances 0.000 claims 5
- OROGSEYTTFOCAN-DNJOTXNNSA-N Codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 4
- 239000011159 matrix material Substances 0.000 claims 4
- 230000003364 opioid Effects 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 229960004715 Morphine Sulfate Drugs 0.000 claims 3
- 230000000202 analgesic Effects 0.000 claims 3
- GRVOTVYEFDAHCL-RTSZDRIGSA-N morphine sulfate pentahydrate Chemical compound O.O.O.O.O.OS(O)(=O)=O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O GRVOTVYEFDAHCL-RTSZDRIGSA-N 0.000 claims 3
- 239000003076 neurotropic agent Substances 0.000 claims 3
- IFKLAQQSCNILHL-QHAWAJNXSA-N Butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 claims 2
- 229960001113 Butorphanol Drugs 0.000 claims 2
- PJMPHNIQZUBGLI-UHFFFAOYSA-N Fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 2
- 229960002428 Fentanyl Drugs 0.000 claims 2
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 2
- LLPOLZWFYMWNKH-CMKMFDCUSA-N Hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims 2
- WVLOADHCBXTIJK-YNHQPCIGSA-N Hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 2
- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims 2
- 229960003406 Levorphanol Drugs 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- USSIQXCVUWKGNF-UHFFFAOYSA-N Methadone Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 2
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycontin Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 2
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims 2
- 229960004739 Sufentanil Drugs 0.000 claims 2
- VOKSWYLNZZRQPF-UHFFFAOYSA-N Talwin Chemical compound C1C2=CC=C(O)C=C2C2(C)C(C)C1N(CC=C(C)C)CC2 VOKSWYLNZZRQPF-UHFFFAOYSA-N 0.000 claims 2
- RMRJXGBAOAMLHD-CTAPUXPBSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-CTAPUXPBSA-N 0.000 claims 2
- 229960001736 buprenorphine Drugs 0.000 claims 2
- 229960004126 codeine Drugs 0.000 claims 2
- 229960002069 diamorphine Drugs 0.000 claims 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims 2
- 229960000240 hydrocodone Drugs 0.000 claims 2
- 229960001410 hydromorphone Drugs 0.000 claims 2
- 229960001797 methadone Drugs 0.000 claims 2
- -1 nalbupine Chemical compound 0.000 claims 2
- 239000003401 opiate antagonist Substances 0.000 claims 2
- 229960002085 oxycodone Drugs 0.000 claims 2
- 229960005118 oxymorphone Drugs 0.000 claims 2
- 229960005301 pentazocine Drugs 0.000 claims 2
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 claims 2
- 230000002459 sustained Effects 0.000 claims 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims 1
- 229960001391 Alfentanil Drugs 0.000 claims 1
- 108010049140 Endorphins Proteins 0.000 claims 1
- 102000009025 Endorphins Human genes 0.000 claims 1
- 108010092674 Enkephalins Proteins 0.000 claims 1
- UCTWMZQNUQWSLP-VIFPVBQESA-N Epinephrine Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N GABA Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 1
- 102000014429 Insulin-like growth factor Human genes 0.000 claims 1
- 108050003490 Insulin-like growth factor Proteins 0.000 claims 1
- SFLSHLFXELFNJZ-MRVPVSSYSA-N L-Noradrenaline Natural products NC[C@@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-MRVPVSSYSA-N 0.000 claims 1
- IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical compound C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 claims 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N Naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims 1
- 229960004127 Naloxone Drugs 0.000 claims 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N Naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims 1
- 229960003086 Naltrexone Drugs 0.000 claims 1
- ALWKGYPQUAPLQC-UHFFFAOYSA-N Neostigmine Chemical compound CN(C)C(=O)OC1=CC=CC([N+](C)(C)C)=C1 ALWKGYPQUAPLQC-UHFFFAOYSA-N 0.000 claims 1
- 229960002362 Neostigmine Drugs 0.000 claims 1
- 102000007072 Nerve Growth Factors Human genes 0.000 claims 1
- 108010008267 Nerve Growth Factors Proteins 0.000 claims 1
- 229960002748 Norepinephrine Drugs 0.000 claims 1
- 239000004952 Polyamide Substances 0.000 claims 1
- 229920000954 Polyglycolide Polymers 0.000 claims 1
- 206010038678 Respiratory depression Diseases 0.000 claims 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
- 229960003692 aminobutyric acid Drugs 0.000 claims 1
- 230000000975 bioactive Effects 0.000 claims 1
- 230000001886 ciliary Effects 0.000 claims 1
- 229960003638 dopamine Drugs 0.000 claims 1
- 229960005139 epinephrine Drugs 0.000 claims 1
- 229940013945 gamma-Aminobutyric Acid Drugs 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 229920000747 poly(lactic acid) polymer Polymers 0.000 claims 1
- 229920002647 polyamide Polymers 0.000 claims 1
- 239000011528 polyamide (building material) Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
Claims (33)
1. Способ эпидурального введения терапевтического соединения позвоночному, включающий инкапсулирование соединения в системе доставки лекарственного средства, имеющей поддерживаемую скорость высвобождения соединения, и эпидуральное введение системы доставки лекарственного средства позвоночному.
2. Способ по п. 1, в котором позвоночное является млекопитающим.
3. Способ по п. 2, в котором млекопитающее является человеком.
4. Способ по п. 1, в котором систему доставки вводят в виде разовой дозы.
5. Способ по п. 1, в котором система доставки лекарственного средства является дисперсной системой.
6. Способ по п. 5, в котором система доставки лекарственного средства содержит лекарственную форму на липидной основе.
7. Способ по п. 5, в котором система доставки лекарственного средства содержит липосомную лекарственную форму.
8. Способ по п. 5, в котором система доставки лекарственного средства содержит мультивезикулярную липосомную лекарственную форму.
9. Способ по п. 7 или 8, в котором терапевтическое соединение является опиоидом.
10. Способ по п. 7 или 8, в котором терапевтическое соединение является пептидом или пептидомиметиком.
11. Способ по п. 9, в котором терапевтическое соединение является морфинсульфатом.
12. Способ по п. 9, в котором терапевтическое соединение является гидроморфоном.
13. Способ по п. 7 или 8, в котором терапевтическое соединение выбирают из группы, состоящей из кодеина, гидрокодона, леворфанола, оксикодона, оксиморфона, диацетилморфина, бупренорфина, налбупина, буторфанола, пентазоцина, метадона, фентанила, суфентанила и алфентанила.
14. Способ по п. 7 или 8, в котором терапевтическое соединение выбирают из группы, состоящей из энкефалинов, эндорфинов, касоморфина, киоторфина и их биоактивных фрагментов.
15. Способ по п. 7 или 8, в котором терапевтическое соединение является антагонистом опиата.
16. Способ по п. 15, в котором антагонист опиата выбирают из группы, состоящей из налоксона и налтрексона.
17. Способ по п. 7 или 8, в котором терапевтическое соединение является нейротропным фактором.
18. Способ по п. 17, в котором нейротропный фактор выбирают из группы, состоящей из инсулиноподобного фактора роста, реснитчатого нейротропного фактора, факторов роста нервов, допамина, эпинефрина, норепинефрина, гамма-аминомасляной кислоты и неостигмина.
19. Способ по п. 1, в котором систему доставки лекарственного средства вводят через эпидуральный катетер.
20. Способ по п. 19, в котором эпидуральный катетер вставляют вниз из цервикальной области.
21. Способ по п. 1, в котором систему доставки лекарственного средства вводят через иглу для подкожных инъекций, вставленную в эпидуральное пространство.
22. Способ уменьшения угнетения дыхания у пациента, которому введено анальгезирующее соединение, включающий эпидуральное введение пациенту разовой дозы анальгезирующего соединения, инкапсулированного в липосомную лекарственную форму с длительным высвобождением.
23. Способ по п. 22, в котором липосомная лекарственная форма содержит мультивезикулярные липосомы.
24. Способ по п. 23, в котором анальгезирующее соединение является опиоидом.
25. Способ по п. 24, в котором опиоид является морфинсульфатом.
26. Способ по п. 24, в котором опиоид выбирают из группы, состоящей из гидроморфона, кодеина, гидрокодона, леворфанола, оксикодона, оксиморфона, диацетилморфина, бупренорфина, налбупина, буторфанола, пентазоцина, метадона, фентанила, суфентанила и алфентанила.
27. Способ по п. 25, в котором доза содержит от примерно 1 до 60 мг морфинсульфата.
28. Способ по п. 1, в котором система доставки лекарственного средства содержит полимерную матрицу.
29. Способ по п. 28, в котором система доставки лекарственного средства является недисперсной.
30. Способ по п. 28, в котором полимерную матрицу выбирают из группы, состоящей из полилактида, полигликолида, сложного полиэфира, полиуретана, полиамида и их комбинаций.
31. Способ по п. 29, в котором полимерная матрица находится в форме, выбранной из группы, состоящей из сферы, цилиндра и пластины.
32. Способ по п. 28, в котором система доставки лекарственного средства является дисперсной системой.
33. Способ по п. 32, в котором полимерная матрица находится в виде микросфер.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/502,569 US5931809A (en) | 1995-07-14 | 1995-07-14 | Epidural administration of therapeutic compounds with sustained rate of release |
| US08/502,569 | 1995-07-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU98102450A true RU98102450A (ru) | 2000-01-27 |
| RU2215522C2 RU2215522C2 (ru) | 2003-11-10 |
Family
ID=23998405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU98102450/14A RU2215522C2 (ru) | 1995-07-14 | 1996-07-12 | Способ эпидурального введения терапевтических соединений с поддерживаемой скоростью высвобождения, способ уменьшения угнетения дыхания |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US5931809A (ru) |
| EP (2) | EP0839027A4 (ru) |
| JP (4) | JP4592119B2 (ru) |
| KR (2) | KR20060012027A (ru) |
| CN (1) | CN1085944C (ru) |
| AU (1) | AU699177B2 (ru) |
| BR (1) | BR9609717A (ru) |
| CA (1) | CA2226870C (ru) |
| HK (1) | HK1014881A1 (ru) |
| NO (1) | NO326261B1 (ru) |
| NZ (1) | NZ312963A (ru) |
| RU (1) | RU2215522C2 (ru) |
| WO (1) | WO1997003652A1 (ru) |
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- 1996-07-12 RU RU98102450/14A patent/RU2215522C2/ru not_active IP Right Cessation
- 1996-07-12 WO PCT/US1996/011642 patent/WO1997003652A1/en not_active Application Discontinuation
- 1996-07-12 EP EP96924471A patent/EP0839027A4/en not_active Ceased
- 1996-07-12 EP EP08017456.8A patent/EP2036542B1/en not_active Expired - Lifetime
- 1996-07-12 NZ NZ312963A patent/NZ312963A/xx not_active IP Right Cessation
- 1996-07-12 KR KR1019980700208A patent/KR100593722B1/ko not_active IP Right Cessation
- 1996-07-12 AU AU64911/96A patent/AU699177B2/en not_active Ceased
- 1996-07-12 JP JP50535497A patent/JP4592119B2/ja not_active Expired - Lifetime
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1997
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1998
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1999
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