RU95107652A - Алкилированные аминоалканимидазолы и триазолы, способ их получения и содержащий их фармацевтический состав - Google Patents

Алкилированные аминоалканимидазолы и триазолы, способ их получения и содержащий их фармацевтический состав

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Publication number
RU95107652A
RU95107652A RU95107652/04A RU95107652A RU95107652A RU 95107652 A RU95107652 A RU 95107652A RU 95107652/04 A RU95107652/04 A RU 95107652/04A RU 95107652 A RU95107652 A RU 95107652A RU 95107652 A RU95107652 A RU 95107652A
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Prior art keywords
compounds
aminoalkaneimidazoles
triazoles
acylated
preparing
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RU95107652/04A
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English (en)
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RU2152933C2 (ru
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Ингеборг Шустер
At]
Хельмут Эггер
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Сандоз Лтд. (CH)
Сандоз Лтд.
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Publication of RU95107652A publication Critical patent/RU95107652A/ru
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Publication of RU2152933C2 publication Critical patent/RU2152933C2/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Lubricants (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение предусматривает азольные соединения, отвечающие формуле Iв которой указанные заместители имеют различное значение, находящиеся в свободной форме или в форме соли. Указанные соединения могут быть получены, например, путем ацилирования или раскрытия азиридинового или оксазольного кольца, их можно использовать в качестве фармацевтических средств, особенно в качестве избирательных ингибиторов 25-гидроксивитамина D3 при лечении заболеваний, связанных с пролиферацией и дифференцировкой тканей, зависимых от витамина D.

Claims (1)

  1. Изобретение предусматривает азольные соединения, отвечающие формуле I
    Figure 00000001

    в которой указанные заместители имеют различное значение, находящиеся в свободной форме или в форме соли. Указанные соединения могут быть получены, например, путем ацилирования или раскрытия азиридинового или оксазольного кольца, их можно использовать в качестве фармацевтических средств, особенно в качестве избирательных ингибиторов 25-гидроксивитамина D3 при лечении заболеваний, связанных с пролиферацией и дифференцировкой тканей, зависимых от витамина D.
RU95107652/04A 1994-05-18 1995-05-16 Ацилированные аминоалкилимидазолы, способ их получения и фармацевтическая композиция RU2152933C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9409882.9 1994-05-18
GB9409882A GB9409882D0 (en) 1994-05-18 1994-05-18 Organic compounds

Publications (2)

Publication Number Publication Date
RU95107652A true RU95107652A (ru) 1997-03-20
RU2152933C2 RU2152933C2 (ru) 2000-07-20

Family

ID=10755289

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95107652/04A RU2152933C2 (ru) 1994-05-18 1995-05-16 Ацилированные аминоалкилимидазолы, способ их получения и фармацевтическая композиция

Country Status (30)

Country Link
US (1) US5622982A (ru)
EP (1) EP0683156B1 (ru)
JP (1) JP2912566B2 (ru)
KR (1) KR100371465B1 (ru)
CN (1) CN1060163C (ru)
AT (1) ATE164576T1 (ru)
AU (1) AU696880B2 (ru)
BR (1) BR9502062A (ru)
CA (1) CA2149459C (ru)
CO (1) CO4290423A1 (ru)
CZ (1) CZ285385B6 (ru)
DE (1) DE69501915T2 (ru)
DK (1) DK0683156T3 (ru)
ES (1) ES2114289T3 (ru)
FI (1) FI112364B (ru)
GB (1) GB9409882D0 (ru)
GR (1) GR3026505T3 (ru)
HK (1) HK1008743A1 (ru)
HU (1) HUT72063A (ru)
IL (1) IL113743A (ru)
MY (1) MY135559A (ru)
NO (1) NO304738B1 (ru)
NZ (1) NZ272129A (ru)
PE (1) PE14896A1 (ru)
PH (1) PH31510A (ru)
RU (1) RU2152933C2 (ru)
SI (1) SI0683156T1 (ru)
SK (1) SK280326B6 (ru)
TW (1) TW351718B (ru)
ZA (1) ZA954074B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869499A (en) * 1993-07-15 1999-02-09 Pfizer Inc Benzyloxyquinuclidines as substance P antagonists
US6162801A (en) * 1995-11-20 2000-12-19 Kita; Kiyoshi External ophthalmic preparation containing vitamin D
WO1998053806A1 (fr) * 1997-05-26 1998-12-03 New Vision Co., Ltd. Compositions medicinales a administration topique renfermant les vitamines d et les vitamines k
US6034251A (en) * 1997-11-07 2000-03-07 Schering Corporation Phenyl-alkyl-imidazoles
TW575562B (en) * 1998-02-19 2004-02-11 Agrevo Uk Ltd Fungicides
IL129596A (en) * 1998-05-08 2003-10-31 Dow Agrosciences Llc Preparation of 2-substituted pyridines
GB0029524D0 (en) * 2000-12-04 2001-01-17 Univ Sheffield Disease treatment
GB0128415D0 (en) * 2001-11-27 2002-01-16 Univ Sheffield Medicaments
US7429604B2 (en) * 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
WO2006036892A2 (en) * 2004-09-24 2006-04-06 Sapphire Therapeutics, Inc. Use of inhibitors of 24-hydroxylase in the treatment of cancer
WO2006032299A1 (en) * 2004-09-24 2006-03-30 Susanna Miettinen Use of inhibitors of 24-hydroxylase in the treatment of cancer
CN104530038A (zh) * 2014-12-10 2015-04-22 沈阳药科大学 酰胺咪唑类衍生物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2041771C3 (de) * 1970-08-22 1979-07-26 Bayer Ag, 5090 Leverkusen derivate
US4191767A (en) * 1977-01-07 1980-03-04 Westwood Pharmaceuticals, Inc. Method for treating fungal infection in mammals with imidazo [1,2-a]quinoxalines
CH655103A5 (de) * 1983-03-11 1986-03-27 Sandoz Ag Azolderivate, verfahren zu ihrer herstellung und ihre verwendung.
CH677925A5 (ru) * 1986-12-03 1991-07-15 Sandoz Ag

Also Published As

Publication number Publication date
SK63595A3 (en) 1995-12-06
GR3026505T3 (en) 1998-07-31
NZ272129A (en) 1996-05-28
CZ126595A3 (en) 1995-11-15
DE69501915T2 (de) 1998-08-27
NO951944D0 (no) 1995-05-16
AU696880B2 (en) 1998-09-24
IL113743A (en) 1999-08-17
FI952383A0 (fi) 1995-05-16
MY135559A (en) 2008-05-30
JPH0853422A (ja) 1996-02-27
KR950032147A (ko) 1995-12-20
NO304738B1 (no) 1999-02-08
PE14896A1 (es) 1996-05-09
HUT72063A (en) 1996-03-28
CA2149459C (en) 2006-09-19
EP0683156A1 (en) 1995-11-22
SI0683156T1 (en) 1998-06-30
RU2152933C2 (ru) 2000-07-20
AU2008995A (en) 1995-11-23
CA2149459A1 (en) 1995-11-19
NO951944L (no) 1995-11-20
JP2912566B2 (ja) 1999-06-28
TW351718B (en) 1999-02-01
DK0683156T3 (da) 1998-10-19
FI952383A (fi) 1995-11-19
HK1008743A1 (en) 1999-05-14
CZ285385B6 (cs) 1999-07-14
CO4290423A1 (es) 1996-04-17
PH31510A (en) 1998-11-03
DE69501915D1 (de) 1998-05-07
FI112364B (fi) 2003-11-28
CN1060163C (zh) 2001-01-03
KR100371465B1 (ko) 2003-03-19
ATE164576T1 (de) 1998-04-15
SK280326B6 (sk) 1999-11-08
EP0683156B1 (en) 1998-04-01
ZA954074B (en) 1996-11-18
GB9409882D0 (en) 1994-07-06
HU9501451D0 (en) 1995-06-28
CN1120039A (zh) 1996-04-10
BR9502062A (pt) 1996-04-30
ES2114289T3 (es) 1998-05-16
US5622982A (en) 1997-04-22
IL113743A0 (en) 1995-08-31

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Effective date: 20110517