RU95106947A - Производные 1-стирилизохинолина, лекарственные средства на их основе, способ их получения и применения - Google Patents

Производные 1-стирилизохинолина, лекарственные средства на их основе, способ их получения и применения

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Publication number
RU95106947A
RU95106947A RU95106947/04A RU95106947A RU95106947A RU 95106947 A RU95106947 A RU 95106947A RU 95106947/04 A RU95106947/04 A RU 95106947/04A RU 95106947 A RU95106947 A RU 95106947A RU 95106947 A RU95106947 A RU 95106947A
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RU
Russia
Prior art keywords
general formula
compounds
lower alkyl
hydrogen
heteroaryl
Prior art date
Application number
RU95106947/04A
Other languages
English (en)
Inventor
Гиула Балог
Hu]
Имре Доман
Габор Власко
Гиула Симиг
Ерзсебет Ковач
Иштван Гиертиан
Андрес Егиед
Иштван Гачалии
Андрес Билекей-Горзо
Каталин Паллаги
Каталин Сземереди
Клара Казо
Original Assignee
Егис Гиогисзергуар Р.Т. (HU)
Егис Гиогисзергуар Р.Т.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Егис Гиогисзергуар Р.Т. (HU), Егис Гиогисзергуар Р.Т. filed Critical Егис Гиогисзергуар Р.Т. (HU)
Publication of RU95106947A publication Critical patent/RU95106947A/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Изобретение относится к лекарственным средствам, обладающим анксиолитическим действием и содержащим в качестве активного вещества производные 1-стирилизохинолина общей формулы In = 1,2,3 или 4 R может иметь одинаковые или разные значения и представлять водород, низший алкил, низший алкоксил или гидроксил, либо два заместителя R, связанные с соседними атомами углерода, могут образовывать в сочетании друг с другом алкилендиоксигруппу; R- водород или низший алкил, Ar - возможно замещенный арил или гетероарил. Изобретение также предлагает способ получения новых соединений общей формулы I, при котором осуществляют взаимодействие соединения общей формулы IIс альдегидом общей формулы III Ar-CHO , где Ar - возможно замещенный арил или гетероарил, в присутствии конденсирующего агента или кислотного катализатора.

Claims (1)

  1. Изобретение относится к лекарственным средствам, обладающим анксиолитическим действием и содержащим в качестве активного вещества производные 1-стирилизохинолина общей формулы I
    Figure 00000001

    n = 1,2,3 или 4 R может иметь одинаковые или разные значения и представлять водород, низший алкил, низший алкоксил или гидроксил, либо два заместителя R, связанные с соседними атомами углерода, могут образовывать в сочетании друг с другом алкилендиоксигруппу; R1 - водород или низший алкил, Ar - возможно замещенный арил или гетероарил. Изобретение также предлагает способ получения новых соединений общей формулы I, при котором осуществляют взаимодействие соединения общей формулы II
    Figure 00000002

    с альдегидом общей формулы III Ar-CHO , где Ar - возможно замещенный арил или гетероарил, в присутствии конденсирующего агента или кислотного катализатора.
RU95106947/04A 1994-05-03 1995-04-28 Производные 1-стирилизохинолина, лекарственные средства на их основе, способ их получения и применения RU95106947A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9401281A HUT71407A (en) 1994-05-03 1994-05-03 Heterocyclic compounds, pharmaceutical compositions containing them, and process for producing the active components
HUP9401281 1994-05-03

Publications (1)

Publication Number Publication Date
RU95106947A true RU95106947A (ru) 1997-03-10

Family

ID=10985144

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95106947/04A RU95106947A (ru) 1994-05-03 1995-04-28 Производные 1-стирилизохинолина, лекарственные средства на их основе, способ их получения и применения

Country Status (14)

Country Link
US (1) US5889018A (ru)
EP (1) EP0680953A1 (ru)
JP (1) JPH0848670A (ru)
KR (1) KR950032131A (ru)
CA (1) CA2148412A1 (ru)
CZ (1) CZ109195A3 (ru)
FR (1) FR2719586B1 (ru)
HR (1) HRP950267A2 (ru)
HU (1) HUT71407A (ru)
IT (1) IT1273613B (ru)
PL (1) PL308417A1 (ru)
RU (1) RU95106947A (ru)
SK (1) SK54595A3 (ru)
YU (1) YU27895A (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK1212002A3 (en) * 1999-07-29 2002-11-06 Egyt Gyogyszervegyeszeti Gyar Isoquinoline derivatives, pharmaceutical compositions containing the same, and a process for the preparation of the active substance
CN107434781A (zh) * 2016-05-27 2017-12-05 河南工业大学 一种1-烯基-异喹啉衍生物的制备方法及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE576532C (de) * 1930-11-28 1933-05-17 C H Boehringer Sohn A G Verfahren zur Darstellung von Isochinolinabkoemmlingen
DE1902402A1 (de) * 1968-05-21 1969-11-27 Dresden Arzneimittel Verfahren zur Herstellung von 1-substituierten 6.7-Dimethoxy-isochinolinen
JPS62145049A (ja) * 1985-12-18 1987-06-29 Mitsubishi Chem Ind Ltd アミノスチリル化合物及びそれを有効成分とするロイコトリエンきつ抗剤

Also Published As

Publication number Publication date
US5889018A (en) 1999-03-30
ITMI950880A1 (it) 1996-11-03
CZ109195A3 (en) 1996-02-14
SK54595A3 (en) 1995-11-08
YU27895A (sh) 1998-07-10
FR2719586A1 (fr) 1995-11-10
IT1273613B (it) 1997-07-08
HU9401281D0 (en) 1994-08-29
ITMI950880A0 (it) 1995-05-03
HRP950267A2 (en) 1997-08-31
JPH0848670A (ja) 1996-02-20
HUT71407A (en) 1995-11-28
KR950032131A (ko) 1995-12-20
FR2719586B1 (fr) 1998-01-02
PL308417A1 (en) 1995-11-13
CA2148412A1 (en) 1995-11-04
EP0680953A1 (en) 1995-11-08

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