RU94031210A - Новые простые эфиры на основе бутилированного гидрокси толуола, их получение, фармацевтическая композиция и способ лечения липидемии и атеросклероза - Google Patents
Новые простые эфиры на основе бутилированного гидрокси толуола, их получение, фармацевтическая композиция и способ лечения липидемии и атеросклерозаInfo
- Publication number
- RU94031210A RU94031210A RU94031210/04A RU94031210A RU94031210A RU 94031210 A RU94031210 A RU 94031210A RU 94031210/04 A RU94031210/04 A RU 94031210/04A RU 94031210 A RU94031210 A RU 94031210A RU 94031210 A RU94031210 A RU 94031210A
- Authority
- RU
- Russia
- Prior art keywords
- atherosclerosis
- toluena
- bottled
- hydroxy
- recovery
- Prior art date
Links
- 206010003210 Arteriosclerosis Diseases 0.000 title claims 2
- 201000001320 atherosclerosis Diseases 0.000 title claims 2
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- -1 HYDROXY Chemical class 0.000 title 1
- 150000002170 ethers Chemical class 0.000 title 1
- 238000011084 recovery Methods 0.000 title 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
- Предложены фармацевтически активные БГТ--ω-пиридиловые эфиры формулы I
где
m = 1, 3, причем при m = 1 Σ = 6-9, а при m = 3 S = 5-11, сумма S = [m + n + 1 (для кислорода)], где связь между двумя атомами углерода фрагмента (CH<Mv>p<D>)<Mv>n<D>, соседнего с пиридиновым кольцом, является простой, двойной или тройной, а величина p принимает значения О, 1 или 2 в зависимости от типа связи, и их фармацевтически приемлемые кислотно-аддитивные соли, фармацевтические композиции на их основе и способ лечения липидемии и атеросклероза с их использованием.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/810,214 US5254549A (en) | 1991-12-19 | 1991-12-19 | New BHT ether compounds and their use as hypolipidemic and antiatherosclerotic drugs |
| US810,214 | 1991-12-19 | ||
| US810214 | 1991-12-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94031210A true RU94031210A (ru) | 1996-03-20 |
| RU2120938C1 RU2120938C1 (ru) | 1998-10-27 |
Family
ID=25203281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94031210A RU2120938C1 (ru) | 1991-12-19 | 1992-12-18 | ω- ПИРИДИЛОВЫЕ ЭФИРЫ БУТИЛИРОВАННОГО ГИДРОКСИТОЛУОЛА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЛЕЧЕНИЯ ГИПЕРЛИПИДЕМИИ И АТЕРОСКЛЕРОЗА |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5254549A (ru) |
| EP (1) | EP0619807A1 (ru) |
| JP (1) | JPH07502271A (ru) |
| AU (1) | AU662193B2 (ru) |
| CA (1) | CA2085687A1 (ru) |
| CZ (1) | CZ283456B6 (ru) |
| FI (1) | FI942908A0 (ru) |
| HU (1) | HU215844B (ru) |
| IL (1) | IL104123A (ru) |
| MX (1) | MX9207427A (ru) |
| NO (1) | NO301473B1 (ru) |
| PL (1) | PL171225B1 (ru) |
| RU (1) | RU2120938C1 (ru) |
| TW (1) | TW221289B (ru) |
| WO (1) | WO1993012089A1 (ru) |
| ZA (1) | ZA929867B (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5677291A (en) * | 1993-12-10 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols |
| US5627172A (en) * | 1994-03-04 | 1997-05-06 | Natural Supplement Association, Incorporated | Method for reduction of serum blood lipids or lipoprotein fraction |
| US5795876A (en) * | 1996-04-30 | 1998-08-18 | Hoechst Marion Rousssel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols |
| US5608095A (en) * | 1996-04-30 | 1997-03-04 | Hoechst Marion Roussel, Inc. | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
| US6114572A (en) * | 1996-11-20 | 2000-09-05 | Hoechst Marion Roussel, Inc. | Substituted phenols and thiophenols useful as antioxidant agents |
| US6121463A (en) * | 1997-06-24 | 2000-09-19 | Hoechst Marion Roussel, Inc. | Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents |
| US6133467A (en) * | 1997-06-25 | 2000-10-17 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol |
| US6475526B1 (en) | 2001-06-05 | 2002-11-05 | Jeffrey B. Smith | Zinc containing compositions for anti-viral use |
| US20080274209A1 (en) * | 2002-11-04 | 2008-11-06 | Integritas Pharma, Inc. | Methods of treating inflammation |
| US6855341B2 (en) * | 2002-11-04 | 2005-02-15 | Jeffrey B. Smith | Anti-viral compositions and methods of making and using the anti-viral compositions |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE271625C (ru) * | ||||
| JPS52125170A (en) * | 1976-04-12 | 1977-10-20 | Yoshitomi Pharmaceut Ind Ltd | Pyridine derivatives |
| DE3431004A1 (de) * | 1984-08-23 | 1986-03-06 | Hoechst Ag, 6230 Frankfurt | Neue 3-pyridylverbindungen und verfahren zu ihrer herstellung |
-
1991
- 1991-12-19 US US07/810,214 patent/US5254549A/en not_active Expired - Fee Related
-
1992
- 1992-12-17 IL IL10412392A patent/IL104123A/en not_active IP Right Cessation
- 1992-12-17 CA CA002085687A patent/CA2085687A1/en not_active Abandoned
- 1992-12-17 TW TW081110130A patent/TW221289B/zh active
- 1992-12-18 JP JP5510638A patent/JPH07502271A/ja active Pending
- 1992-12-18 PL PL92304175A patent/PL171225B1/pl unknown
- 1992-12-18 HU HUP9401820A patent/HU215844B/hu not_active IP Right Cessation
- 1992-12-18 RU RU94031210A patent/RU2120938C1/ru active
- 1992-12-18 ZA ZA929867A patent/ZA929867B/xx unknown
- 1992-12-18 EP EP93900104A patent/EP0619807A1/en not_active Ceased
- 1992-12-18 WO PCT/EP1992/002946 patent/WO1993012089A1/en not_active Application Discontinuation
- 1992-12-18 CZ CZ941352A patent/CZ283456B6/cs not_active IP Right Cessation
- 1992-12-18 AU AU31592/93A patent/AU662193B2/en not_active Ceased
- 1992-12-18 MX MX9207427A patent/MX9207427A/es not_active IP Right Cessation
-
1994
- 1994-06-17 NO NO942307A patent/NO301473B1/no unknown
- 1994-06-17 FI FI942908A patent/FI942908A0/fi unknown
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