RU94018240A - Способ получения антимикробных хинолониллактамов - Google Patents
Способ получения антимикробных хинолониллактамовInfo
- Publication number
- RU94018240A RU94018240A RU94018240/04A RU94018240A RU94018240A RU 94018240 A RU94018240 A RU 94018240A RU 94018240/04 A RU94018240/04 A RU 94018240/04A RU 94018240 A RU94018240 A RU 94018240A RU 94018240 A RU94018240 A RU 94018240A
- Authority
- RU
- Russia
- Prior art keywords
- lactam
- binding
- steps
- moiety
- quinolone
- Prior art date
Links
- 230000000845 anti-microbial Effects 0.000 title claims 2
- 239000004599 antimicrobial Substances 0.000 title 1
- -1 lactam compound Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 3
- 125000003460 beta-lactamyl group Chemical group 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 1
- 125000000687 hydroquinonyl group Chemical class C1(O)=C(C=C(O)C=C1)* 0.000 claims 1
- 150000003951 lactams Chemical class 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- HHXMXAQDOUCLDN-RXMQYKEDSA-N penem Chemical compound S1C=CN2C(=O)C[C@H]21 HHXMXAQDOUCLDN-RXMQYKEDSA-N 0.000 claims 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2(1H)-one Chemical group C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 1
Claims (1)
- Настоящее изобретение представляет способы получения соединений со структурой (Q - L1) - L -(L2 - B), где Q является хинолоновой составляющей, B является беталактамной составляющей, L, L1 и L2 вместе включают карбамат-содержащую связывающую часть, включающие стадии: реагирования лактамного соединения с формулой B - L4-C(=O)-CI, где L4является кислородом, и связывания указанного промежуточного соединения с хинолоновым соединением с формулой Q - L3 - R4 4, где L3 является азотом, R4 4 является водородом, Si (R4 5)3, или Sn (R4 5)3, R4 5 является низшим алкилом. Предпочтительно процесс дополнительно включает стадии, предшествующие стадиям реагирования и связывания, где получаются сложные эфиры лактамного и хинолового соединений. Также предпочтительно стадия связывания включает добавление раствора, содержащего хинолоновое соединение, к раствору, содержащему промежуточное соединение. Стадии процесса также предпочтительно осуществляются при температуре от примерно -80°С до примерно 0°С. Предпочтительными антимикробными соединениями, получаемыми с помощью этих процессов, являются те, где беталактамная составляющая является пенемом.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76961591A | 1991-10-01 | 1991-10-01 | |
US769.615 | 1991-10-01 | ||
US769615 | 1991-10-01 | ||
PCT/US1992/008246 WO1993007154A1 (en) | 1991-10-01 | 1992-09-28 | Process for making antimicrobial quinolonyl lactams |
Publications (2)
Publication Number | Publication Date |
---|---|
RU94018240A true RU94018240A (ru) | 1995-11-10 |
RU2130938C1 RU2130938C1 (ru) | 1999-05-27 |
Family
ID=25085987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94018240A RU2130938C1 (ru) | 1991-10-01 | 1992-09-28 | Способ получения хинолиниллактамов или их солей |
Country Status (22)
Country | Link |
---|---|
US (1) | US5281703A (ru) |
EP (1) | EP0606336B1 (ru) |
KR (1) | KR100253825B1 (ru) |
CN (1) | CN1046523C (ru) |
AT (1) | ATE150463T1 (ru) |
AU (1) | AU667837B2 (ru) |
BR (1) | BR9206590A (ru) |
CA (1) | CA2120493A1 (ru) |
CZ (1) | CZ73194A3 (ru) |
DE (1) | DE69218445T2 (ru) |
DK (1) | DK0606336T3 (ru) |
ES (1) | ES2101119T3 (ru) |
FI (1) | FI941490A (ru) |
GR (1) | GR3023227T3 (ru) |
HU (1) | HUT67423A (ru) |
MX (1) | MX9205620A (ru) |
NO (1) | NO304599B1 (ru) |
NZ (1) | NZ244557A (ru) |
PT (1) | PT100920B (ru) |
RU (1) | RU2130938C1 (ru) |
SK (1) | SK37594A3 (ru) |
WO (1) | WO1993007154A1 (ru) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5646163A (en) * | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
EP0661030B1 (en) * | 1993-12-28 | 2000-07-12 | Kao Corporation | Sanitary napkin |
PT775114E (pt) * | 1994-08-02 | 2000-09-29 | Procter & Gamble | Processo para produzir compostos antimicrobianos |
KR100239200B1 (ko) * | 1994-08-02 | 2000-03-02 | 데이비드 엠 모이어 | 퀴놀로닐 락탐 항생제의 제조 방법 및 신규 중간체 화합물 |
US5607928A (en) * | 1994-08-05 | 1997-03-04 | Zeneca Limited | Carbapenem derivatives containing a bicyclic ketone substituent and their use as anti-infectives |
EP0695753A1 (en) * | 1994-08-05 | 1996-02-07 | Zeneca Limited | Carbapenem derivatives containing a bicyclic substituent, process for their preparation, and their use |
US5693791A (en) * | 1995-04-11 | 1997-12-02 | Truett; William L. | Antibiotics and process for preparation |
WO1999028308A1 (en) * | 1997-11-29 | 1999-06-10 | Truett William L | Antibiotics and process for preparation |
US6437119B1 (en) | 1998-05-07 | 2002-08-20 | William Lawrence Truett | Compounds formed from two or three antibiotics and their processes of preparation |
US6638908B1 (en) * | 2000-08-09 | 2003-10-28 | Yale University | Crystals of the large ribosomal subunit |
US6947844B2 (en) * | 2000-08-09 | 2005-09-20 | Yale University | Modulators of ribosomal function and identification thereof |
IN191798B (ru) | 2000-11-03 | 2004-01-03 | Ranbaxy Lab Ltd | |
ATE257468T1 (de) | 2001-03-30 | 2004-01-15 | Dar Al Dawa Dev And Invest Co | Chinolin-4-on derivate und deren verwendung als antibiotika |
US6952650B2 (en) | 2001-08-03 | 2005-10-04 | Yale University | Modulators of ribosomal function and identification thereof |
IL151012A0 (en) | 2001-08-03 | 2003-02-12 | Ribosomes Structure And Protei | Ribosomes structure and protein synthesis inhibitors |
AR043050A1 (es) | 2002-09-26 | 2005-07-13 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos bifuncionales y metodos para preparar y usar los mismos |
CN1780846A (zh) * | 2003-03-05 | 2006-05-31 | Rib-X医药品有限公司 | 双官能杂环化合物及其制备和使用方法 |
US20070149463A1 (en) * | 2003-10-30 | 2007-06-28 | Oyelere Adegboyega K | Bifunctional macrolide heterocyclic compounds and methods of making and using the same |
JP2007512256A (ja) * | 2003-11-18 | 2007-05-17 | リブ−エックス ファーマシューティカルズ,インコーポレイテッド | 二官能性マクロライド複素環化合物ならびにこれらを製造する方法およびこれらを使用する方法 |
EP1723159B1 (en) | 2004-02-27 | 2019-06-12 | Melinta Therapeutics, Inc. | Macrocyclic compounds and methods of making and using the same |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT49889A (en) * | 1988-03-31 | 1989-11-28 | Hoffmann La Roche | Process for producing acyl derivatives |
EP0366193A3 (en) * | 1988-10-24 | 1992-01-08 | Norwich Eaton Pharmaceuticals, Inc. | Novel antimicrobial quinolonyl lactams |
DE68928925T2 (de) * | 1988-10-24 | 1999-08-26 | Procter & Gamble Pharma | Antimikrobielle Fluorochinolonylcephemderivate |
EP0997466A1 (en) * | 1988-10-24 | 2000-05-03 | PROCTER & GAMBLE PHARMACEUTICALS, INC. | Novel antimicrobial lactam-quinolones |
SG67307A1 (en) * | 1988-10-24 | 1999-09-21 | Procter & Gamble Pharma | Novel antimicrobial quinolonyl lactam esters |
ZA912279B (en) * | 1990-04-09 | 1992-02-26 | Hoffmann La Roche | Carbapenem compounds |
DK0525057T3 (da) * | 1990-04-18 | 2000-07-31 | Procter & Gamble Pharma | Antimikrobielle quinolonyllactamer |
-
1992
- 1992-09-28 BR BR9206590A patent/BR9206590A/pt not_active Application Discontinuation
- 1992-09-28 CZ CS94731A patent/CZ73194A3/cs unknown
- 1992-09-28 CA CA002120493A patent/CA2120493A1/en not_active Abandoned
- 1992-09-28 DK DK92920743.9T patent/DK0606336T3/da active
- 1992-09-28 RU RU94018240A patent/RU2130938C1/ru active
- 1992-09-28 KR KR1019940701029A patent/KR100253825B1/ko not_active IP Right Cessation
- 1992-09-28 DE DE69218445T patent/DE69218445T2/de not_active Expired - Fee Related
- 1992-09-28 AT AT92920743T patent/ATE150463T1/de not_active IP Right Cessation
- 1992-09-28 SK SK375-94A patent/SK37594A3/sk unknown
- 1992-09-28 HU HU9400940A patent/HUT67423A/hu unknown
- 1992-09-28 EP EP92920743A patent/EP0606336B1/en not_active Expired - Lifetime
- 1992-09-28 WO PCT/US1992/008246 patent/WO1993007154A1/en not_active Application Discontinuation
- 1992-09-28 ES ES92920743T patent/ES2101119T3/es not_active Expired - Lifetime
- 1992-09-28 AU AU26938/92A patent/AU667837B2/en not_active Ceased
- 1992-09-30 MX MX9205620A patent/MX9205620A/es not_active IP Right Cessation
- 1992-09-30 NZ NZ244557A patent/NZ244557A/en unknown
- 1992-09-30 CN CN92112821A patent/CN1046523C/zh not_active Expired - Fee Related
- 1992-10-01 PT PT100920A patent/PT100920B/pt not_active IP Right Cessation
-
1993
- 1993-05-07 US US08/059,529 patent/US5281703A/en not_active Expired - Fee Related
-
1994
- 1994-03-25 NO NO941108A patent/NO304599B1/no not_active IP Right Cessation
- 1994-03-30 FI FI941490A patent/FI941490A/fi unknown
-
1997
- 1997-04-22 GR GR970400889T patent/GR3023227T3/el unknown
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