RU93055352A - Способ получения 5-замещенных пирроло /2,3-d/ пиримидинов - Google Patents
Способ получения 5-замещенных пирроло /2,3-d/ пиримидиновInfo
- Publication number
- RU93055352A RU93055352A RU93055352/04A RU93055352A RU93055352A RU 93055352 A RU93055352 A RU 93055352A RU 93055352/04 A RU93055352/04 A RU 93055352/04A RU 93055352 A RU93055352 A RU 93055352A RU 93055352 A RU93055352 A RU 93055352A
- Authority
- RU
- Russia
- Prior art keywords
- pyrimidines
- producing
- substituted pyrrolo
- pyrrolo
- substituted
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- -1 5-substituted pyrrolo [2,3-d] pyrimidines Chemical class 0.000 claims 1
- JJTNLWSCFYERCK-UHFFFAOYSA-N 7H-pyrrolo[2,3-d]pyrimidine Chemical compound N1=CN=C2NC=CC2=C1 JJTNLWSCFYERCK-UHFFFAOYSA-N 0.000 claims 1
- 239000000543 intermediate Substances 0.000 claims 1
Claims (1)
- Предлагаются способы получения 5-замещенных пирроло [2,3-d] пиримидинов, которые могут быть использованы в качестве полупродуктов для получения пирроло [2,3-d] пиримидиновых противоопухолевых агентов или самих противоопухолевых агентов.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95151592A | 1992-09-25 | 1992-09-25 | |
| US07/951,515 | 1992-09-25 | ||
| US07/951515 | 1992-09-25 | ||
| US08/066,831 US5416211A (en) | 1992-09-25 | 1993-05-24 | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
| US08/066,831 | 1993-05-24 | ||
| US08/066831 | 1993-05-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93055352A true RU93055352A (ru) | 1996-12-27 |
| RU2127274C1 RU2127274C1 (ru) | 1999-03-10 |
Family
ID=26747196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93055352A RU2127274C1 (ru) | 1992-09-25 | 1993-09-20 | СПОСОБ ПОЛУЧЕНИЯ 5-ЗАМЕЩЕННЫХ ПИРРОЛО (2,3-α)ПИРИМИДИНОВ |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US5663339A (ru) |
| EP (1) | EP0589720A3 (ru) |
| JP (1) | JPH06211862A (ru) |
| CN (1) | CN1038415C (ru) |
| AU (1) | AU667568B2 (ru) |
| BR (1) | BR9303876A (ru) |
| CA (1) | CA2106630A1 (ru) |
| CZ (1) | CZ283281B6 (ru) |
| FI (2) | FI105032B (ru) |
| HU (1) | HUT70208A (ru) |
| IL (1) | IL107041A (ru) |
| MX (1) | MX9305833A (ru) |
| MY (1) | MY111886A (ru) |
| NO (1) | NO180587C (ru) |
| NZ (1) | NZ248725A (ru) |
| PL (1) | PL173738B1 (ru) |
| RU (1) | RU2127274C1 (ru) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000516961A (ja) * | 1996-08-30 | 2000-12-19 | イーライ・リリー・アンド・カンパニー | 非古典的ピロロ［２，３―ｄ］ピリミジン抗葉酸物質 |
| US7863444B2 (en) | 1997-03-19 | 2011-01-04 | Abbott Laboratories | 4-aminopyrrolopyrimidines as kinase inhibitors |
| TR200001220T2 (tr) * | 1997-09-26 | 2001-05-21 | Eli Lilly And Company | Antifolatlar yapmak için yararlı işlemler ve aramaddeler. |
| US6262262B1 (en) * | 1997-09-26 | 2001-07-17 | Eli Lilly And Company | Processes and intermediates useful to make antifolates |
| US6713474B2 (en) | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| US7071199B1 (en) | 1999-09-17 | 2006-07-04 | Abbott Gmbh & Cco. Kg | Kinase inhibitors as therapeutic agents |
| MXPA03009020A (es) * | 2001-04-04 | 2004-02-17 | Bionumerik Pharmaceuticals Inc | Proceso para acoplar aminoacidos a estructura nuclear de antifolato. |
| CN100344615C (zh) * | 2004-11-25 | 2007-10-24 | 重庆医药工业研究院有限责任公司 | 制备N－(吡咯并[2,3－d]嘧啶－5－基)酰基谷氨酸衍生物的方法及中间体 |
| KR20090052355A (ko) * | 2006-08-14 | 2009-05-25 | 시코르, 인크. | 순도가 높은 페메트렉세드 이산 및 이의 제조 방법 |
| EP2008995B1 (en) | 2007-06-29 | 2013-09-11 | Ricoh Company, Ltd. | Azo compound and method of preparing the azo compound |
| CN101417998B (zh) | 2007-10-24 | 2012-10-24 | 重庆医药工业研究院有限责任公司 | 一种培美曲塞盐的纯化方法 |
| WO2012056285A1 (en) * | 2010-10-25 | 2012-05-03 | Fresenius Kabi Oncology Ltd. | An improved process for the preparation of pemetrexed |
| CN103030640B (zh) * | 2012-06-11 | 2015-04-22 | 江苏豪森医药集团连云港宏创医药有限公司 | 一种培美曲塞或其盐的制备方法 |
| ITRM20120398A1 (it) * | 2012-08-08 | 2014-02-09 | Berlin Chemie Ag | Procedimento di sintesi pemetrexed e suo sale di lisina. |
| EP2997031A1 (en) | 2013-05-17 | 2016-03-23 | Instytut Farmaceutyczny | Process for the preparation of high purity amorphous pemetrexed disodium and crystalline forms of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3- d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid |
| NZ630292A (en) | 2013-11-25 | 2015-02-27 | Shilpa Medicare Ltd | Process for crystalline pemetrexed dipotassium salt |
| CN109721604B (zh) * | 2019-01-25 | 2021-03-23 | 南京亚东启天药业有限公司 | 培美曲塞酸的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO169490C (no) * | 1988-03-24 | 1992-07-01 | Takeda Chemical Industries Ltd | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater |
| JP2983254B2 (ja) * | 1989-06-14 | 1999-11-29 | 武田薬品工業株式会社 | ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体 |
| KR0162654B1 (ko) * | 1989-12-11 | 1998-11-16 | 알렌 제이. 시니스갤리 | N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체 |
| EP0530537B1 (en) * | 1991-08-12 | 1997-01-08 | Takeda Chemical Industries, Ltd. | Condensed pyrimidine derivatives, their production and use as antitumor agents |
| JP3144903B2 (ja) * | 1991-08-21 | 2001-03-12 | エーザイ株式会社 | 縮合ピリミジン誘導体 |
| US5235053A (en) * | 1992-06-22 | 1993-08-10 | Eli Lilly And Company | Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates |
| US5416211A (en) * | 1992-09-25 | 1995-05-16 | Eli Lilly And Company | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
| US5278307A (en) * | 1992-09-25 | 1994-01-11 | Eli Lilly And Company | Process for preparing 4-hydroxypyrrolo(2,3-d)pyrimidine based antifolate compounds and intermediates |
| US5426187A (en) * | 1993-11-30 | 1995-06-20 | Eli Lilly And Company | Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates |
-
1993
- 1993-09-20 HU HU9302654A patent/HUT70208A/hu unknown
- 1993-09-20 IL IL10704193A patent/IL107041A/xx not_active IP Right Cessation
- 1993-09-20 RU RU93055352A patent/RU2127274C1/ru active
- 1993-09-20 CZ CZ931952A patent/CZ283281B6/cs not_active IP Right Cessation
- 1993-09-21 NZ NZ248725A patent/NZ248725A/en unknown
- 1993-09-21 MY MYPI93001924A patent/MY111886A/en unknown
- 1993-09-21 CA CA002106630A patent/CA2106630A1/en not_active Abandoned
- 1993-09-22 MX MX9305833A patent/MX9305833A/es active IP Right Grant
- 1993-09-23 AU AU47575/93A patent/AU667568B2/en not_active Ceased
- 1993-09-23 BR BR9303876A patent/BR9303876A/pt not_active Application Discontinuation
- 1993-09-23 NO NO933395A patent/NO180587C/no not_active IP Right Cessation
- 1993-09-24 CN CN93118292A patent/CN1038415C/zh not_active Expired - Fee Related
- 1993-09-24 PL PL93300487A patent/PL173738B1/pl unknown
- 1993-09-24 FI FI934182A patent/FI105032B/fi active
- 1993-09-24 JP JP5237842A patent/JPH06211862A/ja active Pending
- 1993-09-24 EP EP19930307593 patent/EP0589720A3/en not_active Ceased
-
1994
- 1994-12-22 US US08/362,392 patent/US5663339A/en not_active Expired - Fee Related
-
1996
- 1996-01-31 US US08/594,961 patent/US5644058A/en not_active Expired - Fee Related
- 1996-01-31 US US08/594,971 patent/US5612482A/en not_active Expired - Fee Related
-
1997
- 1997-06-30 US US08/885,268 patent/US5892034A/en not_active Expired - Fee Related
-
1998
- 1998-08-06 FI FI981709A patent/FI981709A0/fi unknown
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