RU93055352A - Способ получения 5-замещенных пирроло /2,3-d/ пиримидинов - Google Patents

Способ получения 5-замещенных пирроло /2,3-d/ пиримидинов

Info

Publication number
RU93055352A
RU93055352A RU93055352/04A RU93055352A RU93055352A RU 93055352 A RU93055352 A RU 93055352A RU 93055352/04 A RU93055352/04 A RU 93055352/04A RU 93055352 A RU93055352 A RU 93055352A RU 93055352 A RU93055352 A RU 93055352A
Authority
RU
Russia
Prior art keywords
pyrimidines
producing
substituted pyrrolo
pyrrolo
substituted
Prior art date
Application number
RU93055352/04A
Other languages
English (en)
Other versions
RU2127274C1 (ru
Inventor
Джексон Барнетт Чарльз
Майкл Вилсон Томас
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/066,831 external-priority patent/US5416211A/en
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of RU93055352A publication Critical patent/RU93055352A/ru
Application granted granted Critical
Publication of RU2127274C1 publication Critical patent/RU2127274C1/ru

Links

Claims (1)

  1. Предлагаются способы получения 5-замещенных пирроло [2,3-d] пиримидинов, которые могут быть использованы в качестве полупродуктов для получения пирроло [2,3-d] пиримидиновых противоопухолевых агентов или самих противоопухолевых агентов.
RU93055352A 1992-09-25 1993-09-20 СПОСОБ ПОЛУЧЕНИЯ 5-ЗАМЕЩЕННЫХ ПИРРОЛО (2,3-α)ПИРИМИДИНОВ RU2127274C1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US95151592A 1992-09-25 1992-09-25
US07/951515 1992-09-25
US07/951,515 1992-09-25
US08/066,831 US5416211A (en) 1992-09-25 1993-05-24 Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
US08/066,831 1993-05-24
US08/066831 1993-05-24

Publications (2)

Publication Number Publication Date
RU93055352A true RU93055352A (ru) 1996-12-27
RU2127274C1 RU2127274C1 (ru) 1999-03-10

Family

ID=26747196

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93055352A RU2127274C1 (ru) 1992-09-25 1993-09-20 СПОСОБ ПОЛУЧЕНИЯ 5-ЗАМЕЩЕННЫХ ПИРРОЛО (2,3-α)ПИРИМИДИНОВ

Country Status (17)

Country Link
US (4) US5663339A (ru)
EP (1) EP0589720A3 (ru)
JP (1) JPH06211862A (ru)
CN (1) CN1038415C (ru)
AU (1) AU667568B2 (ru)
BR (1) BR9303876A (ru)
CA (1) CA2106630A1 (ru)
CZ (1) CZ283281B6 (ru)
FI (2) FI981709A0 (ru)
HU (1) HUT70208A (ru)
IL (1) IL107041A (ru)
MX (1) MX9305833A (ru)
MY (1) MY111886A (ru)
NO (1) NO180587C (ru)
NZ (1) NZ248725A (ru)
PL (1) PL173738B1 (ru)
RU (1) RU2127274C1 (ru)

Families Citing this family (20)

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CA2263907A1 (en) * 1996-08-30 1998-03-05 Christopher Leighon Jordan Nonclassical pyrrolo[2,3-d]pyrimidine antifolates
US7863444B2 (en) 1997-03-19 2011-01-04 Abbott Laboratories 4-aminopyrrolopyrimidines as kinase inhibitors
US6262262B1 (en) * 1997-09-26 2001-07-17 Eli Lilly And Company Processes and intermediates useful to make antifolates
TR200001220T2 (tr) * 1997-09-26 2001-05-21 Eli Lilly And Company Antifolatlar yapmak için yararlı işlemler ve aramaddeler.
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US7071199B1 (en) 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
EP1373225B1 (en) * 2001-04-04 2006-05-24 Bionumerik Pharmaceuticals, Inc. Process for coupling amino acids to an antifolate scaffold
BR0309669A (pt) * 2002-04-23 2005-03-01 Bristol Myers Squibb Co Compostos de anilina de pirrolo-triazina úteis como inibidores de cinase
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
MY145634A (en) * 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
CN100344615C (zh) * 2004-11-25 2007-10-24 重庆医药工业研究院有限责任公司 制备N－(吡咯并[2,3－d]嘧啶－5－基)酰基谷氨酸衍生物的方法及中间体
JP2008543975A (ja) * 2006-08-14 2008-12-04 シコール インコーポレイティド 高度に純粋なペメトレキセド二酸およびその調製方法
EP2008995B1 (en) 2007-06-29 2013-09-11 Ricoh Company, Ltd. Azo compound and method of preparing the azo compound
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
WO2012056285A1 (en) * 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed
CN103030640B (zh) * 2012-06-11 2015-04-22 江苏豪森医药集团连云港宏创医药有限公司 一种培美曲塞或其盐的制备方法
ITRM20120398A1 (it) * 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
EP2997031A1 (en) 2013-05-17 2016-03-23 Instytut Farmaceutyczny Process for the preparation of high purity amorphous pemetrexed disodium and crystalline forms of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3- d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid
NZ630292A (en) 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
CN109721604B (zh) * 2019-01-25 2021-03-23 南京亚东启天药业有限公司 培美曲塞酸的制备方法

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
DE69216509T2 (de) * 1991-08-12 1997-05-28 Takeda Chemical Industries Ltd Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
JP3144903B2 (ja) * 1991-08-21 2001-03-12 エーザイ株式会社 縮合ピリミジン誘導体
US5235053A (en) * 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
US5278307A (en) * 1992-09-25 1994-01-11 Eli Lilly And Company Process for preparing 4-hydroxypyrrolo(2,3-d)pyrimidine based antifolate compounds and intermediates
US5426187A (en) * 1993-11-30 1995-06-20 Eli Lilly And Company Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates

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