RU93004992A - Фенилсульфонамидные соединения и способ лечения - Google Patents

Фенилсульфонамидные соединения и способ лечения

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Publication number
RU93004992A
RU93004992A RU93004992/04A RU93004992A RU93004992A RU 93004992 A RU93004992 A RU 93004992A RU 93004992/04 A RU93004992/04 A RU 93004992/04A RU 93004992 A RU93004992 A RU 93004992A RU 93004992 A RU93004992 A RU 93004992A
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RU
Russia
Prior art keywords
compounds
phenylsulphonamide
treatment method
hydrogen
formula
Prior art date
Application number
RU93004992/04A
Other languages
English (en)
Other versions
RU2133742C1 (ru
Inventor
Муругесан Натесан
Т. Хант Джон
Original Assignee
Е.Р. Сквибб энд Санз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Е.Р. Сквибб энд Санз Инк. filed Critical Е.Р. Сквибб энд Санз Инк.
Publication of RU93004992A publication Critical patent/RU93004992A/ru
Application granted granted Critical
Publication of RU2133742C1 publication Critical patent/RU2133742C1/ru

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Claims (1)

  1. Соединения формулы
    Figure 00000001

    ингибируют активность эндоталина. Символы в приведенной формуле определяются следующим образом: R1, R2 и R3 каждый независимо представляют: (a) водород, за исключением того, что R1 является иным, чем водород; (b) алкил, алкенил, алкинил, алкокси, циклоалкил, циклоалкилалкил, циклоалкенил, циклоалкенилалкил; арил, арилокси аралкил или аралкокси, любой из которых может быть замещен заместителем z1, z2, z3. (c) галоид; (d) гидроксил; (e) циано; (f) нитро; (q)H(О) -С(О)Н или -CО2R6; (h) -CO2H или -CO2R6; (i) -SH, -S(O)nR6, -S(O)m-OH, -S(O)m-OR6, -O-S(O)m-R6, O-S(O)mOH или -O-S(O)m-OR6; (j) = z4-NR2R8; или (k) - z4-N(R1 1)-z5-NR9R1 0; а остальные символы имеют значения, определенные выше.
RU93004992A 1992-05-06 1993-05-05 Фенилсульфонамидные производные изоксазола и способ лечения RU2133742C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87900092A 1992-05-06 1992-05-06
US879.000 1992-05-06
US879,000 1992-05-06

Publications (2)

Publication Number Publication Date
RU93004992A true RU93004992A (ru) 1996-01-27
RU2133742C1 RU2133742C1 (ru) 1999-07-27

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Family Applications (1)

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RU93004992A RU2133742C1 (ru) 1992-05-06 1993-05-05 Фенилсульфонамидные производные изоксазола и способ лечения

Country Status (22)

Country Link
EP (1) EP0569193B1 (ru)
JP (1) JP3286391B2 (ru)
KR (1) KR100277454B1 (ru)
CN (1) CN1066441C (ru)
AT (1) ATE149155T1 (ru)
AU (1) AU659545B2 (ru)
CA (1) CA2095174A1 (ru)
CY (1) CY2016A (ru)
DE (1) DE69308229T2 (ru)
DK (1) DK0569193T3 (ru)
ES (1) ES2100459T3 (ru)
FI (1) FI112655B (ru)
GR (1) GR3023421T3 (ru)
HK (1) HK98197A (ru)
HU (1) HU218938B (ru)
IL (1) IL105481A (ru)
MX (1) MX9302618A (ru)
NO (1) NO303065B1 (ru)
NZ (1) NZ247440A (ru)
PL (1) PL178165B1 (ru)
RU (1) RU2133742C1 (ru)
ZA (1) ZA932914B (ru)

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