ES8404338A1 - Procedimiento para la obtencion de oxazolidin-2-onas. - Google Patents

Procedimiento para la obtencion de oxazolidin-2-onas.

Info

Publication number
ES8404338A1
ES8404338A1 ES519809A ES519809A ES8404338A1 ES 8404338 A1 ES8404338 A1 ES 8404338A1 ES 519809 A ES519809 A ES 519809A ES 519809 A ES519809 A ES 519809A ES 8404338 A1 ES8404338 A1 ES 8404338A1
Authority
ES
Spain
Prior art keywords
atoms
case
ones
cycloalkyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519809A
Other languages
English (en)
Other versions
ES519809A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES519809A0 publication Critical patent/ES519809A0/es
Publication of ES8404338A1 publication Critical patent/ES8404338A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE OXAZOLIDIN-2-ONAS, DE FORMULA (I), EN LA QUE X Y R PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE HALOGENOMETILIZACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R TIENE EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), POR TRATAMIENTO CON FORMALDEHIDO, PARAFORMALDEHIDO O METILAL EN PRESENCIA DEL CORRESPONDIENTE HIDRAZIDO HALOGENADO, EN UN DISOLVENTE INERTE, A LA TEMPERATURA ENTRE C20JC Y 120JC.TAMBIEN SE PUEDE EFECTUAR LA HALOGENACION DE UN COMPUESTO DE FORMULA (III) EN LA QUE R ES EL MISMO QUE EN LA FORMULA (I),POR TRATAMIENTO CON CLORURO O BROMURO DE SULFURILO, A TEMPERATURA ENTRE 100JC Y 150JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CARDIACAS, DE LA CIRCULACION Y DE LOS VASOS.
ES519809A 1982-02-16 1983-02-15 Procedimiento para la obtencion de oxazolidin-2-onas. Expired ES8404338A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823205457 DE3205457A1 (de) 1982-02-16 1982-02-16 Oxazolidin-2-one

Publications (2)

Publication Number Publication Date
ES519809A0 ES519809A0 (es) 1984-04-16
ES8404338A1 true ES8404338A1 (es) 1984-04-16

Family

ID=6155839

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519809A Expired ES8404338A1 (es) 1982-02-16 1983-02-15 Procedimiento para la obtencion de oxazolidin-2-onas.

Country Status (10)

Country Link
EP (1) EP0086403A3 (es)
JP (1) JPS58152872A (es)
AU (1) AU553328B2 (es)
CA (1) CA1198116A (es)
DE (1) DE3205457A1 (es)
ES (1) ES8404338A1 (es)
HU (1) HU188531B (es)
IL (1) IL67907A (es)
PT (1) PT76229A (es)
ZA (1) ZA83993B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1323370C (en) * 1986-09-12 1993-10-19 Davis H. Crater Fluorochemical oxazolidinones
KR0146931B1 (ko) * 1992-04-30 1998-08-17 고바야시 유끼오 옥사졸리딘 유도체 및 그의 약학적으로 허용가능한 염
DK0710657T3 (da) * 1994-11-02 1999-05-25 Merck Patent Gmbh Adhæsionsreceptor-antagonister
WO2010061366A1 (en) * 2008-11-28 2010-06-03 Corden Pharma Ip Limited Manufacture of bisoprolol and intermediates therefor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB834968A (en) * 1957-08-28 1960-05-18 Robins Co Inc A H 5-o-alkoxyphenoxymethyl-2-oxazolidones
FR1284520A (fr) * 1958-11-03 1962-02-16 American Cyanamid Co Procédé de préparation de nouveaux composés de 2-oxazolidinones
US3299088A (en) * 1959-06-19 1967-01-17 Robins Co Inc A H Halo-substituted phenoxymethyl oxazolidones
US3062828A (en) * 1962-02-27 1962-11-06 Robins Co Inc A H 5-(alkoxyphenoxymethyl)-2-oxazolidones
CH484172A (de) * 1965-07-09 1970-01-15 Ciba Geigy Verfahren zur Herstellung eines neuen Oxazolidinons
CH484173A (de) * 1965-07-09 1970-01-15 Ciba Geigy Verfahren zur Herstellung eines neuen Oxazolidinons
CH462815A (de) * 1965-11-17 1968-09-30 Ciba Geigy Verfahren zur Herstellung von neuen heterocyclischen Verbindungen
FR2038200A1 (es) * 1969-04-03 1971-01-08 Ciba Geigy Ag
FR2338268A1 (fr) * 1976-01-16 1977-08-12 Nativelle Spa Nouveaux derives d'oxazolidinone, preparation et application a la synthese d'aryloxypropanolamines

Also Published As

Publication number Publication date
JPS58152872A (ja) 1983-09-10
ZA83993B (en) 1983-11-30
EP0086403A2 (de) 1983-08-24
AU553328B2 (en) 1986-07-10
IL67907A (en) 1986-10-31
IL67907A0 (en) 1983-06-15
CA1198116A (en) 1985-12-17
ES519809A0 (es) 1984-04-16
EP0086403A3 (de) 1984-10-10
AU1087683A (en) 1983-08-25
PT76229A (en) 1983-03-01
HU188531B (en) 1986-04-28
DE3205457A1 (de) 1983-08-25

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