HK98197A - N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists - Google Patents

N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists

Info

Publication number
HK98197A
HK98197A HK98197A HK98197A HK98197A HK 98197 A HK98197 A HK 98197A HK 98197 A HK98197 A HK 98197A HK 98197 A HK98197 A HK 98197A HK 98197 A HK98197 A HK 98197A
Authority
HK
Hong Kong
Prior art keywords
isoxazole
endothelin antagonists
hydrogen
phenylsulfonamide derivatives
phenylsulfonamide
Prior art date
Application number
HK98197A
Other languages
English (en)
Inventor
Natesan Murugesan
John T Hunt
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of HK98197A publication Critical patent/HK98197A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C07D261/16—Benzene-sulfonamido isoxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK98197A 1992-05-06 1997-06-26 N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists HK98197A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87900092A 1992-05-06 1992-05-06

Publications (1)

Publication Number Publication Date
HK98197A true HK98197A (en) 1997-08-08

Family

ID=25373236

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98197A HK98197A (en) 1992-05-06 1997-06-26 N-isoxazole-phenylsulfonamide derivatives and their use as endothelin antagonists

Country Status (22)

Country Link
EP (1) EP0569193B1 (xx)
JP (1) JP3286391B2 (xx)
KR (1) KR100277454B1 (xx)
CN (1) CN1066441C (xx)
AT (1) ATE149155T1 (xx)
AU (1) AU659545B2 (xx)
CA (1) CA2095174A1 (xx)
CY (1) CY2016A (xx)
DE (1) DE69308229T2 (xx)
DK (1) DK0569193T3 (xx)
ES (1) ES2100459T3 (xx)
FI (1) FI112655B (xx)
GR (1) GR3023421T3 (xx)
HK (1) HK98197A (xx)
HU (1) HU218938B (xx)
IL (1) IL105481A (xx)
MX (1) MX9302618A (xx)
NO (1) NO303065B1 (xx)
NZ (1) NZ247440A (xx)
PL (1) PL178165B1 (xx)
RU (1) RU2133742C1 (xx)
ZA (1) ZA932914B (xx)

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US6342610B2 (en) 1993-05-20 2002-01-29 Texas Biotechnology Corp. N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
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Also Published As

Publication number Publication date
ES2100459T3 (es) 1997-06-16
KR930023337A (ko) 1993-12-18
CA2095174A1 (en) 1993-11-07
IL105481A0 (en) 1993-08-18
CN1066441C (zh) 2001-05-30
KR100277454B1 (ko) 2001-01-15
NZ247440A (en) 1995-04-27
DE69308229D1 (de) 1997-04-03
IL105481A (en) 1996-12-05
FI932052A0 (fi) 1993-05-06
CN1084515A (zh) 1994-03-30
ZA932914B (en) 1993-11-12
DK0569193T3 (xx) 1997-03-17
FI932052A (fi) 1993-11-07
EP0569193A1 (en) 1993-11-10
ATE149155T1 (de) 1997-03-15
HU9301305D0 (en) 1993-09-28
HUT65751A (en) 1994-07-28
AU659545B2 (en) 1995-05-18
NO931638D0 (no) 1993-05-05
PL298828A1 (en) 1993-12-27
JP3286391B2 (ja) 2002-05-27
DE69308229T2 (de) 1997-07-17
FI112655B (fi) 2003-12-31
MX9302618A (es) 1994-05-31
GR3023421T3 (en) 1997-08-29
AU3838293A (en) 1993-11-11
RU2133742C1 (ru) 1999-07-27
CY2016A (en) 1998-02-20
JPH0649046A (ja) 1994-02-22
NO303065B1 (no) 1998-05-25
PL178165B1 (pl) 2000-03-31
HU218938B (hu) 2001-01-29
EP0569193B1 (en) 1997-02-26
NO931638L (no) 1993-11-08

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Legal Events

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20040429

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)