RU92016479A - Применение 5,10,15,20-тетракис (4-карбоксифенил) порфина для обнаружения и лечения рака легких - Google Patents
Применение 5,10,15,20-тетракис (4-карбоксифенил) порфина для обнаружения и лечения рака легкихInfo
- Publication number
- RU92016479A RU92016479A RU92016479/14A RU92016479A RU92016479A RU 92016479 A RU92016479 A RU 92016479A RU 92016479/14 A RU92016479/14 A RU 92016479/14A RU 92016479 A RU92016479 A RU 92016479A RU 92016479 A RU92016479 A RU 92016479A
- Authority
- RU
- Russia
- Prior art keywords
- porphine
- carboxyphenyl
- tetrakis
- detection
- lung cancer
- Prior art date
Links
- HJCNSOVRAZFJLK-UHFFFAOYSA-N C1=CC(C(=O)O)=CC=C1C1=CC2=CC([N]3)=CC=C3C=C(C=C3)NC3=CC([N]3)=CC=C3C=C1N2 Chemical compound C1=CC(C(=O)O)=CC=C1C1=CC2=CC([N]3)=CC=C3C=C(C=C3)NC3=CC([N]3)=CC=C3C=C1N2 HJCNSOVRAZFJLK-UHFFFAOYSA-N 0.000 title claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 title claims 2
- 238000001514 detection method Methods 0.000 title claims 2
- 201000005202 lung cancer Diseases 0.000 title claims 2
- 239000000700 tracer Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 238000003325 tomography Methods 0.000 claims 2
- 210000004072 Lung Anatomy 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- RYGMFSIKBFXOCR-IGMARMGPSA-N copper-64 Chemical compound [64Cu] RYGMFSIKBFXOCR-IGMARMGPSA-N 0.000 claims 1
- RYGMFSIKBFXOCR-AKLPVKDBSA-N copper-67 Chemical compound [67Cu] RYGMFSIKBFXOCR-AKLPVKDBSA-N 0.000 claims 1
- 230000003211 malignant Effects 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
Claims (1)
- Применение 5,10,15,20-тетракис(4-карбоксифенил)порфина в качестве флуоресцентного трасера для обнаружения рака легких, а также в качестве радиотрасера в виде его комплекса с Cu-67. Этот комплекс является также источником бета-излучения для селективной деструкции злокачественных образований в легких и источником гамма-излучения, которое можно использовать для анализа изображений мест злокачественных образований, полученных, например с помощью фотонной томографии; оба способа предусматривают их использование in vivo. В случае, когда интерес представляет применение комплекса только в качестве радиотрасера, изотоп меди-67 можно заменить на медь-64. Этот более легкий изотоп меди является источником позитронов и следовательно для обнаружения злокачественных тканей можно использовать метод позитронной томографии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/539,999 US5162231A (en) | 1989-10-25 | 1990-06-15 | Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung |
| US539.999 | 1990-06-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU92016479A true RU92016479A (ru) | 1995-05-10 |
| RU2114430C1 RU2114430C1 (ru) | 1998-06-27 |
Family
ID=24153544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU92016479A RU2114430C1 (ru) | 1990-06-15 | 1991-06-17 | Способ обнаружения и лечения рака легких |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5162231A (ru) |
| EP (1) | EP0533845B1 (ru) |
| JP (1) | JP3047468B2 (ru) |
| KR (1) | KR0171393B1 (ru) |
| AT (1) | ATE251750T1 (ru) |
| AU (2) | AU8061491A (ru) |
| BR (1) | BR9106563A (ru) |
| CA (1) | CA2085464C (ru) |
| DE (1) | DE69133325T2 (ru) |
| DK (1) | DK0533845T3 (ru) |
| FI (1) | FI925673A0 (ru) |
| HU (1) | HUT63499A (ru) |
| NO (1) | NO924820L (ru) |
| RU (1) | RU2114430C1 (ru) |
| WO (2) | WO1991019978A1 (ru) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622685A (en) * | 1990-05-30 | 1997-04-22 | Deutches Krebsforchunszentrum Stiftung Des Offentlichen Rechts | Polyether-substituted porphyrin anti-tumor agents |
| US5252698A (en) * | 1992-10-09 | 1993-10-12 | Sri International | Metal ion porphyrin-containing poly(azine) |
| US5464741A (en) * | 1993-10-08 | 1995-11-07 | Henwell, Inc. | Palladium (II) octaethylporphine alpha-isothiocyanate as a phosphorescent label for immunoassays |
| US6490330B1 (en) * | 1994-04-12 | 2002-12-03 | The Regents Of The University Of California | Production of high specific activity copper -67 |
| US5716958A (en) * | 1994-10-27 | 1998-02-10 | Tobishi Pharmaceutical Co., Ltd. | Amino acid derivative having anti-CCK activity |
| US5756726A (en) * | 1995-06-02 | 1998-05-26 | Pharmacyclics, Inc. | Methods of producing singlet oxygen using compounds having improved functionalization |
| DE69813898T2 (de) | 1997-11-03 | 2004-03-11 | Duke University | Substituierte porphyrinen |
| US6703050B1 (en) * | 1998-09-04 | 2004-03-09 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
| MXPA01007451A (es) | 1999-01-25 | 2004-03-10 | Nat Jewish Med & Res Center | Porfirinas sustituidas. |
| US6984498B2 (en) * | 1999-12-27 | 2006-01-10 | Adair Edwin L | Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques |
| US6190877B1 (en) * | 1999-12-27 | 2001-02-20 | Edwin L. Adair | Method of cancer screening primarily utilizing non-invasive cell collection and fluorescence detection techniques |
| US6750037B2 (en) * | 1999-12-27 | 2004-06-15 | Edwin L. Adair | Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques |
| US6575888B2 (en) * | 2000-01-25 | 2003-06-10 | Biosurface Engineering Technologies, Inc. | Bioabsorbable brachytherapy device |
| KR100390771B1 (ko) * | 2000-08-31 | 2003-07-10 | 한국화학연구원 | 광역학 치료(ｐｄｔ)용 광민감성 물질로 유용한 포르피린유도체 |
| ATE541214T1 (de) | 2000-11-17 | 2012-01-15 | Biomoda Inc | Zusammensetzungen und verfahren zum nachweis von präkanzerösen bedingungen in zell- und gewebeproben unter anwendung von 5,10,15,20- tetrakis(carbophenyl)porphin |
| ATE439134T1 (de) | 2001-01-19 | 2009-08-15 | Nat Jewish Med & Res Center | Medikament zum schutz in der radiotherapie |
| WO2002098431A1 (en) | 2001-06-01 | 2002-12-12 | National Jewish Medical And Research Center | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
| US6566517B2 (en) | 2001-06-06 | 2003-05-20 | Brookhaven Science Associates, Llc | Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy |
| AU2003216502B2 (en) * | 2002-03-01 | 2008-04-10 | Sloan-Kettering Institute For Cancer Research | Prevention of recurrence and metastasis of cancer |
| CA2488500A1 (en) | 2002-06-07 | 2003-12-18 | Duke University | Substituted porphyrins |
| DE60307545T2 (de) * | 2002-06-21 | 2007-10-04 | Adair, Edwin L., Castle Pines Village | Anwendung von Metalloporphyrinen zur Behandlung von Arteriosklerose |
| NZ537896A (en) | 2002-07-23 | 2007-12-21 | Univ Michigan | Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies |
| US20070149496A1 (en) * | 2003-10-31 | 2007-06-28 | Jack Tuszynski | Water-soluble compound |
| US6989443B2 (en) * | 2004-06-28 | 2006-01-24 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| US6995260B2 (en) * | 2004-05-20 | 2006-02-07 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| US20060094682A1 (en) * | 2004-10-29 | 2006-05-04 | Odyssey Thera, Inc. | Kinase inhibitors for the treatment of diabetes and obesity |
| CN101449289B (zh) * | 2006-05-17 | 2013-04-24 | 皇家飞利浦电子股份有限公司 | 基于对成像基准的几何分析根据呼吸相位对4d ct的回顾性分类 |
| US9957293B2 (en) * | 2006-08-23 | 2018-05-01 | Yeda Research And Development Company Ltd. | Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses |
| US8287839B2 (en) * | 2006-12-04 | 2012-10-16 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| US8444953B2 (en) * | 2007-03-22 | 2013-05-21 | Brookhaven Science Associates, Llc | Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof |
| US20080279781A1 (en) * | 2007-05-10 | 2008-11-13 | Brookhaven Science Associates, Llc | Glycosylated Carboranylporphyrins and Uses Thereof |
| RU2506083C2 (ru) | 2008-05-23 | 2014-02-10 | Нэшнл Джуиш Хелт | Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ |
| ES2651068T3 (es) * | 2009-07-17 | 2018-01-24 | Bioaffinity Technologies, Inc. | Sistema y procedimiento de análisis de muestras marcadas con 5,10,15,20 tetraquis(4 carboxifenil)porfirina (TCPP) |
| MX2018015916A (es) | 2016-06-16 | 2019-03-28 | Oncoselect Therapeutics Llc | Compuestos de porfirina y composiciones útiles para el tratamiento de cáncer. |
| CN107589189B (zh) * | 2017-09-06 | 2018-07-10 | 中国农业科学院饲料研究所 | 一种氟甲喹的手性对映体的检测方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4930516B1 (en) * | 1985-11-13 | 1998-08-04 | Laser Diagnostic Instr Inc | Method for detecting cancerous tissue using visible native luminescence |
| US4783529A (en) * | 1985-12-03 | 1988-11-08 | Research Corporation Technologies | Rapid synthesis of radiolabeled porphyrin complexes for medical application |
| US4857300A (en) * | 1987-07-27 | 1989-08-15 | Cytocorp, Inc. | Cytological and histological fixative formulation and methods for using same |
-
1990
- 1990-06-15 US US07/539,999 patent/US5162231A/en not_active Expired - Lifetime
-
1991
- 1991-06-14 AU AU80614/91A patent/AU8061491A/en not_active Abandoned
- 1991-06-14 WO PCT/US1991/004267 patent/WO1991019978A1/en unknown
- 1991-06-17 AU AU81906/91A patent/AU670743B2/en not_active Ceased
- 1991-06-17 BR BR919106563A patent/BR9106563A/pt not_active IP Right Cessation
- 1991-06-17 CA CA002085464A patent/CA2085464C/en not_active Expired - Fee Related
- 1991-06-17 KR KR1019920703213A patent/KR0171393B1/ko not_active IP Right Cessation
- 1991-06-17 JP JP3512285A patent/JP3047468B2/ja not_active Expired - Fee Related
- 1991-06-17 WO PCT/US1991/004132 patent/WO1991019977A1/en active IP Right Grant
- 1991-06-17 HU HU923923A patent/HUT63499A/hu unknown
- 1991-06-17 AT AT91913465T patent/ATE251750T1/de not_active IP Right Cessation
- 1991-06-17 RU RU92016479A patent/RU2114430C1/ru not_active IP Right Cessation
- 1991-06-17 DE DE69133325T patent/DE69133325T2/de not_active Expired - Fee Related
- 1991-06-17 DK DK91913465T patent/DK0533845T3/da active
- 1991-06-17 EP EP91913465A patent/EP0533845B1/en not_active Expired - Lifetime
-
1992
- 1992-07-15 US US07/914,376 patent/US5391547A/en not_active Expired - Lifetime
- 1992-12-14 NO NO92924820A patent/NO924820L/no unknown
- 1992-12-14 FI FI925673A patent/FI925673A0/fi unknown
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