RU92016479A - Применение 5,10,15,20-тетракис (4-карбоксифенил) порфина для обнаружения и лечения рака легких - Google Patents
Применение 5,10,15,20-тетракис (4-карбоксифенил) порфина для обнаружения и лечения рака легкихInfo
- Publication number
- RU92016479A RU92016479A RU92016479/14A RU92016479A RU92016479A RU 92016479 A RU92016479 A RU 92016479A RU 92016479/14 A RU92016479/14 A RU 92016479/14A RU 92016479 A RU92016479 A RU 92016479A RU 92016479 A RU92016479 A RU 92016479A
- Authority
- RU
- Russia
- Prior art keywords
- porphine
- carboxyphenyl
- tetrakis
- detection
- lung cancer
- Prior art date
Links
- HJCNSOVRAZFJLK-UHFFFAOYSA-N C1=CC(C(=O)O)=CC=C1C1=CC2=CC([N]3)=CC=C3C=C(C=C3)NC3=CC([N]3)=CC=C3C=C1N2 Chemical compound C1=CC(C(=O)O)=CC=C1C1=CC2=CC([N]3)=CC=C3C=C(C=C3)NC3=CC([N]3)=CC=C3C=C1N2 HJCNSOVRAZFJLK-UHFFFAOYSA-N 0.000 title claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 title claims 2
- 238000001514 detection method Methods 0.000 title claims 2
- 201000005202 lung cancer Diseases 0.000 title claims 2
- 239000000700 tracer Substances 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 238000003325 tomography Methods 0.000 claims 2
- 210000004072 Lung Anatomy 0.000 claims 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
- 229910052802 copper Inorganic materials 0.000 claims 1
- 239000010949 copper Substances 0.000 claims 1
- RYGMFSIKBFXOCR-IGMARMGPSA-N copper-64 Chemical compound [64Cu] RYGMFSIKBFXOCR-IGMARMGPSA-N 0.000 claims 1
- RYGMFSIKBFXOCR-AKLPVKDBSA-N copper-67 Chemical compound [67Cu] RYGMFSIKBFXOCR-AKLPVKDBSA-N 0.000 claims 1
- 230000003211 malignant Effects 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
Claims (1)
- Применение 5,10,15,20-тетракис(4-карбоксифенил)порфина в качестве флуоресцентного трасера для обнаружения рака легких, а также в качестве радиотрасера в виде его комплекса с Cu-67. Этот комплекс является также источником бета-излучения для селективной деструкции злокачественных образований в легких и источником гамма-излучения, которое можно использовать для анализа изображений мест злокачественных образований, полученных, например с помощью фотонной томографии; оба способа предусматривают их использование in vivo. В случае, когда интерес представляет применение комплекса только в качестве радиотрасера, изотоп меди-67 можно заменить на медь-64. Этот более легкий изотоп меди является источником позитронов и следовательно для обнаружения злокачественных тканей можно использовать метод позитронной томографии.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/539,999 US5162231A (en) | 1989-10-25 | 1990-06-15 | Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung |
| US539.999 | 1990-06-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU92016479A true RU92016479A (ru) | 1995-05-10 |
| RU2114430C1 RU2114430C1 (ru) | 1998-06-27 |
Family
ID=24153544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU92016479A RU2114430C1 (ru) | 1990-06-15 | 1991-06-17 | Способ обнаружения и лечения рака легких |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5162231A (ru) |
| EP (1) | EP0533845B1 (ru) |
| JP (1) | JP3047468B2 (ru) |
| KR (1) | KR0171393B1 (ru) |
| AT (1) | ATE251750T1 (ru) |
| AU (2) | AU8061491A (ru) |
| BR (1) | BR9106563A (ru) |
| CA (1) | CA2085464C (ru) |
| DE (1) | DE69133325T2 (ru) |
| DK (1) | DK0533845T3 (ru) |
| FI (1) | FI925673A (ru) |
| HU (1) | HUT63499A (ru) |
| NO (1) | NO924820L (ru) |
| RU (1) | RU2114430C1 (ru) |
| WO (2) | WO1991019978A1 (ru) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622685A (en) * | 1990-05-30 | 1997-04-22 | Deutches Krebsforchunszentrum Stiftung Des Offentlichen Rechts | Polyether-substituted porphyrin anti-tumor agents |
| US5252698A (en) * | 1992-10-09 | 1993-10-12 | Sri International | Metal ion porphyrin-containing poly(azine) |
| US5464741A (en) * | 1993-10-08 | 1995-11-07 | Henwell, Inc. | Palladium (II) octaethylporphine alpha-isothiocyanate as a phosphorescent label for immunoassays |
| US6490330B1 (en) * | 1994-04-12 | 2002-12-03 | The Regents Of The University Of California | Production of high specific activity copper -67 |
| US5716958A (en) * | 1994-10-27 | 1998-02-10 | Tobishi Pharmaceutical Co., Ltd. | Amino acid derivative having anti-CCK activity |
| US5591422A (en) * | 1995-06-02 | 1997-01-07 | Pharmacyclics, Inc. | Texaphyrin complexes having improved functionalization |
| CA2309154C (en) | 1997-11-03 | 2010-02-16 | Duke University | Substituted porphyrins |
| US6703050B1 (en) * | 1998-09-04 | 2004-03-09 | The Regents Of The University Of Michigan | Methods and compositions for the prevention or treatment of cancer |
| DK1155019T3 (da) | 1999-01-25 | 2006-04-18 | Nat Jewish Med & Res Center | Substituerede porphyriner og deres terapeutiske anvendelse |
| US6190877B1 (en) * | 1999-12-27 | 2001-02-20 | Edwin L. Adair | Method of cancer screening primarily utilizing non-invasive cell collection and fluorescence detection techniques |
| US6750037B2 (en) * | 1999-12-27 | 2004-06-15 | Edwin L. Adair | Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques |
| US6984498B2 (en) * | 1999-12-27 | 2006-01-10 | Adair Edwin L | Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques |
| US6575888B2 (en) * | 2000-01-25 | 2003-06-10 | Biosurface Engineering Technologies, Inc. | Bioabsorbable brachytherapy device |
| KR100390771B1 (ko) * | 2000-08-31 | 2003-07-10 | 한국화학연구원 | 광역학 치료(ｐｄｔ)용 광민감성 물질로 유용한 포르피린유도체 |
| JP4307070B2 (ja) * | 2000-11-17 | 2009-08-05 | バイオモーダ・インコーポレーテツド | ５，１０，１５，２０−テトラキス（カルボキシフェニル）ポルフィンを使用する、細胞および組織サンプルにおける前がん症状を検出するための組成物および方法 |
| EP1392328B1 (en) | 2001-01-19 | 2009-08-12 | National Jewish Medical and Research Center | Medicament for protection in radiotherapy |
| WO2002098431A1 (en) | 2001-06-01 | 2002-12-12 | National Jewish Medical And Research Center | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
| US6566517B2 (en) * | 2001-06-06 | 2003-05-20 | Brookhaven Science Associates, Llc | Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy |
| EP1487983A4 (en) * | 2002-03-01 | 2007-08-15 | Sloan Kettering Inst Cancer | PREVENTING THE REPEAT AND METASTASIS OF CANCER |
| AU2003237500A1 (en) | 2002-06-07 | 2003-12-22 | Duke University | Substituted porphyrins |
| DE60307545T2 (de) * | 2002-06-21 | 2007-10-04 | Adair, Edwin L., Castle Pines Village | Anwendung von Metalloporphyrinen zur Behandlung von Arteriosklerose |
| US7888389B2 (en) | 2002-07-23 | 2011-02-15 | The Regents Of The University Of Michigan | Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies |
| US20070149496A1 (en) * | 2003-10-31 | 2007-06-28 | Jack Tuszynski | Water-soluble compound |
| US6995260B2 (en) * | 2004-05-20 | 2006-02-07 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| US6989443B2 (en) * | 2004-06-28 | 2006-01-24 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| US20060094682A1 (en) * | 2004-10-29 | 2006-05-04 | Odyssey Thera, Inc. | Kinase inhibitors for the treatment of diabetes and obesity |
| US8160675B2 (en) * | 2006-05-17 | 2012-04-17 | Koninklijke Philips Electronics N.V. | Retrospective sorting of 4D CT into breathing phases based on geometric analysis of imaging fiducials |
| US9957293B2 (en) * | 2006-08-23 | 2018-05-01 | Yeda Research And Development Company Ltd. | Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses |
| US8287839B2 (en) * | 2006-12-04 | 2012-10-16 | Brookhaven Science Associates, Llc | Carboranylporphyrins and uses thereof |
| US8444953B2 (en) * | 2007-03-22 | 2013-05-21 | Brookhaven Science Associates, Llc | Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof |
| US20080279781A1 (en) * | 2007-05-10 | 2008-11-13 | Brookhaven Science Associates, Llc | Glycosylated Carboranylporphyrins and Uses Thereof |
| ES2600469T3 (es) | 2008-05-23 | 2017-02-09 | National Jewish Health | Un compuesto para su uso en el tratamiento de lesiones asociadas con la exposición al gas fosgeno o al gas de cloro |
| CN103168234B (zh) * | 2009-07-17 | 2015-11-25 | 保爱菲技术公司 | 用于分析被5，10，15，20四(4-羧基苯基)卟吩(tcpp)标记的样品的系统和方法 |
| CA3028122A1 (en) | 2016-06-16 | 2017-12-21 | Oncoselect Therapeutics, Llc | Porphyrin compounds and compositions useful for treating cancer |
| CN107589189B (zh) * | 2017-09-06 | 2018-07-10 | 中国农业科学院饲料研究所 | 一种氟甲喹的手性对映体的检测方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4930516B1 (en) * | 1985-11-13 | 1998-08-04 | Laser Diagnostic Instr Inc | Method for detecting cancerous tissue using visible native luminescence |
| US4783529A (en) * | 1985-12-03 | 1988-11-08 | Research Corporation Technologies | Rapid synthesis of radiolabeled porphyrin complexes for medical application |
| US4857300A (en) * | 1987-07-27 | 1989-08-15 | Cytocorp, Inc. | Cytological and histological fixative formulation and methods for using same |
-
1990
- 1990-06-15 US US07/539,999 patent/US5162231A/en not_active Expired - Lifetime
-
1991
- 1991-06-14 AU AU80614/91A patent/AU8061491A/en not_active Abandoned
- 1991-06-14 WO PCT/US1991/004267 patent/WO1991019978A1/en unknown
- 1991-06-17 WO PCT/US1991/004132 patent/WO1991019977A1/en active IP Right Grant
- 1991-06-17 AU AU81906/91A patent/AU670743B2/en not_active Ceased
- 1991-06-17 EP EP91913465A patent/EP0533845B1/en not_active Expired - Lifetime
- 1991-06-17 AT AT91913465T patent/ATE251750T1/de not_active IP Right Cessation
- 1991-06-17 HU HU923923A patent/HUT63499A/hu unknown
- 1991-06-17 DE DE69133325T patent/DE69133325T2/de not_active Expired - Fee Related
- 1991-06-17 CA CA002085464A patent/CA2085464C/en not_active Expired - Fee Related
- 1991-06-17 JP JP3512285A patent/JP3047468B2/ja not_active Expired - Fee Related
- 1991-06-17 KR KR1019920703213A patent/KR0171393B1/ko not_active IP Right Cessation
- 1991-06-17 DK DK91913465T patent/DK0533845T3/da active
- 1991-06-17 RU RU92016479A patent/RU2114430C1/ru not_active IP Right Cessation
- 1991-06-17 BR BR919106563A patent/BR9106563A/pt not_active IP Right Cessation
-
1992
- 1992-07-15 US US07/914,376 patent/US5391547A/en not_active Expired - Lifetime
- 1992-12-14 NO NO92924820A patent/NO924820L/no unknown
- 1992-12-14 FI FI925673A patent/FI925673A/fi unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU92016479A (ru) | Применение 5,10,15,20-тетракис (4-карбоксифенил) порфина для обнаружения и лечения рака легких | |
| BR9106563A (pt) | Uso de 5,10,15,20-tetrakis(r-carboxifenila)porfina para detectar e tratar cancer de pulmao | |
| Woodard et al. | Expression of tissue isotope distribution | |
| Spinelli et al. | Novel biomedical applications of Cerenkov radiation and radioluminescence imaging | |
| Thorek et al. | Cerenkov imaging-a new modality for molecular imaging | |
| Carpenter et al. | Cerenkov luminescence endoscopy: improved molecular sensitivity with β−-emitting radiotracers | |
| Park et al. | Luminescence imaging using radionuclides: a potential application in molecular imaging | |
| EP0106267A3 (en) | Apparatus for the diagnosis of body structures into which a gamma-emitting radioactive isotope has been introduced | |
| DE3751809D1 (de) | Intraoperative erstellung des befundes und tumor-therapie mittels endoskop | |
| Carril et al. | Total-body scintigraphy with thallium-201 and iodine-131 in the follow-up of differentiated thyroid cancer | |
| Spinelli et al. | a novel multimodal approach to molecular imaging | |
| DE69913351D1 (de) | Metallkomplexe von chlorinderivaten zum abschirmen von röntgenstrahlen | |
| Lepanto et al. | Gallium-67 scans in children with solid tumors | |
| SE9103837D0 (sv) | Fluorescensdiagnostik av cancer utnyttjande delta-aminolevulinsyra | |
| Deveci et al. | The diagnostic efficiency of 99mTc-EDDA/HYNIC-Octreotate SPECT-CT in comparison with 111In-Pentetrotide in the detection of neuroendocrine tumours | |
| Nakajima et al. | TUMOR IMAGING WITH [111niIn] MONO‐DTPA‐ETHYLENEGLYCOL‐Ga‐DEUTEROPORPHYRIN | |
| Malan et al. | Normal variants, pitfalls and artifacts in Ga-68 DOTATATE PET/CT imaging | |
| Mc Larney et al. | Shortwave infrared detection of medical radioisotope Cerenkov luminescence. | |
| de Lima | Radioisotopes in medicine | |
| Berelowitz et al. | Gallium in the detection and localization of tumours | |
| AU8436791A (en) | Use of radioactive metal ion complexes with all-cis-1,3,5-triamino-2,4,6-cyclohexantriol and their derivates for x-ray diagnosis and in tumor therapy as well asfor producing x-ray diagnostic and tumor therapy agents | |
| Amlani et al. | The continued importance of post-therapy whole body planar imaging in the era of hybrid imaging: a pictorial review | |
| Autiero et al. | Multimodal system for in vivo tumor imaging in mice | |
| Kment et al. | Indium 111-A-bleomycin—A new tracer for imaging orofacial neoplasms | |
| Wong et al. | In vivo assessment of 111In-labeled hematoporphyrin derivative in breast tumor-bearing animals |